CTLA4-IgG reverses asthma manifestations in a mild but not in a more "severe" ongoing murine model

American Journal of Respiratory Cell and Molecular Biology

Volumn 25, Issue 6, 2001, Pages 751-760

  Deurloo, D T ^a   Van Esch, B C A M ^a   Hofstra, C L ^a   Nijkamp, F P ^a   Van Oosterhout, A J M ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; BRONCHUS; MURINAE;

EID: 0035194362     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.25.6.4607     Document Type: Article

References (36)

1. Allergy and allergic diseases: First of two parts
2. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
3. Two types of murine helper T cell clone: I. Definition according to profiles of lymphokine activities and secreted proteins
4. The role of allergy in the development of asthma
5. CD28/B7 system of T cell costimulation
6. Inhibition of T cell costimulation abrogates airway hyperresponsiveness in a murine model
7. B7-CD28/CTLA-4 costimulatory pathways are required for the development of T helper cell 2-mediated allergic airway responses to inhaled antigens
8. Costimulation through B7-2 (CD86) is required for the induction of a lung mucosal T helper cell 2 (TH2) immune response and altered airway responsiveness
9. Murine CTLA4-IgG treatment inhibits airway eosinophilia and hyperresponsiveness and attenuates IgE upregulation in a murine model of allergic asthma
10. CTLA4Ig inhibits airway eosinophilia and hyperresponsiveness by regulating the development of Th1/Th2 subsets in a murine model of asthma
11. Activation of naive, memory and effector T cells
12. Do effector and memory T helper cells also need B7 ligand costimulatory signals?
13. Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production
14. Functional responses and costimulator dependence of memory CD4+ T cells
15. Bronchoconstriction and airway hyperresponsiveness after ovalbumin inhalation in sensitized mice
16. Antigen-stimulated lung CD4+ cells produce IL-5. While lymph node CD4+ cells produce Th2 cytokines concomitant with airway eosinophilia and hyperresponsiveness
17. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography
18. Absence of late airway response despite increased airway responsiveness and eosinophilia in a murine model of asthma
19. An essential role of mast cells in the development of airway hyperresponsiveness in a murine asthma model
20. Prostaglandin D2 as a mediator of allergic asthma
21. Impact of in utero Th2 immunity on T cell deviation and subsequent immediate-type hypersensitivity in the neonate
22. CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris
23. The expanding B7 superfamily: Increasing complexity in costimulatory signals regulating T cell function
24. B7-H3: A costimulatory molecule for T cell activation and IFN-gamma production
25. B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells
26. A theory of self-nonself discrimination
27. A cell culture model for T lymphocyte clonal anergy
28. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement
29. CTLA-4 regulates tolerance induction and T cell differentiation in vivo
30. Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia
31. Prolonged allergen exposure induces structural airway changes in sensitized rats
32. Role of IgE in the development of allergic airway inflammation and airway hyperresponsiveness - A murine model
33. Differential effects of endogenous and exogenous interferon-gamma on immunoglobulin E, cellular infiltration, and airway responsiveness in a murine model of allergic asthma
34. Dynamics of eosinophil infiltration in the bronchial mucosa before and after the late asthmatic reaction
35. Glucocorticoids upregulate CD40 ligand expression and induce CD40L-dependent immunoglobulin isotype switching
36. Effect of dexamethasone and endogenous corticosterone on airway hyperresponsiveness and eosinophilia in the mouse