IL-10: A key regulator of allergic disease

Clinical and Experimental Allergy

Volumn 31, Issue 5, 2001, Pages 667-669

  Barnes, P J ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; CD4 ANTIGEN; CHEMOKINE; CORTICOSTEROID; CYCLOOXYGENASE 2; CYTOKINE; EOTAXIN; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HISTAMINE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR; INTERLEUKIN 12; INTERLEUKIN 1BETA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NITRIC OXIDE SYNTHASE; PHOSPHODIESTERASE; RANTES; RECOMBINANT INTERLEUKIN 10; THEOPHYLLINE; TISSUE INHIBITOR OF METALLOPROTEINASE; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC DISEASE; ANTIINFLAMMATORY ACTIVITY; ASTHMA; CYTOKINE PRODUCTION; DISEASE SEVERITY; EDITORIAL; GENE; GENETIC POLYMORPHISM; HUMAN; NONHUMAN; PRIORITY JOURNAL;

HUMANS; HYPERSENSITIVITY; INTERLEUKIN-10;

EID: 0034839865     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2001.01118.x     Document Type: Editorial

References (37)

1. Interleukin-10 and its receptor
2. Interleukin-10 is localized to and released by human lung mast cells
3. Interleukin (IL)-10 inhibits nuclear factor kappa B activation in human monocytes. IL-10 and IL-4 suppress cytokine synthesis by different mechanisms
4. Stimulus-specific inhibition of IL-5 by cAMP-elevating agents and IL-10 reveals differential mechanisms of action
5. Interleukin-10 does not mediate the inhibitory effect of PDE4 inhibitors and other cAMP-elevating drugs on lipopolysaccharide-induced tumor necrosis factor-α generation from human peripheral blood monocytes
6. B7/CD28-dependent IL-5 production by human resting T cells is inhibited by IL-10
7. Inhibition of induced expression of macrophage inflammatory protein-1α in human blood monocytes and alveolar macrophages by interleukin-10: Differential sensitivities in human blood monocytes and alveolar macrophages
8. Expression of RANTES in human airway epithelial cells: Effect of corticosteroids and interleukins-4, 10 and 13
9. Expression and release of interleukin-8 by human airway smooth muscle cells: Inhibition by Th2 cytokines and corticosteroids
10. Induction of eotaxin expression and release from human airway smooth muscle cells by IL-1β and TNFα: Effects of IL-10 and corticosteroids
11. Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-gamma in murine macrophages
12. Inhibition by interleukin-10 of inducible cyclooxygenase expression in lipopolysaccharide-stimulated monocytes: Its underlying mechanism in comparison with interleukin-4
13. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression
14. Regulation of interleukin-1 receptor antagonist by Th1 and Th2 cytokines
15. IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes
16. Interleukin 10 inhibits lipopolysaccharide-induced survival and cytokine production by human peripheral blood eosinophils
17. Inhibition of IgE-induced activation of human mast cells by interleukin-10
18. Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice
19. Endogenous interleukin-10 suppresses allergen-induced airway inflammation and nonspecific airway responsiveness
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23. Interleukin-10 level in sputum is reduced in bronchial asthma, COPD and in smokers
24. Inhaled corticosteroids increase IL-10 but reduce MIP-1α, GM-CSF and IFN-γ release from alveolar macrophages in asthma
25. Alveolar macrophage-induced suppression of peripheral blood mononuclear cell responsiveness is reversed by in vitro allergen exposure in bronchial asthma
26. Diminished IL-10 production in subjects with allergy after infection with influenza A virus
27. Kinetics of IL-10 production alter segmental antigen challenge of atopic asthmatic subjects
28. Increased interleukin-10 and macrophage inflammatory protein-1α release from blood monocytes ex vivo during late-phase response to allergen in asthma
29. An investigation of polymorphism in the interleukin-10 gene promoter
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31. IL-10 gene promoter polymorphisms in rheumatoid arthritis
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33. IL-10: A potential therapy for allergic inflammation?
34. Pharmacodynamics of subcutaneous recombinant human interleukin-10 in healthy volunteers
35. Adenoviral vector-mediated interleukin-10 expression in vivo: Intramuscular gene transfer inhibits cytokine responses in endotoxemia
36. Anti-inflammatory effects of theophylline: Modulation of cytokine production
37. Anti-inflammatory activities of cAMP-elevating agents: Enhancement of IL-10 synthesis and concurrent suppression of TNF production