Inhibition of mast cell tryptase by inhaled APC 366 attenuates allergen-induced late-phase airway obstruction in asthma

Journal of Allergy and Clinical Immunology

Volumn 107, Issue 6, 2001, Pages 1039-1045

  Krishna, Mamidipudi Thirumala ^a   Chauhan, Anoop ^a   Little, Louise ^a   Sampson, Karen ^a   Hawksworth, Richard ^b   Mant, Tim ^b   Djukanovic, Ratko ^b   Lee, Tak ^c   Holgate, Stephen ^b  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b Guy's Drug Research Unit Ltd   (United Kingdom)

^c GUY S HOSPITAL   (United Kingdom)

Author keywords

Airway inflammation; APC 366; Asthma; Bronchial hyperresponsiveness; Early asthmatic response; Late asthmatic response; Mast cell; Tryptase

Indexed keywords

ALLERGEN; HISTAMINE; N (1 HYDROXY 2 NAPHTHOYL)ARGINYLPROLINAMIDE; TRYPTASE;

ADULT; AEROSOL; ALLERGIC ASTHMA; AREA UNDER THE CURVE; ARTICLE; BRONCHUS HYPERREACTIVITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HUMAN; MALE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROVOCATION TEST; RANDOMIZED CONTROLLED TRIAL; SHORT COURSE THERAPY;

EID: 0035013541     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2001.115631     Document Type: Article

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