Costimulation of T cells

American Journal of Respiratory and Critical Care Medicine

Volumn 162, Issue 4 II, 2000, Pages

  Bugeon, L ^a   Dallman, M J ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CD86 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GENE PRODUCT; HYBRID PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; CELL STIMULATION; CONFERENCE PAPER; GENETIC CODE; GRAFT VERSUS HOST REACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RAT; T LYMPHOCYTE ACTIVATION;

EID: 0033767126     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.162.supplement_3.15tac5     Document Type: Conference Paper

References (49)

1. Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway
2. Regulation of interleukin-2 enhancer activity by the T cell accessory molecule CD28
3. T cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression
4. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
5. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA41g
6. Coexpression and functional cooperation of CTLA4 and CD28 on activated T lymphocytes
7. Transplantation tolerance induced by CTLA4 Ig
8. T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo
9. The complexities of T-cell costimulation: CD28 and beyond
10. CTLA4 can function as a negative regulator of T cell activation
11. CD28 and CTLA4 have opposing effects on the response of T cells to stimulation
12. Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 co-stimulation and inhibited by CTLA4
13. CTLA4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting cells
14. CTLA4-ligation blocks CD28-dependent T cell activation
15. Loss of CTLA4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA4
16. Lymphoproliferative disorders with early lethality in mice deficient in CTLA4
17. Co-stimulation in T cell responses
18. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo
19. Models of T cell anergy: Is there a common molecular mechanism?
20. Do effector and memory T cells also need B7 ligand costimulatory signals
21. Differential up-regulation of the B7-B1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen
22. Regulation of immunostimulatory function and costimulatory molecule (B7-B1 and B7-2) expression on murine dendritic cells
23. Comparative analysis of B7-B1 and B7-2 costimulatory ligands: Expression and function
24. The tissue distribution of the B7-B2 costimulator in mice: Abundant expression on dendritic cells in situ and during maturation in vitro
25. The B7 and CD28 receptor families
26. Human BT-1 (CD80) and B7-B2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA4 receptors
27. Differential effects of CTLA4 substitutions on the binding of human CD80 (B7-B1) and CD86 (B7-2)
28. Covalent dimerization of CD28/ CTLA4 and oligomerization of CD80/CD86 regulate T cell costimulatory interactions
29. CD80 (B7-B1) binds both CD28 and CTLA4 with a low affinity and very fast kinetics
30. A negative regulatory function of B7 revealed in B7-B1 transgenic mice
31. Is CTLA4 a master switch for peripheral T cell tolerance?
32. Genomic organization of the mouse B-lymphocyte activation antigen B7
33. Identification of an alternatively spliced form of the murine homologue of B7
34. Mutational analysis and an alternatively spliced product of B7 defines its CD28/ CTLA4-binding site on immunoglobulin C-like domain
35. Characterization of the murine B7-B1 genomic locus reveals an additional exon encoding an alternative cytoplasmic domain and a chromosomal location of chromosome 16, band B5
36. Alternative splicing in the control of gene expression
37. A naturally occurring soluble isoform of murine Fas generated by alternative splicing
38. Cloning and characterization of a new isoform of the interleukin 1 receptor antagonist
39. New forms of dog CD80 and CD86 transcripts that encode secreted B7 molecules
40. Detection of a soluble form of B7-B1 (CD80) in synovial fluid from patients with arthritis using monoclonal antibodies against distinct epitopes of human B7-1
41. B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFα
42. T-cell co-stimulation through B7RP-1 and ICOS
43. B7-H1 a third member of the B7 family, co-stimulates T-cell proliferation and IL-10 secretion
44. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
45. Inflammatory cytokines IFN-γ plus TNF-α induce regulated expression of CD80 (B7-B1) but not CD86 (B7-2) on murine fibroblasts
46. Suppression of murine allergic contact dermatitis by CTLA4-Ig: Tolerance induction of Th2 responses requires additional blockade of CD40-ligand
47. Structure and evolution of the extended B7 family
48. Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4-Ig plus donor-specific blood transfusion
49. Analysis of the B7 costimulatory pathway in allograft rejection