A novel transcription factor inhibitor, SP100030, inhibits cytokine gene expression, but not airway eosinophilia or hyperresponsiveness in sensitized and allergen-exposed rat

British Journal of Pharmacology

Volumn 134, Issue 5, 2001, Pages 1029-1036

  Huang, Tung Jung ^a,b   Adcock, Ian M ^b   Chung, K Fan ^b  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Airway inflammation; AP 1; Bronchial hyperresponsiveness; NF B; SP100030; Th1 and Th2 cytokines

Indexed keywords

ACETYLCHOLINE; ALLERGEN; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 5; MESSENGER RNA; PROTEIN INHIBITOR; SP 100030; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; DRUG MECHANISM; EOSINOPHILIA; GENE EXPRESSION; LUNG LAVAGE; LYMPHOCYTIC INFILTRATION; MALE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RAT; RESPIRATORY TRACT INFLAMMATION; SENSITIZATION; T LYMPHOCYTE SUBPOPULATION;

EID: 0035163864     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704344     Document Type: Article

References (50)

1. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation
2. Identification of activated T-cellslymphocytes and eosinophils in bronchial biopsies in stable atopic asthma
3. Transcription factors in asthma
4. Inflammatory mediators of asthma: An update
5. Inhibition of macrophage inflammatory protein-1 alpha expression by IL-10. Differential sensitivities in human blood monocytes and alveolar macrophages
6. Normal bronchial epithelial cells constitutively produce the antiinflammatory cytokine interleukin-10 which is down-regulated in cystic fibrosis
7. Attenuation of allergic airway inflammation in IL-4 deficient mice
8. Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysaccharide
9. Single step method of RNA isolation by acid guanidium thiocyanate-phenol chloroform extraction
10. Role of inflammation in the hyperreactivity of the airways in asthma
11. Cytokines in asthma
12. + T-lymphocyte activation in acute severe asthma. Relationship to disease severity
13. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity
14. C-fos proto-oncogen expression in bronchial biopsies of asthmatics
15. Characterization of allergen-induced bronchial hyperresponsiveness and airway inflammation in actively sensitized brown-Norway rats
16. Infection of mice with Mycobacterium bovis-Bacillus Calmette-Guerin (BCG) suppresses allergen-induced airway eosinophilia
17. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells
18. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model
19. The effect of a T cell-specific NF- B inhibitor on in vitro cytokine production and collagen-induced arthritis
20. SP100030 is a novel T-cell-specific transcription factor inhibitor that possesses immunosuppressive activity in vivo
21. T-cells subsets and activation in bronchial mucosa of sensitized Brown-Norway rats after single allergen exposure
22. Antiinterleukin-5 antibody prevents airway hyperresponsiveness in a murine model of airway sensitization
23. Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma
24. Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation
25. Activation and localization of transcription factor, nuclear factor-kappaB, in asthma
26. Alpha4 integrin-dependent eotaxin induction of bronchial hyperresponsiveness and eosinophil migration in interleukin-5 transgenic mice
27. Prevention of Th2-like cell responses by coadministration of IL-12 and IL-18 is associated with inhibition of antigen-induced airway hyperresponsiveness, eosinophilia, and serum IgE levels
28. + T-cell depletion on bronchial hyperresponsiveness and inflammation in sensitized and allergen-exposed Brown-Norway rats
29. Inhibitory effects of endogenous and exogenous interferon- on bronchial hyperresponsiveness, allergic inflammation and T-helper 2 cytokines in Brown-Norway rats
30. Differential regulation of cytokine expression after allergen exposure of sensitized rats by cyclosporin A and corticosteroids: Relationship to bronchial hyperresponsiveness
31. Evaluation of airway hyperreactivity in interleukin-5 transgenic mice
32. + T cells enhances pulmonary inflammation but not airway responsiveness after antigen challenge in rats
33. Induction of pulmonary allergic responses by antigen-specific Th2 cells
34. Effects of an antibody to interleukin-5 in a monkey model of asthma
35. Inhibitory effect of the TRFK-5 anti-IL-5 antibody in a guinea pig model of asthma
36. +T cell-mediated but MHC class II-restricted CD4+T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production
37. Effects of interleukm-5 inhibition on antigen-induced airway hyperresponsiveness and cell accumulation in guinea pigs
38. Interleukin-10
39. A novel inhibitor of nuclear factor-kappa B and activator protein-1 transcription factors in T cells suppresses host-versus-graft alloreactivity in vivo
40. Inflammation and the late phase reaction in asthma: The effect of polymorphonuclear leukocyte depletion on airways obstruction and bronchial hyperreactivity in an animal model
41. Neutrophil depletion inhibits airway hyperresponsiveness induced by ozone exposure
42. Depletion of OX-8 lymphocytes from the blood and airways using monoclonal antibodies enhances the late airway response in rats
43. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
44. Interleukin-5, eosinophils and disease
45. Structure, regulation and function of NF-kappa B
46. Interleukin-2: Inception, impact, and implications
47. Interleukin 10 inhibits lipopolysaccharide-induced survival and cytokine production by human peripheral blood eosinophils
48. Inhibitory effects of IL-10 on allergen-induced airway inflammation and airway responses in Brown-Norway rats
49. Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammation
50. Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice