Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2

Journal of Experimental Medicine

Volumn 193, Issue 2, 2001, Pages 255-261

  Hirai, Hiroyuki ^a,b   Tanaka, Kazuya ^a   Yoshie, Osamu ^c   Ogawa, Kazuyuki ^a   Kenmotsu, Kazumi ^a   Takamori, Yasushi ^a   Ichimasa, Michiko ^b   Sugamura, Kazuo ^d   Nakamura, Masataka ^e   Takano, Shoichi ^a   Nagata, Kinya ^a  

^a BML   (Japan)

^b IBARAKI UNIVERSITY   (Japan)

^c KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Allergic inflammation; Cell migration; G i type G protein; Prostanoid receptor; T cells

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; MEMBRANE RECEPTOR; PROSTAGLANDIN D2; PROSTANOID RECEPTOR;

ALLERGY; ARTICLE; BASOPHIL; CALCIUM MOBILIZATION; CELL ACTIVATION; CELL MIGRATION; CHEMOTAXIS; CONTROLLED STUDY; EOSINOPHIL; HELPER CELL; HUMAN; HUMAN CELL; INFLAMMATION; MAST CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TH2 CELL;

BASE SEQUENCE; BASOPHILS; CELL LINE; CHEMOTAXIS, LEUKOCYTE; DNA PRIMERS; EOSINOPHILS; HUMANS; PHYLOGENY; PROSTAGLANDIN D2; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; SIGNAL TRANSDUCTION; TH2 CELLS;

EID: 0035862329     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.193.2.255     Document Type: Article

References (28)

1. The molecular biology of leukocyte chemoattractant receptors
2. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
3. Cutaneous late-phase response to allergen. Mediator release and inflammatory cell infiltration
4. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
5. Selective expression of a novel surface molecule by human Th2 cells in vivo
6. CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s)
7. CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease
8. Prostanoids and their receptors
9. Molecular cloning and characterization of the human prostanoid DP receptor
10. Prostanoid receptors: Structures, properties, and functions
11. 4 receptor
12. 4 receptor BLT2. A new therapeutic target in inflammation and immunological disorders
13. 2 generation after activation of rat and human mast cells with anti-IgE
14. 2 as a mediator of allergic asthma
15. Biochemical and functional bases of the regulatory and protective roles of the human eosinophils
16. Mediators of inflammation
17. 2 to rat brain synaptic membrane
18. Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist
19. 2
20. 2
21. 2 and its analogues
22. Effects of a selective DP receptor agonist (BW 245C) and antagonist (BW A868C) on the canine colonic epithelium: An argument for a different DP receptor?
23. 2 on canine proximal colon
24. 2 causes accumulation of eosinophils in the lumen of the dog trachea
25. 2 modulates human neutrophil intracellular calcium flux and inhibits superoxide release via its ring carbonyl
26. Vasodilation in multistep paradigm of leucocyte extravasation
27. Chemokines and chemokine receptors in T-cell priming and Th1/Th2- mediated responses
28. Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine