Properties of gap junction blockers and their behavioural, cognitive and electrophysiological effects: Animal and human studies

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 33, Issue 2, 2009, Pages 181-198

  Juszczak, Grzegorz R ^a   Swiergiel, Artur H ^a,b  

^a INSTITUTE OF GENETICS AND ANIMAL BREEDING   (Poland)

^b UNIVERSITY OF GDA SK   (Poland)

Author keywords

Behaviour; Blockers; EEG; Electrical synapses; Gap junctions; Side effects

Indexed keywords

2 AMINOETHOXYDIPHENYLBORANE; ANANDAMIDE; ANESTHETIC AGENT; CARBENOXOLONE; DIPHENHYDRAMINE; ENFLURANE; FENAMIC ACID DERIVATIVE; FLUFENAMIC ACID; GLYCYRRHETINIC ACID; GLYCYRRHETINIC ACID DERIVATIVE; HALOTHANE; HEPTANOL; ISOFLURANE; MECLOFENAMIC ACID; MEFLOQUINE; MINERALOCORTICOID RECEPTOR; NIFLUMIC ACID; OCTANOL; OLEAMIDE; PHENYTOIN; PROPIONATE SODIUM; PROPIONIC ACID DERIVATIVE; PROPOFOL; QUINIDINE; QUININE; QUININE DERIVATIVE; RETINOIC ACID; SPERMINE; SULFONIC ACID DERIVATIVE; THIOPENTAL; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ADD ON THERAPY; AGITATION; ALKALOSIS; ANXIETY DISORDER; ATAXIA; AUDITORY HALLUCINATION; BEHAVIOR; BLINDNESS; BLURRED VISION; COGNITION; COLOR VISION DEFECT; COMA; CONFUSION; DELIRIUM; DELUSION; DEPRESSION; DIARRHEA; DIZZINESS; DROWSINESS; DRUG ACTIVITY; DRUG EFFECT; DRUG INDUCED HEADACHE; DYSPNEA; ELECTRIC ACTIVITY; ELECTROPHYSIOLOGY; FEVER; GAP JUNCTION; GASTROINTESTINAL SYMPTOM; HALLUCINATION; HEADACHE; HEARING; HEARING LOSS; HEART DISEASE; HEART VENTRICLE TACHYCARDIA; HEARTBURN; HEMIANOPIA; HUMAN; HYPERTENSION; INSOMNIA; INVOLUNTARY MOVEMENT; KIDNEY FAILURE; LEG SWELLING; LETHARGY; LUNG INFILTRATE; MUSCLE WEAKNESS; MYDRIASIS; NAUSEA; NERVE CELL NETWORK; NEUROSCIENCE; NEUROTOXICITY; NIGHTMARE; NONHUMAN; NYSTAGMUS; OPHTHALMOPLEGIA; PANIC; PARALYSIS; PARESIS; PARESTHESIA; PLEURA EFFUSION; POTASSIUM DEPLETION; POTASSIUM EXCRETION; PSYCHOSIS; RASH; RESPIRATORY DISTRESS; RESTLESSNESS; REVIEW; RHEUMATIC DISEASE; SEIZURE; SIDE EFFECT; SLURRED SPEECH; SODIUM RETENTION; SOMNOLENCE; SWEATING; TACHYCARDIA; THORAX PAIN; TINNITUS; TREMOR; VASODILATATION; VERTIGO; VISUAL HALLUCINATION; VISUAL IMPAIRMENT; VIVID DREAM; VOMITING; WATER RETENTION; WEIGHT GAIN;

ANIMALS; BEHAVIOR; BEHAVIOR, ANIMAL; COGNITION; ELECTROPHYSIOLOGY; GAP JUNCTIONS; HUMANS;

EID: 60149107686     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2008.12.014     Document Type: Review

References (348)

1. Agarwal A.K., and Rao S.S. Effect of quinidine on kidney biochemistry and function in male Sprague-Dawley rats. Food Chem Toxicol 33 (1995) 203-207
2. Alisky J.M., Chertkova E.L., and Iczkowski K.A. Drug interactions and pharmacogenetic reactions are the basis for chloroquine and mefloquine-induced psychosis. Med Hypotheses 67 (2006) 1090-1094
3. Allison D.W., Ohran A.J., Stobbs S.H., Mameli M., Valenzuela C.F., Sudweeks S.N., et al. Connexin-36 gap junctions mediate electrical coupling between ventral tegmental area GABA neurons. Synapse (New York, N.Y 60 (2006) 20-31
4. Alloway J.A., and Salata M.P. Quinidine-induced rheumatic syndromes. Semin Arthritis Rheum 24 (1995) 315-322
5. Amabeoku G.J., and Farmer C.C. Gamma-aminobutyric acid and mefloquine-induced seizures in mice. Prog Neuropsychopharmacol Biol Psychiatry 29 (2005) 917-921
6. Ameri A. The effects of cannabinoids on the brain. Prog Neurobiol 58 (1999) 315-348
7. Amzica F. In vivo electrophysiological evidences for cortical neuron-glia interactions during slow (< 1 Hz) and paroxysmal sleep oscillations. J Physiol Paris 96 (2002) 209-219
8. Ando K., and Takada K. Trialwise tracking method for measuring drug-affected sensory threshold changes in animals. Neurobehav Toxicol 1 Suppl 1 (1979) 45-52
9. Asl M.N., and Hosseinzadeh H. Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds. Phytother Res 22 (2008) 709-724
10. Axmacher N., Elger C.E., and Fell J. Ripples in the medial temporal lobe are relevant for human memory consolidation. Brain 131 (2008) 1806-1817
11. Bai D., del Corsso C., Srinivas M., and Spray D.C. Block of specific gap junction channel subtypes by 2-aminoethoxydiphenyl borate (2-APB). J Pharmacol Exp Ther 319 (2006) 1452-1458
12. Bain L.S., and Masheter H.C. Flufenamic acid and indomethacin in rheumatoid arthritis. Ann Physic Med (1966) 104-108 Suppl
13. Ballestero J.A., Plazas P.V., Kracun S., Gomez-Casati M.E., Taranda J., Rothlin C.V., et al. Effects of quinine, quinidine, and chloroquine on alpha9alpha10 nicotinic cholinergic receptors. Mol Pharmacology 68 (2005) 822-829
14. Barraud de Lagerie S., Comets E., Gautrand C., Fernandez C., Auchere D., Singlas E., et al. Cerebral uptake of mefloquine enantiomers with and without the P-gp inhibitor elacridar (GF1210918) in mice. Br J Pharmacol 141 (2004) 1214-1222
15. Basar E., Basar-Eroglu C., Karakas S., and Schurmann M. Brain oscillations in perception and memory. Int J Psychophysiol 35 (2000) 95-124
16. Bateman D.N., and Dyson E.H. Quinine toxicity. Adverse Drug React Acute Poisoning Rev 5 (1986) 215-233
17. Baudry S., Pham Y.T., Baune B., Vidrequin S., Crevoisier C., Gimenez F., et al. Stereoselective passage of mefloquine through the blood-brain barrier in the rat. J Pharm Pharmacol 49 (1997) 1086-1090
18. Bennett M.V., and Zukin R.S. Electrical coupling and neuronal synchronization in the mammalian brain. Neuron 41 (2004) 495-511
19. Berger T., Luscher H.R., and Giugliano M. Transient rhythmic network activity in the somatosensory cortex evoked by distributed input in vitro. Neuroscience 140 (2006) 1401-1413
20. Bevans C.G., and Harris A.L. Regulation of connexin channels by pH. Direct action of the protonated form of taurine and other aminosulfonates. J Biol chem 274 (1999) 3711-3719
21. Bialer M., Johannessen S.I., Levy R.H., Perucca E., Tomson T., and White H.S. Progress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT IX). Epilepsy Res 83 (2009) 1-43
22. Bland B.H., and Oddie S.D. Theta band oscillation and synchrony in the hippocampal formation and associated structures: the case for its role in sensorimotor integration. Behav Brain Res 127 (2001) 119-136
23. Blenkinsop T.A., and Lang E.J. Block of inferior olive gap junctional coupling decreases Purkinje cell complex spike synchrony and rhythmicity. J Neurosci 26 (2006) 1739-1748
24. Boger D.L., Patterson J.E., and Jin Q. Structural requirements for 5-HT2A and 5-HT1A serotonin receptor potentiation by the biologically active lipid oleamide. Proc Natl Acad Sci U S A 95 (1998) 4102-4107
25. Boland M.E., Roper S.M., and Henry J.A. Complications of quinine poisoning. Lancet 1 (1985) 384-385
26. Bootman M.D., Collins T.J., Mackenzie L., Roderick H.L., Berridge M.J., and Peppiatt C.M. 2-aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release. Faseb J 16 (2002) 1145-1150
27. Bostanci M.O., and Bagirici F. Anticonvulsive effects of quinine on penicillin-induced epileptiform activity: an in vivo study. Seizure 16 (2007) 166-172
28. Bostanci M.O., and Bagirici F. The effects of octanol on penicillin induced epileptiform activity in rats: an in vivo study. Epilepsy Res 71 (2006) 188-194
29. Bremner J.D., and McCaffery P. The neurobiology of retinoic acid in affective disorders. Prog Neuro-psychopharmacol Biol Psychiatry 32 (2008) 315-331
30. Breuer W., and Skorecki K.L. Inhibition of prostaglandin E2 synthesis by a blocker of epithelial chloride channels. Biochem Biophys Res Commun 163 (1989) 398-405
31. Brocks B.E. A comparison of flufenamic acid and phenylbutazone in osteoarthritis of the hip. Ann Phys Med (1966) 114-118 Suppl
32. Buchanan T.A., Lyness R.W., Collins A.D., Gardiner T.A., and Archer D.B. An experimental study of quinine blindness. Eye (London, England) 1 Pt 4 (1987) 522-524
33. Buhl D.L., Harris K.D., Hormuzdi S.G., Monyer H., and Buzsaki G. Selective impairment of hippocampal gamma oscillations in connexin-36 knock-out mouse in vivo. J Neurosci 23 (2003) 1013-1018
34. Bujalska I., Shimojo M., Howie A., and Stewart P.M. Human 11 beta-hydroxysteroid dehydrogenase: studies on the stably transfected isoforms and localization of the type 2 isozyme within renal tissue. Steroids 62 (1997) 77-82
35. Buschman T.J., and Miller E.K. Top-down versus bottom-up control of attention in the prefrontal and posterior parietal cortices. Science 315 (2007) 1860-1862
36. Bushara K.O., Goldstein S.R., Grimes Jr. G.J., Burstein A.H., and Hallett M. Pilot trial of 1-octanol in essential tremor. Neurology 62 (2004) 122-124
37. Chaperon F., and Thiebot M.H. Behavioral effects of cannabinoid agents in animals. Crit Rev Neurobiol 13 (1999) 243-281
38. Cheer J.F., Cadogan A.K., Marsden C.A., Fone K.C., and Kendall D.A. Modification of 5-HT2 receptor mediated behaviour in the rat by oleamide and the role of cannabinoid receptors. Neuropharmacology 38 (1999) 533-541
39. Chepkova A.N., Sergeeva O.A., and Haas H.L. Carbenoxolone impairs LTP and blocks NMDA receptors in murine hippocampus. Neuropharmacology 55 (2008) 139-147
40. Chung M.K., Lee H., Mizuno A., Suzuki M., and Caterina M.J. 2-aminoethoxydiphenyl borate activates and sensitizes the heat-gated ion channel TRPV3. J Neurosci 24 (2004) 5177-5182
41. Chung M.K., Guler A.D., and Caterina M.J. Biphasic currents evoked by chemical or thermal activation of the heat-gated ion channel, TRPV3. The Journal of biological chemistry 280 (2005) 15928-15941
42. Cocchi A., and Invernizzi G. An electroencephalographic investigation in acute quinine poisoning. Electroencephalogr Clin Neurophysiol 25 (1968) 82-83
43. Connors B.W., and Long M.A. Electrical synapses in the mammalian brain. Ann Rev Neurosci 27 (2004) 393-418
44. Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of glycyrrhetinic acid, potassium glycyrrhetinate, disodium succinoyl glycyrrhetinate, glyceryl glycyrrhetinate, glycyrrhetinyl stearate, stearyl glycyrrhetinate, glycyrrhizic acid, ammonium glycyrrhizate, dipotassium glycyrrhizate, disodium glycyrrhizate, trisodium glycyrrhizate, methyl glycyrrhizate, and potassium glycyrrhizinate. Int J Toxicol 26 Suppl 2 (2007) 79-112
45. Coyne L., Lees G., Nicholson R.A., Zheng J., and Neufield K.D. The sleep hormone oleamide modulates inhibitory ionotropic receptors in mammalian CNS in vitro. Br J Pharmacol 135 (2002) 1977-1987
46. Coyne L., Su J., Patten D., and Halliwell R.F. Characterization of the interaction between fenamates and hippocampal neuron GABA(A) receptors. Neurochem Int 51 (2007) 440-446
47. Craig S. Phenytoin poisoning. Neurocritical care 3 (2005) 161-170
48. Cravatt B.F., Prospero-Garcia O., Siuzdak G., Gilula N.B., Henriksen S.J., Boger D.L., et al. Chemical characterization of a family of brain lipids that induce sleep. Science 268 (1995) 1506-1509
49. Crick F., and Koch C. Towards a neurobiological theory of consciousness. Semin Neurosci 2 (1990) 263-275
50. Cruikshank S.J., Hopperstad M., Younger M., Connors B.W., Spray D.C., and Srinivas M. Potent block of Cx36 and Cx50 gap junction channels by mefloquine. Proc Natl Acad Sci U S A 101 (2004) 12364-12369
51. Cunningham M.O., Halliday D.M., Davies C.H., Traub R.D., Buhl E.H., and Whittington M.A. Coexistence of gamma and high-frequency oscillations in rat medial entorhinal cortex in vitro. J Physiol 559 (2004) 347-353
52. Dagenais C., Zong J., Ducharme J., and Pollack G.M. Effect of mdr1a P-glycoprotein gene disruption, gender, and substrate concentration on brain uptake of selected compounds. Pharm Res 18 (2001) 957-963
53. Dagenais C., Graff C.L., and Pollack G.M. Variable modulation of opioid brain uptake by P-glycoprotein in mice. Biochem Pharmacol 67 (2004) 269-276
54. Davidson J.S., and Baumgarten I.M. Glycyrrhetinic acid derivatives: a novel class of inhibitors of gap-junctional intercellular communication. Structure-activity relationships. J Pharmacol Exp Ther 246 (1988) 1104-1107
55. Davidson J.S., Baumgarten I.M., and Harley E.H. Reversible inhibition of intercellular junctional communication by glycyrrhetinic acid. Biochem Biophys Res Commun 134 (1986) 29-36
56. Davies G.J., Rhodes J., and Calcraft B.J. Complications of carbenoxolone therapy. Br Med J 3 (1974) 400-402
57. De Botton S., Dombret H., Sanz M., Miguel J.S., Caillot D., Zittoun R., et al. Incidence, clinical features, and outcome of all trans-retinoic acid syndrome in 413 cases of newly diagnosed acute promyelocytic leukemia. The European APL Group. Blood 92 (1998) 2712-2718
58. de Curtis M., Manfridi A., and Biella G. Activity-dependent pH shifts and periodic recurrence of spontaneous interictal spikes in a model of focal epileptogenesis. J Neurosci 18 (1998) 7543-7551
59. De Salcedo I., Fonseca Ferreira F.M., Silva J.L., and Carrington M.D. Some metabolic and hormonal effects of flufenamic acid. Ann Phys Med (1966) 62-69 Suppl
60. De Zeeuw C.I., Chorev E., Devor A., Manor Y., Van Der Giessen R.S., De Jeu M.T., et al. Deformation of network connectivity in the inferior olive of connexin 36-deficient mice is compensated by morphological and electrophysiological changes at the single neuron level. J Neurosci 23 (2003) 4700-4711
61. Dean J.B., Ballantyne D., Cardone D.L., Erlichman J.S., and Solomon I.C. Role of gap junctions in CO(2) chemoreception and respiratory control. Am J Physiol Lung Cell Mol Physiol 283 (2002) L665-L670
62. Deleu D., and Schmedding E. Acute psychosis as idiosyncratic reaction to quinidine: report of two cases. Br Med J (Clin Res Ed) 294 (1987) 1001-1002
63. Dildy-Mayfield J.E., Mihic S.J., Liu Y., Deitrich R.A., and Harris R.A. Actions of long chain alcohols on GABAA and glutamate receptors: relation to in vivo effects. Br J Pharmacol 118 (1996) 378-384
64. Dobbins K.R., and Saul R.F. Transient visual loss after licorice ingestion. J Neuroophthalmol 20 (2000) 38-41
65. Dobrydneva Y., and Blackmore P. 2-Aminoethoxydiphenyl borate directly inhibits store-operated calcium entry channels in human platelets. Molecular pharmacology 60 (2001) 541-552
66. Dougalis A., Lees G., and Ganellin C.R. The sleep inducing brain lipid cis-oleamide (cOA) does not modulate serotonergic transmission in the CA1 pyramidal neurons of the hippocampus in vitro. Neuropharmacology 46 (2004) 63-73
67. Dow G., Bauman R., Caridha D., Cabezas M., Du F., Gomez-Lobo R., et al. Mefloquine induces dose-related neurological effects in a rat model. Antimicrob Agents Chemother 50 (2006) 1045-1053
68. Drager U.C. Retinoic acid signaling in the functioning brain. Sci STKE 2006 (2006) pe10
69. Draguhn A., Traub R.D., Schmitz D., and Jefferys J.G. Electrical coupling underlies high-frequency oscillations in the hippocampus in vitro. Nature 394 (1998) 189-192
70. Draguhn A., Traub R.D., Bibbig A., and Schmitz D. Ripple (approximately 200-Hz) oscillations in temporal structures. J Clin Neurophysiol 17 (2000) 361-376
71. Eggermont J.J., and Kenmochi M. Salicylate and quinine selectively increase spontaneous firing rates in secondary auditory cortex. Hear Res 117 (1998) 149-160
72. El-Mehairy M.M., Shaker A., Bahgat N.E., Hamza S., and Salam M.S. A double-blind comparison of niflumic acid with phenylbutazone, oxyphenylbutazone and placebo in the treatment of osteoarthrosis. Rheumatol Rehabil 13 (1974) 198-203
73. El Idrissi A., Messing J., Scalia J., and Trenkner E. Prevention of epileptic seizures by taurine. Adv Exp Med Biol 526 (2003) 515-525
74. Engel A.K., and Singer W. Temporal binding and the neural correlates of sensory awareness. Trends Cogn Sci 5 (2001) 16-25
75. Eskandari S., Zampighi G.A., Leung D.W., Wright E.M., and Loo D.D. Inhibition of gap junction hemichannels by chloride channel blockers. J Membr Biol 185 (2002) 93-102
76. Evoniuk G., and Skolnick P. Picrate and niflumate block anion modulation of radioligand binding to the gamma-aminobutyric acid/benzodiazepine receptor complex. Mol Pharmacol 34 (1988) 837-842
77. Farrugia G., Rae J.L., and Szurszewski J.H. Characterization of an outward potassium current in canine jejunal circular smooth muscle and its activation by fenamates. J Physiol 468 (1993) 297-310
78. Fedorova I., Hashimoto A., Fecik R.A., Hedrick M.P., Hanus L.O., Boger D.L., et al. Behavioral evidence for the interaction of oleamide with multiple neurotransmitter systems. J Pharmacol Exp Ther 299 (2001) 332-342
79. Felder C.C., Joyce K.E., Briley E.M., Mansouri J., Mackie K., Blond O., et al. Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. Mol Pharmacol 48 (1995) 443-450
80. Fisher C.M. Visual disturbances associated with quinidine and quinine. Neurology 31 (1981) 1569-1571
81. Frisch C., De Souza-Silva M.A., Sohl G., Guldenagel M., Willecke K., Huston J.P., et al. Stimulus complexity dependent memory impairment and changes in motor performance after deletion of the neuronal gap junction protein connexin36 in mice. Behav Brain Res 157 (2005) 177-185
82. Fromm M.F., Kim R.B., Stein C.M., Wilkinson G.R., and Roden D.M. Inhibition of P-glycoprotein-mediated drug transport: a unifying mechanism to explain the interaction between digoxin and quinidine [see comments]. Circulation 99 (1999) 552-557
83. Fuentealba P., Crochet S., Timofeev I., Bazhenov M., Sejnowski T.J., and Steriade M. Experimental evidence and modeling studies support a synchronizing role for electrical coupling in the cat thalamic reticular neurons in vivo. Eur J Neurosci 20 (2004) 111-119
84. Fukuda T., and Kosaka T. Ultrastructural study of gap junctions between dendrites of parvalbumin-containing GABAergic neurons in various neocortical areas of the adult rat. Neuroscience 120 (2003) 5-20
85. Fukuda T., Kosaka T., Singer W., and Galuske R.A. Gap junctions among dendrites of cortical GABAergic neurons establish a dense and widespread intercolumnar network. J Neurosci 26 (2006) 3434-3443
86. Funao T., Oda Y., Tanaka K., and Asada A. The P-glycoprotein inhibitor quinidine decreases the threshold for bupivacaine-induced, but not lidocaine-induced, convulsions in rats. Can J Anaesth 50 (2003) 805-811
87. Gajda Z., Gyengesi E., Hermesz E., Ali K.S., and Szente M. Involvement of gap junctions in the manifestation and control of the duration of seizures in rats in vivo. Epilepsia 44 (2003) 1596-1600
88. Gajda Z., Szupera Z., Blazso G., and Szente M. Quinine, a blocker of neuronal cx36 channels, suppresses seizure activity in rat neocortex in vivo. Epilepsia 46 (2005) 1581-1591
89. Galarreta M., and Hestrin S. A network of fast-spiking cells in the neocortex connected by electrical synapses. Nature 402 (1999) 72-75
90. Garcia-Rill E., Heister D.S., Ye M., Charlesworth A., and Hayar A. Electrical coupling: novel mechanism for sleep-wake control. Sleep 30 (2007) 1405-1414
91. Gareri P., Condorelli D., Belluardo N., Gratteri S., Ferreri G., Donato Di Paola E., et al. Influence of carbenoxolone on the anticonvulsant efficacy of conventional antiepileptic drugs against audiogenic seizures in DBA/2 mice. Eur J Pharmacol 484 (2004) 49-56
92. Gareri P., Condorelli D., Belluardo N., Russo E., Loiacono A., Barresi V., et al. Anticonvulsant effects of carbenoxolone in genetically epilepsy prone rats (GEPRs). Neuropharmacology 47 (2004) 1205-1216
93. Gareri P., Condorelli D., Belluardo N., Citraro R., Barresi V., Trovato-Salinato A., et al. Antiabsence effects of carbenoxolone in two genetic animal models of absence epilepsy (WAG/Rij rats and lh/lh mice). Neuropharmacology 49 (2005) 551-563
94. Gatev P., Darbin O., and Wichmann T. Oscillations in the basal ganglia under normal conditions and in movement disorders. Mov Disord 21 (2006) 1566-1577
95. Gatzonis S.D., Angelopoulos E., Sarigiannis P., Mantouvalos V., Ploumbidis D., and Siafakas A. Acute psychosis due to treatment with phenytoin in a nonepileptic patient. Epilepsy Behav 4 (2003) 771-772
96. George F.R., and Collins A.C. Prostaglandin synthetase inhibitors antagonize the depressant effects of ethanol. Pharmacol Biochem Behav 10 (1979) 865-869
97. Geyer M.A. Behavioral studies of hallucinogenic drugs in animals: implications for schizophrenia research. Pharmacopsychiatry 31 Suppl 2 (1998) 73-79
98. Gibson J.R., Beierlein M., and Connors B.W. Two networks of electrically coupled inhibitory neurons in neocortex. Nature 402 (1999) 75-79
99. Gibson J.R., Beierlein M., and Connors B.W. Functional properties of electrical synapses between inhibitory interneurons of neocortical layer 4. J Neurophysiol 93 (2005) 467-480
100. Gigout S., Louvel J., Kawasaki H., D'Antuono M., Armand V., Kurcewicz I., et al. Effects of gap junction blockers on human neocortical synchronization. Neurobiol Dis 22 (2006) 496-508
101. Gigout S., Louvel J., and Pumain R. Effects in vitro and in vivo of a gap junction blocker on epileptiform activities in a genetic model of absence epilepsy. Epilepsy Res 69 (2006) 15-29
102. Gimenez-Llort L., Ferre S., De Vera N., and Martinez E. Motor depressant effects of systemically administered polyamines in mice: involvement of central NMDA receptors. Eur J Pharmacol 318 (1996) 231-238
103. Ginsburg B.C., and Lamb R.J. Taurine and ethanol interactions: behavioral effects in mice. Eur J Pharmacol 578 (2008) 228-237
104. Gogelein H., Dahlem D., Englert H.C., and Lang H.J. Flufenamic acid, mefenamic acid and niflumic acid inhibit single nonselective cation channels in the rat exocrine pancreas. FEBS letters 268 (1990) 79-82
105. Golebiewski H., Eckersdorf B., and Konopacki J. Electrical coupling underlies theta rhythm in freely moving cats. Eur J Neurosci 24 (2006) 1759-1770
106. Gomez-Sanchez E.P., and Gomez-Sanchez C.E. Central hypertensinogenic effects of glycyrrhizic acid and carbenoxolone. Am J Physiol 263 (1992) E1125-E1130
107. Grace A.A., and Camm A.J. Quinidine. N Engl J Med 338 (1998) 35-45
108. Granvil C.P., Krausz K.W., Gelboin H.V., Idle J.R., and Gonzalez F.J. 4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine. J Pharmacol Exp Ther 301 (2002) 1025-1032
109. Grenier F., Timofeev I., and Steriade M. Focal synchronization of ripples (80-200 Hz) in neocortex and their neuronal correlates. J Neurophysiol 86 (2001) 1884-1898
110. Grenier F., Timofeev I., and Steriade M. Neocortical very fast oscillations (ripples, 80-200 Hz) during seizures: intracellular correlates. J Neurophysiol 89 (2003) 841-852
111. Gribble F.M., Davis T.M., Higham C.E., Clark A., and Ashcroft F.M. The antimalarial agent mefloquine inhibits ATP-sensitive K-channels. Br J Pharmacol 131 (2000) 756-760
112. Gu Q., Lin R.L., Hu H.Z., Zhu M.X., and Lee L.Y. 2-aminoethoxydiphenyl borate stimulates pulmonary C neurons via the activation of TRPV channels. Am J Physiol Lung Cell Mol Physiol 288 (2005) L932-L941
113. Guan X., Cravatt B.F., Ehring G.R., Hall J.E., Boger D.L., Lerner R.A., et al. The sleep-inducing lipid oleamide deconvolutes gap junction communication and calcium wave transmission in glial cells. J Cell Biol 139 (1997) 1785-1792
114. Guitton M.J., Caston J., Ruel J., Johnson R.M., Pujol R., and Puel J.L. Salicylate induces tinnitus through activation of cochlear NMDA receptors. J Neurosci 23 (2003) 3944-3952
115. Guldenagel M., Ammermuller J., Feigenspan A., Teubner B., Degen J., Sohl G., et al. Visual transmission deficits in mice with targeted disruption of the gap junction gene connexin36. J Neurosci 21 (2001) 6036-6044
116. Halpert A.G., Olmstead M.C., and Beninger R.J. Mechanisms and abuse liability of the anti-histamine dimenhydrinate. Neurosci Biobehav Rev 26 (2002) 61-67
117. Hanafusa J., Mune T., Tanahashi T., Isomura Y., Suwa T., Isaji M., et al. Altered corticosteroid metabolism differentially affects pituitary corticotropin response. Am J Physiol 282 (2002) E466-E473
118. Hara Y., and Kizaki K. Antimalarial drugs inhibit the acetylcholine-receptor-operated potassium current in atrial myocytes. Heart Lung Circ 11 (2002) 112-116
119. Harashima H., Sawada Y., Sugiyama Y., Iga T., and Hanano M. Analysis of nonlinear tissue distribution of quinidine in rats by physiologically based pharmacokinetics. J Pharmacokinet Biopharm 13 (1985) 425-440
120. Harks E.G., de Roos A.D., Peters P.H., de Haan L.H., Brouwer A., Ypey D.L., et al. Fenamates: a novel class of reversible gap junction blockers. J Pharmacol Exp Ther 298 (2001) 1033-1041
121. Hasselmo M.E., Hay J., Ilyn M., and Gorchetchnikov A. Neuromodulation, theta rhythm and rat spatial navigation. Neural Netw 15 (2002) 689-707
122. Hayeshi R., Masimirembwa C., Mukanganyama S., and Ungell A.L. The potential inhibitory effect of antiparasitic drugs and natural products on P-glycoprotein mediated efflux. Eur J Pharm Sci 29 (2006) 70-81
123. Heine M., and Wicher D. Ca2+ resting current and Ca2+-induced Ca2+ release in insect neurosecretory neurons. Neuroreport 9 (1998) 3309-3314
124. Helix N., Strobaek D., Dahl B.H., and Christophersen P. Inhibition of the endogenous volume-regulated anion channel (VRAC) in HEK293 cells by acidic di-aryl-ureas. J Membr Biol 196 (2003) 83-94
125. Hersh E.V., Cooper S., Betts N., Wedell D., MacAfee K., Quinn P., et al. Single dose and multidose analgesic study of ibuprofen and meclofenamate sodium after third molar surgery. Oral Surg Oral Med Oral Pathol 76 (1993) 680-687
126. Hestrin S., and Galarreta M. Electrical synapses define networks of neocortical GABAergic neurons. Trends Neurosci 28 (2005) 304-309
127. Hewitt A., Barrie R., Graham M., Bogus K., Leiter J.C., and Erlichman J.S. Ventilatory effects of gap junction blockade in the RTN in awake rats. Am J Physiol Regul Integr Comp Physiol 287 (2004) R1407-R1418
128. Hill A.G. Review of flufenamic acid in rheumatoid arthritis. Ann Phys Med (1966) 87-92 Suppl
129. Hirsch S.R., Richardson-Andrews R., Costall B., Kelly M.E., de Belleroche J., and Naylor R.J. The effects of some polyamines on putative behavioural indices of mesolimbic versus striatal dopaminergic function. Psychopharmacology 93 (1987) 101-104
130. Holmes E.L. Experimental observations on flufenamic, mefenamic, and meclofenamic acids. IV. Toleration by normal human subjects. Ann Phys Med (1966) 36-49 Suppl
131. Hormuzdi S.G., Pais I., LeBeau F.E., Towers S.K., Rozov A., Buhl E.H., et al. Impaired electrical signaling disrupts gamma frequency oscillations in connexin 36-deficient mice. Neuron 31 (2001) 487-495
132. Hosseinzadeh H., and Nassiri Asl M. Anticonvulsant, sedative and muscle relaxant effects of carbenoxolone in mice. BMC Pharmacol 3 (2003) 3
133. Hosseinzadeh H., Asl M.N., Parvardeh S., and Tagi Mansouri S.M. The effects of carbenoxolone on spatial learning in the Morris water maze task in rats. Med Sci Monit 11 (2005) BR88-BR94
134. Hsiao P., Bui T., Ho R.J., and Unadkat J.D. In vitro-to-in vivo prediction of P-glycoprotein-based drug interactions at the human and rodent blood-brain barrier. Drug Metab Dispos Biol Chem 36 (2008) 481-484
135. Hu H.Z., Gu Q., Wang C., Colton C.K., Tang J., Kinoshita-Kawada M., et al. 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. J Biol Chem 279 (2004) 35741-35748
136. Huang C.J., and Moczydlowski E. Cytoplasmic polyamines as permeant blockers and modulators of the voltage-gated sodium channel. Biophys J 80 (2001) 1262-1279
137. Hughes S.W., Lorincz M., Cope D.W., Blethyn K.L., Kekesi K.A., Parri H.R., et al. Synchronized oscillations at alpha and theta frequencies in the lateral geniculate nucleus. Neuron 42 (2004) 253-268
138. Huitron-Resendiz S., Gombart L., Cravatt B.F., and Henriksen S.J. Effect of oleamide on sleep and its relationship to blood pressure, body temperature, and locomotor activity in rats. Exp Neurol 172 (2001) 235-243
139. Iacobas D.A., Iacobas S., and Spray D.C. Connexin-dependent transcellular transcriptomic networks in mouse brain. Prog Biophys Mol Biol 94 (2007) 169-185
140. Idrus R.B., Mohamad N.B., Morat P.B., Saim A., and Abdul Kadir K.B. Differential effect of adrenocorticosteroids on 11 beta-hydroxysteroid dehydrogenase bioactivity at the anterior pituitary and hypothalamus in rats. Steroids 61 (1996) 448-452
141. Iversen L. Cannabis and the brain. Brain 126 (2003) 1252-1270
142. Jager W., Idrizbegovic E., Karlsson K.K., and Alvan G. Quinine-induced hearing loss in the guinea pig is not affected by the Ca2+ channel antagonist verapamil. Acta Otolaryngol 117 (1997) 46-48
143. Jahromi S.S., Wentlandt K., Piran S., and Carlen P.L. Anticonvulsant actions of gap junctional blockers in an in vitro seizure model. J Neurophysiol 88 (2002) 1893-1902
144. Jarboe J.K., and Hallworth R. The effect of quinine on outer hair cell shape, compliance and force. Hear Res 132 (1999) 43-50
145. Jastreboff P.J., Brennan J.F., and Sasaki C.T. Quinine-induced tinnitus in rats. Arch Otolaryngol Head Neck Surg 117 (1991) 1162-1166
146. Javorsky D.J., Tremont G., Keitner G.I., and Parmentier A.H. Cognitive and neuropsychiatric side effects of mefloquine. J Neuropsychiatry Clin Neurosci 13 (2001) 302
147. Jellinck P.H., Monder C., McEwen B.S., and Sakai R.R. Differential inhibition of 11 beta-hydroxysteroid dehydrogenase by carbenoxolone in rat brain regions and peripheral tissues. J Steroid Biochem Mol Biol 46 (1993) 209-213
148. Jerram T., and Greenhalgh N. Quinine psychosis. Br J Psychiatry 152 (1988) 864
149. Johnson A.G., Day R.O., and Seldon W.A. A functional psychosis precipitated by quinidine. Med J Aust 153 (1990) 47-49
150. Johnston M.F., Simon S.A., and Ramon F. Interaction of anaesthetics with electrical synapses. Nature 286 (1980) 498-500
151. Jones A.L., and Proudfoot A.T. Features and management of poisoning with modern drugs used to treat epilepsy. Qjm 91 (1998) 325-332
152. Kahana M.J., Seelig D., and Madsen J.R. Theta returns. Curr Opin Neurobiol 11 (2001) 739-744
153. Katewa S.D., and Katyare S.S. Antimalarials inhibit human erythrocyte membrane acetylcholinesterase. Drug Chem Toxicol 28 (2005) 467-482
154. Kaump D.H. Experimental observations on flufenamic, mefanamic and meclofenamic acids. II. Toxicology in animals. Ann Phys Med (1966) 16-23 Suppl
155. Kenmochi M., and Eggermont J.J. Salicylate and quinine affect the central nervous system. Hear Res 113 (1997) 110-116
156. Kirchner A., Breustedt J., Rosche B., Heinemann U.F., and Schmieden V. Effects of taurine and glycine on epileptiform activity induced by removal of Mg2+ in combined rat entorhinal cortex-hippocampal slices. Epilepsia 44 (2003) 1145-1152
157. Klimesch W. EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. Brain Res Brain Res Rev 29 (1999) 169-195
158. Koehler R.C., Gebremedhin D., and Harder D.R. Role of astrocytes in cerebrovascular regulation. J Appl Physiol 100 (2006) 307-317
159. Kohling R., Gladwell S.J., Bracci E., Vreugdenhil M., and Jefferys J.G. Prolonged epileptiform bursting induced by 0-Mg(2+) in rat hippocampal slices depends on gap junctional coupling. Neuroscience 105 (2001) 579-587
160. Konopacki J., Kowalczyk T., and Golebiewski H. Electrical coupling underlies theta oscillations recorded in hippocampal formation slices. Brain Res 1019 (2004) 270-274
161. Koumi S., Sato R., Hayakawa H., and Okumura H. Quinidine blocks cardiac sodium current after removal of the fast inactivation process with chloramine-T. J Mol Cell Cardiol 23 (1991) 427-438
162. Kukoyi O., and Carney C.P. Curses, madness, and mefloquine. Psychosomatics 44 (2003) 339-341
163. Kusuhara H., Suzuki H., Terasaki T., Kakee A., Lemaire M., and Sugiyama Y. P-Glycoprotein mediates the efflux of quinidine across the blood-brain barrier. J Pharmacol Exp Ther 283 (1997) 574-580
164. Landisman C.E., Long M.A., Beierlein M., Deans M.R., Paul D.L., and Connors B.W. Electrical synapses in the thalamic reticular nucleus. J Neurosci 22 (2002) 1002-1009
165. Lane M.A., and Bailey S.J. Role of retinoid signalling in the adult brain. Prog Neurobiol 75 (2005) 275-293
166. LeBeau F.E., Towers S.K., Traub R.D., Whittington M.A., and Buhl E.H. Fast network oscillations induced by potassium transients in the rat hippocampus in vitro. J Physiol 542 (2002) 167-179
167. Lee H.S., and Go M.L. Effects of mefloquine on Ca2+ uptake and release by dog brain microsomes. Arch Int Pharmacodyn Ther 331 (1996) 221-231
168. Lee Y.T., and Wang Q. Inhibition of hKv2.1, a major human neuronal voltage-gated K+ channel, by meclofenamic acid. Eur J Pharmacol 378 (1999) 349-356
169. Lee G., Dallas S., Hong M., and Bendayan R. Drug transporters in the central nervous system: brain barriers and brain parenchyma considerations. Pharmacol Rev 53 (2001) 569-596
170. Lerma J., and Martin del Rio R. Chloride transport blockers prevent N-methyl-D-aspartate receptor-channel complex activation. Mol Pharmacol 41 (1992) 217-222
171. Leshchenko Y., Likhodii S., Yue W., Burnham W.M., and Perez Velazquez J.L. Carbenoxolone does not cross the blood brain barrier: an HPLC study. BMC Neurosci 7 (2006) 3
172. Leznik E., and Llinas R. Role of gap junctions in synchronized neuronal oscillations in the inferior olive. J Neurophysiol 94 (2005) 2447-2456
173. Lim L.Y., and Go M.L. The anticholinesterase activity of mefloquine. Clin Exp Pharmacol Physiol 12 (1985) 527-531
174. Lin X., Chen S., and Tee D. Effects of quinine on the excitability and voltage-dependent currents of isolated spiral ganglion neurons in culture. J Neurophysiol 79 (1998) 2503-2512
175. Lisman J.E., and Idiart M.A. Storage of 7 +/- 2 short-term memories in oscillatory subcycles. Science (New York, N.Y 267 (1995) 1512-1515
176. Llinas R., Ribary U., Contreras D., and Pedroarena C. The neuronal basis for consciousness. Philos Trans R Soc Lond B Biol Sci 353 (1998) 1841-1849
177. Lobarinas E., Yang G., Sun W., Ding D., Mirza N., Dalby-Brown W., et al. Salicylate- and quinine-induced tinnitus and effects of memantine. Acta Otolaryngol (2006) 13-19 Suppl
178. Lobel H.O., Coyne P.E., and Rosenthal P.J. Drug overdoses with antimalarial agents: prescribing and dispensing errors. Jama 280 (1998) 1483
179. Lorenc-Koci E., Wojcikowski J., Kot M., Haduch A., Boksa J., and Daniel W.A. Disposition of 1,2,3,4,-tetrahydroisoquinoline in the brain of male Wistar and Dark Agouti rats. Brain Res 996 (2004) 168-179
180. Lyon R.C., McComb J.A., Schreurs J., and Goldstein D.B. A relationship between alcohol intoxication and the disordering of brain membranes by a series of short-chain alcohols. J Pharmacol Exp Ther 218 (1981) 669-675
181. Maier N., Guldenagel M., Sohl G., Siegmund H., Willecke K., and Draguhn A. Reduction of high-frequency network oscillations (ripples) and pathological network discharges in hippocampal slices from connexin 36-deficient mice. J Physiol 541 (2002) 521-528
182. Maier N., Nimmrich V., and Draguhn A. Cellular and network mechanisms underlying spontaneous sharp wave-ripple complexes in mouse hippocampal slices. J Physiol 550 (2003) 873-887
183. Maksay G., Korpi E.R., and Uusi-Oukari M. Bimodal action of furosemide on convulsant [3H]EBOB binding to cerebellar and cortical GABA(A) receptors. Neurochem Int 33 (1998) 353-358
184. Mantz J., Cordier J., and Giaume C. Effects of general anesthetics on intercellular communications mediated by gap junctions between astrocytes in primary culture. Anesthesiology 78 (1993) 892-901
185. Martin F.C., and Handforth A. Carbenoxolone and mefloquine suppress tremor in the harmaline mouse model of essential tremor. Mov Disord 21 (2006) 1641-1649
186. Mascia M.P., Machu T.K., and Harris R.A. Enhancement of homomeric glycine receptor function by long-chain alcohols and anaesthetics. Br J Pharmacol 119 (1996) 1331-1336
187. Matchkov V.V., Rahman A., Peng H., Nilsson H., and Aalkjaer C. Junctional and nonjunctional effects of heptanol and glycyrrhetinic acid derivates in rat mesenteric small arteries. Br J Pharmacol 142 (2004) 961-972
188. McConnell H.W., Mitchell S.C., Smith R.L., and Brewster M. Trimethylaminuria associated with seizures and behavioural disturbance: a case report. Seizure 6 (1997) 317-321
189. McCracken C.B., and Roberts D.C. Neuronal GAP junctions: expression, function, and implications for behavior. Int Rev Neurobiol 73 (2006) 125-151
190. McCreery M.J., and Hunt W.A. Physico-chemical correlates of alcohol intoxication. Neuropharmacology 17 (1978) 451-461
191. Meier C.R., Wilcock K., and Jick S.S. The risk of severe depression, psychosis or panic attacks with prophylactic antimalarials. Drug Saf 27 (2004) 203-213
192. Mendelson W.B., and Basile A.S. The hypnotic actions of the fatty acid amide, oleamide. Neuropsychopharmacology 25 (2001) S36-39
193. Mey J., and McCaffery P. Retinoic acid signaling in the nervous system of adult vertebrates. Neuroscientist 10 (2004) 409-421
194. Middleton S.J., Racca C., Cunningham M.O., Traub R.D., Monyer H., Knopfel T., et al. High-frequency network oscillations in cerebellar cortex. Neuron 58 (2008) 763-774
195. Mikov M., Kevresan S., Kuhajda K., Jakovljevic V., and Vasovic V. 3Alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate as blood-brain barrier permeator. Pol J Pharmacol 56 (2004) 367-371
196. Misra U.K., Gawdi G., and Pizzo S.V. Chloroquine, quinine and quinidine inhibit calcium release from macrophage intracellular stores by blocking inositol 1,4,5-trisphosphate binding to its receptor. J Cell Biochem 64 (1997) 225-232
197. Montgomery R.D. Side effects of carbenoxolone sodium: a study of ambulant therapy of gastric ulcer. Gut 8 (1967) 148-150
198. Moore H., and Grace A.A. A role for electrotonic coupling in the striatum in the expression of dopamine receptor-mediated stereotypies. Neuropsychopharmacology 27 (2002) 980-992
199. Murillo-Rodriguez E., Giordano M., Cabeza R., Henriksen S.J., Mendez Diaz M., Navarro L., et al. Oleamide modulates memory in rats. Neurosci Lett 313 (2001) 61-64
200. Musa H., and Veenstra R.D. Voltage-dependent blockade of connexin40 gap junctions by spermine. Biophys J 84 (2003) 205-219
201. Nassiri-Asl M., Zamansoltani F., and Torabinejad B. Antiepileptic effects of quinine in the pentylenetetrazole model of seizure. Seizure (2008) 10.1016/j.seizure.2008.08.002
202. Nemani V.M., and Binder D.K. Emerging role of gap junctions in epilepsy. Histol Histopathol 20 (2005) 253-259
203. Nichols C.G., Makhina E.N., Pearson W.L., Sha Q., and Lopatin A.N. Inward rectification and implications for cardiac excitability. Circ Res 78 (1996) 1-7
204. Nilsen K.E., Kelso A.R., and Cock H.R. Antiepileptic effect of gap-junction blockers in a rat model of refractory focal cortical epilepsy. Epilepsia 47 (2006) 1169-1175
205. Nimmrich V., Maier N., Schmitz D., and Draguhn A. Induced sharp wave-ripple complexes in the absence of synaptic inhibition in mouse hippocampal slices. J Physiol 563 (2005) 663-670
206. Nolan E.B., Harrison L.M., Lahoste G.J., and Ruskin D.N. Behavioral synergism between D(1) and D(2) dopamine receptors in mice does not depend on gap junctions. Synapse (New York, N.Y 61 (2007) 279-287
207. Nwangwu P.U., Stohs S.J., Mereish K., Holcslaw T.L., Rosenberg H., and Small L.D. A comparative study on the antiarrhythmic activity and acute toxicity of quinidine and four new analogs in mice. Toxicology 16 (1980) 73-80
208. Ochi K., and Eggermont J.J. Effects of quinine on neural activity in cat primary auditory cortex. Hear Res 105 (1997) 105-118
209. Ochs H.R., Greenblatt D.J., Lloyd B.L., Woo E., Sonntag M., and Smith T.W. Entry of quinidine into cerebrospinal fluid. Am Heart J 100 (1980) 341-346
210. Okamoto Y., Wang J., Morishita J., and Ueda N. Biosynthetic pathways of the endocannabinoid anandamide. Chem Biodiversity 4 (2007) 1842-1857
211. Okura T., Hattori A., Takano Y., Sato T., Hammarlund-Udenaes M., Terasaki T., et al. Involvement of the pyrilamine transporter, a putative organic cation transporter, in blood-brain barrier transport of oxycodone. Drug Metab Dispos Biol Chem 36 (2008) 2005-2013
212. Osifo N.G. The regional uptake of chloroquine in the rat brain. Toxicol Appl Pharmacol 50 (1979) 109-114
213. Ottolia M., and Toro L. Potentiation of large conductance KCa channels by niflumic, flufenamic, and mefenamic acids. Biophys J 67 (1994) 2272-2279
214. Ouagazzal A.M., Moreau J.L., Pauly-Evers M., and Jenck F. Impact of environmental housing conditions on the emotional responses of mice deficient for nociceptin/orphanin FQ peptide precursor gene. Behav Brain Res 144 (2003) 111-117
215. Ozog M.A., Siushansian R., and Naus C.C. Blocked gap junctional coupling increases glutamate-induced neurotoxicity in neuron-astrocyte co-cultures. J Neuropathol Exp neurology 61 (2002) 132-141
216. Palade P., Dettbarn C., Volpe P., Alderson B., and Otero A.S. Direct inhibition of inositol-1,4,5-trisphosphate-induced Ca2+ release from brain microsomes by K+ channel blockers. Mol Pharmacol 36 (1989) 664-672
217. Palmer D.G., Barbezat G.O., Gibbins B.L., Grennan D.M., Lum J., Myers D.B., et al. A single-blind crossover trial of the anti-inflammatory drug sodium meclofenamate and placebo, including an evaluation of hand grip and of lymphocyte responsiveness. Curr Med Res Opin 7 (1981) 359-369
218. Palva S., and Palva J.M. New vistas for alpha-frequency band oscillations. Trends Neurosci 30 (2007) 150-158
219. Pan F., Mills S.L., and Massey S.C. Screening of gap junction antagonists on dye coupling in the rabbit retina. Vis Neurosci 24 (2007) 609-618
220. Parisian K., Wages P., Smith A., Jarosz J., Hewitt A., Leiter J.C., et al. Ventilatory effects of gap junction blockade in the NTS in awake rats. Respir Physiol Neurobiol 142 (2004) 127-143
221. Parpura V., Scemes E., and Spray D.C. Mechanisms of glutamate release from astrocytes: gap junction "hemichannels", purinergic receptors and exocytotic release. Neurochem Int 45 (2004) 259-264
222. Pellegrini P. Clinical experiences in the treatment of pain in rheumatology. Clin J Pain 7 Suppl 1 (1991) S77-S80
223. Peracchia C. Effects of the anesthetics heptanol, halothane and isoflurane on gap junction conductance in crayfish septate axons: a calcium- and hydrogen-independent phenomenon potentiated by caffeine and theophylline, and inhibited by 4-aminopyridine. J Membr Biol 121 (1991) 67-78
224. Peretz A., Degani N., Nachman R., Uziyel Y., Gibor G., Shabat D., et al. Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties. Mol Pharmacol 67 (2005) 1053-1066
225. Perez-Velazquez J.L., Valiante T.A., and Carlen P.L. Modulation of gap junctional mechanisms during calcium-free induced field burst activity: a possible role for electrotonic coupling in epileptogenesis. J Neurosci 14 (1994) 4308-4317
226. Perez Velazquez J.L., and Carlen P.L. Gap junctions, synchrony and seizures. Trends Neurosci 23 (2000) 68-74
227. Perry E.K., and Perry R.H. Acetylcholine and hallucinations: disease-related compared to drug-induced alterations in human consciousness. Brain Cogn 28 (1995) 240-258
228. Pham Y.T., Nosten F., Farinotti R., White N.J., and Gimenez F. Cerebral uptake of mefloquine enantiomers in fatal cerebral malaria. Int J Clin Pharmacol Ther 37 (1999) 58-61
229. Pham Y.T., Regina A., Farinotti R., Couraud P., Wainer I.W., Roux F., et al. Interactions of racemic mefloquine and its enantiomers with P-glycoprotein in an immortalised rat brain capillary endothelial cell line, GPNT. Biochim Biophys Acta 1524 (2000) 212-219
230. Phelps S.J., Baldree L.A., Boucher B.A., and Hogue S.L. Neuropsychiatric toxicity of phenytoin. Importance of monitoring phenytoin levels. Clin Pediatr 32 (1993) 107-110
231. Pinto L.H., and Enroth-Cugell C. Tests of the mouse visual system. Mamm Genome 11 (2000) 531-536
232. Pouplana R., Perez C., Sanchez J., Lozano J.J., and Puig-Parellada P. The structural and electronical factors that contribute affinity for the time-dependent inhibition of PGHS-1 by indomethacin, diclofenac and fenamates. J Comput-Aided Mol Des 13 (1999) 297-313
233. Pous E., Gascon J., Obach J., and Corachan M. Mefloquine-induced grand mal seizure during malaria chemoprophylaxis in a non-epileptic subject. Trans R Soc Trop Med Hyg 89 (1995) 434
234. Prasad R.S., Kodali V.R., Khuraijam G.S., Cho M., and Travers J.P. Acute confusion and blindness from quinine toxicity. Eur J Emerg Med 10 (2003) 353-356
235. Priller J., Briley E.M., Mansouri J., Devane W.A., Mackie K., and Felder C.C. Mead ethanolamide, a novel eicosanoid, is an agonist for the central (CB1) and peripheral (CB2) cannabinoid receptors. Mol Pharmacol 48 (1995) 288-292
236. Proulx E., Leshchenko Y., Kokarovtseva L., Khokhotva V., El-Beheiry M., Snead III O.C., et al. Functional contribution of specific brain areas to absence seizures: role of thalamic gap-junctional coupling. Eur J Neurosci 23 (2006) 489-496
237. Pussard E., Merzouk M., and Barennes H. Increased uptake of quinine into the brain by inhibition of P-glycoprotein. Eur J Pharm Sci 32 (2007) 123-127
238. Quintanilla J. Psychosis due to quinidine intoxication. Am J Psychiatry 113 (1957) 1031-1032
239. Radovanovic D., Meier P.J., Guirguis M., Lorent J.P., and Kupferschmidt H. Dose-dependent toxicity of diphenhydramine overdose. Human Exp Toxicol 19 (2000) 489-495
240. Rajan K.T., Hill A.G., Barr A., and Whitwell E. Flufenamic acid in rheumatoid arthritis. Ann Rheum Dis 26 (1967) 43-46
241. Ransom R.W., and Deschenes N.L. Polyamines regulate glycine interaction with the N-methyl-D-aspartate receptor. Synapse (New York, N.Y 5 (1990) 294-298
242. Rekling J.C., Shao X.M., and Feldman J.L. Electrical coupling and excitatory synaptic transmission between rhythmogenic respiratory neurons in the preBotzinger complex. J Neurosci 20 (2000) RC113
243. Rendi-Wagner P., Noedl H., Wernsdorfer W.H., Wiedermann G., Mikolasek A., and Kollaritsch H. Unexpected frequency, duration and spectrum of adverse events after therapeutic dose of mefloquine in healthy adults. Acta Trop 81 (2002) 167-173
244. Roche R.J., Silamut K., Pukrittayakamee S., Looareesuwan S., Molunto P., Boonamrung S., et al. Quinine induces reversible high-tone hearing loss. Br J Clin Pharmacol 29 (1990) 780-782
245. Roopun A.K., Middleton S.J., Cunningham M.O., LeBeau F.E., Bibbig A., Whittington M.A., et al. A beta2-frequency (20-30 Hz) oscillation in nonsynaptic networks of somatosensory cortex. Proc Natl Acad Sci U S A 103 (2006) 15646-15650
246. Rorig B., and Sutor B. Nitric oxide-stimulated increase in intracellular cGMP modulates gap junction coupling in rat neocortex. Neuroreport 7 (1996) 569-572
247. Rorig B., and Sutor B. Regulation of gap junction coupling in the developing neocortex. Mol Neurobiol 12 (1996) 225-249
248. Rorig B., and Sutor B. Serotonin regulates gap junction coupling in the developing rat somatosensory cortex. Eur J Neurosci 8 (1996) 1685-1695
249. Rorig B., Klausa G., and Sutor B. Beta-adrenoreceptor activation reduces dye-coupling between immature rat neocortical neurones. Neuroreport 6 (1995) 1811-1815
250. Rorig B., Klausa G., and Sutor B. Dye coupling between pyramidal neurons in developing rat prefrontal and frontal cortex is reduced by protein kinase A activation and dopamine. J Neurosci 15 (1995) 7386-7400
251. Rorig B., Klausa G., and Sutor B. Intracellular acidification reduced gap junction coupling between immature rat neocortical pyramidal neurones. J Physiol 490 Pt 1 (1996) 31-49
252. Ross R.A. Anandamide and vanilloid TRPV1 receptors. Br J Pharmacol 140 (2003) 790-801
253. Rouach N., Segal M., Koulakoff A., Giaume C., and Avignone E. Carbenoxolone blockade of neuronal network activity in culture is not mediated by an action on gap junctions. J Physiol 553 (2003) 729-745
254. Rowe N.H., Aseltine L.F., and Turner J.L. Control of pain with meclofenamate sodium following removal of an impacted molar. Oral Surg Oral Med Oral Pathol 59 (1985) 446-448
255. Ruff T.A., Sherwen S.J., and Donnan G.A. Seizure associated with mefloquine for malaria prophylaxis. Med J Aust 161 (1994) 453
256. Ruppersberg J.P. Intracellular regulation of inward rectifier K+ channels. Pflugers Arch 441 (2000) 1-11
257. Sakurada T., Onodera K., Tadano T., and Kisara K. Effects of polyamines on the central nervous system. Jpn J Pharmacol 25 (1975) 653-661
258. Salameh A., and Dhein S. Pharmacology of gap junctions. New pharmacological targets for treatment of arrhythmia, seizure and cancer?. Biochim Biophys Acta 1719 (2005) 36-58
259. Salenius S., and Hari R. Synchronous cortical oscillatory activity during motor action. Curr Opin Neurobiol 13 (2003) 678-684
260. Sauvage J.P., Ditisheim A., Bessede J.P., and David N. Double-blind, placebo-controlled, multi-centre trial of the efficacy and tolerance of niflumic acid ('Nifluril') capsules in the treatment of tonsillitis in adults. Curr Med Res Opin 11 (1990) 631-637
261. Sayyah M., Rezaie M., Haghighi S., and Amanzadeh A. Intra-amygdala all-trans retinoic acid inhibits amygdala-kindled seizures in rats. Epilepsy Res 75 (2007) 97-103
262. Scemes E., and Spray D.C. Increased intercellular communication in mouse astrocytes exposed to hyposmotic shocks. Glia 24 (1998) 74-84
263. Schmitz D., Schuchmann S., Fisahn A., Draguhn A., Buhl E.H., Petrasch-Parwez E., et al. Axo-axonal coupling. A novel mechanism for ultrafast neuronal communication. Neuron 31 (2001) 831-840
264. Schnitzler A., Timmermann L., and Gross J. Physiological and pathological oscillatory networks in the human motor system. J Physiol Paris 99 (2006) 3-7
265. Schultz B.D., Singh A.K., Devor D.C., and Bridges R.J. Pharmacology of CFTR chloride channel activity. Physiol Rev 79 (1999) S109-144
266. Seiler N. Pharmacological aspects of cytotoxic polyamine analogs and derivatives for cancer therapy. Pharmacol Ther 107 (2005) 99-119
267. Shill H.A., Bushara K.O., Mari Z., Reich M., and Hallett M. Open-label dose-escalation study of oral 1-octanol in patients with essential tremor. Neurology 62 (2004) 2320-2322
268. Shirhan M.D., Moochhala S.M., Ng P.Y., Lu J., Ng K.C., Teo A.L., et al. Spermine reduces infarction and neurological deficit following a rat model of middle cerebral artery occlusion: a magnetic resonance imaging study. Neuroscience 124 (2004) 299-304
269. Silamut K., White N.J., Looareesuwan S., and Warrell D.A. Binding of quinine to plasma proteins in falciparum malaria. Am J Trop Med Hyg 34 (1985) 681-686
270. Simon A., Olah S., Molnar G., Szabadics J., and Tamas G. Gap-junctional coupling between neurogliaform cells and various interneuron types in the neocortex. J Neurosci 25 (2005) 6278-6285
271. Sinkkonen S.T., Mansikkamaki S., Moykkynen T., Luddens H., Uusi-Oukari M., and Korpi E.R. Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug. Mol Pharmacol 64 (2003) 753-763
272. Sinton C.M., Krosser B.I., Walton K.D., and Llinas R.R. The effectiveness of different isomers of octanol as blockers of harmaline-induced tremor. Pflugers Arch 414 (1989) 31-36
273. Smart D., Gunthorpe M.J., Jerman J.C., Nasir S., Gray J., Muir A.I., et al. The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1). Br J Pharmacol 129 (2000) 227-230
274. Smilkstein M.J., Kulig K.W., and Rumack B.H. Acute toxic blindness: unrecognized quinine poisoning. Ann Emerg Med 16 (1987) 98-101
275. Sohl G., Maxeiner S., and Willecke K. Expression and functions of neuronal gap junctions. Nat Rev Neurosci 6 (2005) 191-200
276. Sonnewald U., and Kondziella D. Neuronal glial interaction in different neurological diseases studied by ex vivo 13C NMR spectroscopy. NMR Biomed 16 (2003) 424-429
277. Soro A., Panarelli M., Holloway C.D., Fraser R., and Kenyon C.J. In vivo and in vitro effects of carbenoxolone on glucocorticoid receptor binding and glucocorticoid activity. Steroids 62 (1997) 388-394
278. Sowunmi A., Adio R.A., Oduola A.M., Ogundahunsi O.A., and Salako L.A. Acute psychosis after mefloquine. Report of six cases. Trop Geogr Med 47 (1995) 179-180
279. Spray D.C., Rozental R., and Srinivas M. Prospects for rational development of pharmacological gap junction channel blockers. Current drug targets 3 (2002) 455-464
280. Spray D.C., Ye Z.C., and Ransom B.R. Functional connexin "hemichannels": a critical appraisal. Glia 54 (2006) 758-773
281. Srinivas M., Hopperstad M.G., and Spray D.C. Quinine blocks specific gap junction channel subtypes. Proc Natl Acad Sci U S A 98 (2001) 10942-10947
282. Srinivas M., and Spray D.C. Closure of gap junction channels by arylaminobenzoates. Mol Pharmacol 63 (2003) 1389-1397
283. Steriade M. Grouping of brain rhythms in corticothalamic systems. Neuroscience 137 (2006) 1087-1106
284. Stobbs S.H., Ohran A.J., Lassen M.B., Allison D.W., Brown J.E., and Steffensen S.C. Ethanol suppression of ventral tegmental area GABA neuron electrical transmission involves N-methyl-D-aspartate receptors. J Pharmacol Exp Ther 311 (2004) 282-289
285. Su X., Vicker N., Lawrence H., Smith A., Purohit A., Reed M.J., et al. Inhibition of human and rat 11beta-hydroxysteroid dehydrogenase type 1 by 18beta-glycyrrhetinic acid derivatives. J Steroid Biochem Mol Biol 104 (2007) 312-320
286. Suadicani S.O., Brosnan C.F., and Scemes E. P2X7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2+ signaling. J Neurosci 26 (2006) 1378-1385
287. Summers W.K., Allen R.E., and Pitts Jr. F.N. Does physostigmine reverse quinidine delirium?. West J Med 135 (1981) 411-414
288. Sun M., and Xu C. Neuroprotective mechanism of taurine due to up-regulating calpastatin and down-regulating calpain and caspase-3 during focal cerebral ischemia. Cell Mol Neurobiol 28 (2008) 593-611
289. Suzuki T., Chiang H.J., and Misawa M. Effects of quinidine and cimetidine on the methamphetamine level in the rat brain. Jpn J Pharmacol 43 (1987) 103-106
290. Suzuki T., Fan Chiang H.J., Misawa M., and Yanaura S. Effects of quinidine and cimetidine on methamphetamine stereotypy in rats. J Pharmacobio-dyn 10 (1987) 152-155
291. Swerdlow N.R., Braff D.L., Taaid N., and Geyer M.A. Assessing the validity of an animal model of deficient sensorimotor gating in schizophrenic patients. Arch Gen Psychiatry 51 (1994) 139-154
292. Szente M., Gajda Z., Said Ali K., and Hermesz E. Involvement of electrical coupling in the in vivo ictal epileptiform activity induced by 4-aminopyridine in the neocortex. Neuroscience 115 (2002) 1067-1078
293. Tallon-Baudry C. Oscillatory synchrony and human visual cognition. J Physiol Paris 97 (2003) 355-363
294. Tange R.A., Dreschler W.A., Claessen F.A., and Perenboom R.M. Ototoxic reactions of quinine in healthy persons and patients with Plasmodium falciparum infection. Auris Nasus Larynx 24 (1997) 131-136
295. Tao L., and Harris A.L. 2-aminoethoxydiphenyl borate directly inhibits channels composed of connexin26 and/or connexin32. Mol Pharmacol 71 (2007) 570-579
296. Tella S.R., and Goldberg S.R. Monoamine transporter and sodium channel mechanisms in the rapid pressor response to cocaine. Pharmacol Biochem Behav 59 (1998) 305-312
297. Theis M., Sohl G., Eiberger J., and Willecke K. Emerging complexities in identity and function of glial connexins. Trends Neurosci 28 (2005) 188-195
298. Thomas E.A., Cravatt B.F., and Sutcliffe J.G. The endogenous lipid oleamide activates serotonin 5-HT7 neurons in mouse thalamus and hypothalamus. J Neurochem 72 (1999) 2370-2378
299. Todorovic S.M., and Lingle C.J. Pharmacological properties of T-type Ca2+ current in adult rat sensory neurons: effects of anticonvulsant and anesthetic agents. J Neurophysiol 79 (1998) 240-252
300. Tor P.C., Lee H.Y., and Tan C.H. Mefloquine-induced mania in a 22-year-old Chinese man. Singap Med J 47 (2006) 549-550
301. Townend B.S., Sturm J.W., and Whyte S. Quinine associated blindness. Aust Fam Physician 33 (2004) 627-628
302. Tran T.M., Browning J., and Dell M.L. Psychosis with paranoid delusions after a therapeutic dose of mefloquine: a case report. Malar J 5 (2006) 74
303. Traub R.D., Kopell N., Bibbig A., Buhl E.H., LeBeau F.E., and Whittington M.A. Gap junctions between interneuron dendrites can enhance synchrony of gamma oscillations in distributed networks. J Neurosci 21 (2001) 9478-9486
304. Traub R.D., Michelson-Law H., Bibbig A.E., Buhl E.H., and Whittington M.A. Gap junctions, fast oscillations and the initiation of seizures. Adv Exp Med Biol 548 (2004) 110-122
305. Travagli R.A., Dunwiddie T.V., and Williams J.T. Opioid inhibition in locus coeruleus. J Neurophysiol 74 (1995) 518-528
306. Turpie A.G., and Thomson T.J. Carbenoxolone sodium in the treatment of gastric ulcer with special reference to side-effects. Gut 6 (1965) 591-594
307. van den Bosch A.E., van der Klooster J.M., Zuidgeest D.M., Ouwendijk R.J., and Dees A. Severe hypokalaemic paralysis and rhabdomyolysis due to ingestion of liquorice. Neth J Med 63 (2005) 146-148
308. Vasovic V., Banic B., and Jakovljevic V. Effect of caffeine on quinidine transport to the central nervous system in rats. J Basic Clin Physiol Pharmacol 18 (2007) 1-10
309. Venance L., Piomelli D., Glowinski J., and Giaume C. Inhibition by anandamide of gap junctions and intercellular calcium signalling in striatal astrocytes. Nature 376 (1995) 590-594
310. Verdon B., Zheng J., Nicholson R.A., Ganelli C.R., and Lees G. Stereoselective modulatory actions of oleamide on GABA(A) receptors and voltage-gated Na(+) channels in vitro: a putative endogenous ligand for depressant drug sites in CNS. Br J Pharmacol 129 (2000) 283-290
311. Verghese C. Quinine psychosis. Br J Psychiatry 153 (1988) 575-576
312. Verrotti A., Manco R., Matricardi S., Franzoni E., and Chiarelli F. Antiepileptic drugs and visual function. Pediatric neurology 36 (2007) 353-360
313. Vessey J.P., Lalonde M.R., Mizan H.A., Welch N.C., Kelly M.E., and Barnes S. Carbenoxolone inhibition of voltage-gated Ca channels and synaptic transmission in the retina. J Neurophysiol 92 (2004) 1252-1256
314. Wallenstein M.C. Effect of prostaglandin synthetase inhibitors on non-analgesic actions of morphine. Eur J Pharmacol 90 (1983) 65-73
315. Wallenstein M.C. Differential effect of prostaglandin synthetase inhibitor pretreatment on pentylenetetrazol-induced seizures in rat. Arch Int Pharmacodyn Ther 275 (1985) 93-104
316. Wallenstein M.C. Differential effects of prostaglandin synthetase inhibitors on EEG in rat. Eur J Pharmacol 111 (1985) 201-209
317. Wambebe C., Sokomba E., and Amabeoku G. Effect of quinine on electroshock and pentylenetetrazol-induced seizures in mice. Prog Neuropsychopharmacol Biol Psychiatry 14 (1990) 121-127
318. Wang X., Inukai T., Greer M.A., and Greer S.E. Rat Prl and TSH secretion are regulated differently by K(+)-channel blockers. Am J Physiol 266 (1994) E39-E43
319. Wang H.S., Dixon J.E., and McKinnon D. Unexpected and differential effects of Cl- channel blockers on the Kv4.3 and Kv4.2 K+ channels. Implications for the study of the I(to2) current. Circ Res 81 (1997) 711-718
320. Wang Q., Wang Y.X., Yu M., and Kotlikoff M.I. Ca(2+)-activated Cl- currents are activated by metabolic inhibition in rat pulmonary artery smooth muscle cells. Am J Physiol 273 (1997) C520-C530
321. Weiler R., He S., and Vaney D.I. Retinoic acid modulates gap junctional permeability between horizontal cells of the mammalian retina. Eur J Neurosci 11 (1999) 3346-3350
322. Weingart R., and Bukauskas F.F. Long-chain n-alkanols and arachidonic acid interfere with the Vm-sensitive gating mechanism of gap junction channels. Pflugers Arch 435 (1998) 310-319
323. Weiss S.M., Benwell K., Cliffe I.A., Gillespie R.J., Knight A.R., Lerpiniere J., et al. Discovery of nonxanthine adenosine A2A receptor antagonists for the treatment of Parkinson's disease. Neurology 61 (2003) S101-S106
324. Wentlandt K., Samoilova M., Carlen P.L., and El Beheiry H. General anesthetics inhibit gap junction communication in cultured organotypic hippocampal slices. Anesth Analg 102 (2006) 1692-1698
325. White M.M., and Aylwin M. Niflumic and flufenamic acids are potent reversible blockers of Ca2(+)-activated Cl- channels in Xenopus oocytes. Mol pharmacol 37 (1990) 720-724
326. Williams K. Interactions of polyamines with ion channels. Biochem J 325 Pt 2 (1997) 289-297
327. Willkens R.F., and Vreede P. Sodium meclofenamate ('Meclomen') in the treatment of rheumatoid arthritis: a double-blind comparison with aspirin and placebo. Pharmatherapeutica 2 (1981) 587-596
328. Wolf F., and Kirchhoff F. Neuroscience. Imaging astrocyte activity. Science 320 (2008) 1597-1599
329. Woodward R.M., Polenzani L., and Miledi R. Effects of fenamates and other nonsteroidal anti-inflammatory drugs on rat brain GABAA receptors expressed in Xenopus oocytes. J Pharmacol Exp Ther 268 (1994) 806-817
330. Wrobel A. Beta activity: a carrier for visual attention. Acta Neurobiol Exp 60 (2000) 247-260
331. Wu G., and Hamill O.P. NPPB block of Ca(++)-activated Cl- currents in Xenopus oocytes. Pflugers Arch 420 (1992) 227-229
332. Wu C.F., Li C.L., Song H.R., Zhang H.F., Yang J.Y., and Wang Y.L. Selective effect of oleamide, an endogenous sleep-inducing lipid amide, on pentylenetetrazole-induced seizures in mice. J Pharm Pharmacol 55 (2003) 1159-1162
333. Xu S.Z., Zeng F., Boulay G., Grimm C., Harteneck C., and Beech D.J. Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect. Br J Pharmacol 145 (2005) 405-414
334. Yamawaki N., Stanford I.M., Hall S.D., and Woodhall G.L. Pharmacologically induced and stimulus evoked rhythmic neuronal oscillatory activity in the primary motor cortex in vitro. Neuroscience 151 (2008) 386-395
335. Yang J.Y., Wu C.F., and Song H.R. Studies on the sedative and hypnotic effects of oleamide in mice. Arzneim-Forsch 49 (1999) 663-667
336. Yatani A., Wakamori M., Mikala G., and Bahinski A. Block of transient outward-type cloned cardiac K+ channel currents by quinidine. Circ Res 73 (1993) 351-359
337. Ye Z.C., Wyeth M.S., Baltan-Tekkok S., and Ransom B.R. Functional hemichannels in astrocytes: a novel mechanism of glutamate release. J Neurosci 23 (2003) 3588-3596
338. Ylinen A., Bragin A., Nadasdy Z., Jando G., Szabo I., Sik A., et al. Sharp wave-associated high-frequency oscillation (200 Hz) in the intact hippocampus: network and intracellular mechanisms. J Neurosci 15 (1995) 30-46
339. Zahn J.R., Brinton G.F., and Norton E. Ocular quinine toxicity followed by electroretinogram, electro-oculogram, and pattern visually evoked potential. Am J Optom Physiol Opt 58 (1981) 492-498
340. Zhang D.Q., and McMahon D.G. Direct gating by retinoic acid of retinal electrical synapses. Proc Natl Acad Sci U S A 97 (2000) 14754-14759
341. Zhang Y., Perez Velazquez J.L., Tian G.F., Wu C.P., Skinner F.K., Carlen P.L., et al. Slow oscillations (
342. Zhang Z.H., Kang Y.M., Yu Y., Wei S.G., Schmidt T.J., Johnson A.K., et al. 11beta-hydroxysteroid dehydrogenase type 2 activity in hypothalamic paraventricular nucleus modulates sympathetic excitation. Hypertension 48 (2006) 127-133
343. Zhao H.B., Yu N., and Fleming C.R. Gap junctional hemichannel-mediated ATP release and hearing controls in the inner ear. Proc Natl Acad Sci U S A 102 (2005) 18724-18729
344. Zhao H.B., Kikuchi T., Ngezahayo A., and White T.W. Gap junctions and cochlear homeostasis. J membr biol 209 (2006) 177-186
345. Zheng J., Ren T., Parthasarathi A., and Nuttall A.L. Quinine-induced alterations of electrically evoked otoacoustic emissions and cochlear potentials in guinea pigs. Hear Res 154 (2001) 124-134
346. Zhou S.S., Gao Z., Dong L., Ding Y.F., Zhang X.D., Wang Y.M., et al. Anion channels influence ECC by modulating L-type Ca(2+) channel in ventricular myocytes. J Appl Physiol 93 (2002) 1660-1668
347. Zhou S.S., Yang J., Li Y.Q., Zhao L.Y., Xu M., and Ding Y.F. Effect of Cl- channel blockers on aconitine-induced arrhythmias in rat heart. Exp physiol 90 (2005) 865-872
348. Zhou S.S., Zhang L.B., Sun W.P., Xiao F.C., Zhou Y.M., Li Y.J., et al. Effects of monocarboxylic acid-derived Cl- channel blockers on depolarization-activated potassium currents in rat ventricular myocytes. Exp physiol 92 (2007) 549-559