Prospects for rational development of pharmacological gap junction channel blockers

Current Drug Targets

Volumn 3, Issue 6, 2002, Pages 455-464

  Spray, David C ^a   Rozental, Renato ^a   Srinivas, Miduturu ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 ACETAMIDO 4' ISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; ALCOHOL DERIVATIVE; BENZYLQUININIUM; BETA CATENIN; CAVEOLIN; CAVEOLIN 1; CHLORIDE CHANNEL BLOCKING AGENT; CONNEXIN 32; CONNEXIN 43; FENAMIC ACID DERIVATIVE; FLUFENAMIC ACID; FUROSEMIDE; GAP JUNCTION PROTEIN; GLYCYRRHIZIC ACID DERIVATIVE; HALOTHANE; HYDROXYSTEROID DEHYDROGENASE; LOCAL ANESTHETIC AGENT; MECLOFENAMIC ACID; MEFLOQUINE; NIFLUMIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; OCCLUDIN; PROSTAGLANDIN SYNTHASE; PROTEIN INHIBITOR; PROTEIN KINASE C; QUININE; QUININE DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; CHANNEL GATING; CHEMICAL ANALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SELECTIVITY; ENZYME INHIBITION; GAP JUNCTION; GENE DELETION; GENETIC DISORDER; HEART PROTECTION; HUMAN; NEUROPROTECTION; NONHUMAN; PROTEIN FUNCTION; PROTEIN TARGETING; REVIEW;

ANIMALS; CONNEXINS; DRUG DELIVERY SYSTEMS; GAP JUNCTIONS; HUMANS; ION CHANNELS;

EID: 0036888975     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389450023347353     Document Type: Review

References (91)

1. Rozental, R., Srinivas, M., and Spray, D.C. (2000) Methods in Molecular Biology: Connexin Methods and Protocols, pp.447-476.
2. Plum, A., Hallas, G., Magin, T., Dombrowski, F., Hagendorff, A., Schumacher, B., Wolpert, C., Kim, J., Lamers, W.H., Evert, M., Meda, P., Traub, O., Willecke, K. (2000) Curr. Biol. 10, 1083-91.
3. White, T.W., Paul D.L. (1999) Annu. Rev. Physiol. 61, 283-310.
4. Krutovskikh, V., Yamasaki, H. (2000) Mutat. Res. 462, 197-207.
5. Gabriel, H.D., Jung, D., Butzler, C., Temme, A., Traub, O., Winterhager, E., Willecke, K. (1998) J. Cell Biol. 140, 1453-61.
6. Rami. A., Volkmann, T., Winckler, J. (2001) Exp. Neurol. 170, 297-304.
7. Cotrina, M.L., Kang, J., Lin, J.H., Bueno, E., Hansen,T.W., He, L., Liu, Y., Nedergaard, M. (1998) J. Neurosci. 18, 2520-37.
8. Rawanduzy, A., Hansen, A., Hansen, T.W., Nedergaard, M. (1997) J. Neurosurg. 87, 916-20
9. Cotrina, M.L., Kang, J., Lin, J.H., Bueno, E., Hansen, T.W., He, L., Liu, Y., Nedergaard, M. (1998) J. Neurosci. 18, 2520-37.
10. Pitts, J.D. (1994) Mol. Carcinog. 11, 127-30
11. Andrade-Rozental, A.F., Rozental, R., Hopperstad, M.G., Wu, J.K., Vrionis, F.D., Spray, D.C. (2000) Brain Res. Rev. 32, 308-15.
12. Estin, D., Li, M., Spray, D., Wu, J.K. (1999) Neurosurgery 44, 361-8
13. White, T.W. and Paul, D.L. (1999) Annu. Rev. Physiol. 61, 283-310.
14. Verselis, V.K. and Veenstra, R.D. (2000) Advances in Molecular and Cell Biology 129-192,
15. Spray, D.C. and Scemes, E. (1998) In: pH and Brain Function (Kaila, K. and Ransom, B.R. eds), Academic Press, NY, pp.477-489.
16. Srinivas, M., Rozental, R., Kojima, T., Dermietzel, R., Mehler, M., Condorelli, D.F., Kessler, J.A. and Spray, D.C. (1999) J. Neurosci. 19, 9848-9855.
17. Srinivas, M., Costa, M., Gao, Y., Fort, A., Fishman, G.I. and Spray, D.C. (1999) J. Physiol. 517(3), 673-689.
18. Moreno, A.P., Rook, M.B., Fishman, G.I. and Spray, D.C. (1994) Biophys. J. 67, 113-119.
19. Bukauskas, F.F., Bukauskiene, A., Verselis, V.K. (2002) J. Gen. Physiol. 119, 171-86.
20. Harriss, A.L. (2001) Q. Rev. Biophys. 34(3), 325-472.
21. Purnick, P.E., Benjamin, D.C., Verselis, V.K.., Bargiello, T.A., Dowd, T.L. (2000) Arch. Biochem. Biophys. 381, 181-90.
22. Harris, A.L., Spray, D.C., Bennett, M.V. (1983) J. Neurosci. 3, 79-100.
23. Peracchia, C., Sotkis, A., Wang, X.G., Peracchia, L,L., Persechini, A. (2000) J. Biol. Chem. 275, 26220-4.
24. Eckert ,R. (2002) Pflugers Arch. 443, 843-51.
25. Spray, D.C., Harris, A.L., Bennett, M.V. (1981) Science 211, 712-5.
26. Spray, D.C. and Burt, J.M. (1990) Amer. J. Physiol. 258, C195-C207.
27. Ek-Vitorin, J.F., Calero, G., Morley, G.E., Coombs, W., Taffet, S.M. and Delmar, M. (1996) Biophys. J. 7, 1273-1284.
28. Morley, E.G., Traffet, S.M. and Delmar, M. (1996) Biophys. J. 70, 1294-1302.
29. Calero, G., Kanemitsu, M., Taffet, S.M., Lau, A.F. and Delmar, M. (1998) Circ. Res. 18, 929-935.
30. Duffy, H.S., Sorgen, P., Taffet, S., Girvin, M., Delmar, M. and Spray, D.C. (2002) J. Biol. Chem. in press.
31. Malchow, R.P., Quian, H. and Ripps, H. (1994) J. Gen. Physiol. 104, 1039-1055.
32. White, T.W., Deans, M.R., O'Brien, J., Al-Ubaidi, M.R., Goodenough, D.A., Ripps, H. and Bruzzone, R. (1999) Eur. J. Neurosci. 11, 1883-1890
33. Srinivas, M., Hopperstad, M.G. and Spray, D.C. (2001) PNAS 98, 10942-10947.
34. White, M.M. and Aylwin, M. (1990) Niflumic and flufenamic acids are potent reversible blockers of Ca2+-activated Cl- channels in Xenopus oocytes. Mol. Pharmacol. 37, 720-724.
35. Gögelein, H., Dahlem, D., Englert, H.C. and Lang, H.J. (1990) Flufenamic acid, mefenamic acid and niflumic acid inhibit single nonselective cation channels in the rat exocrine pancreas. FEBS Lett. 268, 79-82
36. Harks, E.G.A., De Roos, A.D.G., Peters, P.H.J., DeHaan, L.H., Brouwer, A., Ypey, D.L., VanZoelen, E.J.J., Theuvenet A.P.R. (2001) J. Pharmacol. And Exp. Therapeut. 298, 1033-1041.
37. Eskandari, S., Zampighi, E.S., Leung D.W., Wright, E.M., Loo, D.D. (2002) J. Xlembr. Biol. 185, 93-102
38. Davidson, J.S., Baumgarten, I.M., Harley, F.H. (1986) Biochem. Biophys. Res. Commun. 134, 29-36.
39. Davidson, J.S., Baurrigarten, I.M. (1988). J. Pharmacol. Exp. Ther. 246, 1104-1107.
40. Goldberg, G.S., Moreno, A.P., Bechberger, J.F., Hearn, S.S., Shivers, R.R., MacPhee, D.J., Zhang, Y.C., Naus, C.C. (1996) Exp. Cell Res. 222, 48-53.43.
41. Guan, X., Wilson, S., Schlender, K.K., Ruch, R.J. (1996) Mol. Carcinog. 16, 157-64.
42. Johnston, M.F., Simon, S.A. and Ramon, F. (1980) Nature 286, 498-500.
43. Scemes, E., Suadicani, S.O., Spray, D.C. (2000). J. Neurosci. 20, 1435-45.
44. Bastiaanse, E.M., Jongsma, H.J., can dr Laarse, A. and Takens-Kwak, B.R. (1993) J. Membr. Biol. 136, 135-145.
45. Takens-Kwak, B.R., Jongsma, H.J., Rook, M.B. and Can Ginneken, A.C. (1992) Am. J. Physiol. 262, C1531-C1538
46. Burt, J.M. and Spray, D.C. (1989) Circ. Research 65, 829-837.
47. John, S.A., Kondo, R., Wang, S.Y., Goldhaber, J.I., Weiss, J.N. (1999) J. Biol. Chem. 274, 236-40
48. Kondo, R.P., Wang, S.Y., John, S.A., Weiss, J.N., Goldhaber, J.I. (2000) J. Mol. Cell Cardiol. 32, 1859-72
49. Contreras, J.E., Sanchez, H.A., Eugenin, E.A., Speidel, D., Theis, M., Willecke, K., Bukauskas, F.F., Bennett, M.V., Saez, J.C. (2002) Proc. Natl. Acad. Sci. USA 99(l), 495-500.
50. Cotrina, M.L., Lin, J.H., Alves-Rodrigues, A., Liu, S., Li, J., Azmi-Ghadimi, H., Kang, J., Naus, C.C., Nedergaard, M. (1998) Proc. Natl. Acad. Sci. USA 95, 15735-40.
51. Stout, C.E., Costantin, J.L., Naus, C.C., Charles, A.C. (2002) J. Biol. Chem. 277, 10482-8.
52. Schwarze, W. Kolb (1984) Pflugers Arch. 402, 281-91
53. Blatz, A.L., Magleby, K.L. (1983) Biophys. J. 43, 237-41
54. Buettner, R., Papoutsoglou, G., Scemes, E., Spray, D., Dermietzel, R. (2000) Proc. Natl. Acad. Sci. USA 97, 3201-6.
55. Schein, S.J., Colombini, M., Finkelstein, A. (1976) J. Membr. Biol. 30, 99-120.
56. Spray, D.C., Harris, A.L., Bennett, M.V. (1979) Science 204, 432-4.
57. Harris, A.L., Spray, D.C., Bennett, M.V. (1981) J. Gen. Physiol. 77, 95-117.
58. Beyer, E.C., Steinberg, T.H. (1991) J. Biol, Chem. 266, 7971-4.
59. Alves, L.A., Coutinho-Silva, R., Persechini, P.M., Spray, D.C., Savino, W., Campos, de Carvalho, A.C. (1996) Blood 88, 328-34.
60. Surprenant, A., Rassendren, F., Kawashima, E., North, R.A., Buell, G. (1996) Science 272, 735-8.
61. Paul, D.L., Ebihara, L., Takemoto, L.J., Swenson, K.I., Goodenough, D.A. (1981) J. Cell Biol. 115, 1077-89.
62. Pfahnl, A., Dahl, G. (1998) Biophys. J. 175, 2323-31.
63. Trexler, E.B., Bennett, M.V., Bargiello, T.A., Verselis, V.K. (1996) Proc. Natl. Acad. Sci. USA 93(12), 5836-41.
64. Naus, C.C., Bond, S.L., Bechberger, J.F., Rushlow, W. (2002) Brain Res. Rev. 32, 259-66.
65. Iacobas, D.A., Iacobas, S., Urban, M., Spray, D.C. (2002) Soc. Neurosci. Abstr., in press.
66. Duffy, H.S., Delamr, M., Spray, D.C. (2002) J. Physiol. Paris, in press.
67. Spray, D.C., Duffy, H.S., Scemes, E. (1999) Adv. Exp. Med. Biol. 468, 339-59.
68. Giepmans, B.N.G. and Moolenaar, W.H. (1998) Current Biol. 8, 931-4.
69. Toyofuku, T., Yabuki, M., Otsu, M., Kuzuya, K., Hori, M. and Tada, M. (1998) J. Biol. Chem. 12723-12731.
70. Toyofuku, T., Akamatsu, Y., Zhang, H., Kuzuya, T., Tada, M. and Hori, M. (2001) J. Biol. Chem. 276, 1780-1788.
71. Loo, L., Kanemitsu, M.Y. and Lau, A.F. (1999) Mol. Carcinogenesis 25, 187-195.
72. Geipmans, B.N.G., Hengeveld, T., Postma, F. and Moolenaar, W.H. (2002) J. Biol. Chemistry 276, 8544-8549.
73. Schubert, A.L., Schubert, W., Spray, D.C., Lisanti, M.P. (2002) Biochemistry 41, 5754-64,
74. Geipmans, B.N.G., Verlaan, I., Hengeveld, T., Janssen, H., Calafat, J., Falk, M.M. and Moolenaar, W.H. (2001) Current Biol. II, 1364-1368.
75. Ai, Z., Fischer, A., Spray, D.C., Brown, A.M.C. and Fishman, G.I. (2000) J. Clin. Invest. 105, 161-171.
76. Xu, X., Li, W.E.I., Huang, G.Y., Meyer, R., Chen, T., Luo, Y., Thomas, M.P., Radice, G.L. and Lo, C.W. (2002) J. Cell Biol. 154, 217-229.
77. Kojima, T., Sawada, N., Chiba, H., Kokai, Y., Yamamoto, M., Urban, M., Lee, G.H., Hertzberg, E.L., Mochizuki, Y., Spray, D.C. (1999) Biochem. Biophys. Res. Commun. 266, 222-9.
78. Nusrat, A., Chen, J.A., Foley, S.C., Liang, T.W., Tom, J., Cromwell, M., Quan, C. and Mrsny, R.J. (2000) J. Biol. Chem. 275, 29816-29822.
79. Laing, J.G., Manley-Markowski, R.N. Koval, M., Civitelli, R., Steinberg, T.H. (2001) J. Biol. Chem. 276, 23051-5.
80. Meyer, R.A., Laird, D.N., Revel, J.P. and Johnson, R.G. (1992) J. Cell Biol. 119, 179-189.
81. Hofer, A. and Dermiezel, R. (1998) Glia 24, 141-154.
82. Dahl, G., Nonner, R. and Werner, R. (1994) Biophys. J. 67, 1816-1822.
83. Boitano, S. and Evans, W.H. (2000) Am. J. Physiol. Lung Cell Mol. Physiol. 279, L623-L630.
84. Chaytor, A.T. Evans, W.H. and Griffith, T.M. (1997) J. Physiol. 516, 679-685
85. Kwak, BR. and Johngsma, H.J. (1999) J. Physiol. 516, 679-685.
86. Warner, A.E,, Clements, D.K., Parileh, S., Evans, W.H. and DeHaan, R.L. (1995) J. Physiol. 488, 721-728.
87. Berthoud, V.M., Beyer, E.C., Seul, K.H. (2000) Amer. J. Physiol. Lung Cell Mol. Physiol. 279, L619-L622.
88. Aonuma, S., Kohama, Y., Akai, K., Komiyama, Y, Nakajima, S., Wakabayashi, M., Makino, T. (1980) Chem. Pharm. Bull. 28, (11), 3332-9.
89. Aonuma, S., Kohama, Y., Makino, T., Hattori, K. (1983) Yakugaku Zasshi 103, (6), 662-6.
90. Dhein, S. and Tudyka, T. (1995) Drugs 49, 851-855.
91. Dhein, S., Tudyka, T., Schott, M., Gotttwald, W., Piecha, D., Muller, A. and Klaus, W. (1995) Naunyn Schmiedeberg's Arch. Pharmacol. 351, 130-134.