Stereoselective modulatory actions of oleamide on GABA(A) receptors and voltage-gated Na+ channels in vitro: A putative endogenous ligand for depressant drug sites in CNS

British Journal of Pharmacology

Volumn 129, Issue 2, 2000, Pages 283-290

  Verdon, Bernard ^a   Zheng, Jian ^b   Nicholson, Russell A ^b   Ganellin, C Robin ^c   Lees, George ^a  

^a UNIVERSITY OF SUNDERLAND   (United Kingdom)

^b SIMON FRASER UNIVERSITY   (Canada)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

cis 9,10 octadecenoamide (oleamide); Cultured rat cortical neurons; Electrophysiology patch clamp; Endogenous sleep regulator; GABA(A) receptor; Hypnotic anaesthetic anticonvulsant drugs; Mouse synaptoneurosomes synaptosomes; Sustained repetitive firing; Transmitter release

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ANTICONVULSIVE AGENT; BARBITURIC ACID DERIVATIVE; CALCIUM ION; CENTRAL DEPRESSANT AGENT; OLEAMIDE; POTASSIUM ION; SEDATIVE AGENT; SODIUM CHANNEL; VERATRIDINE;

4 AMINOBUTYRIC ACID RELEASE; ACTION POTENTIAL; ANIMAL CELL; AROUSAL; ARTICLE; BRAIN CORTEX; CELL CULTURE; CENTRAL NERVOUS SYSTEM; CHANNEL GATING; CONTROLLED STUDY; DEPOLARIZATION; ELECTROPHYSIOLOGY; EMBRYO; MEMBRANE CURRENT; MOUSE; NERVE CELL; NERVE CELL NETWORK; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; STEREOCHEMISTRY; SYNAPTIC INHIBITION; SYNAPTOSOME;

EID: 0033984882     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703051     Document Type: Article

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