Ethanol suppression of ventral tegmental area GABA neuron electrical transmission involves N-methyl-D-aspartate receptors

Journal of Pharmacology and Experimental Therapeutics

Volumn 311, Issue 1, 2004, Pages 282-289

  Stobbs, Sarah H ^a   Ohran, Allison J ^a   Lassen, Matthew B ^a   Allison, David W ^a   Brown, J Elliott ^a   Steffensen, Scott C ^a  

^a BRIGHAM YOUNG UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ALCOHOL; CHLORDIAZEPOXIDE; CONNEXIN 36; DIZOCILPINE; DOPAMINE; METHOHEXITAL; MUSCIMOL; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; QUINIDINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAPSULA INTERNA; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DRUG EFFECT; ELECTRIC CONDUCTIVITY; GABAERGIC TRANSMISSION; GAP JUNCTION; MALE; MICROELECTRODE; MICROELECTROPHORESIS; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR INTRINSIC ACTIVITY; REWARD; SPIKE; SYNAPTIC TRANSMISSION; VENTRAL TEGMENTUM;

ANIMALS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CONNEXINS; DOPAMINE; ETHANOL; GAMMA-AMINOBUTYRIC ACID; GAP JUNCTIONS; HYPNOTICS AND SEDATIVES; MALE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; VENTRAL TEGMENTAL AREA;

EID: 4644243450     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.071860     Document Type: Article

References (38)

1. Appel SB, Liu Z, McElvain MA, and Brodie MS (2003) Ethanol excitation of dopaminergic ventral tegmental area neurons is blocked by quinidine. J Pharmacol Exp Ther 306:437-446.
2. Bennett MV (2002) Neoreticularism and neuronal polarization. Prog Brain Res 136:189-201.
3. Berretta N, Paolucci E, Bernardi G, and Mercuri NB (2001) Glutamate receptor stimulation induces a persistent rhythmicity of the GABAergic inputs to rat midbrain dopaminergic neurons. Eur J Neurosci 14:777-784.
4. Brodie MS and Appel SB (1998) The effects of ethanol on dopaminergic neurons of the ventral tegmental area studied with intracellular recording in brain slices. Alcohol Clin Exp Res 22:236-244.
5. Brodie MS, Shefner SA, and Dunwiddie TV (1990) Ethanol increases the firing rate of dopamine neurons of the rat ventral tegmental area in vitro. Brain Res Brain Res Rev 508:65-69.
6. Buzsaki G and Chrobak JJ (1995) Temporal structure in spatially organized neuronal ensembles: a role for interneuronal networks. Curr Opin Neurobiol 5:504-510.
7. Carlen PL, Skinner F, Zhang L, Naus C, Kushnir M, and Perez Velazquez JL (2000) The role of gap junctions in seizures. Brain Res Rev 32:235-241.
8. Chester JA and Cunningham CL (2002) GABA(A) receptor modulation of the rewarding and aversive effects of ethanol. Alcohol 26:131-143.
9. A receptors in mediating the effects of alcohol in the central nervous system. J Psychiatry Neurosci 28:263-274.
10. Di Chiara G (2002) Electrophysiological Pharmacology of Mesencephalic Dopamine Neurons. Springer, Berlin, Germany.
11. Diana M, Pistis M, Carboni S, Gessa GL, and Rossetti ZL (1993) Profound decrement of mesolimbic dopaminergic neuronal activity during ethanol withdrawal syndrome in rats: electrophysiological and biochemical evidence. Proc Natl Acad Sci USA 90:7966-7969.
12. Diana M, Pistis M, Muntoni A, and Gessa G (1996) Mesolimbic dopaminergic reduction outlasts ethanol withdrawal syndrome: evidence of protracted abstinence. Neuroscience 71:411-415.
13. Galarreta M and Hestrin S (2001) Electrical synapses between GABA-releasing interneurons. Nat Rev Neurosci 2:425-433.
14. Gallegos RA, Criado JE, Lee RS, Henriksen SJ, and Steffensen SC (1999) Adaptive responses of GABAergic neurons in the ventral tegmental area to chronic ethanol. J Pharmacol Exp Ther 291:1045-1053.
15. Harris RA (1999) Ethanol actions on multiple ion channels: which are important? Alcohol Clin Exp Res 23:1563-1570.
16. Kitai ST, Shepard PD, Callaway JC, and Scroggs R (1999) Afferent modulation of dopamine neuron firing patterns. Curr Opin Neurobiol 9:690-697.
17. Mantz J, Cordier J, and Giaume C (1993) Effects of general anesthetics on intercellular communications mediated by gap junctions between astrocytes in primary culture. Anesthesiology 78:892-901.
18. McBride WJ, Murphy JM, Gatto GJ, Levy AD, Yoshimoto K, Lumeng L, and Li TK (1993) CNS mechanisms of alcohol self-administration. Alcohol Alcohol Suppl 2:463-467.
19. Mereu G and Gessa GL (1985) Low doses of ethanol inhibit the firing of neurons in the substantia nigra, pars reticulata: a GABAergic effect? Brain Res 348:201-203.
20. O'Donnell P, Greene J, Pabello N, Lewis BL, and Grace AA (1999) Modulation of cell firing in the nucleus accumbens. Ann NY Acad Sci 877:157-175.
21. Overton PG and Clark D (1997) Burst firing in midbrain dopaminergic neurons. Brain Res Brain Res Rev 25:312-334.
22. Perez-Velazquez JL, Valiante TA, and Carlen PL (1994) Modulation of gap junctional mechanisms during calcium-free induced field burst activity: a possible role for electrotonic coupling in epileptogenesis. J Neurosci 14:4308-4317.
23. Rash JE, Yasumura T, Dudek FE, and Nagy JI (2001) Cell-specific expression of connexins and evidence of restricted gap junctional coupling between glial cells and between neurons. J Neurosci 21:1983-2000.
24. Roerig B and Feller MB (2000) Neurotransmitters and gap junctions in developing neural circuits. Brain Res Brain Res Rev 32:86-114.
25. Rozental R, Giaume C, and Spray DC (2000) Gap junctions in the nervous system. Brain Res Brain Res Rev 32:11-15.
26. Spray DC, Dermietzel R (1996) Gap Junctions in the Nervous System: An Introduction. R.G. Landes Company, Austin, TX.
27. Srinivas M, Hopperstad MG, and Spray DC (2001) Quinine blocks specific gap junction channel subtypes. Proc Natl Acad Sci USA 98:10942-10947.
28. Steffensen SC, Lee RS, Henriksen SJ, Packer TL, and Cook DR (2002) A novel electroencephalographic analysis method discriminates alcohol effects from those of other sedative/hypnotics. J Neurosci Methods 115:145-156.
29. Steffensen SC, Nie Z, Criado JR, and Siggins GR (2000) Ethanol inhibition of N-methyl-D-aspartate responses involves presynaptic gamma-aminobutyric acid(B) receptors. J Pharmacol Exp Ther 294:637-647.
30. Steffensen SC, Stobbs SH, Allison DW, Lassen MB, Brown JE, and Henriksen SJ (2003) Ventral tegmental area GABA neurons form a network of dopamine-sensitive electrical synapses: role in brain stimulation reward. Soc Neurosci Abstr 29:679.674.
31. Steffensen SC, Svingos AL, Pickel VM, and Henriksen SJ (1998) Electrophysiological characterization of GABAergic neurons in the ventral tegmental area. J Neurosci 18:8803-8815.
32. Tamas G, Buhl EH, Lorincz A, and Somogyi P (2000) Proximally targeted GABAergic synapses and gap junctions synchronize cortical interneurons. Nat Neurosci 3:366-371.
33. Uusisaari M, Smirnov S, Voipio J, and Kaila K (2002) Spontaneous epileptiform activity mediated by GABA(A) receptors and gap junctions in the rat hippocampal slice following long-term exposure to GABA(B) antagonists. Neuropharmacology 43:563-572.
34. Weiler R, Pottek M, He S, and Vaney DI (2000) Modulation of coupling between retinal horizontal cells by retinoic acid and endogenous dopamine. Brain Res Brain Res Rev 32:121-129.
35. Weiss F, Lorang MT, Bloom FE, and Koob GF (1993) Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants. J Pharmacol Exp Ther 267:250-258.
36. Wise RA (1996) Addictive drugs and brain stimulation reward. Annu Rev Neurosci 19:319-340.
37. Wozniak KM, Pert A, Mele A, and Linnoila M (1991) Focal application of alcohols elevates extracellular dopamine in rat brain: a microdialysis study. Brain Res 540:31-40.
38. Yang Q and Michelson HB (2001) Gap junctions synchronize the firing of inhibitory interneurons in guinea pig hippocampus. Brain Res 907:139-143.