Neuronal GAP Junctions: Expression, Function, And Implications For Behavior

International Review of Neurobiology

Volumn 73, Issue , 2006, Pages 125-151

  McCracken, Clinton B ^a   Roberts, David C S ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; BEHAVIOR; BIOLOGICAL MODEL; CELL JUNCTION; GENETICS; HUMAN; METABOLISM; NERVE CELL; NERVE CELL PLASTICITY; PHYSIOLOGY; REVIEW; SYNAPSE; ULTRASTRUCTURE;

ANIMALS; BEHAVIOR; GAP JUNCTIONS; HUMANS; MODELS, BIOLOGICAL; NEURONAL PLASTICITY; NEURONS; SYNAPSES;

EID: 33646850700     PISSN: 00747742     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0074-7742(06)73004-5     Document Type: Review

References (191)

1. Altevogt B.M., and Paul D.L. Four classes of intercellular channels between glial cells in the CNS. J. Neurosci. 24 (2004) 4313-4323
2. Alvarez-Maubecin V., Garcia-Hernandez F., Williams J.T., and Van Bockstaele E.J. Functional coupling between neurons and glia. J. Neurosci. 20 (2000) 4091-4098
3. Andrew R.D., MacVicar B.A., Dudek F.E., and Hatton G.I. Dye transfer through gap junctions between neuroendocrine cells of rat hypothalamus. Science 211 (1981) 1187-1189
4. Baker R., and Llinas R. Electrotonic coupling between neurones in the rat mesencephalic nucleus. J. Physiol. 212 (1971) 45-63
5. Barr L., Dewey M.M., and Berger W. Propagation of action potentials and the structure of the nexus in cardiac muscle. J. Gen. Physiol. 48 (1965) 797-823
6. Bartos M., Vida I., Frotscher M., Meyer A., Monyer H., Geiger J.R., and Jonas P. Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks. Proc. Natl. Acad. Sci. USA 99 (2002) 13222-13227
7. Bear M.F., Connors B.W., and Paradiso M.A. "Neuroscience: Exploring the Brain,". 2nd ed. (2001), Lippincott Williams & Wilkins, Baltimore
8. Belluardo N., Mudo G., Trovato-Salinaro A., Le Gurun S., Charollais A., Serre-Beinier V., Amato G., Haefliger J.A., Meda P., and Condorelli D.F. Expression of connexin36 in the adult and developing rat brain. Brain Res. 865 (2000) 121-138
9. Bennett M.V.L. Gap junctions as electrical synapses. J. Neurocytol. 26 (1997) 349-366
10. Bennett M.V.L., Crain S.M., and Grundfest H. Electrophysiology of supramedullary neurons in Spheroides maculatus. I: Orthodromic and antidromic responses. J. Gen. Physiol. 43 (1959) 159-188
11. Bennett M.V.L., and Zukin R.S. Electrical coupling and neuronal synchronization in the mammalian brain. Neuron 41 (2004) 495-511
12. Bernardini G., Peracchia C., and Peracchia L.L. Reversible effects of heptanol on gap junction structure and cell-to-cell electrical coupling. Eur. J. Cell Biol. 34 (1984) 307-312
13. Blatow M., Rozov A., Katona I., Hormuzdi S.G., Meyer A.H., Whittington M.A., Caputi A., and Monyer H. A novel network of multipolar bursting interneurons generates theta frequency oscillations in neocortex. Neuron 38 (2003) 805-817
14. Boger D.L., Henriksen S.J., and Cravatt B.F. Oleamide: An endogenous sleep-inducing lipid and prototypical member of a new class of biological signaling molecules. Curr. Pharm. Des. 4 (1998) 303-314
15. Boger D.L., Patterson J.E., Guan X., Cravatt B.F., Lerner R.A., and Gilula N.B. Chemical requirements for inhibition of gap junction communication by the biologically active lipid oleamide. Proc. Natl. Acad. Sci. USA 95 (1998) 4810-4815
16. Bruzzone R., Hormuzdi S.G., Barbe M.T., Herb A., and Monyer H. Pannexins, a family of gap junction proteins expressed in brain. Proc. Natl. Acad. Sci. USA 100 (2003) 13644-13649
17. Buhl D.L., Harris K.D., Hormuzdi S.G., Monyer H., and Buzsaki G. Selective impairment of hippocampal gamma oscillations in connexin-36 knock-out mouse in vivo. J. Neurosci. 23 (2003) 1013-1018
18. Burt J.M., and Spray D.C. Volatile anesthetics block intercellular communication between neonatal rat myocardial cells. Circ. Res. 65 (1989) 829-837
19. Buzsaki G., and Chrobak J.J. Temporal structure in spatially organized neuronal ensembles: A role for interneuronal networks. Curr. Opin. Neurobiol. 5 (1995) 504-510
20. Buzsaki G., and Draguhn A. Neuronal oscillations in cortical networks. Science 304 (2004) 1926-1929
21. Carlen P.L., Skinner F., Zhang L., Naus C., Kushnir M., and Perez Velazquez J.L. The role of gap junctions in seizures. Brain Res. Rev. 32 (2000) 235-241
22. Cepeda C., Walsh J.P., Hull C.D., Howard S.G., Buchwald N.A., and Levine M.S. Dye-coupling in the neostriatum of the rat: I. Modulation by dopamine-depleting lesions. Synapse 4 (1989) 229-237
23. Chesler M. Regulation and modulation of pH in the brain. Physiol Rev. 83 (2003) 1183-1221
24. Chu Z., Galarreta M., and Hestrin S. Synaptic interactions of late-spiking neocortical neurons in layer 1. J. Neurosci. 23 (2003) 96-102
25. Church J., and Baimbridge K.G. Exposure to high-pH medium increases the incidence and extent of dye coupling between rat hippocampal CA1 pyramidal neurons in vitro. J. Neurosci. 11 (1991) 3289-3295
26. Condorelli D.F., Belluardo N., Trovato-Salinaro A., and Mudo G. Expression of Cx36 in mammalian neurons. Brain Res. Rev. 32 (2000) 72-85
27. Condorelli D.F., Parenti R., Spinella F., Trovato Salinaro A., Belluardo N., Cardile V., and Cicirata F. Cloning of a new gap junction gene (Cx36) highly expressed in mammalian brain neurons. Eur. J. Neurosci. 10 (1998) 1202-1208
28. Condorelli D.F., Trovato-Salinaro A., Mudo G., Mirone M.B., and Belluardo N. Cellular expression of connexins in the rat brain: Neuronal localization, effects of kainate-induced seizures and expression in apoptotic neuronal cells. Eur. J. Neurosci. 18 (2003) 1807-1827
29. Connors B.W., Benardo L.S., and Prince D.A. Coupling between neurons of the developing rat neocortex. J. Neurosci. 3 (1983) 773-782
30. Connors B.W., and Long M.A. Electrical synapses in the mammalian brain. Annu. Rev. Neurosci. 27 (2004) 393-418
31. De Zeeuw C.I., Chorev E., Devor A., Manor Y., Van Der Giessen R.S., De Jeu M.T., Hoogenraad C.C., Bijman J., Ruigrok T.J., French P., Jaarsma D., Kistler W.M., et al. Deformation of network connectivity in the inferior olive of connexin 36-deficient mice is compensated by morphological and electrophysiological changes at the single neuron level. J. Neurosci. 23 (2003) 4700-4711
32. Deans M.R., Gibson J.R., Sellitto C., Connors B.W., and Paul D.L. Synchronous activity of inhibitory networks in neocortex requires electrical synapses containing connexin36. Neuron 31 (2001) 477-485
33. Degen J., Meier C., Van Der Giessen R.S., Sohl G., Petrasch-Parwez E., Urschel S., Dermietzel R., Schilling K., De Zeeuw C.I., and Willecke K. Expression pattern of lacZ reporter gene representing connexin36 in transgenic mice. J. Comp. Neurol. 473 (2004) 511-525
34. Del Re A.M., and Woodwald J.J. Inhibition of gap junction currents by the abused solvent toluene. Drug Alcohol Depend. 78 (2005) 221-224
35. Dere E., Souza-Silva M.A., Frisch C., Teubner B., Sohl G., Willecke K., and Huston J.P. Connexin30-deficient mice show increased emotionality and decreased rearing activity in the open-field along with neurochemical changes. Eur. J. Neurosci. 18 (2003) 629-638
36. Dermietzel R., Farooq M., Kessler J.A., Althaus H., Hertzberg E.L., and Spray D.C. Oligodendrocytes express gap junction proteins connexin32 and connexin45. Glia 20 (1997) 101-114
37. Dermietzel R., Traub O., Hwang T.K., Beyer E., Bennett M.V.L., Spray D.C., and Willecke K. Differential expression of three gap junction proteins in developing and mature brain tissues. Proc. Natl. Acad. Sci. USA 86 (1989) 10148-10152
38. Devor A., and Yarom Y. Electrotonic coupling in the inferior olivary nucleus revealed by simultaneous double patch recordings. J. Neurophysiol. 87 (2002) 3048-3058
39. Draguhn A., Traub R.D., Schmitz D., and Jefferys J.G. Electrical coupling underlies high-frequency oscillations in the hippocampus in vitro. Nature 394 (1998) 189-192
40. Eccles J.C. The synapse: From electrical to chemical transmission. Annu. Rev. Neurosci. 5 (1982) 325-339
41. Eghbali B., Kessler J.A., Reid L.M., Roy C., and Spray D.C. Involvement of gap junctions in tumorigenesis: Transfection of tumor cells with connexin32 cDNA retards growth in vivo. Proc. Natl. Acad. Sci. USA 88 (1991) 10701-10705
42. Eghbali B., Kessler J.A., and Spray D.C. Expression of gap junction channels in communication-incompetent cells after stable transfection with cDNA encoding connexin 32. Proc. Natl. Acad. Sci. USA 87 (1990) 1328-1331
43. Evans W.H., and Martin P.E. Gap junctions: Structure and function. Mol. Membr. Biol. 19 (2002) 121-136
44. Filippov M.A., Hormuzdi S.G., Fuchs E.C., and Monyer H. A reporter allele for investigating connexin 26 gene expression in the mouse brain. Eur. J. Neurosci. 18 (2003) 3183-3192
45. Frisch C., Souza-Silva M.A., Sohl G., Guldenagel M., Willecke K., Huston J.P., and Dere E. Stimulus complexity dependent memory impairment and changes in motor performance after deletion of the neuronal gap junction protein connexin36 in mice. Behav. Brain Res. 157 (2005) 177-185
46. Frisch C., Theis M., Souza Silva M.A., Dere E., Sohl G., Teubner B., Namestkova K., Willecke K., and Huston J.P. Mice with astrocyte-directed inactivation of connexin43 exhibit increased exploratory behaviour, impaired motor capacities, and changes in brain acetylcholine levels. Eur. J. Neurosci. 18 (2003) 2313-2318
47. Fukuda T., and Kosaka T. Gap junctions linking the dendritic network of GABAergic interneurons in the hippocampus. J. Neurosci. 20 (2000) 1519-1528
48. Fukuda T., and Kosaka T. Ultrastructural study of gap junctions between dendrites of parvalbumin-containing GABAergic neurons in various neocortical areas of the adult rat. Neuroscience 120 (2003) 5-20
49. Furshpan E.J., and Potter D.D. Transmission at the giant motor synapses of the crayfish. J. Physiol. 145 (1959) 289-325
50. Gajda Z., Gyengesi E., Hermesz E., Ali K.S., and Szente M. Involvement of gap junctions in the manifestation and control of the duration of seizures in rats in vivo. Epilepsia 44 (2003) 1596-1600
51. Galarreta M., Erdelyi F., Szabo G., and Hestrin S. Electrical coupling among irregular-spiking GABAergic interneurons expressing cannabinoid receptors. J. Neurosci. 24 (2004) 9770-9778
52. Galarreta M., and Hestrin S. A network of fast-spiking cells in the neocortex connected by electrical synapses. Nature 402 (1999) 72-75
53. Galarreta M., and Hestrin S. Electrical synapses between GABA-releasing interneurons. Nat. Rev. Neurosci. 2 (2001) 425-433
54. Galarreta M., and Hestrin S. Spike transmission and synchrony detection in networks of GABAergic interneurons. Science 292 (2001) 2295-2299
55. Galarreta M., and Hestrin S. Electrical and chemical synapses among parvalbumin fast-spiking GABAergic interneurons in adult mouse neocortex. Proc. Natl. Acad. Sci. USA 99 (2002) 12438-12443
56. Gibson J.R., Beierlein M., and Connors B.W. Two networks of electrically coupled inhibitory neurons in neocortex. Nature 402 (1999) 75-79
57. Gibson J.R., Beierlein M., and Connors B.W. Functional properties of electrical synapses between inhibitory interneurons of neocortical layer 4. J. Neurophysiol. 93 (2005) 467-480
58. Grace A.A., and Bunney B.S. Intracellular and extracellular electrophysiology of nigral dopaminergic neurons-3: Evidence for electrotonic coupling. Neuroscience 10 (1983) 333-348
59. Guan X., Cravatt B.F., Ehring G.R., Hall J.E., Boger D.L., Lerner R.A., and Gilula N.B. The sleep-inducing lipid oleamide deconvolutes gap junction communication and calcium wave transmission in glial cells. J. Cell Biol. 139 (1997) 1785-1792
60. Guldenagel M., Ammermuller J., Feigenspan A., Teubner B., Degen J., Sohl G., Willecke K., and Weiler R. Visual transmission deficits in mice with targeted disruption of the gap junction gene connexin36. J. Neurosci. 21 (2001) 6036-6044
61. Gutnick M.J., Lobel-Yaakov R., and Rimon G. Incidence of neuronal dye-coupling in neocortical slices depends on the plane of section. Neuroscience 15 (1985) 659-666
62. Gutnick M.J., and Prince D.A. Dye coupling and possible electrotonic coupling in the guinea pig neocortical slice. Science 211 (1981) 67-70
63. Hampson E.C., Vaney D.I., and Weiler R. Dopaminergic modulation of gap junction permeability between amacrine cells in mammalian retina. J. Neurosci. 12 (1992) 4911-4922
64. Hampson E.C., Weiler R., and Vaney D.I. pH-gated dopaminergic modulation of horizontal cell gap junctions in mammalian retina. Proc. R. Soc. Lond. B Biol. Sci. 255 (1994) 67-72
65. Harris A.L. Emerging issues of connexin channels: Biophysics fills the gap. Q. Rev. Biophys. 34 (2001) 325-472
66. Honma S., De S., Li D., Shuler C.F., and Turman Jr. J.E. Developmental regulation of connexins 26, 32, 36, and 43 in trigeminal neurons. Synapse 52 (2004) 258-271
67. Hormuzdi S.G., Pais I., LeBeau F.E., Towers S.K., Rozov A., Buhl E.H., Whittington M.A., and Monyer H. Impaired electrical signaling disrupts gamma frequency oscillations in connexin 36-deficient mice. Neuron 31 (2001) 487-495
68. Jahromi S.S., Wentlandt K., Piran S., and Carlen P.L. Anticonvulsant actions of gap junctional blockers in an in vitro seizure model. J. Neurophysiol. 88 (2002) 1893-1902
69. Kandel E.R., Schwartz J.H., and Jessel T.M. "Principles of Neural Science,". 4th ed. (2000), McGraw-Hill, New York
70. Kandler K., and Katz L.C. Coordination of neuronal activity in developing visual cortex by gap junction-mediated biochemical communication. J. Neurosci. 18 (1998) 1419-1427
71. Katsumaru H., Kosaka T., Heizmann C.W., and Hama K. Gap junctions on GABAergic neurons containing the calcium-binding protein parvalbumin in the rat hippocampus (CA1 region). Exp. Brain Res. 72 (1988) 363-370
72. Koos T., and Tepper J.M. Inhibitory control of neostriatal projection neurons by GABAergic interneurons. Nat. Neurosci. 2 (1999) 467-472
73. Korn H., Sotelo C., and Crepel F. Electronic coupling between neurons in the rat lateral vestibular nucleus. Exp. Brain Res. 16 (1973) 255-275
74. Kosaka T. Neuronal gap junctions in the polymorph layer of the rat dentate gyrus. Brain Res. 277 (1983) 347-351
75. Kosaka T., and Hama K. Gap junctions between non-pyramidal cell dendrites in the rat hippocampus (CA1 and CA3 regions): A combined Golgi-electron microscopy study. J. Comp. Neurol. 231 (1985) 150-161
76. Kumar N.M., and Gilula N.B. The gap junction communication channel. Cell 84 (1996) 381-388
77. Kunzelmann P., Blumcke I., Traub O., Dermietzel R., and Willecke K. Coexpression of connexin45 and -32 in oligodendrocytes of rat brain. J. Neurocytol. 26 (1997) 17-22
78. Landisman C.E., Long M.A., Beierlein M., Deans M.R., Paul D.L., and Connors B.W. Electrical synapses in the thalamic reticular nucleus. J. Neurosci. 22 (2002) 1002-1009
79. Lasater E.M. Retinal horizontal cell gap junctional conductance is modulated by dopamine through a cyclic AMP-dependent protein kinase. Proc. Natl. Acad. Sci. USA 84 (1987) 7319-7323
80. Lin J.Y., van Wyk M., Bowala T.K., Teo M.Y., and Lipski J. Dendritic projections and dye-coupling in dopaminergic neurons of the substantia nigra examined in horizontal brain slices from young rats. J. Neurophysiol. 90 (2003) 2531-2535
81. Liu X.B., and Jones E.G. Fine structural localization of connexin-36 immunoreactivity in mouse cerebral cortex and thalamus. J. Comp. Neurol. 466 (2003) 457-467
82. Llinas R., Baker R., and Sotelo C. Electrotonic coupling between neurons in cat inferior olive. J. Neurophysiol. 37 (1974) 560-571
83. Long M.A., Deans M.R., Paul D.L., and Connors B.W. Rhythmicity without synchrony in the electrically uncoupled inferior olive. J. Neurosci. 22 (2002) 10898-10905
84. Long M.A., Jutras M.J., Connors B.W., and Burwell R.D. Electrical synapses coordinate activity in the suprachiasmatic nucleus. Nat. Neurosci. 8 (2005) 61-66
85. Long M.A., Landisman C.E., and Connors B.W. Small clusters of electrically coupled neurons generate synchronous rhythms in the thalamic reticular nucleus. J. Neurosci. 24 (2004) 341-349
86. MacVicar B.A., and Dudek F.E. Dye-coupling betwen CA3 pyramidal cells in slices of rat hippocampus. Brain Res. 196 (1980) 494-497
87. MacVicar B.A., and Dudek F.E. Electrotonic coupling between pyramidal cells: A direct demonstration in rat hippocampal slices. Science 213 (1981) 782-784
88. MacVicar B.A., and Dudek F.E. Electrotonic coupling between pyramidal cells: A direct demonstration in rat hippocampal slices. Science 213 (1981) 782-785
89. MacVicar B.A., Ropert N., and Krnjevic K. Dye-coupling between pyramidal cells of rat hippocampus in vivo. Brain Res. 238 (1982) 239-244
90. Mann-Metzer P., and Yarom Y. Electrotonic coupling interacts with intrinsic properties to generate synchronized activity in cerebellar networks of inhibitory interneurons. J. Neurosci. 19 (1999) 3298-3306
91. Marder E. Electrical synapses: Beyond speed and synchrony to computation. Curr. Biol. 8 (1998) R795-R797
92. Margineanu D.G., and Klitgaard H. Can gap-junction blockade preferentially inhibit neuronal hypersynchrony vs. excitability?. Neuropharmacology 41 (2001) 377-383
93. Maxeiner S., Kruger O., Schilling K., Traub O., Urschel S., and Willecke K. Spatiotemporal transcription of connexin45 during brain development results in neuronal expression in adult mice. Neuroscience 119 (2003) 689-700
94. McCracken C.B., Patel K.M., Vrana K.E., Paul D.L., and Roberts D.C.S. Amphetamine withdrawal produces region-specific and time-dependent changes in connexin36 expression in rat brain. Synapse 56 (2005) 39-44
95. McCracken C.B., Hamby S.M., Patel K.M., Morgan D., Vrana K.E., and Roberts D.C. Extended cocaine self-adminisration and deprivation produces region specific and time-dependent changes in connexin 36 expression in rat brain (2005)
96. McHahon D.G., Knapp A.G., and Dowling J.E. Horizontal cell gap junctions: Single-channel conductance and modulation by dopamine. Proc. Natl. Acad. Sci. USA 86 (1989) 7639-7643
97. Meier C., Petrasch-Parwez E., Habbes H.W., Teubner B., Guldenagel M., Degen J., Sohl G., Willecke K., and Dermietzel R. Immunohistochemical detection of the neuronal connexin36 in the mouse central nervous system in comparison to connexin36-deficient tissues. Histochem. Cell Biol. 117 (2002) 461-471
98. Meyer A.H., Katona I., Blatow M., Rozov A., and Monyer H. In vivo labeling of parvalbumin-positive interneurons and analysis of electrical coupling in identified neurons. J. Neurosci. 22 (2002) 7055-7064
99. Micevych P.E., and Abelson L. Distribution of mRNAs coding for liver and heart gap junction proteins in the rat central nervous system. J. Comp. Neurol. 305 (1991) 96-118
100. Micevych P.E., Popper P., and Hatton G.I. Connexin 32 mRNA levels in the rat supraoptic nucleus: Up-regulation prior to parturition and during lactation. Neuroendocrinology 63 (1996) 39-45
101. Mills S.L., and Massey S.C. Differential properties of two gap junctional pathways made by AII amacrine cells. Nature 377 (1995) 734-737
102. Mitropoulou G., and Bruzzone R. Modulation of perch connexin35 hemi-channels by cyclic AMP requires a protein kinase A phosphorylation site. J. Neurosci. Res. 72 (2003) 147-157
103. Montoro R.J., and Yuste R. Gap junctions in developing neocortex: A review. Brain Res. Rev. 47 (2004) 216-226
104. Moore H., and Grace A.A. A role for electrotonic coupling in the striatum in the expression of dopamine receptor-mediated stereotypies. Neuropsychopharmacology 27 (2002) 980-992
105. Moreno A.P., Eghbali B., and Spray D.C. Connexin32 gap junction channels in stably transfected cells: Unitary conductance. Biophys. J. 60 (1991) 1254-1266
106. Nadarajah B., and Parnavelas J.G. Gap junction-mediated communication in the developing and adult cerebral cortex. Novartis Found. Symp. 219 (1999) 157-170
107. Nadarajah B., Thomaidou D., Evans W.H., and Parnavelas J.G. Gap junctions in the adult cerebral cortex: Regional differences in their distribution and cellular expression of connexins. J. Comp. Neurol. 376 (1996) 326-342
108. Nagy J.I., Dudek F.E., and Rash J.E. Update on connexins and gap junctions in neurons and glia in the mammalian nervous system. Brain Res. Rev. 47 (2004) 191-215
109. Nagy J.I., Ionescu A.V., Lynn B.D., and Rash J.E. Coupling of astrocyte connexins Cx26, Cx30, Cx43 to oligodendrocyte Cx29, Cx32, Cx47: Implications from normal and connexin32 knockout mice. Glia 44 (2003) 205-218
110. Nagy J.I., Li X., Rempel J., Stelmack G., Patel D., Staines W.A., Yasumura T., and Rash J.E. Connexin26 in adult rodent central nervous system: Demonstration at astrocytic gap junctions and colocalization with connexin30 and connexin43. J. Comp. Neurol. 441 (2001) 302-323
111. O'Donnell P., and Grace A.A. Dopaminergic modulation of dye coupling between neurons in the core and shell regions of the nucleus accumbens. J. Neurosci. 13 (1993) 3456-3471
112. O'Donnell P., and Grace A.A. Different effects of subchronic clozapine and haloperidol on dye coupling between neurons in the rat striatal complex. Neuroscience 66 (1995) 763-767
113. Ochalski P.A., Frankenstein U.N., Hertzberg E.L., and Nagy J.I. Connexin-43 in rat spinal cord: Localization in astrocytes and identification of heterotypic astro-oligodendrocytic gap junctions. Neuroscience 76 (1997) 931-945
114. Onn S.P., and Grace A.A. Repeated treatment with haloperidol and clozapine exerts differential effects on dye coupling between neurons in subregions of striatum and nucleus accumbens. J. Neurosci. 15 (1996) 7024-7036
115. Onn S.P., and Grace A.A. Alterations in electrophysiological activity and dye coupling of striatal spiny and aspiny neurons in dopamine-denervated rat striatum recorded in vivo. Synapse 33 (1999) 1-15
116. Onn S.P., and Grace A.A. Amphetamine withdrawal alters bistable states and cellular coupling in rat prefrontal cortex and nucleus accumbens neurons recorded in vivo. J. Neurosci. 20 (2000) 2332-2345
117. Panchin Y., Kelmanson I., Matz M., Lukyanov K., Usman N., and Lukyanov S. A ubiquitous family of putative gap junction molecules. Curr. Biol. 10 (2000) 473-474
118. Pappas G.D., Asada Y., and Bennett M.V.L. Morphological correlates of increased coupling resistance at an electrotonic synapse. J. Cell Biol. 49 (1971) 173-188
119. Paul D.L. Molecular cloning of cDNA for rat liver gap junction protein. J. Cell Biol. 103 (1986) 123-134
120. Paulson P.E., and Robinson T.E. Amphetamine-induced time-dependent sensitization of dopamine neurotransmission in the dorsal and ventral striatum: A microdialysis study in behaving rats. Synapse 19 (1995) 56-65
121. Peinado A., Yuste R., and Katz L.C. Extensive dye coupling between rat neocortical neurons during the period of circuit formation. Neuron 10 (1993) 103-114
122. Peracchia C. Calcium effects on gap junction structure and cell coupling. Nature 271 (1978) 669-671
123. Peracchia C., Sotkis A., Wang X.G., Peracchia L.L., and Persechini A. Calmodulin directly gates gap junction channels. J. Biol. Chem. 275 (2000) 26220-26224
124. 2+/calmodulin-dependent kinase II mediates simultaneous enhancement of gap-junctional conductance and glutamatergic transmission. Proc. Natl. Acad. Sci. USA 95 (1998) 13272-13277
125. Pereda A.E., and Faber D.S. Activity-dependent short-term enhancement of intercellular coupling. J. Neurosci. 16 (1996) 983-992
126. Perez Velazquez J.L., and Carlen P.L. Gap junctions, synchrony and seizures. Trends Neurosci. 23 (2000) 68-74
127. Phelan P., and Starich T.A. Innexins get into the gap. Bioessays 23 (2001) 388-396
128. Piccolino M., Neyton J., and Gerschenfeld H.M. Decrease of gap junction permeability induced by dopamine and cyclic adenosine 3′:5′-monophosphate in horizontal cells of turtle retina. J. Neurosci. 4 (1984) 2477-2488
129. Piccolino M., Witkovsky P., and Trimarchi C. Dopaminergic mechanisms underlying the reduction of electrical coupling between horizontal cells of the turtle retina induced by d-amphetamine, bicuculline, and veratridine. J. Neurosci. 7 (1987) 2273-2284
130. Pickar D. Perspectives on a time-dependent model of neuroleptic action. Schizophr. Bull. 14 (1988) 255-268
131. Placantonakis D.G., Bukovsky A.A., Zeng X.H., Kiem H.P., and Welsh J.P. Fundamental role of inferior olive connexin 36 in muscle coherence during tremor. Proc. Natl. Acad. Sci. USA 101 (2004) 7164-7169
132. Priest C.A., Thompson A.J., and Keller A. Gap junction proteins in inhibitory neurons of the adult barrel neocortex. Somatosens. Mot. Res. 18 (2001) 245-252
133. Rash J.E., Dillman R.K., Bilhartz B.L., Duffy H.S., Whalen L.R., and Yasumura T. Mixed synapses discovered and mapped throughout mammalian spinal cord. Proc. Natl. Acad. Sci. USA 93 (1996) 4235-4239
134. Rash J.E., Pereda A., Kamasawa N., Furman C.S., Yasumura T., Davidson K.G., Dudek F.E., Olson C., Li X., and Nagy J.I. High-resolution proteomic mapping in the vertebrate central nervous system: Close proximity of connexin35 to NMDA glutamate receptor clusters and co-localization of connexin36 with immunoreactivity for zonula occludens protein-1 (ZO-1). J. Neurocytol. 33 (2004) 131-151
135. Rash J.E., Staines W.A., Yasumura T., Patel D., Furman C.S., Stelmack G.L., and Nagy J.I. Immunogold evidence that neuronal gap junctions in adult rat brain and spinal cord contain connexin-36 but not connexin-32 or connexin-43. Proc. Natl. Acad. Sci. USA 97 (2000) 7573-7578
136. Rash J.E., Yasumura T., Davidson K.G., Furman C.S., Dudek F.E., and Nagy J.I. Identification of cells expressing Cx43, Cx30, Cx26, Cx32 and Cx36 in gap junctions of rat brain and spinal cord. Cell Commun. Adhes. 8 (2001) 315-320
137. Rash J.E., Yasumura T., Dudek F.E., and Nagy J.I. Cell-specific expression of connexins and evidence of restricted gap junctional coupling between glial cells and between neurons. J. Neurosci. 21 (2001) 1983-2000
138. Revel J.P., and Karnovsky M.J. Hexagonal array of subunits in intercellular junctions of the mouse heart and liver. J. Cell Biol. 33 (1967) C7-C12
139. Revel J.P., Yee A.G., and Hudspeth A.J. Gap junctions between electrotonically coupled cells in tissue culture and in brown fat. Proc. Natl. Acad. Sci. USA 68 (1971) 2924-2927
140. Rorig B., Klausa G., and Sutor B. Beta-adrenoreceptor activation reduces dye-coupling between immature rat neocortical neurones. Neuroreport 6 (1995) 1811-1815
141. Rorig B., Klausa G., and Sutor B. Dye coupling between pyramidal neurons in developing rat prefrontal and frontal cortex is reduced by protein kinase A activation and dopamine. J. Neurosci. 15 (1995) 7386-7400
142. Rorig B., Klausa G., and Sutor B. Intracellular acidification reduced gap junction coupling between immature rat neocortical pyramidal neurones. J. Physiol. 490 Pt 1 (1996) 31-49
143. Rorig B., and Sutor B. Nitric oxide-stimulated increase in intracellular cGMP modulates gap junction coupling in rat neocortex. Neuroreport 7 (1996) 569-572
144. Rorig B., and Sutor B. Regulation of gap junction coupling in the developing neocortex. Mol. Neurobiol. 12 (1996) 225-249
145. Rorig B., and Sutor B. Serotonin regulates gap junction coupling in the developing rat somatosensory cortex. Eur. J. Neurosci. 8 (1996) 1685-1695
146. Rozental R., Srinivas M., Gokhan S., Urban M., Dermietzel R., Kessler J.A., Spray D.C., and Mehler M.F. Temporal expression of neuronal connexins during hippocampal ontogeny. Brain Res. Rev. 32 (2000) 57-71
147. Rozental R., Srinivas M., and Spray D.C. How to close a gap junction channel. Efficacies and potencies of uncoupling agents. Methods Mol. Biol. 154 (2001) 447-476
148. Saez J.C., Berthoud V.M., Branes M.C., Martinez A.D., and Beyer E.C. Plasma membrane channels formed by connexins: Their regulation and functions. Physiol. Rev. 83 (2003) 1359-1400
149. Scherer S.S., Deschenes S.M., Xu Y.T., Grinspan J.B., Fischbeck K.H., and Paul D.L. Connexin32 is a myelin-related protein in the PNS and CNS. J. Neurosci. 15 (1995) 8281-8294
150. Schmitz D., Schuchmann S., Fisahn A., Draguhn A., Buhl E.H., Petrasch-Parwez E., Dermietzel R., Heinemann U., and Traub R.D. Axo-axonal coupling: A novel mechanism for ultrafast neuronal communication. Neuron 31 (2001) 831-840
151. Shiosaka S., Yamamoto T., Hertzberg E.L., and Nagy J.I. Gap junction protein in rat hippocampus: Correlative light and electron microscope immunohistochemical localization. J. Comp. Neurol. 281 (1989) 282-297
152. Simburger E., Stang A., Kremer M., and Dermietzel R. Expression of connexin43 mRNA in adult rodent brain. Histochem. Cell Biol. 107 (1997) 127-137
153. Singer W. Consciousness and the binding problem. Ann. N. Y. Acad. Sci. 929 (2001) 123-146
154. Singer W., and Gray C.M. Visual feature integration and the temporal correlation hypothesis. Annu. Rev. Neurosci. 18 (1995) 555-586
155. Sloper J.J. Gap junctions between dendrites in the primate neocortex. Brain Res. 44 (1972) 641-646
156. Sloper J.J., and Powell T.P. Gap junctions between dendrites and somata of neurons in the primate sensori-motor cortex. Proc. R. Soc. Lond. B Biol. Sci. 203 (1978) 39-47
157. Sohl G., Degen J., Teubner B., and Willecke K. The murine gap junction gene connexin36 is highly expressed in mouse retina and regulated during brain development. FEBS Lett. 428 (1998) 27-31
158. Sohl G., Odermatt B., Maxeiner S., Degen J., and Willecke K. New insights into the expression and function of neural connexins with transgenic mouse mutants. Brain Res. Rev. 47 (2004) 245-259
159. Solomon I.C., Halat T.J., El-Maghrabi M.R., and O'Neal M.H. Localization of connexin26 and connexin32 in putative CO(2)-chemosensitive brainstem regions in rat. Respir. Physiol. 129 (2001) 101-121
160. Sotelo C., Llinas R., and Baker R. Structural study of inferior olivary nucleus of the cat: Morphological correlates of electrotonic coupling. J. Neurophysiol. 37 (1974) 541-559
161. Spray D.C., Harris A.L., and Bennett M.V.L. Gap junctional conductance is a simple and sensitive function of intracellular pH. Science 211 (1981) 712-715
162. Spray D.C., White R.L., de Carvalho A.C., Harris A.L., and Bennett M.V.L. Gating of gap junction channels. Biophys. J. 45 (1984) 219-230
163. Squire L.R., Bloom F.E., McConnell S., Roberts J.L., Spitzer N., and Zigmond M.J. "Fundamental Neuroscience,". 2nd ed. (2002), Academic Press, San Diego
164. Srinivas M., Rozental R., Kojima T., Dermietzel R., Mehler M., Condorelli D.F., Kessler J.A., and Spray D.C. Functional properties of channels formed by the neuronal gap junction protein connexin36. J. Neurosci. 19 (1999) 9848-9855
165. Stewart W.W. Functional connections between cells as revealed by dye-coupling with a highly fluorescent naphthalimide tracer. Cell 14 (1978) 741-759
166. Stewart W.W. Lucifer dyes-highly fluorescent dyes for biological tracing. Nature 292 (1981) 17-21
167. Stobbs S.H., Ohran A.J., Lassen M.B., Allison D.W., Brown J.E., and Steffensen S.C. Ethanol suppression of ventral tegmental area GABA neuron electrical transmission involves N-methyl-D-aspartate receptors. J. Pharmacol. Exp. Ther. 311 (2004) 282-289
168. Stuart G.J., Dodt H.U., and Sakmann B. Patch-clamp recordings from the soma and dendrites of neurons in brain slices using infrared video microscopy. Pflugers Arch. 423 (1993) 511-518
169. Tamas G., Buhl E.H., Lorincz A., and Somogyi P. Proximally targeted GABAergic synapses and gap junctions synchronize cortical interneurons. Nat. Neurosci. 3 (2000) 366-371
170. Teubner B., Degen J., Sohl G., Guldenagel M., Bukauskas F.F., Trexler E.B., Verselis V.K., De Zeeuw C.I., Lee C.G., Kozak C.A., Petrasch-Parwez E., Dermietzel R., and Willecke K. Functional expression of the murine connexin 36 gene coding for a neuron-specific gap junctional protein. J. Membr. Biol. 176 (2000) 249-262
171. Theis M., Sohl G., Speidel D., Kuhn R., and Willecke K. Connexin43 is not expressed in principal cells of mouse cortex and hippocampus. Eur. J. Neurosci. 18 (2003) 267-274
172. Traub R.D. Fast oscillations and epilepsy. Epilepsy Curr. 3 (2003) 77-79
173. Traub R.D., Draguhn A., Whittington M.A., Baldeweg T., Bibbig A., Buhl E.H., and Schmitz D. Axonal gap junctions between principal neurons: A novel source of network oscillations, and perhaps epileptogenesis. Rev. Neurosci. 13 (2002) 1-30
174. Traub R.D., Kopell N., Bibbig A., Buhl E.H., LeBeau F.E., and Whittington M.A. Gap junctions between interneuron dendrites can enhance synchrony of gamma oscillations in distributed networks. J. Neurosci. 21 (2001) 9478-9486
175. Traub R.D., Pais I., Bibbig A., LeBeau F.E., Buhl E.H., Hormuzdi S.G., Monyer H., and Whittington M.A. Contrasting roles of axonal (pyramidal cell) and dendritic (interneuron) electrical coupling in the generation of neuronal network oscillations. Proc. Natl. Acad. Sci. USA 100 (2003) 1370-1374
176. Traub R.D., Schmitz D., Jefferys J.G., and Draguhn A. High-frequency population oscillations are predicted to occur in hippocampal pyramidal neuronal networks interconnected by axoaxonal gap junctions. Neuroscience 92 (1999) 407-426
177. Traub R.D., Whittington M.A., Buhl E.H., LeBeau F.E., Bibbig A., Boyd S., Cross H., and Baldeweg T. A possible role for gap junctions in generation of very fast EEG oscillations preceding the onset of, and perhaps initiating, seizures. Epilepsia 42 (2001) 153-170
178. Ungerstedt U. Stereotaxic mapping of the monamine pathways in the rat brain. Acta Physiol. Scand. Suppl. 367 (1971) 1-48
179. Uusisaari M., Smirnov S., Voipio J., and Kaila K. Spontaneous epileptiform activity mediated by GABA(A) receptors and gap junctions in the rat hippocampal slice following long-term exposure to GABA(B) antagonists. Neuropharmacology 43 (2002) 563-572
180. Vandecasteele M., Glowinski J., and Venance L. Electrical synapses between dopaminergic neurons of the substantia nigra pars compacta. J. Neurosci. 25 (2005) 291-298
181. Vanderschuren L.J., and Kalivas P.W. Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: A critical review of preclinical studies. Psychopharm 151 (2000) 99-120
182. Venance L., Glowinski J., and Giaume C. Electrical and chemical transmissions between striatal GABAergic output neurons in rat brain slices. J. Physiol. 559 (2004) 215-230
183. Venance L., Piomelli D., Glowinski J., and Giaume C. Inhibition by anandamide of gap junctions and intercellular calcium signalling in striatal astrocytes. Nature 376 (1995) 590-594
184. Venance L., Rozov A., Blatow M., Burnashev N., Feldmeyer D., and Monyer H. Connexin expression in electrically coupled postnatal rat brain neurons. Proc. Natl. Acad. Sci. USA 97 (2000) 10260-10265
185. Watanabe A. The interaction of electrical activity among neurons of lobster cardiac ganglion. Jpn. J. Physiol. 8 (1958) 305-318
186. Weickert S., Ray A., Zoidl G., and Dermietzel R. Expression of neural connexins and pannexin1 in the hippocampus and inferior olive: A quantitative approach. Mol Brain Res. 133 (2005) 102-109
187. Wentlandt K., Kushnir M., Naus C.C., and Carlen P.L. Ethanol inhibits gap-junctional coupling between P19 cells. Alcohol. Clin. Exp. Res. 28 (2004) 1284-1290
188. Willecke K., Eiberger J., Degen J., Eckardt D., Romualdi A., Guldenagel M., Deutsch U., and Sohl G. Structural and functional diversity of connexin genes in the mouse and human genome. Biol. Chem. 383 (2002) 725-737
189. Yang X.D., Korn H., and Faber D.S. Long-term potentiation of electronic coupling at mixed synapses. Nature 348 (1990) 542-545
190. Zhang C., Finger T.E., and Restrepo D. Mature olfactory receptor neurons express connexin 43. J. Comp. Neurol. 426 (2000) 1-12
191. Zhang C., and Restrepo D. Expression of connexin 45 in the olfactory system. Brain Res. 929 (2002) 37-47