The P-glycoprotein inhibitor guinidine decreases the threshold for bupivacaine-induced, but not lidocaine-induced, convulsions in rats

Canadian Journal of Anesthesia

Volumn 50, Issue 8, 2003, Pages 805-811

  Funao, Tomoharu ^a   Oda, Yutaka ^a   Tanaka, Katsuaki ^a   Asada, Akira ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BUPIVACAINE; CALCIUM CHANNEL BLOCKING AGENT; CYCLOSPORIN; DEETHYLLIDOCAINE; DRUG DERIVATIVE; DRUG METABOLITE; EPHEDRINE; GLYCOPROTEIN P; LIDOCAINE; LOCAL ANESTHETIC AGENT; PROTEIN INHIBITOR; QUINIDINE; QUINIDINE DERIVATIVE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RIFAMPICIN; ROPIVACAINE; STEROID; VASODILATOR AGENT; VERAPAMIL;

ANESTHESIA INDUCTION; ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD GAS ANALYSIS; BRAIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; CONVULSION; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG METABOLISM; HEMODYNAMICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IATROGENIC DISEASE; MALE; METABOLISM; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PH; PRIORITY JOURNAL; RANDOMIZATION; RAT; RAT STRAIN; STATISTICAL SIGNIFICANCE; TOXICITY TESTING;

EID: 0344394429     PISSN: 0832610X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03019376     Document Type: Article

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