Human 11β-hydroxysteroid dehydrogenase: Studies on the stably transfected isoforms and localization of the type 2 isozyme within renal tissue

Steroids

Volumn 62, Issue 1, 1997, Pages 77-82

  Bujalska, Iwona ^a   Shimojo, Masako ^a   Howie, Alex ^b   Stewart, Paul M ^a  

^a UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

11 hydroxysteroid dehydrogenase; cortisol; cortisone; hypertension; transfection

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; GLUCOCORTICOID; ISOENZYME; MINERALOCORTICOID;

BLOOD PRESSURE REGULATION; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME LOCALIZATION; FETUS CELL; HUMAN; HUMAN CELL; KIDNEY CELL; STEROIDOGENESIS; TISSUE DISTRIBUTION;

OVIS ARIES;

EID: 0031034683     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-128X(96)00163-8     Document Type: Conference Paper

References (30)

1. Monder C, White PC (1993). 11β-Hydroxysteroid dehydrogenase. Vitam Horm 47:187-271.
2. Stewart PM (1994). 11β-Hydroxysteroid dehydrogenase. Ballieres Clin Endocrinol Metab 8:357-378.
3. Moore CCD, Mellon SH, Murai J, Siiteri PK, Miller WL (1993). Structure and function of the hepatic form of 11β-hydroxysteroid dehydrogenase in the squirrel monkey, an animal model of glucocorticoid resistance. Endocrinology 133:368-375.
4. +-dependent enzyme and differs from the clones "type I" isoform. J Clin Endocrinol Metab 79:480-484.
5. Tannin GM, Agarwal AK, MOnder C, New MI, White PC (1991). The human gene for 11β-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization. J Biol Chem 266: 16653-16658.
6. Whorwood CB, Mason JI, Ricketts ML, Howie AJ, Stewart PM (1995). Detection of human 11β-hydroxysteroid dehydrogenase isoforms using reverse transcriptase-polymerase chain reaction and localization of the type 2 isoform to renal collecting ducts. Mol Cell Endocrinol 110:R7-R12.
7. Brown RW, Chapman KE, Edwards CRW, Seckl JR (1993). Human placental 11β-hydroxysteroid dehydrogenase: evidence for and partial purification of a distinct NAD-dependent isoform. Endocrinology 132:2614-2621.
8. Albiston AL, Obeyesekere VR, Smith RE, Krozowski ZS (1994). Cloning and tissue distribution of the human 11β-hydroxysteroid dehydrogenase type 2 enzyme. Mol Cell Endocrinol 105:R11-R17.
9. Edwards CRW, Stewart PM (1991). The cortisol-cortisone shuttle and apparent specificity of glucocorticoid and mineralocorticoid receptors. J Steroid Biochem Mol Biol 39:859-865.
10. Wilson RC, Krozowski ZS, Li K, Obeyesekere VR, Razzaghy-Azar M, Harbison MD, Wei JQ, Shackleton CHL, Funder JW, New MI (1995). A mutation in the HSD11B2 gene in a family with apparent mineralocorticoid excess. J Clin Endocrinol Metab 80:2263-2266.
11. Mune T, Rogerson FM, Nikkila H, Agarwal AK, White PC (1995). Human hypertension caused by mutations in the kidney isozyme of 11β-hydroxysteroid dehydrogenase. Nature Genet 10:394-399.
12. Stewart PM, Krozowski ZS, Gupta A, Milford DV, Howie AJ, Sheppard MC, Whorwood CB (1996). Hypertension in the syndrome of apparent mineralocorticoid excess due to mutation of the 11β-hydroxysteroid dehydrogenase type 2 gene. Lancet 347:88-91.
13. Murphy BEP (1981). Specificity of human 11β-hydroxysteroid dehydrogenase. J Steroid Biochem 14:807-809.
14. Pasquarette MM, Stewart PM, Ricketts ML, Imaishi K, Mason JI (1996). Regulation of 11β-hydroxysteroid dehydrogenase type 2 activity and mRNA in human choriocarcinoma cells. J Mol Endocrinol 16:269-275.
15. Stewart PM, Wallace AM, Valentino R, Burt D, Shackleton CHL, Edwards CRW (1987). Mineralocorticoid activity of liquorice: 11β-hydroxysteroid dehydrogenase deficiency comes of age. Lancet ii: 821-824.
16. Stewart PM, Wallace AM, Atherden SM, Shearing C, Edwards CRW (1990). Mineralocorticoid activity of carbenoxolone: contrasting effects of carbenoxolone and liquorice on 11β-hydroxysteroid dehydrogenase activity in man. Clin Sci 78:49-54.
17. Souness GW, Morris DJ (1989). The antinatriuretic and kaluretic effects of the glucocorticoids corticosterone and cortisol following pre-treatment with carbenoxolone sodium (a liquorice derivative) in the adrenalectomized rat. Endocrinology 124:1588-1590.
18. Monder C, Stewart PM, Lakshmi V, Valentino R, Burt D, Edwards CRW (1989). Licorice inhibits corticosteroid 11β-dehydrogenase of rat liver and kidney: in vivo and in vitro studies. Endocrinology 124:1046-1053.
19. MacKenzie MA, Hoefnagels WHL, Jansen RWMM, Benraad TJ, Kloppenborg PWC (1990). The influence of glycyrrhetinic acid on plasma cortisol and cortisone in healthy young volunteers. J Clin Endocrinol Metab 70:1637-1643.
20. Farese RV, Biglieri EG, Shackleton CHL, Irony I, Gomez-Fontes R (1991). Licorice-induced hypermineralocorticoidism. N Engl J Med 325:1225-1227.
21. Souness GW, Latif SA, Laurenzo JL, Morris DJ (1995). 11α- and 11β-hydroxyprogesterone, potent inhibitors of 11β-hydroxysteroid dehydrogenase (isoforms 1 and 2) confer marked mineralocorticoid activity on corticosterone in the rat. Endocrinology 136:1809-1812.
22. Krozowski ZS, Maguire JA, Stein-Oakley AN, Dowling J, Smith RE, Andrews RK (1995). Immunohistochemical localization of the 11β-hydroxysteroid dehydrogenase type II enzyme in human kidney and placenta. J Clin Endocrinol Metab 80:2203-2209.
23. Kyossev Z, Walker PD, Reeves WB (1996). Immunolocalization of NAD-dependent 11β-hydroxysteroid dehydrogenase in human kidney and colon. Kidney Int 49:271-281.
24. Stewart PM, Corrie JET, Shackleton CHL, Edwards CRW (1988). Syndrome of apparent mineralocorticoid excess: a defect in the cortisol-cortisone shuttle. J Clin Invest 82:340-349.
25. Mahesh VB, Ulrich F (1960). Metabolism of cortisol and cortisone by various tissues and subcellular particles. J Biol Chem 235:356-360.
26. Kobayashi N, Schulz W, Hierholzer K (1987). Corticosteroid metabolism in rat kidney in vitro. IV. Subcellular sites of 11β-hydroxysteroid dehydrogenase activity. Pflugers Arch 408:46-53.
27. Robertson NM, Schulman G, Karnik S, Alnemri E, Litwack G (1993). Demonstration of nuclear translocation of the mineralocorticoid receptor (MR) using an anti-MR antibody and confocal laser scanning microscopy. Mol Endocrinol 7:1226-1239.
28. Lombes M, Farman N, Oblin ME, Baulieu EE, Bonvalet JP, Erlanger BF, Gasc JM (1990). Immunohistochemical localization of renal mineralocorticoid receptor by using an anti-idiotypic antibody that is an internal image of aldosterone. Proc Natl Acad Sci USA 87:1086-1088.
29. Krozowski ZS, Rundle SE, Wallace C, Castell MJ, Shen JH, Dowling J, Funder JW, Smith AI (1989). Immunolocalization of renal mineralocorticoid receptors with an antiserum against a peptide deduced from the complementary deoxyribonucleic acid sequence. Endocrinology 123:192-198.
30. Pearce PT, McNally M, Funder JW (1986). Nuclear localization of type 1 aldosterone binding sites in steroid-unexposed GH3 cells. Clin Exp Pharmacol Physiol 13:647-654.