Mechanisms and abuse liability of the anti-histamine dimenhydrinate

Neuroscience and Biobehavioral Reviews

Volumn 26, Issue 1, 2002, Pages 61-67

  Halpert, Alison G ^a   Olmstead, Mary C ^a   Beninger, Richard J ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

8 Chlorotheophylline; Anti histamine; Dimenhydrinate; Diphenhydramine; Drug abuse; Histamine; Review

Indexed keywords

8 CHLOROTHEOPHYLLINE; ACETYLCHOLINE; ADENOSINE; ANTIEMETIC AGENT; ANTIHISTAMINIC AGENT; DIMENHYDRINATE; DOPAMINE; HISTAMINE H1 RECEPTOR ANTAGONIST; NEUROTRANSMITTER; NON PRESCRIPTION DRUG; NORADRENALIN; OPIATE; SEROTONIN; STREET DRUG;

ANIMAL BEHAVIOR; ANTICHOLINERGIC EFFECT; CONDITIONING; DRUG ABUSE; DRUG DISCRIMINATION; DRUG MECHANISM; DRUG SELF ADMINISTRATION; EUPHORIA; HALLUCINATION; HUMAN; INSTRUMENTAL CONDITIONING; MENTAL PATIENT; NEUROCHEMISTRY; NONHUMAN; PLACE PREFERENCE; PRIORITY JOURNAL; REVIEW; SUBSTANCE ABUSE; TRANQUILIZING ACTIVITY;

EID: 0036159134     PISSN: 01497634     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0149-7634(01)00038-0     Document Type: Short Survey

References (60)

1. Histamine, bradykinin, and their antagonists
2. Dimenhydrinate addiction in a schizophrenic woman
3. Some behavioural effects of histamine H1 antagonists in squirrel monkeys
4. Delirium from misuse of dimenhydrinate
5. The physiology of brain histamine
6. Central and peripheral monoaminergic membrane-pump blockade by some addictive analgesics and antihistamines
7. Discriminative stimulus properties of methylxanthines and their metabolites in rats
8. Antiparkinsonian drugs: inhibition of dopamine uptake in the corpus striatum as a possible mechanism of action
9. Dimenhydrinate dependence and withdrawal
10. Diphenhydramine dependence: a need for awareness
11. Risk of abuse of diphenhydramine in children and adolescents with chronic illnesses
12. Increased levels of extracellular dopamine in neostriatum and nucleus accumbens after histamine H1 receptor blockade
13. Discriminative stimulus properties of histamine H1-antagonists in animals trained to discriminate D-amphetamine or pentobarbital
14. Mesocortical dopamine systems and reward
15. Activation of mesolimbic dopaminergic neurons following central administration of histamine is mediated by H1 receptors
16. Analgesia and abuse potential: an accidental association or a common substrate?
17. Dimenhydrinate abuse among adolescents
18. The prevention and treatment of motion sickness. I. Seasickness
19. Action of dimenhydrinate (Dramamine) and other drugs on vestibular function
20. Diphenhydramine as an antidepressant
21. Catecholamine uptake by synaptosomes from rat brain: Structure-activity relationships of drugs with differential effects on dopamine and norepinephrine neurons
22. Effects of diphenhydramine and dimenhydrinate on vestibular neuronal activity of cat: a search for the locus of their antimotion sickness action
23. Histamine-induced arousal in the conscious and pentobarbital-pretreated rat
24. Neural mechanisms of drug reinforcement
25. Dimenhydrinate (Dramamine) abuse: hallucinogenic experiences with a proprietary antihistamine
26. Central nervous system effects of meclizine and dimenhydrinate: evidence of acute tolerance to antihistamines
27. 1 antagonists of operant behaviour in the squirrel monkey
28. 1 antagonists as behavioural stimulants in the squirrel monkey
29. The effect of caffiene, theophylline and amphetamine on operant responding of the mouse
30. Methylxanthines elevate reinforcement threshold for electrical brain stimulation: role of adenosine receptors and phosphodiesterase inhibition
31. Reinforcing, subjective, and performance effects of lorazepam and diphenhydramine in humans
32. Effects of dimenhydrinate on gastric tachyarrhythmia and symptoms of vection-induced motion sickness
33. The in vivo pharmacological profile of histamine (H1) antagonists in the rat
34. Is there a risk for dependency with therapeutic doses of dimenhydrinate?
35. Overview of the effects of theophylline
36. Subjective and behavioural effects of diphenhydramine, lorazepam and methocarbamol: evaluation of abuse liability
37. 2-histamine blockers applied to the nucleus basalis magnocellularis region modulate anxiety and reinforcement related processes
38. Tricyclic antidepressants: interactions with histamine and muscarinic acetylcholine receptors
39. The neural basis of drug craving: an incentive-sensitization theory of addiction
40. Adolescent dimenhydrinate abuse: resurgence of an old problem
41. Analgesic effects of antihistamines
42. Maintenance of H1 antagonists self-injection in baboons
43. Drugs used in the treatment of asthma
44. Tís and blues: abuse of pentazocine and tripelennamine
45. Effect of Dramamine on Deiter's nerve cells of rats following vestibular stimulation
46. CNS stimulant-like discriminative stimulus properties of H1-antagonists in rats
47. Adenosine receptors and behavioural actions of methylxanthines
48. Psychomotor stimulant effects of methylxanthines in squirrel monkeys: relation to adenosine antagonism
49. The effectiveness of Dramamine in the prevention of airsickness
50. Possible explanation of 'T's and Blues' interaction: Tripelennamine (TRIP) and pentazocine (PTZ) are potent ligands for psychotomimetic sigma opioid receptor
51. Drug interactions in the reinforcing effects of over-the-counter cough syrups
52. Potentiation of pentazocine conditioned place preference by tripelennamine in rats
53. Effects of the histaminergic system on the morphine-induced conditioned place preference in mice
54. Neuropharmacology of motion sickness and emesis: a review
55. The tuberomammillary nucleus region as a reinforcement inhibiting substrate: facilitation of ipsihypothalamic self-stimulation by unilateral ibotenic acid lesions
56. Chemical studies of behaviour: VI. Placebo and Dramamine as methodological controls, and effects on moods, emotions and motivations
57. A psychomotor stimulant theory of addiction
58. Brain dopamine and reward
59. 1-histaminergic receptor blocker as measured with place-preference and self-stimulation behaviour