Antiepileptic effect of gap-junction blockers in a rat model of refractory focal cortical epilepsy

Epilepsia

Volumn 47, Issue 7, 2006, Pages 1169-1175

  Nilsen, Karen E ^a   Kelso, Andrew R C ^a   Cock, Hannah R ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Connexin; Epilepsy; Focal application; Gap junction; Seizure

Indexed keywords

ANTICONVULSIVE AGENT; CARBENOXOLONE; MECLOFENAMIC ACID; SODIUM CHLORIDE; TETANUS TOXIN;

ANESTHESIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT THERAPY; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG INFUSION; DRUG TOLERABILITY; ELECTROENCEPHALOGRAM; ELECTROMYOGRAM; FOCAL EPILEPSY; GAP JUNCTION; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; SEDATION;

ADMINISTRATION, TOPICAL; ANIMALS; ANTICONVULSANTS; BEHAVIOR, ANIMAL; CARBENOXOLONE; CEREBRAL CORTEX; CONNEXINS; DISEASE MODELS, ANIMAL; DRUG RESISTANCE; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; GAP JUNCTIONS; INFUSION PUMPS; INJECTIONS, INTRALESIONAL; MECLOFENAMIC ACID; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES; STEREOTAXIC TECHNIQUES; TETANUS TOXIN;

EID: 33746173312     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2006.00540.x     Document Type: Article

References (35)

1. Sander JW. The epidemiology of epilepsy revisited. Curr Opin Neurol 2003;16:165-170.
2. Jacobs MP, Fischbach GD, Davis MR, et al. Future directions for epilepsy research. Neurology 2001;57:1536-1542.
3. Carlen PL, Skinner F, Zhang L, et al. The role of gap junctions in seizures [Review]. Brain Res Brain Res Rev 2000;32:235-241.
4. Bragin A, Wilson CL, Almajano J, et al. High-frequency oscillations after status epilepticus: epileptogenesis and seizure genesis. Epilepsia 2004;45:1017-1023.
5. Hosseinzadeh H, Nassiri AM. Anticonvulsant, sedative and muscle relaxant effects of carbenoxolone in mice. BMC Pharmacol 2003;3:3.
6. Gajda Z, Szupera Z, Blazso G, et al. Quinine, a blocker of neuronal Cx36 channels, suppresses seizure activity in rat neocortex in vivo. Epilepsia 2005;46:1581-1591.
7. Gajda Z, Gyengesi E, Hermesz E, et al. Involvement of gap junctions in the manifestation and control of the duration of seizures in rats in vivo. Epilepsia 2003;44:1596-1600.
8. Nilsen KE, Walker MC, Cock HR. Characterization of the tetanus toxin model of refractory focal neocortical epilepsy in the rat. Epilepsia 2005;46:179-188.
9. Kelso ARC, Nilsen KE, Cock HR. Focal delivery of standard antiepileptic drugs in the tetanus toxin model of epilepsy in rats. J Neurol 2005;252(suppl 2):II/17. Ref Type: Abstract
10. Draguhn A, Traub RD, Schmitz D, et al. Electrical coupling underlies high-frequency oscillations in the hippocampus in vitro. Nature 1998;394:189-192.
11. Sohl G, Maxeiner S, Willecke K. Expression and functions of neuronal gap junctions. Nat Rev Neurosci 2005;6:191-200.
12. 2+ seizures. Epilepsia 2005;46:1188-1197.
13. Perez Velazquez JL, Carlen PL. Gap junctions, synchrony and seizures. Trends Neurosci 2000;23:68-74.
14. Traub RD, Whittington MA, Buhl EH, et al. A possible role for gap junctions in generation of very fast EEG oscillations preceding the onset of, and perhaps initiating, seizures. Epilepsia 2001;42:153-170.
15. Samoilova M, Li J, Pelletier MR, et al. Epileptiform activity in hippocampal slice cultures exposed chronically to bicuculline: increased gap junctional function and expression. J Neurochem 2003;86:687-699.
16. Sohl G, Guldenagel M, Beck H, et al. Expression of connexin genes in hippocampus of kainate-treated and kindled rats under conditions of experimental epilepsy. Brain Res Mol Brain Res 2000;83:44-51.
17. Rouach N, Avignone E, Meme W, et al. Gap junctions and connexin expression in the normal and pathological central nervous system [Review]. Biol Cell 2002;94:457-475.
18. Mas C, Taske N, Deutsch S, et al. Association of the connexin 36 gene with juvenile myoclonic epilepsy. J Med Genet 2004;41:e93.
19. Benarroch EE. Neuron-astrocyte interactions: partnership for normal function and disease in the central nervous system. Mayo Clinic Proc 2005;80:1326.
20. Stout CE, Costantin JL, Naus CCG, et al. Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels. J Biol Chem 2002;277:10482-10488.
21. Harks EGA, De Roos ADG, Peters PHJ, et al. Fenamates: a novel class of reversible gap junction blockers. J Pharmacol Exp Ther 2001;298:1033-1041.
22. Peretz A, Degani N, Nachman R, et al. Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties. Mol Pharmacol 2005;67:1053-1066.
23. Smith AJ, Oxley B, Malpas S, et al. Compounds exhibiting selective efficacy for different beta subunits of human recombinant gamma-aminobutyric acid(A) receptors. J Pharmacol Exp Ther 2004;311:601-609.
24. Davidson JS, Baumgarten IM. Glycyrrhetinic acid derivatives: a novel class of inhibitors of gap-junctional intercellular communication: structure-activity relationships. J Pharmacol Exp Ther 1988;246:1104-1107.
25. Jahromi SS, Wentlandt K, Piran S, et al. Anticonvulsant actions of gap junctional blockers in an in vitro seizure model. J Neurophysiol 2002;88:1893-1902.
26. Ross FM, Gwyn P, Spanswick D, et al. Carbenoxolone depresses spontaneous epileptiform activity in the CA1 region of rat hippocampal slices. Neuroscience 2000;100:789-796.
27. Kohling R, Gladwell SJ, Bracci E, et al. Prolonged epileptiform bursting induced by 0-Mg(2+) in rat hippocampal slices depends on gap junctional coupling. Neuroscience 2001;105:579-587.
28. Nyikos L, Lasztozi B, Antal K, et al. Desynchronisation of spontaneously recurrent experimental seizures proceeds with a single rhythm. Neuroscience 2003;121:705-717.
29. Gigout S, Louvel J, Pumain R. Antiepileptic effect of a gap junction blocker in a model of absence epilepsy. Epilepsia 2005;46(suppl 6):361.
30. Edwards HE, Vimal S, Burnham WM. The acute anticonvulsant effects of deoxycorticosterone in developing rats: role of metabolites and mineralocorticoid-receptor responses. Epilepsia 2005;46:1888-1897.
31. Tian GF, Azmi H, Takano T, et al. An astrocytic basis of epilepsy. Nat Med 2005;11:973-981.
32. Nilsen KE, Cock HR. Focal treatment for refractory epilepsy: hope for the future? Brain Res Rev 2004;44:141-153.
33. Wang PP, Frazier J, Brem H. Local drug delivery to the brain. Adv Drug Deliv Rev 2002;54:987-1013.
34. Carson BS, Wu QZ, Tyler B, et al. New approach to tumor therapy for inoperable areas of the brain: chronic intraparenchymal drug delivery. J Neuro-Oncol 2002;60:151-158.
35. Gill SS, Patel NK, Hotton GR, et al. Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. Nat Med 2003;9:589-595.