Connexin-dependent transcellular transcriptomic networks in mouse brain

Progress in Biophysics and Molecular Biology

Volumn 94, Issue 1-2, 2007, Pages 169-185

  Iacobas, Dumitru A ^a   Iacobas, Sanda ^a   Spray, David C ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Cx32; Cx36; Cx43; Gap junction; Gja1; Gja9; Gjb1; Transcription factors

Indexed keywords

GAP JUNCTION PROTEIN; NERVE PROTEIN; PROTEOME; TRANSCRIPTION FACTOR;

ANIMAL; ANTIBODY SPECIFICITY; BRAIN; METABOLISM; MOUSE; NERVE CELL NETWORK; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION;

ANIMALS; BRAIN; CONNEXINS; MICE; NERVE NET; NERVE TISSUE PROTEINS; ORGAN SPECIFICITY; PROTEOME; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION; TRANSCRIPTION FACTORS;

EID: 34249066108     PISSN: 00796107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbiomolbio.2007.03.015     Document Type: Review

References (50)

1. Ai Z., Fischer A., Spray D.C., Brown A.M., and Fishman G.I. Wnt-1 regulation of connexin43 in cardiac myocytes. J. Clin. Invest. 105 2 (2000) 161-171
2. Altevogt B.M., and Paul D.L. Four classes of intercellular channels between glial cells in the CNS. J. Neurosci. 24 18 (2004) 4313-4323
3. Brand-Schieber E., Werner P., Iacobas D.A., Iacobas S., Beelitz M., Lowery S.L., Spray D.C., and Scemes E. Connexin43, the major gap junction protein of astrocytes, is down-regulated in inflamed white matter in an animal model of multiple sclerosis. J. Neurosci. Res. 80 6 (2005) 798-808
4. Dobrenis K., Chang H.Y., Pina-Benabou M.H., Woodroffe A., Lee S.C., Rozenta R., Spray D.C., and Scemes E. Human and mouse microglia express connexin36, and functional gap junctions are formed between rodent microglia and neurons. J. Neurosci. Res. 82 3 (2005) 306-315
5. Duffy H.S., Fort A.G., and Spray D.C. Cardiac connexins: genes to nexus. Adv. Cardiol. 42 (2006) 1-17
6. Fields R.D. Nerve impulses regulate myelination through purinergic signalling. Novartis Found. Symp. 276 (2006) 148-158 discussion 158-161, 233-237, 275-281 (Review)
7. Fields R.D., and Burnstock G. Purinergic signalling in neuron-glia interactions. Nat. Rev. Neurosci. 7 6 (2006) 423-436 (Review)
8. Fu C.T., Bechberger J.F., Ozog M.A., Perbal B., and Naus C.C. CCN3 (NOV) interacts with connexin43 in C6 glioma cells: possible mechanism of connexin-mediated growth suppression. J. Biol. Chem. 279 35 (2004) 36943-36950
9. Gellhaus A., Dong X., Propson S., Maass K., Klein-Hitpass L., Kibschull M., Traub O., Willecke K., Perbal B., Lye S.J., and Winterhager E. Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells. J. Biol. Chem. 279 35 (2004) 36931-36942
10. Haydon P.G. Neuroglial networks: neurons and glia talk to each other. Curr. Biol. 10 19 (2000) R712-R714
11. Iacobas D.A., Urban M., Massimi A., and Spray D.C. Improved procedure to mine the spotted cDNA arrays. J. Biomol. Tech. 13 1 (2002) 5-19
12. Iacobas D.A., Urban M., Massimi A., Iacobas S., and Spray D.C. Hits and misses from gene expression ratio measurements in cDNA microarray studies. J. Biomol. Tech. 13 3 (2002) 143-157
13. Iacobas D.A., Urban M., Iacobas S., and Spray D.C. Control and variability of gene expression in mouse brain and in a neuroblastoma cell line. Rom. J. Physiol. 39-40 (2002) 71-90
14. Iacobas D.A., Urban M., Iacobas S., and Spray D.C. Transcriptomic characterization of four classes of cell-cell/matrix genes in brains and hearts of wild type and connexin43 null mice. Rom. J. Physiol. 40 (2003) 91-116
15. Iacobas D.A., Urban M., Iacobas S., Scemes E., and Spray D.C. Array analysis of gene expression in connexin43 null astrocytes. Physiol. Genomics 15 3 (2003) 177-190
16. Iacobas D.A., Scemes E., and Spray D.C. Gene expression alterations in connexin null mice extend beyond the gap junction. Neurochem. Int. 45 2-3 (2004) 243-250
17. Iacobas D.A., Iacobas S., Urban-Maldonado M., and Spray D.C. Sensitivity of the brain transcriptome to connexin ablation. Biochim. Biophys. Acta 1711 2 (2005) 183-196
18. Iacobas D.A., Iacobas S., Li W.E., Zoidl G., Dermietzel R., and Spray D.C. Genes controlling multiple functional pathways are transcriptionally regulated in connexin43 null mouse heart. Physiol. Genomics 20 3 (2005) 211-223
19. Iacobas D.A., Iacobas S., and Spray D.C. Use of cDNA arrays to explore gene expression in genetically manipulated mice and cell lines. In: Dhein S., Mohr F.W., and Delmar M. (Eds). Practical Methods in Cardiovascular Research (2005), Springer, Berlin, Heidelberg, New York 907-915
20. 2+ wave spread in glia. Biophys. J. 90 1 (2006) 24-41
21. Iacobas D.A., Fan C., Iacobas S., Spray D.C., and Haddad G.G. Transcriptomic changes in developing kidney exposed to chronic hypoxia. Biochem. Biophys. Res. Comm. 349 1 (2006) 329-338
22. Iacobas D.A., Iacobas S., and Spray D.C. Connexin43 and the brain transcriptome of the newborn mice. Genomics 89 1 (2007) 113-123
23. Ishibashi T., Dakin K.A., Stevens B., Lee P.R., Kozlov S.V., Stewart C.L., and Fields R.D. Astrocytes promote myelination in response to electrical impulses. Neuron 49 6 (2006) 823-832
24. Kardami E., Dang X., Iacobas D.A., Nickel B.E., Jeyaraman M., Srisakuldee W., Makazan J., Tanguy S., and Spray D.C. The role of connexins in controlling cell growth and gene expression. Prog Biophys Mol Biol. 94 (2007) 244-263
25. Lin J.H., Yang J., Liu S., Takano T., Wang X., Gao Q., Willecke K., and Nedergaard M. Connexin mediates gap junction-independent resistance to cellular injury. J. Neurosci. 23 (2003) 430-441
26. Loddenkemper T., Grote K., Evers S., Oelerich M., and Stogbauer F. Neurological manifestations of the oculodentodigital dysplasia syndrome. J. Neurol. 249 5 (2002) 584-595
27. Massa P.T., and Mugnaini E. Cell junctions and intramembrane particles of astrocytes and oligodendrocytes: a freeze-fracture study. Neuroscience 7 2 (1982) 523-538
28. Moreno A.P. Biophysical properties of homomeric and heteromultimeric channels formed by cardiac connexins. Cardiovasc. Res. 62 2 (2004) 276-286 (Review)
29. Nagy J.I., Dudek F.E., and Rash J.E. Update on connexins and gap junctions in neurons and glia in the mammalian nervous system. Brain Res. Brain Res. Rev. 47 1-3 (2004) 191-215 (Review)
30. Naus C.C. Gap junctions and tumour progression. Can. J. Physiol. Pharmacol. 80 2 (2002) 136-141 (Review)
31. Naus C.C., Bond S.L., Bechberger J.F., and Rushlow W. Identification of genes differentially expressed in C6 glioma cells transfected with connexin43. Brain Res. Brain Res. Rev. 32 1 (2000) 259-266
32. Nedergaard M., Ransom B., and Goldman S.A. New roles for astrocytes: redefining the functional architecture of the brain. Trends Neurosci. 26 10 (2003) 523-530
33. Penes M.C., Li X., and Nagy J.I. Expression of zonula occludens-1 (ZO-1) and the transcription factor ZO-1-associated nucleic acid-binding protein (ZONAB)-MsY3 in glial cells and colocalization at oligodendrocyte and astrocyte gap junctions in mouse brain. Eur. J. Neurosci. 22 2 (2005) 404-418
34. Rash J.E., Duffy H.S., Dudek F.E., Bilhartz B.L., Whalen L.R., and Yasumura T. Grid-mapped freeze-fracture analysis of gap junctions in gray and white matter of adult rat central nervous system, with evidence for a "panglial syncytium" that is not coupled to neurons. J. Comp. Neurol. 388 2 (1997) 265-292
35. Reaume A.G., de Sousa P.A., Kulkarni S., Langille B.L., Zhu D., Davies T.C., Juneja S.C., Kidder G.M., and Rossant J. Cardiac malformation in neonatal mice lacking connexin43. Science 267 5205 (1995) 1831-1834
36. Rouach N., Avignone E., Meme W., Koulakoff A., Venance L., Blomstrand F., and Giaume C. Gap junctions and connexin expression in the normal and pathological central nervous system. Biol. Cell 94 (2002) 457-475
37. Rozental R., Andrade-Rozental A.F., Zheng X., Urban M., Spray D.C., and Chiu F.C. Gap junction-mediated bidirectional signaling between human fetal hippocampal neurons and astrocytes. Dev. Neurosci. 23 6 (2001) 420-431
38. Sager R. Expression genetics in cancer: shifting the focus from DNA to RNA. Proc. Natl. Acad. Sci. USA 94 3 (1997) 952-955 (Review)
39. Scemes E., Suadicani S.O., and Spray D.C. Intercellular communication in spinal cord astrocytes: fine tuning between gap junctions and P2 nucleotide receptors in calcium wave propagation. J. Neurosci. 20 4 (2000) 1435-1445
40. Sohl G., Maxeiner S., and Willecke K. Expression and functions of neuronal gap junctions. Nat. Rev. Neurosci. 6 3 (2005) 191-200 (Review)
41. Spray D.C. Illuminating gap junctions. Nat. Methods 2 1 (2005) 12-14
42. Spray D.C., Ye Z.C., and Ransom B.R. Functional connexin "hemichannels": a critical appraisal. Glia 54 7 (2006) 758-773
43. Stains J.P., and Civitelli R. Gap junctions regulate extracellular signal-regulated kinase signaling to affect gene transcription. Mol. Biol. Cell 16 1 (2005) 64-72
44. Stains J.P., Lecanda F., Screen J., Towler D.A., and Civitelli R. Gap junctional communication modulates gene transcription by altering the recruitment of Sp1 and Sp3 to connexin-response elements in osteoblast promoters. J. Biol. Chem. 278 27 (2003) 24377-24387
45. Suadicani S.O., De Pina-Benabou M.H., Urban-Maldonado M., Spray D.C., and Scemes E. Acute downregulation of Cx43 alters P2Y receptor expression levels in mouse spinal cord astrocytes. Glia 42 (2003) 160-171
46. Theis M., Sohl G., Eiberger J., and Willecke K. Emerging complexities in identity and function of glial connexins. Trends Neurosci. 28 4 (2005) 188-195 (Review)
47. Valiunas V., Polosina Y.Y., Miller H., Potapova I.A., Valiuniene L., Doronin S., Mathias R.T., Robinson R.B., Rosen M.R., Cohen I.S., and Brink P.R. Connexin-specific cell-to-cell transfer of short interfering RNA by gap junctions. J. Physiol. 568 Pt 2 (2005) 459-468
48. Vandecasteele, M., Glowinski, J., Venance, L., 2006. Connexin mRNA expression in single dopaminergic neurons of substantia nigra pars compacta. Neurosci. Res. (Epub ahead of print).
49. Willecke K., Eiberger J., Degen J., Eckardt D., Romualdi A., Guldenagel M., Deutsch U., and Sohl G. Structural and functional diversity of connexin genes in the mouse and human genome. Biol. Chem. 383 5 (2002) 725-737 (Review)
50. Xu X., Li W.E., Huang G.Y., Meyer R., Chen T., Luo Y., Thomas M.P., Radice G.L., and Lo C.W. Modulation of mouse neural crest cell motility by N-cadherin and connexin43 gap junctions. J. Cell. Biol. 154 1 (2001) 217-230