The Conserved KMN Network Constitutes the Core Microtubule-Binding Site of the Kinetochore

Cell

Volumn 127, Issue 5, 2006, Pages 983-997

  Cheeseman, Iain M ^a   Chappie, Joshua S ^b   Wilson Kubalek, Elizabeth M ^b   Desai, Arshad ^a  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA B KINASE; PROTEIN; PROTEIN KNL 1; PROTEIN MIS12; PROTEIN NDC80; PROTEIN NUF2; PROTEIN SPC24; PROTEIN SPC25; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CENTROMERE; COMPLEX FORMATION; ENZYME PHOSPHORYLATION; MICROTUBULE; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; ULTRASTRUCTURE;

EID: 33751232957     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2006.09.039     Document Type: Article

References (32)

1. Cheeseman I.M., Brew C., Wolyniak M., Desai A., Anderson S., Muster N., Yates J.R., Huffaker T.C., Drubin D.G., and Barnes G. Implication of a novel multiprotein Dam1p complex in outer kinetochore function. J. Cell Biol. 155 (2001) 1137-1146
2. Cheeseman I.M., Anderson S., Jwa M., Green E.M., Kang J., Yates III J.R., Chan C.S., Drubin D.G., and Barnes G. Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p. Cell 111 (2002) 163-172
3. Cheeseman I.M., Niessen S., Anderson S., Hyndman F., Yates III J.R., Oegema K., and Desai A. A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. Genes Dev. 18 (2004) 2255-2268
4. Ciferri C., De Luca J., Monzani S., Ferrari K.J., Ristic D., Wyman C., Stark H., Kilmartin J., Salmon E.D., and Musacchio A. Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore. J. Biol. Chem. 280 (2005) 29088-29095
5. Cleveland D.W., Mao Y., and Sullivan K.F. Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling. Cell 112 (2003) 407-421
6. De Wulf P., McAinsh A.D., and Sorger P.K. Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev. 17 (2003) 2902-2921
7. DeLuca J.G., Dong Y., Hergert P., Strauss J., Hickey J.M., Salmon E.D., and McEwen B.F. Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites. Mol. Biol. Cell 16 (2005) 519-531
8. DeLuca J.G., Gall W.E., Ciferri C., Cimini D., Musacchio A., and Salmon E.D. Kinetochore microtubule dynamics and attachment stability are regulated by Hecl. Cell 127 (2006) 969-982 this issue
9. Desai A., Verma S., Mitchison T.J., and Walczak C.E. Kin I kinesins are microtubule-destabilizing enzymes. Cell 96 (1999) 69-78
10. Desai A., Rybina S., Muller-Reichert T., Shevchenko A., Shevchenko A., Hyman A., and Oegema K. KNL-1 directs assembly of the microtubule-binding interface of the kinetochore in C. elegans. Genes Dev. 17 (2003) 2421-2435
11. Emanuele M.J., McCleland M.L., Satinover D.L., and Stukenberg P.T. Measuring the stoichiometry and physical interactions between components elucidates the architecture of the vertebrate kinetochore. Mol. Biol. Cell 16 (2005) 4882-4892
12. Howell B.J., McEwen B.F., Canman J.C., Hoffman D.B., Farrar E.M., Rieder C.L., and Salmon E.D. Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation. J. Cell Biol. 155 (2001) 1159-1172
13. Joglekar A.P., Bouck D.C., Molk J.N., Bloom K.S., and Salmon E.D. Molecular architecture of a kinetochore-microtubule attachment site. Nat. Cell Biol. 8 (2006) 581-585
14. Kar S., Fan J., Smith M.J., Goedert M., and Amos L.A. Repeat motifs of tau bind to the insides of microtubules in the absence of taxol. EMBO J. 22 (2003) 70-77
15. Kline S.L., Cheeseman I.M., Hori T., Fukagawa T., and Desai A. The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation. J. Cell Biol. 173 (2006) 9-17
16. Kline-Smith S.L., Sandall S., and Desai A. Kinetochore-spindle microtubule interactions during mitosis. Curr. Opin. Cell Biol. 17 (2005) 35-46
17. Maddox P., Straight A., Coughlin P., Mitchison T.J., and Salmon E.D. Direct observation of microtubule dynamics at kinetochores in Xenopus extract spindles: implications for spindle mechanics. J. Cell Biol. 162 (2003) 377-382
18. Maiato H., DeLuca J., Salmon E.D., and Earnshaw W.C. The dynamic kinetochore-microtubule interface. J. Cell Sci. 117 (2004) 5461-5477
19. Maiato H., Khodjakov A., and Rieder C.L. Drosophila CLASP is required for the incorporation of microtubule subunits into fluxing kinetochore fibres. Nat. Cell Biol. 7 (2005) 42-47
20. McCleland M.L., Kallio M.J., Barrett-Wilt G.A., Kestner C.A., Shabanowitz J., Hunt D.F., Gorbsky G.J., and Stukenberg P.T. The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment. Curr. Biol. 14 (2004) 131-137
21. Nekrasov V.S., Smith M.A., Peak-Chew S., and Kilmartin J.V. Interactions between centromere complexes in Saccharomyces cerevisiae. Mol. Biol. Cell 14 (2003) 4931-4946
22. Obuse C., Iwasaki O., Kiyomitsu T., Goshima G., Toyoda Y., and Yanagida M. A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. Nat. Cell Biol. 6 (2004) 1135-1141
23. Pinsky B.A., and Biggins S. The spindle checkpoint: tension versus attachment. Trends Cell Biol. 15 (2005) 486-493
24. Putkey F.R., Cramer T., Morphew M.K., Silk A.D., Johnson R.S., McIntosh J.R., and Cleveland D.W. Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E. Dev. Cell 3 (2002) 351-365
25. Rieder C.L. The formation, structure, and composition of the mammalian kinetochore and kinetochore fiber. Int. Rev. Cytol. 79 (1982) 1-58
26. Rieder C.L., and Salmon E.D. The vertebrate cell kinetochore and its roles during mitosis. Trends Cell Biol. 8 (1998) 310-318
27. Sanchez-Perez I., Renwick S.J., Crawley K., Karig I., Buck V., Meadows J.C., Franco-Sanchez A., Fleig U., Toda T., and Millar J.B. The DASH complex and Klp5/Klp6 kinesin coordinate bipolar chromosome attachment in fission yeast. EMBO J. 24 (2005) 2931-2943
28. Schrader F. Mitosis: The Movement of Chromosomes in Cell Division. Second Edition (1953), Columbia University Press, New York
29. Tan S. A modular polycistronic expression system for overexpressing protein complexes in Escherichia coli. Protein Expr. Purif. 21 (2001) 224-234
30. Tanaka T.U., Rachidi N., Janke C., Pereira G., Galova M., Schiebel E., Stark M.J.R., and Nasmyth K. Evidence that the Ipl1-Sli15 (Aurora Kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections. Cell 108 (2002) 317-329
31. Wei R.R., Sorger P.K., and Harrison S.C. Molecular organization of the Ndc80 complex, an essential kinetochore component. Proc. Natl. Acad. Sci. USA 102 (2005) 5363-5367
32. Wigge P.A., and Kilmartin J.V. The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation. J. Cell Biol. 152 (2001) 349-360