The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores

Nature Cell Biology

Volumn 8, Issue 1, 2006, Pages 78-83

  Pinsky, Benjamin A ^a   Kung, Charles ^b   Shokat, Kevan M ^b,c   Biggins, Sue ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA A KINASE; AURORA B KINASE; CELL PROTEIN; FUNGAL PROTEIN; PROTEIN DAM1; PROTEIN KINASE; PROTEIN LPL1; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CELL MUTANT; CENTROMERE; CHROMOSOME SEGREGATION; ENZYME ACTIVATION; MICROTUBULE; MITOSIS SPINDLE; NONHUMAN; PRIORITY JOURNAL; YEAST CELL;

CELL CYCLE; HEAT; KINETOCHORES; MITOTIC SPINDLE APPARATUS; MODELS, BIOLOGICAL; MUTATION; PROTEIN KINASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCETALES;

EID: 30344462087     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1341     Document Type: Article

References (29)

1. Pinsky, B.A. & Biggins, S. The spindle checkpoint: Tension vs. attachment. Trends Cell Biol. 15, 486-493 (2005).
2. Lew, D.J. & Burke, D.J. The spindle assembly and spindle position checkpoints. Annu. Rev. Genet. 37, 251-282 (2003).
3. Biggins, S. & Murray, A.W. The budding yeast protein kinase lpl1/Aurora allows the absence of tension to activate the spindle checkpoint. Genes Dev. 15, 3118-3129 (2001).
4. Nicklas, R.B. & Ward, S.C. Elements of error correction in mitosis: microtubule capture, release, and tension. J. Cell Biol. 126, 1241-1253 (1994).
5. King, J.M. & Nicklas, R.B. Tension on chromosomes increases the number of kinetochore microtubules but only within limits. J. Cell Sci. 113, 3815-3823 (2000).
6. Vagnarelli, P. & Earnshaw, W.C. Chromosomal passengers: The four-dimensional regulation of mitotic events. Chromosoma 113, 211-222 (2004).
7. Cheeseman, I.M. et al. Phospho-regulation of kinetochore-microtubule attachments by the aurora kinase lpl1p. Cell 111, 163-172 (2002).
8. Winey, M. et al. Three-dimensional ultrastructural analysis of the Saccharomyces cerevisiae mitotic spindle. J. Cell Biol. 129, 1601-1615 (1995).
9. McAinsh, A.D., Tytell, J.D. & Sorger, P.K. Structure, function, and regulation of budding yeast kinetochores. Annu. Rev. Cell. Dev. Biol. 19, 519-539 (2003).
10. Pinsky, B.A., Tatsutani, S.Y., Collins, K.A. & Biggins, S. An Mtw1 complex promotes kinetochore biorientation that is monitored by the lpl1/ Aurora protein kinase. Dev. Cell 5, 735-745 (2003).
11. Biggins, S. et al. The conserved protein kinase lpl1 regulates microtubule binding to kinetochores in budding yeast. Genes Dev. 13, 532-544 (1999).
12. Kim, J.H., Kang, J.S. & Chan, C.S. Sli15 associates with the lpl1 protein kinase to promote proper chromosome segregation in Saccharomyces cerevisiae. J. Cell Biol. 145, 1381-1394 (1999).
13. Tanaka, T.U. et al. Evidence that the lpl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome biorientation by altering kinetochore-spindle pole connections. Cell 108, 317-329 (2002).
14. De Wulf, P., McAinsh, A.D. & Sorger, P.K. Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev. 17, 2902-2921 (2003).
15. Bishop, A.C., Buzko, O. & Shokat, K.M. Magic bullets for protein kinases. Trends Cell Biol. 11, 167-172 (2001).
16. Indjeian, V.B., Stern, B.M. & Murray, A.W. The centromeric protein Sgo1 is required to sense lack of tension on mitotic chromosomes. Science 307, 130-133 (2005).
17. Nicklas, R.B., Waters, J.C., Salmon, E.D. & Ward, S.C. Checkpoint signals in grasshopper meiosis are sensitive to microtubule attachment, but tension is still essential. J. Cell Sci. 114, 4173-4183 (2001).
18. Draviam, V.M., Xie, S. & Sorger, P.K. Chromosome segregation and genomic stability. Curr. Opin. Genet. Dev. 14, 120-125 (2004).
19. Bharadwaj, R. & Yu, H. The spindle checkpoint, aneuploidy, and cancer. Oncogene 23, 2016-2027 (2004).
20. Sherman, F., Fink, G. & Lawrence, C. in Methods in Yeast Genetics (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1974).
21. Rose, M.D., Winston, F. & Heiter, P. in Methods in Yeast Genetics (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1990).
22. Brown, M.T., Goetsch, L. & Hartwell, L.H. MIF2 is required for mitotic spindle integrity during anaphase spindle elongation in Saccharomyces cerevisiae. J. Cell Biol. 123, 387-403 (1993).
23. Osborne, M.A., Schlenstedt, G., Jinks, T. & Silver, P.A. Nuf2, a spindle pole body-associated protein required for nuclear division in yeast. J. Cell Biol. 125, 853-866 (1994).
24. Wigge, P.A. et al. Analysis of the Saccharomyces spindle pole by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. J. Cell Biol. 141, 967-977 (1998).
25. Li, Y. et al. The mitotic spindle is required for loading of the DASH complex onto the kinetochore. Genes Dev. 16, 183-197 (2002).
26. Elliott, S., Knop, M., Schlenstedt, G. & Schiebel, E. Spc29p is a component of the Spc110p subcomplex and is essential for spindle pole body duplication. Proc. Natl Acad. Sci. USA 96, 6205-6210 (1999).
27. Longtine, M.S. et al. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 14, 953-961 (1998).
28. Minshull, J. et al. Protein phosphatase 2A regulates MPF activity and sister chromatid cohesion in budding yeast. Curr. Biol. 6, 1609-1620 (1996).
29. Buvelot, S., Tatsutani, S.Y., Vermaak, D. & Biggins, S. The budding yeast lpl1/Aurora protein kinase regulates mitotic spindle disassembly. J. Cell Biol. 160, 329-339 (2003).