MLN8054, a small-molecule inhibitor of Aurora A, causes spindle pole and chromosome congression defects leading to aneuploidy

Molecular and Cellular Biology

Volumn 27, Issue 12, 2007, Pages 4513-4525

  Hoar, Kara ^a   Chakravarty, Arijit ^a   Rabino, Claudia ^a   Wysong, Deborah ^a   Bowman, Douglas ^a   Roy, Natalie ^a   Ecsedy, Jeffrey A ^a  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA A KINASE; AURORA KINASE INHIBITOR; MLN 8054; UNCLASSIFIED DRUG;

ANAPHASE; ANEUPLOIDY; ARTICLE; CANCER CELL; CELL DEATH; CELL DIVISION; CENTROSOME; CHROMATIN; CHROMOSOME ABERRATION; CHROMOSOME SEGREGATION; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; METAPHASE; MITOSIS SPINDLE; PRIORITY JOURNAL; SPINDLE POLE BODY; TELOPHASE;

ANEUPLOIDY; BENZAZEPINES; BLOTTING, WESTERN; CENTROSOME; CHROMOSOME SEGREGATION; CHROMOSOMES, HUMAN; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HCT116 CELLS; HUMANS; MICROSCOPY, VIDEO; MITOTIC SPINDLE APPARATUS; MODELS, BIOLOGICAL; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; TIME FACTORS;

EID: 34250201840     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.02364-06     Document Type: Article

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