Aurora Kinase Promotes Turnover of Kinetochore Microtubules to Reduce Chromosome Segregation Errors

Current Biology

Volumn 16, Issue 17, 2006, Pages 1711-1718

  Cimini, Daniela ^a   Wan, Xiaohu ^a   Hirel, Christophe B ^b   Salmon, E D ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b NONE

Author keywords

CELLCYCLE

Indexed keywords

AURORA KINASE; PROTEIN SERINE THREONINE KINASE;

ANIMAL; ARTICLE; CELL LINE; CENTROMERE; CHROMOSOME SEGREGATION; DRUG ANTAGONISM; FEMALE; METABOLISM; MICROTUBULE; MITOSIS; MITOSIS SPINDLE; PHYSIOLOGY; RAT KANGAROO;

ANIMALS; CELL LINE; CHROMOSOME SEGREGATION; FEMALE; KINETOCHORES; MICROTUBULES; MITOSIS; MITOTIC SPINDLE APPARATUS; POTOROIDAE; PROTEIN-SERINE-THREONINE KINASES;

EID: 33750612373     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2006.07.022     Document Type: Article

References (35)

1. Cimini D., Howell B., Maddox P., Khodjakov A., Degrassi F., and Salmon E.D. Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells. J. Cell Biol. 153 (2001) 517-527
2. Cimini D., Fioravanti D., Salmon E.D., and Degrassi F. Merotelic kinetochore orientation versus chromosome mono-orientation in the origin of lagging chromosomes in human primary cells. J. Cell Sci. 115 (2002) 507-515
3. Cimini D., Moree B., Canman J.C., and Salmon E.D. Merotelic kinetochore orientation occurs frequently during early mitosis in mammalian tissue cells and error correction is achieved by two different mechanisms. J. Cell Sci. 116 (2003) 4213-4225
4. Khodjakov A., Cole R.W., McEwen B.F., Buttle K.F., and Rieder C.L. Chromosome fragments possessing only one kinetochore can congress to the spindle equator. J. Cell Biol. 136 (1997) 229-240
5. Wise D.A., and Brinkley B.R. Mitosis in cells with unreplicated genomes (MUGs): Spindle assembly and behavior of centromere fragments. Cell Motil. Cytoskeleton 36 (1997) 291-302
6. Cimini D., Cameron L.A., and Salmon E.D. Anaphase spindle mechanics prevent mis-segregation of merotelically oriented chromosomes. Curr. Biol. 14 (2004) 2149-2155
7. Lampson M.A., Renduchitala K., Khodjakov A., and Kapoor T.M. Correcting improper chromosome-spindle attachments during cell division. Nat. Cell Biol. 6 (2004) 232-237
8. Ault J.G., and Nicklas R.B. Tension, microtubule rearrangements, and the proper distribution of chromosomes in mitosis. Chromosoma 98 (1989) 33-39
9. Pinsky B.A., Kung C., Shokat K.M., and Biggins S. The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores. Nat. Cell Biol. 8 (2006) 78-83
10. Kline-Smith S.L., Khodjakov A., Hergert P., and Walczak C.E. Depletion of centromeric MCAK leads to chromosome congression and segregation defects due to improper kinetochore attachments. Mol. Biol. Cell 15 (2004) 1146-1159
11. Ohi R., Coughlin M.L., Lane W.S., and Mitchison T.J. An inner centromere protein that stimulates the microtubule depolymerizing activity of a KinI kinesin. Dev. Cell 5 (2003) 309-321
12. Maiato H., DeLuca J., Salmon E.D., and Earnshaw W.C. The dynamic kinetochore-microtubule interface. J. Cell Sci. 117 (2004) 5461-5477
13. Ditchfield C., Johnson V.L., Tighe A., Ellston R., Haworth C., Johnson T., Mortlock A., Keen N., and Taylor S.S. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J. Cell Biol. 161 (2003) 267-280
14. Murata-Hori M., Tatsuka M., and Wang Y.L. Probing the dynamics and functions of aurora B kinase in living cells during mitosis and cytokinesis. Mol. Biol. Cell 13 (2002) 1099-1108
15. Salmon E.D., Cimini D., Cameron L.A., and DeLuca J.G. Merotelic kinetochores in mammalian tissue cells. Philos. Trans. R. Soc. Lond. B Biol. Sci. 360 (2005) 553-568
16. Cameron L.A., Yang G., Cimini D., Canman J.C., Kisurina-Evgenieva O., Khodjakov A., Danuser G., and Salmon E.D. Kinesin 5-independent poleward flux of kinetochore microtubules in PtK1 cells. J. Cell Biol. 173 (2006) 173-179
17. Zhai Y., Kronebusch P.J., and Borisy G.G. Kinetochore microtubule dynamics and the metaphase-anaphase transition. J. Cell Biol. 131 (1995) 721-734
18. Mitchison T.J. Polewards microtubule flux in the mitotic spindle: Evidence from photoactivation of fluorescence. J. Cell Biol. 109 (1989) 637-652
19. Mitchison T.J., and Salmon E.D. Poleward kinetochore fiber movement occurs during both metaphase and anaphase-A in newt lung cell mitosis. J. Cell Biol. 119 (1992) 569-582
20. Salic A., Waters J.C., and Mitchison T.J. Vertebrate shugoshin links sister centromere cohesion and kinetochore microtubule stability in mitosis. Cell 118 (2004) 567-578
21. Waters J.C., Mitchison T.J., Rieder C.L., and Salmon E.D. The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do work. Mol. Biol. Cell 7 (1996) 1547-1558
22. Waters J.C., Skibbens R.V., and Salmon E.D. Oscillating mitotic newt lung cell kinetochores are, on average, under tension and rarely push. J. Cell Sci. 109 (1996) 2823-2831
23. Saxton W.M., Stemple D.L., Leslie R.J., Salmon E.D., Zavortink M., and McIntosh J.R. Tubulin dynamics in cultured mammalian cells. J. Cell Biol. 99 (1984) 2175-2186
24. Murata-Hori M., and Wang Y.L. The kinase activity of aurora B is required for kinetochore-microtubule interactions during mitosis. Curr. Biol. 12 (2002) 894-899
25. Ganem N.J., Upton K., and Compton D.A. Efficient mitosis in human cells lacking poleward microtubule flux. Curr. Biol. 15 (2005) 1827-1832
26. Shindo M., Nakano H., Kuroyanagi H., Shirasawa T., Mihara M., Gilbert D.J., Jenkins N.A., Copeland N.G., Yagita H., and Okumura K. cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2. Biochem. Biophys. Res. Commun. 244 (1998) 285-292
27. King J.M., and Nicklas R.B. Tension on chromosomes increases the number of kinetochore microtubules but only within limits. J. Cell Sci. 113 (2000) 3815-3823
28. Maddox P., Straight A., Coughlin P., Mitchison T.J., and Salmon E.D. Direct observation of microtubule dynamics at kinetochores in Xenopus extract spindles: Implications for spindle mechanics. J. Cell Biol. 162 (2003) 377-382
29. Murata-Hori M., and Wang Y.L. Both midzone and astral microtubules are involved in the delivery of cytokinesis signals: Insights from the mobility of aurora B. J. Cell Biol. 159 (2002) 45-53
30. Kang J., Cheeseman I.M., Kallstrom G., Velmurugan S., Barnes G., and Chan C.S. Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation. J. Cell Biol. 155 (2001) 763-774
31. Shang C., Hazbun T.R., Cheeseman I.M., Aranda J., Fields S., Drubin D.G., and Barnes G. Kinetochore protein interactions and their regulation by the Aurora kinase Ipl1p. Mol. Biol. Cell 14 (2003) 3342-3355
32. Andrews P.D., Ovechkina Y., Morrice N., Wagenbach M., Duncan K., Wordeman L., and Swedlow J.R. Aurora B regulates MCAK at the mitotic centromere. Dev. Cell 6 (2004) 253-268
33. Lan W., Zhang X., Kline-Smith S.L., Rosasco S.E., Barrett-Wilt G.A., Shabanowitz J., Hunt D.F., Walczak C.E., and Stukenberg P.T. Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity. Curr. Biol. 14 (2004) 273-286
34. Ohi R., Sapra T., Howard J., and Mitchison T.J. Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation. Mol. Biol. Cell 15 (2004) 2895-2906
35. Knowlton A.L., Lan W., and Stukenberg P.T. Aurora B is enriched at merotelic attachment sites, where it regulates MCAK. Curr. Biol. 16 (2006) 1705-1710 this issue