PDX-1 and MafA play a crucial role in pancreatic β-cell differentiation and maintenance of mature β-cell function

Endocrine Journal

Volumn 55, Issue 2, 2008, Pages 235-252

  Kaneto, Hideaki ^a   Miyatsuka, Takeshi ^a   Kawamori, Dan ^a   Yamamoto, Kaoru ^a   Kato, Ken ^a   Shiraiwa, Toshihiko ^a   Katakami, Naoto ^a   Yamasaki, Yoshimitsu ^a   Matsuhisa, Munehide ^a   Matsuoka, Taka Aki ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

cell differentiation; cell glucose toxicity; MafA; Pancreas development; PDX 1

Indexed keywords

GLUCOKINASE; GLUCOSE; GLUCOSE TRANSPORTER 2; HYBRID PROTEIN; PROTEIN VP16; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR PDX 1; TRANSCRIPTION FACTOR PDX 1 VP 16 FUSION PROTEIN;

ACINAR TO DUCTAL METAPLASIA; CELL DIFFERENTIATION; DNA BINDING; DOWN REGULATION; GENE; GENETIC TRANSCRIPTION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOSYLATION; HUMAN; HYPERGLYCEMIA; INSULIN GENE; INSULIN RELEASE; INSULIN SYNTHESIS; MATURITY ONSET DIABETES MELLITUS; METAPLASIA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PANCREAS; PANCREAS ISLET BETA CELL; PROTEIN DOMAIN; PROTEIN EXPRESSION; REVIEW; TRANSCRIPTION FACTOR PDX 1 GENE; X1HBOX8 VP 16 GENE;

ANIMALS; CELL DIFFERENTIATION; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; GLUCOSE; HOMEODOMAIN PROTEINS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MAF TRANSCRIPTION FACTORS, LARGE; MICE; RATS; TRANS-ACTIVATORS;

EID: 43449091944     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.K07E-041     Document Type: Review

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