메뉴 건너뛰기




Volumn 414, Issue 6865, 2001, Pages 788-791

Diabetes mellitus and genetically programmed defects in β-cell function

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DEVELOPING COUNTRIES; GENES; INSULIN; MUTAGENESIS; TISSUE;

EID: 0035856943     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/414788a     Document Type: Review
Times cited : (424)

References (59)
  • 1
    • 0035160931 scopus 로고    scopus 로고
    • Report of the expert committee on the diagnosis and classification of diabetes mellitus
    • (2001) Diabetes Care , vol.24 , pp. S5-S20
  • 8
    • 0033599038 scopus 로고    scopus 로고
    • Dominant negative mutations in human PPAR associated with severe insulin resistance, diabetes mellitus and hypertension
    • (1999) Nature , vol.402 , pp. 880-883
    • Barroso, I.1
  • 12
    • 0029962261 scopus 로고    scopus 로고
    • Liver-enriched transcription factors and hepatocyte differentiation
    • (1996) FASEB J. , vol.10 , pp. 267-282
    • Cereghini, S.1
  • 13
    • 0034892164 scopus 로고    scopus 로고
    • Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF) 1 and HNF 4 families: Functional and pathological consequences
    • (2001) J. Mol. Endocrinol. , vol.27 , pp. 11-29
    • Ryffel, G.U.1
  • 18
    • 0035512077 scopus 로고    scopus 로고
    • Loss of HNF-1α function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism
    • (2001) Diabetes , vol.50 , pp. 2472-2480
    • Shih, D.Q.1
  • 19
    • 0030695028 scopus 로고    scopus 로고
    • Diminished insulin and glucagon secretory responses to arginine in nondiabetic subjects with a mutation in the hepatocyte nuclear factor-4α/MODYI gene
    • (1997) Diabetes , vol.46 , pp. 1749-1754
    • Herman, W.H.1
  • 20
    • 18144452590 scopus 로고    scopus 로고
    • Defective insulin secretion in hepatocyte nuclear factor 1α-deficient mice
    • (1998) J. Clin. Invest. , vol.101 , pp. 2215-2222
    • Pontoglio, M.1
  • 27
    • 0032718689 scopus 로고    scopus 로고
    • Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus
    • (1999) J. Clin. Invest. , vol.104 , pp. R41-R48
    • Hani, E.H.1
  • 28
    • 0033755186 scopus 로고    scopus 로고
    • Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene)
    • (2000) Diabetes , vol.49 , pp. 1856-1864
    • Clocquet, A.R.1
  • 30
    • 0032700272 scopus 로고    scopus 로고
    • Mutations in NEUROD 1 are associated with the development of type 2 diabetes mellitus
    • (1999) Nature Genet. , vol.23 , pp. 323-328
    • Malecki, M.T.1
  • 31
    • 0033856122 scopus 로고    scopus 로고
    • Nonsense mutation of islet-1 gene (Q310X) found in a type 2 diabetic patient with a strong family history
    • (2000) Diabetes , vol.49 , pp. 1597-1600
    • Shimomura, H.1
  • 34
    • 0033762782 scopus 로고    scopus 로고
    • Impaired insulin secretion and β-cell loss in tissue-specific knockout mice with mitochondrial diabetes
    • (2000) Nature Genet. , vol.26 , pp. 336-340
    • Silva, J.P.1
  • 37
    • 0031913829 scopus 로고    scopus 로고
    • Role of apoptosis in failure of β-cell mass compensation for insulin resistance and β-cell defects in the male Zucker diabetic fatty rat
    • (1998) Diabetes , vol.47 , pp. 358-364
    • Pick, A.1
  • 38
    • 0028985060 scopus 로고
    • Pancreatic β-cells in obesity. Evidence for induction of functional, morphological, and metabolic abnormalities by increased long chain fatty acids
    • (1995) J. Biol. Chem. , vol.270 , pp. 1295-1299
    • Milburn, J.1
  • 39
    • 0030874158 scopus 로고    scopus 로고
    • Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity and the onset of diabetes
    • (1997) Diabetes , vol.46 , pp. 1434-1439
    • Cockburn, B.N.1
  • 42
    • 0034781057 scopus 로고    scopus 로고
    • Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt/PKBα
    • (2001) Nature Med. , vol.7 , pp. 1133-1137
    • Tuttle, R.L.1
  • 43
    • 0035875087 scopus 로고    scopus 로고
    • Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β cell dysfunction, and type 2 diabetes
    • (2001) Cell , vol.105 , pp. 745-755
    • Zhang, C.Y.1
  • 45
    • 0033624575 scopus 로고    scopus 로고
    • The common PPAR-Pro 12Ala polymorphism is associated with decreased risk of type 2 diabetes
    • (2000) Nature Genet. , vol.26 , pp. 76-80
    • Altshuler, D.1
  • 46
    • 0035123646 scopus 로고    scopus 로고
    • Evidence for gene-nutrient interaction at the PPAR-locus
    • (2001) Diabetes , vol.50 , pp. 686-689
    • Luan, J.1
  • 48
    • 0033857387 scopus 로고    scopus 로고
    • Treatment of insulin resistance with peroxisome proliferator-activated receptor agonists
    • (2000) J. Clin. Invest. , vol.106 , pp. 467-472
    • Olefsky, J.M.1
  • 50
    • 0033811933 scopus 로고    scopus 로고
    • Expression of the peroxisome proliferator-activated receptor (PPAR) in normal human pancreatic islets
    • (2000) Diabetologia , vol.43 , pp. 1165-1169
    • Dubois, M.1
  • 51
    • 0033524937 scopus 로고    scopus 로고
    • Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes
    • (1999) Cell , vol.96 , pp. 329-339
    • Kulkarni, R.N.1
  • 52
    • 0035265835 scopus 로고    scopus 로고
    • Selective insulin signaling through A and B insulin receptors regulates transcription of the insulin and glucokinase genes in pancreatic β cells
    • (2001) Molecular Cell , vol.7 , pp. 559-570
    • Leibiger, B.1
  • 53
    • 0033772073 scopus 로고    scopus 로고
    • Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
    • (2000) Nature Genet. , vol.26 , pp. 163-175
    • Horikawa, Y.1
  • 54
    • 0033797241 scopus 로고    scopus 로고
    • A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance
    • (2000) J. Clin. Invest. , vol.106 , pp. R69-R73
    • Baier, L.J.1
  • 55
    • 0035458548 scopus 로고    scopus 로고
    • Calpains play a role in insulin secretion and action
    • (2001) Diabetes , vol.50 , pp. 2013-2020
    • Sreenan, S.K.1
  • 56
    • 0034893106 scopus 로고    scopus 로고
    • A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): Analysis of 573 pedigrees provides independent replication of a locus on chromosome 1q
    • (2001) Am. J. Hum. Genet. , vol.69 , pp. 553-569
    • Wiltshire, S.1
  • 57
    • 85018111925 scopus 로고    scopus 로고
    • (2001)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.