메뉴 건너뛰기




Volumn 45, Issue 11, 1996, Pages 1478-1488

The human glucokinase gene β-cell-type promoter: An essential role of insulin promoter factor 1/PDX-1 in its activation in HIT-T15 cells

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOKINASE;

EID: 0029909387     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.45.11.1478     Document Type: Article
Times cited : (206)

References (47)
  • 1
    • 0021741559 scopus 로고
    • Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells
    • Ashcroft FM, Harrison DR, Ashcroft SJ: Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells. Nature 312:446-448, 1984
    • (1984) Nature , vol.312 , pp. 446-448
    • Ashcroft, F.M.1    Harrison, D.R.2    Ashcroft, S.J.3
  • 2
    • 0022346359 scopus 로고
    • Control of insulin gene expression in pancreatic β-cells and in an insulin-producing cell line, RIN-5F cells: Regulation of insulin mRNA stability
    • Welsh M, Nielsen DA, MacKrell AJ, Steiner DP: Control of insulin gene expression in pancreatic β-cells and in an insulin-producing cell line, RIN-5F cells: regulation of insulin mRNA stability. J Biol Chem 260:13590-13594, 1980
    • (1980) J Biol Chem , vol.260 , pp. 13590-13594
    • Welsh, M.1    Nielsen, D.A.2    MacKrell, A.J.3    Steiner, D.P.4
  • 3
    • 0021247064 scopus 로고
    • New perspectives on pancreatic islet glucokinase
    • Meglasson MD, Matschinsky FM: New perspectives on pancreatic islet glucokinase. Am J Physiol 246:E1-E13, 1984
    • (1984) Am J Physiol , vol.246
    • Meglasson, M.D.1    Matschinsky, F.M.2
  • 4
    • 0022467904 scopus 로고
    • Pancreatic islet glucose metabolism and regulation of insulin secretion
    • Meglasson MD, Matschinsky KM: Pancreatic islet glucose metabolism and regulation of insulin secretion. Diabetes Metab Rev 2:163-214, 1980
    • (1980) Diabetes Metab Rev , vol.2 , pp. 163-214
    • Meglasson, M.D.1    Matschinsky, K.M.2
  • 5
    • 0022538272 scopus 로고
    • Tissue-specific expression of glucokinase: Identification of the gene product in liver and pancreatic islets
    • Iynedjian PB, Mobius G, Seitz HJ, Wollheim CB, Renold AE: Tissue-specific expression of glucokinase: identification of the gene product in liver and pancreatic islets. Proc Natl Acad Sci USA 83:1998-2001, 1986
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 1998-2001
    • Iynedjian, P.B.1    Mobius, G.2    Seitz, H.J.3    Wollheim, C.B.4    Renold, A.E.5
  • 6
    • 0025773360 scopus 로고
    • Effects of alternate RNA splicing on GK isoform activities in the pancreatic islet, liver, and pituitary
    • Liang Y, Jetton TL, Zimmerman EC, Najafi H, Matschinsky FM, Magnuson MA: Effects of alternate RNA splicing on GK isoform activities in the pancreatic islet, liver, and pituitary. J Biol Chem 266:6999-7007, 1991
    • (1991) J Biol Chem , vol.266 , pp. 6999-7007
    • Liang, Y.1    Jetton, T.L.2    Zimmerman, E.C.3    Najafi, H.4    Matschinsky, F.M.5    Magnuson, M.A.6
  • 7
    • 0028101926 scopus 로고
    • Analysis of upstream glucokinase promoter activity in transgenic mice and identification in rare neuroendocrine cells in the brain and gut
    • Jetton TL, Liang Y, Pettepher CC, Zimmerman EC, Cox FG, Horvath K, Matschinsky FM, Magnuson MA: Analysis of upstream glucokinase promoter activity in transgenic mice and identification in rare neuroendocrine cells in the brain and gut. J Biol Chem 269:3641-3054, 1994
    • (1994) J Biol Chem , vol.269 , pp. 3641-13054
    • Jetton, T.L.1    Liang, Y.2    Pettepher, C.C.3    Zimmerman, E.C.4    Cox, F.G.5    Horvath, K.6    Matschinsky, F.M.7    Magnuson, M.A.8
  • 8
    • 0026655031 scopus 로고
    • Human glucokinase gene: Isolation, structural characterization and identification of a microsatellite repeat polymorphism
    • Tanizawa Y, Matsutani A, Chiu KC, Permutt MA: Human glucokinase gene: isolation, structural characterization and identification of a microsatellite repeat polymorphism. Mol Endocrinol 6:1070-1081, 1992
    • (1992) Mol Endocrinol , vol.6 , pp. 1070-1081
    • Tanizawa, Y.1    Matsutani, A.2    Chiu, K.C.3    Permutt, M.A.4
  • 9
    • 0024596435 scopus 로고
    • Mutagenesis of the rat insulin II 5′-flanking region defines sequences important for expression in HIT-T15 cells
    • Crowe DT, Tsai M-J: Mutagenesis of the rat insulin II 5′-flanking region defines sequences important for expression in HIT-T15 cells. Mol Cell Biol 9:1784-1789, 1989
    • (1989) Mol Cell Biol , vol.9 , pp. 1784-1789
    • Crowe, D.T.1    Tsai, M.-J.2
  • 10
    • 0023477391 scopus 로고
    • A nuitational analysis of the insulin gene transcription control region: Expression in β cells is dependent on two related sequences within the enhancer
    • Karlsson O, Edlund T, Moss JB, Rutter WJ, Walker M: A nuitational analysis of the insulin gene transcription control region: expression in β cells is dependent on two related sequences within the enhancer. Proc Natl Acad Sci USA 84:8819-8823, 1987
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 8819-8823
    • Karlsson, O.1    Edlund, T.2    Moss, J.B.3    Rutter, W.J.4    Walker, M.5
  • 11
    • 0025361461 scopus 로고
    • Positive and negative regulation of the human insulin gene by multiple trans-acting factors
    • Boam DS, Clark AE, Docherty K: Positive and negative regulation of the human insulin gene by multiple trans-acting factors. J Biol Chem 265:8285-8296, 1990
    • (1990) J Biol Chem , vol.265 , pp. 8285-8296
    • Boam, D.S.1    Clark, A.E.2    Docherty, K.3
  • 13
    • 2642628564 scopus 로고
    • A β-cell-specific protein binds to the two major regulatory sequences of the insulin gene enhancer
    • Ohlsson H, Karlsson O, Edlund T: A β-cell-specific protein binds to the two major regulatory sequences of the insulin gene enhancer. Proc Natl Acad Sci USA 85:4228-4231, 1988
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 4228-4231
    • Ohlsson, H.1    Karlsson, O.2    Edlund, T.3
  • 14
    • 0026386775 scopus 로고
    • Novel insulin promoter- And enhancer-binding proteins that discriminate between pancreatic α- and β-cells
    • Ohlsson H, Thor S, Edlund T: Novel insulin promoter- and enhancer-binding proteins that discriminate between pancreatic α- and β-cells. Mol Endocrinol 5:897-904, 1991
    • (1991) Mol Endocrinol , vol.5 , pp. 897-904
    • Ohlsson, H.1    Thor, S.2    Edlund, T.3
  • 15
    • 0026602931 scopus 로고
    • The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical β-cell nuclear complexes
    • German MS, Moss LG, Wang J, Rutter WJ: The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical β-cell nuclear complexes. Mol Cell Biol 12:1777-1788, 1992
    • (1992) Mol Cell Biol , vol.12 , pp. 1777-1788
    • German, M.S.1    Moss, L.G.2    Wang, J.3    Rutter, W.J.4
  • 16
    • 0024462439 scopus 로고
    • An alternate promoter in the glucokinase gene is active in the pancreatic β cell
    • Magnuson MA, Shelton KD: An alternate promoter in the glucokinase gene is active in the pancreatic β cell. J Biol Chem 264:15936-15942, 1989
    • (1989) J Biol Chem , vol.264 , pp. 15936-15942
    • Magnuson, M.A.1    Shelton, K.D.2
  • 17
    • 0026687778 scopus 로고
    • Multiple elements in the upstream glucokinase promoter contribute to transcription in insulinoma cells
    • Shelton KD, Franklin AJ, Khoor A, Beechem J, Magnuson MA: Multiple elements in the upstream glucokinase promoter contribute to transcription in insulinoma cells. Mol Cell Biol 12:4578-4589, 1992
    • (1992) Mol Cell Biol , vol.12 , pp. 4578-4589
    • Shelton, K.D.1    Franklin, A.J.2    Khoor, A.3    Beechem, J.4    Magnuson, M.A.5
  • 20
    • 0026754672 scopus 로고
    • Primary pancreatic β-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young
    • Velho G, Froguel P, Clement K, Pueyo ME, Rakotoambinina B, Zouali H, Passa P, Cohen D, Robert JJ: Primary pancreatic β-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young. Lancet 340:1162-1163, 1992
    • (1992) Lancet , vol.340 , pp. 1162-1163
    • Velho, G.1    Froguel, P.2    Clement, K.3    Pueyo, M.E.4    Rakotoambinina, B.5    Zouali, H.6    Passa, P.7    Cohen, D.8    Robert, J.J.9
  • 22
    • 0024623863 scopus 로고
    • A DNA cassette containing a trimerized SV40 polyadenylation signal which efficiently blocks spurious plasmid-initiated transcription
    • Maxwell IH, Harrison GS, Wood WM, Maxwel F: A DNA cassette containing a trimerized SV40 polyadenylation signal which efficiently blocks spurious plasmid-initiated transcription. Biotechniques 7:276-280, 1989
    • (1989) Biotechniques , vol.7 , pp. 276-280
    • Maxwell, I.H.1    Harrison, G.S.2    Wood, W.M.3    Maxwel, F.4
  • 23
    • 0027384997 scopus 로고
    • IPF1, a homeodomain-containing transactivator of the insulin gene
    • Ohlsson H, Karlsson K, Edlund T: IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J 12:4251-4259, 1993
    • (1993) EMBO J , vol.12 , pp. 4251-4259
    • Ohlsson, H.1    Karlsson, K.2    Edlund, T.3
  • 24
    • 0025281303 scopus 로고
    • Establishment of a pancreatic β cell line that retains glucose-inducible insulin secretion: Special reference to expression of glucose transporter isoforms
    • Miyazaki J, Araki K, Yamato E, Ikegami H, Asano T, Shibasaki Y, Oka Y, Yamamura K: Establishment of a pancreatic β cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology 127:126-132, 1990
    • (1990) Endocrinology , vol.127 , pp. 126-132
    • Miyazaki, J.1    Araki, K.2    Yamato, E.3    Ikegami, H.4    Asano, T.5    Shibasaki, Y.6    Oka, Y.7    Yamamura, K.8
  • 25
    • 0023078285 scopus 로고
    • Identification of regulatory elements of cloned genes with functional assays
    • Rosenthal N: Identification of regulatory elements of cloned genes with functional assays. Methods Enzymol 152:704-720, 1987
    • (1987) Methods Enzymol , vol.152 , pp. 704-720
    • Rosenthal, N.1
  • 27
    • 0027408634 scopus 로고
    • Cell-free activation of a DNA-binding protein by epidermal growth factor
    • Sadowski HB, Gilman MZ: Cell-free activation of a DNA-binding protein by epidermal growth factor. Nature 362:79-83, 1993
    • (1993) Nature , vol.362 , pp. 79-83
    • Sadowski, H.B.1    Gilman, M.Z.2
  • 28
    • 0027373441 scopus 로고
    • Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells
    • Leonard J, Peers B, Johnson T, Ferreri K, Lee S, Montminy MK: Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells. Mol Endocrinol 7:1275-1283, 1993
    • (1993) Mol Endocrinol , vol.7 , pp. 1275-1283
    • Leonard, J.1    Peers, B.2    Johnson, T.3    Ferreri, K.4    Lee, S.5    Montminy, M.K.6
  • 29
    • 0028567837 scopus 로고
    • Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1
    • Peers B, Leonard J, Sharma S, Teitelman G, Montminy MR: Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1. Mol Endocrinol 8:1798-1806, 1994
    • (1994) Mol Endocrinol , vol.8 , pp. 1798-1806
    • Peers, B.1    Leonard, J.2    Sharma, S.3    Teitelman, G.4    Montminy, M.R.5
  • 30
    • 0027944249 scopus 로고
    • Transcriptional regulation of the human insulin gene is dependent on the homeo-domain protein STF-1/IPF1 acting through the CT boxes
    • Petersen HV, Serup P, Leonard J, Michelsen RK, Madsen OD: Transcriptional regulation of the human insulin gene is dependent on the homeo-domain protein STF-1/IPF1 acting through the CT boxes. Proc Natl Acad Sci USA 91:10465-10469, 1994
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 10465-10469
    • Petersen, H.V.1    Serup, P.2    Leonard, J.3    Michelsen, R.K.4    Madsen, O.D.5
  • 31
    • 0026639664 scopus 로고
    • Control of insulin gene expression by glucose
    • Goodison S, Kenna S, Ashcroft SJ: Control of insulin gene expression by glucose. Biochem J 285:563-568, 1992
    • (1992) Biochem J , vol.285 , pp. 563-568
    • Goodison, S.1    Kenna, S.2    Ashcroft, S.J.3
  • 32
    • 0027154077 scopus 로고
    • Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat 1 and the human insulin promoters
    • Melloul D, Ben-Neriah Y, Cerasi E: Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat 1 and the human insulin promoters. Proc Natl Acad Sci USA 90:3865-3869, 1993
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 3865-3869
    • Melloul, D.1    Ben-Neriah, Y.2    Cerasi, E.3
  • 33
    • 0025292710 scopus 로고
    • Pan: A transcriptional regulator that binds chymotrypsin, insulin, and AP-1 enhancer motifs
    • Nelson C, Shen LP, Meister A, Fodor E, Rutter WJ: Pan: a transcriptional regulator that binds chymotrypsin, insulin, and AP-1 enhancer motifs. Genes Dev 4:1035-1043, 1990
    • (1990) Genes Dev , vol.4 , pp. 1035-1043
    • Nelson, C.1    Shen, L.P.2    Meister, A.3    Fodor, E.4    Rutter, W.J.5
  • 34
    • 0026020867 scopus 로고
    • An inhibitory domain of E12 transcription factor prevents DNA binding in E12 homodimers but not in E12 heterodimers
    • Sun XH, Baltimore D: An inhibitory domain of E12 transcription factor prevents DNA binding in E12 homodimers but not in E12 heterodimers Cell 64:459-470, 1991
    • (1991) Cell , vol.64 , pp. 459-470
    • Sun, X.H.1    Baltimore, D.2
  • 35
    • 0028941181 scopus 로고
    • Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor
    • Naya FJ, Christine MMS, Tsai M-J: Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. Genes Dev 9:1009-1019, 1995
    • (1995) Genes Dev , vol.9 , pp. 1009-1019
    • Naya, F.J.1    Christine, M.M.S.2    Tsai, M.-J.3
  • 36
    • 0028050241 scopus 로고
    • Isolation and characterization of a novel transcription factor that binds to and activates insulin control element-mediated expression
    • Robinson GL, Cordle SR, Henderson E, Weil PA, Teitelman G, Stein R: Isolation and characterization of a novel transcription factor that binds to and activates insulin control element-mediated expression. Mol Cell Biol 14:6704-6714, 1994
    • (1994) Mol Cell Biol , vol.14 , pp. 6704-6714
    • Robinson, G.L.1    Cordle, S.R.2    Henderson, E.3    Weil, P.A.4    Teitelman, G.5    Stein, R.6
  • 37
    • 0025280050 scopus 로고
    • Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- And a Cys-His domain
    • Karlsson O, Thor S, Norberg T, Ohlsson H, Edlund T: Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain. Nature 344:879-882, 1990
    • (1990) Nature , vol.344 , pp. 879-882
    • Karlsson, O.1    Thor, S.2    Norberg, T.3    Ohlsson, H.4    Edlund, T.5
  • 38
    • 0026471057 scopus 로고
    • Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein
    • German MS, Wang J, Chadwick RB, Rutter WJ: Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein. Genes Dev 6:2165-2176, 1992
    • (1992) Genes Dev , vol.6 , pp. 2165-2176
    • German, M.S.1    Wang, J.2    Chadwick, R.B.3    Rutter, W.J.4
  • 39
    • 0026742624 scopus 로고
    • Hepatocytc unclear factor 1α is expressed in a hamster insulinoma line and transactivates the rat insulin I gene
    • Emens LA, Landers DW, Moss LG: Hepatocytc unclear factor 1α is expressed in a hamster insulinoma line and transactivates the rat insulin I gene. Proc Natl Acad Sci USA 89:7300-7304, 1992
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 7300-7304
    • Emens, L.A.1    Landers, D.W.2    Moss, L.G.3
  • 40
    • 0028149890 scopus 로고
    • Insulin-promoter-factor 1 is required for pancreatic development in mice
    • Jonsson J, Carlsson L, Edlund T, Edlund H: Insulin-promoter-factor 1 is required for pancreatic development in mice. Nature 371:600-609, 1994
    • (1994) Nature , vol.371 , pp. 600-609
    • Jonsson, J.1    Carlsson, L.2    Edlund, T.3    Edlund, H.4
  • 41
    • 0028074442 scopus 로고
    • Effects of glucose on insulin secretion, glucokinase activity, and transgene expression in transgenic mouse islets containing an upstream glucokinase promoter-human growth hormone fusion gene
    • Liang Y, Thomas TL, Zimmerman EC, Najafi H, Berner DK, Matchinsky FM, Magnuson MA: Effects of glucose on insulin secretion, glucokinase activity, and transgene expression in transgenic mouse islets containing an upstream glucokinase promoter-human growth hormone fusion gene. Diabetes 43:1138-1145, 1994
    • (1994) Diabetes , vol.43 , pp. 1138-1145
    • Liang, Y.1    Thomas, T.L.2    Zimmerman, E.C.3    Najafi, H.4    Berner, D.K.5    Matchinsky, F.M.6    Magnuson, M.A.7
  • 42
    • 0028358092 scopus 로고
    • The insulin gene contains multiple transcriptional elements that respond to glucose
    • German MS, Wang J: The insulin gene contains multiple transcriptional elements that respond to glucose. Mol Cell Biol 14:4067-4075, 1994
    • (1994) Mol Cell Biol , vol.14 , pp. 4067-4075
    • German, M.S.1    Wang, J.2
  • 43
    • 0028127761 scopus 로고
    • Glucose-induced transcription of the insulin gene is mediated by the factors required for β-cell-type-specific expression
    • Sharma A, Stein R: Glucose-induced transcription of the insulin gene is mediated by the factors required for β-cell-type-specific expression. Mol Cell Biol 14:871-879, 1994
    • (1994) Mol Cell Biol , vol.14 , pp. 871-879
    • Sharma, A.1    Stein, R.2
  • 44
    • 0028057602 scopus 로고
    • Positive and negative regulatory elements are involved in transcriptional control of the rat glucokinase gene in the insulin producing cell line HIT M2.2.2
    • Leibiger IB, Walther R, Pett U, Leibiger B: Positive and negative regulatory elements are involved in transcriptional control of the rat glucokinase gene in the insulin producing cell line HIT M2.2.2. FEBS Lett 337:161-166, 1994
    • (1994) FEBS Lett , vol.337 , pp. 161-166
    • Leibiger, I.B.1    Walther, R.2    Pett, U.3    Leibiger, B.4
  • 46
    • 0027237191 scopus 로고
    • Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein
    • Olson LK, Redmon JB, Towel HC, Robertson RP: Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein. J Clin Invest 92:514-519, 1993
    • (1993) J Clin Invest , vol.92 , pp. 514-519
    • Olson, L.K.1    Redmon, J.B.2    Towel, H.C.3    Robertson, R.P.4
  • 47
    • 0029073426 scopus 로고
    • Reduction of insulin gene transcription in HIT-T15 β cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression
    • Olson LK, Sharma A, Peshavaria M, Wright CVE, Towle HC, Robertson RP, Stein R: Reduction of insulin gene transcription in HIT-T15 β cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression. Proc Natl Acad Sci USA 92:9127-9131, 1995
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9127-9131
    • Olson, L.K.1    Sharma, A.2    Peshavaria, M.3    Wright, C.V.E.4    Towle, H.C.5    Robertson, R.P.6    Stein, R.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.