Pancreatic duodenal homeobox-1, PDX-1, a major regulator of beta cell identity and function

Diabetologia

Volumn 44, Issue 10, 2001, Pages 1203-1214

  McKinnon, C M ^a   Docherty, K ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Diabetes mellitus; Gene expression; Insulin gene; Islets of Langerhans; Transcription

Indexed keywords

GLUCOKINASE; HOMEODOMAIN PROTEIN; INSULIN; PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG;

CELL DIFFERENTIATION; CELL PROLIFERATION; DIABETES MELLITUS; GENE CONTROL; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE MUTATION; HOMEOBOX; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; REVIEW;

ANIMALS; CELL DIFFERENTIATION; CELL DIVISION; DIABETES MELLITUS, TYPE 2; GENE EXPRESSION REGULATION; GLUCOSE INTOLERANCE; HETEROZYGOTE; HOMEODOMAIN PROTEINS; HOMOZYGOTE; HUMANS; ISLETS OF LANGERHANS; MUTATION; PANCREAS; TRANS-ACTIVATORS;

EID: 0034775035     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250100628     Document Type: Review

References (124)

1. A mutational analysis of the insulin gene transcription control region: Expression in beta cells is dependent on two related sequences within the enhancer
2. The insulin gene promoter. A simplified nomenclature
3. A beta-cell-specific protein binds to the two major regulatory sequences of the insulin gene enhancer
4. Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor
5. Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix- loop-helix protein
6. A tissue-specific nuclear factor binds to multiple sites in the human insulin-gene enhancer
7. Individual protein-binding domains of the insulin gene enhancer positively activate beta-cell-specific transcription
8. Positive and negative regulation of the human insulin gene by multiple transacting factors
9. Two proteins act as the IUF1 insulin gene enhancer binding factor
10. Novel insulin promoter- and enhancer-binding proteins that discriminate between pancreatic alpha- and beta-cells
11. IPF1, a homeodomain-containing transactivator of the insulin gene
12. Xlhox 8 a novel Xenopus homeoprotein restricted to a narrow band of endoderm
13. Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells
14. IDX-1: A new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene
15. The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells
16. Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters
17. Purification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells
18. XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor
19. The pancreatic homeodomain transcription factor IDX1/IPF1 is expressed in neural cells during brain development
20. Functional regions of the homeodomain protein IDX-1 required for transactivation of the rat somatostatin gene
21. Functional characterization of the transactivation properties of the PDX-1 homeodomain protein
22. Isolation, characterization, and chromosomal mapping of the human insulin promoter factor 1 (IPF-1) gene
23. Localization of human homeodomain transcription factor insulin promoter factor 1 (IPF1) to chromosome band 13q12.1
24. Mapping of the insulin promoter factor 1 gene (Ipf1) to distal mouse chromosome 5
25. Pd × 1, a homeodomain transcription factor required for pancreas development, maps to rat chromosome 12
26. Conservation of PDX-1 structure, function, and expression in zebrafish
27. Transcriptional activation of the GLUT2 gene by the IPF-1/ STF-1/IDX-1 homeobox factor
28. The human glucokinase gene beta-cell-type promoter: An essential role of insulin promoter factor 1/PDX-1 in its activationq in HIT-T15 cells
29. Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1
30. Identification of cis- and trans-active factors regulating human islet amyloid polypeptide gene expression in pancreatic beta-cells
31. Insulin upstream factor 1 and a novel ubiquitous factor bind to the human islet amyloid polypeptide/amylin gene promoter
32. Pancreatic homeodomain transcription factor IDX1/IPF1 expressed in developing brain regulates somatostatin gene transcription in embryonic neural cells
33. Functional conservation of regulatory elements in the pdx-1 gene: PDX-1 and hepatocyte nuclear factor 3β transcription factors mediate beta- cell-specific expression
34. An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2)
35. The insulin and islet amyloid polypeptide genes contain similar cell- specific promoter elements that bind identical beta-cell nuclear complexes
36. Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1
37. Transcription factor BETA2 acts cooperatively with E2A and PDX1 to activate the insulin gene promoter
38. The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter
39. E2A gene products are not required for insulin gene expression
40. Mapping nutrient regulatory sequences in the insulin gene
41. The NeuroD1/BETA2 sequences essential for insulin gene transcription colocalize with those necessary for neurogenesis and p300/CREB binding protein binding
42. Pancreatic β cells express a diverse set of homeobox genes
43. Beta-cell-specific inactivation of the mouse Ipf1/ Pdx-1 gene results in loss of the beta-cell phenotype and maturity onset diabetes
44. Impaired expression of transcription factor IUF1 in a pancreatic beta-cell line derived from a patient with persistent hyperinsulinaemic hypoglycaemia of infancy (nesidioblastosis)
45. Suppression of transcription factor PDX-1/IPF1/STF-1/IDX-1 causes no decrease in insulin mRNA in MIN6 cells
46. Defective glucose-regulated insulin gene expression associated with PDX- 1 deficiency in the Psammomys obesus model of type 2 diabetes. 3
47. Increase in PDX-1 levels suppresses insulin gene expression in RIN 1046-38 cells
48. Functional and cooperative interactions between the homeodomain PDX1, Pbx, and Prep1 factors on the somatostatin promoter
49. The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: Importance of the FPWMK motif and of the homeodomain
50. Pancreatic islet expression of the homeobox factor STF-1 relies on an E- box motif that binds USF
51. Up-stream stimulatory factor regulates Pdx-1 gene expression in differentiated pancreatic beta-cells
52. Hepatocyte nuclear factor 3β is involved in pancreatic β cell specific expression of the pd × 1 gene
53. Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1
54. Pancreatic beta cell-specific transcription of the pdx-1 gene. The role of conserved upstream control regions and their hepatic nuclear factor 3β sites
55. A pancreatic β-cell-specific enhancer in the human Pdx-1 gene is regulated by HNF-3β, HNF-1α and SPs transcription factors
56. Regulation of insulin gene expression by glucose and calcium in transfected primary islet cultures
57. Control of insulin gene expression by glucose
58. Glucose modulates the binding activity of the beta-cell transcription factor IUF1 in a phosphorylation-dependent manner
59. Possible involvement of atypical protein kinase C (PKCξ) in glucose- sensitive expression of the human insulin gene: DNA-binding activity and transcriptional activity of pancreatic and duodenal homeobox gene-1 (PDX-1) are enhanced via calphostin C-sensitive but phorbol 12- myristate 13-acetate (PMA) and Go 6976-insensitive pathway
60. Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways
61. Insulin stimulates pancreatic-duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic beta cells
62. Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic beta-cells
63. Glucose-dependent translocation of insulin promoter factor-1 (IPF-1) between the nuclear periphery and the nucleoplasm of single MIN6 beta-cells
64. Identification of a nuclear localization signal, RRMKWKK, in the homeodomain transcription factor PDX-1
65. The nuclear localization signal (NLS) of PDX-1 is part of the homeodomain and represents a novel type of NLS
66. Phosphorylation dependent intranuclear shuttling of PDX-1 in pancreatic β cells
67. Glucose-stimulated preproinsulin gene expression and nuclear trans- location of pancreatic duodenum homeobox-1 require activation of phosphatidylinositol 3-kinase but not p38 MAPK/SAPK2
68. Glucose stimulates the activation domain potential of the PDX-1 homeodomain transcription factor
69. Regulation of the insulin gene by glucose: Stimulation of trans-activation potency of human PDX-1 N-terminal domain
70. The PDX-1 activation domain provides specific functions necessary for transcriptional stimulation in pancreatic beta-cells
71. Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells
72. Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells
73. Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats
74. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas
75. Transforming growth factor beta induction of insulin gene expression is mediated by pancreatic and duodenal homeobox gene-1 in rat insulinoma cells
76. Glucagon-like peptide 1 increases glucose-dependent activity of the homeoprotein IDX-1 transactivating domain in pancreatic beta-cells
77. Glucagonlike peptide-1 agonist stimulation of Beta cell growth and development
78. The insulin gene contains multiple transcriptional elements that respond to glucose
79. Glucose modulation of insulin mRNA levels is dependent on transcription factor PDX-1 and occurs independently of changes in intracellular Ca2+
80. Glucose regulates islet amyloid polypeptide gene transcription in a PDX1- and calcium- dependent manner
81. Pancreas: How to get there from the gut?
82. Attenuation of FGF signalling in mouse beta-cells leads to diabetes
83. Notochord repression of endodermal Sonic hedgehog permits pancreas development
84. Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor
85. Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells
86. Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9
87. Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice
88. The Beta cell transcription factors and development of the pancreas
89. Ablation of islet endocrine cells by targeted expression of hormonepromoter-driven toxigenes
90. Insulin-promoter-factor 1 is required for pancreas development in mice
91. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
92. Notch signalling controls pancreatic cell differentiation
93. Control of endodermal endocrine development by Hes-1
94. Linear correlation between beta-cell mass and body weight throughout the lifespan in Lewis rats: Role of beta-cell hyperplasia and hypertrophy
95. Islet growth and development in the adult
96. Beta-cell proliferation in normal and streptozotocin-treated newborn rats: Site, dynamics and capacity
97. Extra-insular beta cells associated with ductules are frequent in adult human pancreas
98. Alpha-Cell neogenesis in an animal model of IDDM
99. Differentiation of new insulin-producing cells is induced by injury in adult pancreatic islets
100. Demonstration of two different processes of beta-cell regeneration in a new diabetic mouse model induced by selective perfusion of alloxan
101. Transcription factor expression during pancreatic islet regeneration
102. The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration
103. Growth Pattern of pancreatic islets in animals
104. Adult human pancreatic duct and islet cells exhibit similarities in expression and differences in phosphorylation and complex formation of the homeodomain protein Ipf-1
105. PDX:PBX complexes are required for normal proliferation of pancreatic cells during development
106. PDX-1 and Msx-2 expression in the regenerating and developing pancreas
107. Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence
108. Early-onset type-II diabetes mellitus (MODY4) linked to IPF1
109. Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene)
110. Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus
111. Mis-sense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes
112. Functional consequences of mutations in the MODY4 gene (IPF1) and coexistence with MODY3 mutations
113. Insulin promoter factor-1 gene mutation linked to early- onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein
114. Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein beta and transactivator islet duodenum homeobox-1 in rat pancreatic beta cells during the development of diabetes mellitus
115. Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes
116. Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression
117. Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels
118. In vitro cultivation of human islets from expanded ductal tissue
119. Sustained proliferation of PDX-1 + cells derived from human islets
120. PDX-1 and cell-cell contact act in synergy to promote Delta-cell development in a human pancreatic endocrine precursor cell line
121. Adult human cytokeratin 19-positive cells reexpress insulin promoter factor 1 in vitro: Further evidence for pluripotent pancreatic stem cells in humans
122. Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro
123. Multi-potential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes
124. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia