Activation of the Hexosamine Pathway Leads to Deterioration of Pancreatic β-Cell Function through the Induction of Oxidative Stress

Journal of Biological Chemistry

Volumn 276, Issue 33, 2001, Pages 31099-31104

  Kaneto, Hideaki ^b   Xu, Gang ^b   Song, Ki Ho ^b   Suzuma, Kiyoshi ^b   Bonner Weir, Susan ^b   Sharma, Arun ^b   Weir, Gordon C ^a  

^a JOSLIN DIABETES CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYMES; INSULIN; OXIDATION; VIRUSES;

GLYCOSYLATION;

BIOCHEMISTRY;

ACETYLCYSTEINE; ADENOVIRUS VECTOR; GLUCOSAMINE; GLUCOSE; GLUTAMINE FRUCTOSE 6 PHOSPHATE AMINOTRANSFERASE; HEXOSAMINE; HYDROGEN PEROXIDE; INSULIN; N ACETYL BETA GLUCOSAMINIDASE; O (2 ACETAMIDO 2 DEOXY DEXTRO GLUCOPYRANOSYLIDENE)AMINO N PHENYLCARBAMATE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DNA BINDING; ENZYME ACTIVATION; GENE; GENE OVEREXPRESSION; GLUCOKINASE GENE; GLUT2 GENE; GLYCOSYLATION; INSULIN GENE; INSULIN RESISTANCE; MALE; NONHUMAN; O LINKED GLYCOSYLATION; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; ANIMAL; BIOSYNTHESIS; CELL CULTURE; HYPERGLYCEMIA; METABOLISM; PANCREAS ISLET; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

ADENOVIRIDAE; ANIMALIA;

ANIMALS; CELLS, CULTURED; DIABETES MELLITUS; GLUTAMINE-FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING); GLYCOSYLATION; HEXOSAMINES; HYPERGLYCEMIA; ISLETS OF LANGERHANS; MALE; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0035903192     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M104115200     Document Type: Article

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