Chronic exposure of βTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator

Journal of Clinical Investigation

Volumn 97, Issue 4, 1996, Pages 1041-1046

  Poitout, Vincent ^a,c   Olson, L Karl ^a,d   Robertson, R Paul ^a,b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIV OF MINNESOTA HOSP AND CLINIC   (United States)

^c HÔTEL DIEU   (France)

^d MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

glucose toxicity; insulin gene; RIPE3b1; STF 1; transcription factor

Indexed keywords

BETA ACTIN; CHLORAMPHENICOL ACETYLTRANSFERASE; GLUCOSE; INSULIN; MESSENGER RNA; TRANSCRIPTION FACTOR; DNA BINDING PROTEIN; HOMEODOMAIN PROTEIN; INSULIN PROMOTER FACTOR 1; PRIMER DNA; TRANSACTIVATOR PROTEIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CIS ISOMER; CONCENTRATION RESPONSE; GLUCOSE TRANSPORT SYSTEM; HUMAN; HUMAN CELL; INSULIN RESPONSE; INSULIN SYNTHESIS; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; ANIMAL; CELL LINE; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE; PANCREAS ISLET; PROMOTER REGION; RAT; TRANSGENIC MOUSE;

ANIMALS; BASE SEQUENCE; BINDING SITES; CELL LINE; DNA PRIMERS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GLUCOSE; HOMEODOMAIN PROTEINS; INSULIN; ISLETS OF LANGERHANS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); RATS; RNA, MESSENGER; TRANS-ACTIVATORS;

EID: 0029664752     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118496     Document Type: Article

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