Identification of a portable repression domain and an E1A-responsive activation domain in Pax4: A possible role of Pax4 as a transcriptional repressor in the pancreas

Molecular and Cellular Biology

Volumn 19, Issue 12, 1999, Pages 8281-8291

  Fujitani, Yoshio ^a   Kajimoto, Yoshitaka ^a   Yasuda, Tetsuyuki ^a   Matsuoka, Taka Aki ^a   Kaneto, Hideaki ^a   Umayahara, Yutaka ^a   Fujita, Noriko ^a   Watada, Hirotaka ^a   Miyazaki, Jun Ichi ^a   Yamasaki, Yoshimitsu ^a   Hori, Masatsugu ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; VIRUS PROTEIN;

ARTICLE; BINDING SITE; CELL MATURATION; GENE OVEREXPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN PROCESSING; TRANSACTIVATION; TRANSCRIPTION REGULATION;

EID: 0033508033     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.12.8281     Document Type: Article

References (60)

1. Ayer, D. E., Q. A. Lawrence, and R. N. Elsenman. 1995. Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast represser Sin3. Cell 80:767-776.
2. Boyer, T. G., and A. J. Berk. 1993. Functional interaction of adenovirus E1A with holo-TFIID. Genes Dev. 7:1810-1823.
3. Chen, Y. T., C. Holcomb, and H. P. H. Moore. 1993. Expression and localization of two low molecular weight GTP-binding proteins, Rab8 and Rab10, by epitope tag. Proc. Natl. Acad. Sci. USA 90:6508-6512.
4. Chittenden, T., D. M. Livingston, and W. G. Kaelin, Jr. 1991. The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein. Cell 65:1073-1082.
5. Czerny, T., and M. Busslinger. 1995. DNA-binding and transactivation properties of Pax-6: three amino acids in the paired domain are responsible for the different sequence recognition of Pax-6 and BSAP (Pax-5). Mol. Cell. Biol. 15:2858-2871.
6. Czerny, T., G. Schaffner, and M. Busslinger. 1993. DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site. Genes Dev. 7:2048-2061.
7. Dai, P., H. Akimaru, V. Tanaka, D. X. Hou, T. Yasukawa, C. Kanei-Ishii, T. Takahashi, and S. Ishii. 1996. CBP as a transcriptional coactivator of c-Myb. Genes Dev. 10:528-540.
8. Dam, H., D. Wilhelm, I. Herr, A. Steffen, P. Herrlich, and P. Angel. 1995. ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. EMBO J. 14:1798-1811.
9. Dooley, T. P., M. Miranda, N. C. Jones, and M. L. DePamphilis. 1989. Transactivation of the adenovirus EIIA promoter in the absence of adenovirus E1A protein is restricted to mouse oocytes and preimplantation embryos. Development 107:945-956.
10. Dörfler, P., and M. Busslinger. 1996. C-terminal activating and inhibitory domains determine the transactivation potential of BSAP (Pax-5), Pax-2 and Pax-8, EMBO J. 15:1971-1982.
11. Duncan, M. K., J. I. Haynes II, A. Cvekl, and J. Piatigorsky. 1998. Dual roles for Pax-6: a transcriptional repressor of lens fiber cell-specific β-crystallin genes. Mol. Cell. Biol. 18:5579-5586.
12. Epstein, J., J. Cai, T. Glaser, L. Jepeal, and R. Maas. 1994. Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes. J. Biol. Chem. 269:8355-8361.
13. Fondell, J. D., F. Brunei, K. Hisatake, and R. G. Roeder. 1996. Unliganded thyroid hormone receptor a can target TATA-binding protein for transcriptional repression. Mol. Cell. Biol. 16:281-287.
14. Fujitani, Y., and Y. Kajimoto. Unpublished observation.
15. Furnkawa, M., Y. Eto, and I. Kojima. 1995. Expression of immunoreactive activin A in fetal rat pancreas. Endocrine J. 42:63-68.
16. Glaser, T., L. Jepeal, J. G. Edwards, S. R. Young, J. Favor, and R. L. Maas. 1994. Pax6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous defects. Nat. Genet. 7:463-471.
17. Hanna-Rose, W., and U. Hansen. 1996. Active repression mechanisms of eukaryotic transcription repressors. Trends Genet. 12:229-234.
18. Hartley, R. S., A. L. Lewellyn, and J. L. Maller. 1994. MAP kinase is activated during mesoderm induction in Xenopus laevis. Dev. Biol. 163: 521-524.
19. Imperiale, M. J., H. T. Kao, L. T. Feldman, J. R. Nevins, and S. Strickland. 1984. Common control of the heat shock gene and early adenovirus genes: evidence for a cellular E1A-like activity. Mol. Cell. Biol. 4:867-874.
20. Inoue, H., J. Nomiyama, K. Nakai, A. Matsutani, Y. Tanizavra, and Y. Oka. 1998. Isolation of full-length cDNA of mouse PAX4 gene and identification of its human homologue. Biochem. Biophys. Res. Commun. 243:628-633.
21. Jimenez, G., Z. Paroush, and D. Esh-Horowicz. 1997. Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed. Genes Dev. 11:3072-3082.
22. Jun, S., and C. Desplan. 1996. Cooperative interactions between paired domain and homeodomain. Development 122:2639-2650.
23. Kalousová, A., V. Benes, J. Paces, V. Paces, and Z. Kozmik. 1999. DNA binding and transactivation properties of the paired and homeobox protein Pax4. Biochem. Biophys. Res. Commun. 259:510-518.
24. Kaneto, H., J. Miyagawa, Y. Kajimoto, K. Yamamoto, H. Watada, Y. Umayahara, T. Hanafusa, Y. Matsuzawa, Y. Yamasaki, S. Higashiyama, and N. Taniguchi. 1997. Expression of heparin-binding epidermal growth factor-like growth factor during pancreas development. J. Biol. Chem. 272:29137-29143.
25. Katagiri, H., J. Terasaki, T. Murata, H. Ishihara, T. Ogihara, K. Inukai, Y. Fukushima, M. Anai, M. Kikuchi, J. Miyazaki, Y. Yazaki, and Y. Oka. 1995. A novel isoform of syntaxin-binding protein homologous to yeast Sec1 expressed ubiquitously in mammalian cells. J. Biol. Chem. 270:4963-4966.
26. Kowenz-Leutz, E., G. Twamley, S. Ansieau, and A. Leutz, 1994. Novel mechanism of C/EBP β (NF-M) transcriptional control: activation through derepression. Genes Dev. 15:2781-2791.
27. Li, C., and J. L. Manley. 1998. Even-skipped represses transcription by binding TATA binding protein and blocking the TFIID-TATA box interaction. Mol. Cell. Biol. 18:3771-3781.
28. Lillie, J. W., and M. R. Green. 1989. Transcriptional activation by adenovirus E1A protein. Nature 338:39-44.
29. Liu, F., and M. R. Green. 1994. Promoter targeting by adenovirus E1a through interaction with different cellular DNA-binding domains. Nature 368:520-525.
30. Livingstone, C., G. Patel, and N. Jones. 1995. ATF-2 contains a phosphorylation-dependent transcriptional activation domain. EMBO J. 14:1785-1797.
31. Magnaghi, P., C. Roberts, S. Lorain, M. Lipinski, and P. J. Scamber. 1998. HIRA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3. Nat. Genet. 20:74-77.
32. Mansouri, A., M. Hallonet, and P. Gruss. 1996. Pax genes and their roles in cell differentiation and development. Curr. Opin. Cell Biol. 8:851-857.
33. Minoguchi, S., Y. Taniguchi, H. Kato, T. Okazaki, L. J. Strobl, U. Zimber-Stroubl, G. W. Bornkamm, and T. Honjo. 1997. RBP-L, a transcription factor related to RBP-Jκ. Mol. Cell. Biol. 17:2679-2687.
34. Moran, E., and M. B. Mathews. 1987. Multiple functional domains in the adenovirus E1A gene. Cell 48:177-178.
35. Nevins, J. R. 1992. E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424-429.
36. Otonkoski, T., G. M. Beattie, J. S. Rubin, A. D. Lopez, A. Baird, and A. Hayek. 1994. Hepatocyte growth factor/scatter factor has insulinotropic activity in human fetal pancreatic cells. Diabetes 43:947-953.
37. Paroush, Z., R. L. Finley, Jr., T. Kidd, S. M. Wainwright, P. W. Ingham, R. Brent, and D. Ish-Horowicz. 1994. Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with Hairy-related bHLH proteins. Cell 79:805-815.
38. Peshavaria, M., E. Henderson, A. Sharma, C. V. E. Wright, and R. Stein. 1997. Functional characterization of the transactivation properties of the PDX-1 homeodomain protein. Mol. Cell. Biol. 17:3987-3996.
39. Phelan, S. A., and M. R. Locken. 1998. Identification of a new binding motif for the paired domain of Pax-3 and unusual characteristics of spacing of bipartite recognition elements on binding and transcription activation. J. Biol. Chem. 273:19153-19159.
40. Puri, P. L., M. L. Avantaggiati, C. Balsann, N. Sang, A. Graessmann, A. Giordano, and M. Levrero. 1997. p300 is required for MyoD-dependent cell cycle arrest and muscle-specific gene transcription. EMBO J. 15:369-383.
41. Qiu, V., A. Sharma, and R. Slein. 1998. p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene. Mol. Cell. Biol. 18:2957-2964.
42. Rodrigues, G. A., M. Park, and J. Schlessinger. 1997. Activation of the JNK pathway is essential for transformation by the Met oncogene. EMBO J. 16: 2634-2645.
43. Sadowski, H. B., and M. Z. Gilman. 1993. Cell-free activation of a DNA-binding protein by epidermal growth factor. Nature 362:79-83.
44. Sadowski, I., and M. Ptashne. 1989. A vector for expressing GAL4 (1-147) fusions in mammalian cells. Nucleic Acids Res. 17:7539-7539.
45. Sander, M., A. Neubuser, J. Kalamaras, H. C. Ee, G. R. Martin, and M. S. German. 1997. Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. Genes Dev. 11:1662-1673.
46. Shenk, T., and J. Flint. 1991. Transcriptional and transforming activities of the adenovirus E1A proteins. Adv. Cancer Res. 57:47-85.
47. Slack, J. M. W. 1995. Developmental biology of the pancreas. Development 121:1569-1580.
48. Smith, S. B., H. C. Ee, J. R. Conners, and M. S. German. 1999. Pairedhomeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic development. Mol. Cell. Biol. 19:8272-8280.
49. Sosa-Pineda, B., K. Chowdhury, M. Torres, G. Oliver, and P. Gruss. 1997. The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas. Nature 386:399-402.
50. St-Onge, L., B. Sosa-Pineda, K. Chowdhury, A. Mansouri, and P. Gruss. 1997. Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas. Nature 387:406-409.
51. Svensson, C., and G. Akusjarvi. 1984. Adenovirus 2 early region 1A stimulates expression of both viral and cellular genes. EMBO J. 3:789-794.
52. Tang, H. K., S. Singh, and G. F. Saunders. 1998. Dissection of the transactivation function of the transcription factor encoded by the eye developmental gene Pax6. J. Biol. Chem. 273:7210-7221.
53. Teitelman, G., S. Alpert, J. M. Polak, A. Martinez, and D. Hanahan. 1993. Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide. Development 118:1031-1039.
54. Turner, D. L., and H. Weintraub. 1994. Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate. Genes Dev. 8:1434-1447.
55. Turner, J., and M. Crossley. 1998. Cloning and characterization of mCtBP2, a co-repressor that associates with basic Kruppel-like factor and other mammalian transcriptional regulators. EMBO J. 17:5129-5140.
56. Turque, N., S. Plaza, F. Radvanyi, C. Carriere, and S. Saule. 1994. PaxQNR/ Pax-6, a paired box-and homeobox-containing gene expressed in neurons, is also expressed in pancreatic endocrine cells. Mol. Endocrinol. 8:929-938.
57. Walther, C., J. L. Guenet, D. Simon, U. Deutsch, B. Jostes, M. D. Goulding, D. Plachov, R. Balling, and P. Gruss. 1991. Pax: a murine multigene family of paired box-containing genes. Genomics 11:424-434.
58. Walther, C., and P. Grass. 1991. Pax-6, a murine paired box gene, is expressed in the developing CNS. Development 113:1435-1449.
59. Whyte, P., N. W. Williamson, and E. Harlow. 1989. Cellular targets for transformation by the adenovirus E1A proteins. Cell 56:67-75.
60. Wiggan, O., A. Taniguchi-Sidle, and P. A. Hamel. 1998. Interaction of the pRB-family proteins with factors containing paired-like homeodomains. Oncogene 16:227-236.