메뉴 건너뛰기




Volumn 11, Issue 13, 1997, Pages 1662-1673

Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development

Author keywords

Glucagon; Insulin; Islet; pancreas development; PAX6; Transcription

Indexed keywords

AMYLASE; GLUCAGON; HYBRID PROTEIN; INSULIN; MESSENGER RNA; SOMATOSTATIN; TRANSCRIPTION FACTOR;

EID: 1842330860     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.11.13.1662     Document Type: Article
Times cited : (482)

References (62)
  • 1
    • 0029950724 scopus 로고    scopus 로고
    • The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice
    • Ahlgren, U., J. Jonsson, and H. Edlund. 1996. The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice. Development 122: 1409-1416.
    • (1996) Development , vol.122 , pp. 1409-1416
    • Ahlgren, U.1    Jonsson, J.2    Edlund, H.3
  • 2
    • 0031020002 scopus 로고    scopus 로고
    • Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells
    • Ahlgren, U., S.L. Pfaff, T.M. Jessell, T. Edlund, and H. Edlund. 1997. Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells. Nature 385: 257-260.
    • (1997) Nature , vol.385 , pp. 257-260
    • Ahlgren, U.1    Pfaff, S.L.2    Jessell, T.M.3    Edlund, T.4    Edlund, H.5
  • 4
    • 0028062796 scopus 로고
    • Characterization of Pax-6 and Hoxa-1 binding to the promoter region of the neural cell adhesion molecule L1
    • Chalepakis, G., J. Wijnholds, P. Giese, M. Schachner, and P. Gruss. 1994. Characterization of Pax-6 and Hoxa-1 binding to the promoter region of the neural cell adhesion molecule L1. DNA Cell. Biol. 13: 891-900.
    • (1994) DNA Cell. Biol. , vol.13 , pp. 891-900
    • Chalepakis, G.1    Wijnholds, J.2    Giese, P.3    Schachner, M.4    Gruss, P.5
  • 5
    • 0028869811 scopus 로고
    • Transcriptional regulation of the mouse alpha A-crystallin gene: Activation dependent on a cyclic AMP-responsive element (DE1/CRE) and a Pax-6-binding site
    • Cvekl, A., F. Kashanchi, C.M. Sax, J.N. Brady, and J. Piatigorsky. 1995a. Transcriptional regulation of the mouse alpha A-crystallin gene: Activation dependent on a cyclic AMP-responsive element (DE1/CRE) and a Pax-6-binding site. Mol. Cell. Biol. 15: 653-660.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 653-660
    • Cvekl, A.1    Kashanchi, F.2    Sax, C.M.3    Brady, J.N.4    Piatigorsky, J.5
  • 6
    • 0029013330 scopus 로고
    • Pax-6 and lens-specific transcription of the chicken delta 1-crystallin gene
    • Cvekl, A., C.M. Sax, X. Li, J.B. McDermott, and J. Piatigorsky. 1995b. Pax-6 and lens-specific transcription of the chicken delta 1-crystallin gene. Proc. Natl. Acad. Sci. 92: 4681-4685.
    • (1995) Proc. Natl. Acad. Sci. , vol.92 , pp. 4681-4685
    • Cvekl, A.1    Sax, C.M.2    Li, X.3    McDermott, J.B.4    Piatigorsky, J.5
  • 7
    • 0027426925 scopus 로고
    • DNA sequence recognition by Pax proteins: Bipartite structure of the paired domain and its binding site
    • Czerny, T., G. Schaffner, and M. Busslinger. 1993. DNA sequence recognition by Pax proteins: Bipartite structure of the paired domain and its binding site. Genes & Dev. 7: 2048-2061.
    • (1993) Genes & Dev. , vol.7 , pp. 2048-2061
    • Czerny, T.1    Schaffner, G.2    Busslinger, M.3
  • 8
    • 0021100690 scopus 로고
    • Accurate transcription initiation by RNA Polymerase II in a soluble extract from isolated mammalian nuclei
    • Dignam, J.D., R.M. Lebowitz, and R.G. Roeder. 1983. Accurate transcription initiation by RNA Polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11: 1475-1489.
    • (1983) Nucleic Acids Res. , vol.11 , pp. 1475-1489
    • Dignam, J.D.1    Lebowitz, R.M.2    Roeder, R.G.3
  • 9
    • 0026742624 scopus 로고
    • Hepatocyte nuclear factor 1 alpha is expressed in a hamster insulinoma line and transactivates the rat insulin I gene
    • Emens, L.A., D.W. Landers, and L.G. Moss. 1992. Hepatocyte nuclear factor 1 alpha is expressed in a hamster insulinoma line and transactivates the rat insulin I gene. Proc. Natl. Acad. Sci. 89: 7300-7304.
    • (1992) Proc. Natl. Acad. Sci. , vol.89 , pp. 7300-7304
    • Emens, L.A.1    Landers, D.W.2    Moss, L.G.3
  • 10
    • 0028239775 scopus 로고
    • Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes
    • Epstein, J., J. Cai, T. Glaser, L. Jepeal, and R. Maas. 1994. Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes. J. Biol. Chem. 269: 8355-8361.
    • (1994) J. Biol. Chem. , vol.269 , pp. 8355-8361
    • Epstein, J.1    Cai, J.2    Glaser, T.3    Jepeal, L.4    Maas, R.5
  • 11
    • 0028358092 scopus 로고
    • The insulin gene contains multiple transcriptional elements that respond to glucose
    • German, M.S. and J. Wang. 1994. The insulin gene contains multiple transcriptional elements that respond to glucose. Mol. Cell. Biol. 14: 4067-4075.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 4067-4075
    • German, M.S.1    Wang, J.2
  • 12
    • 0026602931 scopus 로고
    • The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical β-cell nuclear complexes
    • German, M.S., L.G. Moss, J. Wang, and W.J. Rutter. 1992a. The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical β-cell nuclear complexes. Mol. Cell. Biol. 12: 1777-1788.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 1777-1788
    • German, M.S.1    Moss, L.G.2    Wang, J.3    Rutter, W.J.4
  • 13
    • 0026471057 scopus 로고
    • Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: Building a functional insulin minienhancer complex
    • German, M.S., J. Wang, R.B. Chadwick, and W.J. Rutter. 1992b. Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: Building a functional insulin minienhancer complex. Genes & Dev. 6: 2165-2176.
    • (1992) Genes & Dev. , vol.6 , pp. 2165-2176
    • German, M.S.1    Wang, J.2    Chadwick, R.B.3    Rutter, W.J.4
  • 15
    • 0028074973 scopus 로고
    • PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects
    • published erratum appears in Nature Genet., 1994 Oct; 8(2): 203
    • Glaser, T., L. Jepeal, J.G. Edwards, S.R. Young, J. Favor, and R.L. Maas. 1994. PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects [published erratum appears in Nature Genet., 1994 Oct; 8(2): 203]. Nature Genet. 7: 463-471.
    • (1994) Nature Genet. , vol.7 , pp. 463-471
    • Glaser, T.1    Jepeal, L.2    Edwards, J.G.3    Young, S.R.4    Favor, J.5    Maas, R.L.6
  • 16
    • 0027497981 scopus 로고
    • Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord
    • Goulding, M.D., A. Lumsden, and P. Gruss. 1993. Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord. Development 117: 1001-1016.
    • (1993) Development , vol.117 , pp. 1001-1016
    • Goulding, M.D.1    Lumsden, A.2    Gruss, P.3
  • 17
    • 0028869514 scopus 로고
    • Expression of marine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny
    • Guz, Y., M.R. Montminy, R. Stein, J. Leonard, L.W. Gamer, C.V. Wright, and G. Teitelman. 1995. Expression of marine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Development 121: 11-18.
    • (1995) Development , vol.121 , pp. 11-18
    • Guz, Y.1    Montminy, M.R.2    Stein, R.3    Leonard, J.4    Gamer, L.W.5    Wright, C.V.6    Teitelman, G.7
  • 18
    • 0022423125 scopus 로고
    • A novel strategy for constructing clustered point mutations
    • Haltiner, M., T. Kempe, and R. Tjian. 1985. A novel strategy for constructing clustered point mutations. Nucleic Acids Res. 13: 1015-1025.
    • (1985) Nucleic Acids Res. , vol.13 , pp. 1015-1025
    • Haltiner, M.1    Kempe, T.2    Tjian, R.3
  • 19
    • 0026586614 scopus 로고
    • Mouse mutations and human disorders are paired
    • Hill, R. and V. Van Heyningen. 1992. Mouse mutations and human disorders are paired. Trends Genet. 8: 119-120.
    • (1992) Trends Genet. , vol.8 , pp. 119-120
    • Hill, R.1    Van Heyningen, V.2
  • 20
    • 0026345992 scopus 로고
    • Mouse small eye results from mutations in a paired-like homeobox-containing gene
    • published erratum appears in Nature 1992, Feb 20; 355(6362): 750
    • Hill, R.E., J. Favor, B.L. Hogan, C.C. Ton, G.F. Saunders, I.M. Hanson, J. Prosser, T. Jordan, N.D. Hastie, and V. van Heyningen. 1991. Mouse small eye results from mutations in a paired-like homeobox-containing gene [published erratum appears in Nature 1992, Feb 20; 355(6362): 750]. Nature 354: 522-525.
    • (1991) Nature , vol.354 , pp. 522-525
    • Hill, R.E.1    Favor, J.2    Hogan, B.L.3    Ton, C.C.4    Saunders, G.F.5    Hanson, I.M.6    Prosser, J.7    Jordan, T.8    Hastie, N.D.9    Van Heyningen, V.10
  • 21
    • 0023787751 scopus 로고
    • Small eye (Sey): A mouse model for the genetic analysis of craniofacial abnormalities
    • Hogan, B.L., E.M. Hirst, G. Horsburgh, and C.M. Hetherington. 1988. Small eye (Sey): A mouse model for the genetic analysis of craniofacial abnormalities. Development 103(Suppl.) 115-119.
    • (1988) Development , vol.103 , Issue.SUPPL. , pp. 115-119
    • Hogan, B.L.1    Hirst, E.M.2    Horsburgh, G.3    Hetherington, C.M.4
  • 22
    • 0029763995 scopus 로고    scopus 로고
    • mRNA profiling of rat islet tumors reveals Nkx 6.1 as a beta-cell-specific homeodomain transcription factor
    • Jensen, J., P. Serup, C. Karlsen, T.F. Nielsen, and O.D. Madsen. 1996. mRNA profiling of rat islet tumors reveals Nkx 6.1 as a beta-cell-specific homeodomain transcription factor. J. Biol. Chem. 271: 18749-18758.
    • (1996) J. Biol. Chem. , vol.271 , pp. 18749-18758
    • Jensen, J.1    Serup, P.2    Karlsen, C.3    Nielsen, T.F.4    Madsen, O.D.5
  • 24
    • 0023477391 scopus 로고
    • A mutational analysis of the insulin gene transcription control region: Expression in beta cells is dependent on two related sequences within the enhancer
    • Karlsson, O., T. Edlund, J.B. Moss, W.J. Rutter, and M.D. Walker. 1987. A mutational analysis of the insulin gene transcription control region: Expression in beta cells is dependent on two related sequences within the enhancer. Proc. Natl. Acad. Sci. 84: 8819-8823.
    • (1987) Proc. Natl. Acad. Sci. , vol.84 , pp. 8819-8823
    • Karlsson, O.1    Edlund, T.2    Moss, J.B.3    Rutter, W.J.4    Walker, M.D.5
  • 26
    • 0025358693 scopus 로고
    • A pancreatic islet cell-specific enhancer-like element in the glucagon gene contains two domains binding distinct cellular proteins
    • Knepel, W., L. Jepeal, and J.F. Habener. 1990. A pancreatic islet cell-specific enhancer-like element in the glucagon gene contains two domains binding distinct cellular proteins. J. Biol. Chem. 265: 8725-8735.
    • (1990) J. Biol. Chem. , vol.265 , pp. 8725-8735
    • Knepel, W.1    Jepeal, L.2    Habener, J.F.3
  • 27
    • 0025935925 scopus 로고
    • The pancreatic islet-specific glucagon G3 transcription factors recognize control elements in the rat somatostatin and insulin-I genes
    • Knepel, W., M. Vallejo, J.A. Chafitz, and J.F. Habener. 1991. The pancreatic islet-specific glucagon G3 transcription factors recognize control elements in the rat somatostatin and insulin-I genes. Mol. Endocrinol. 5: 1457-1466.
    • (1991) Mol. Endocrinol. , vol.5 , pp. 1457-1466
    • Knepel, W.1    Vallejo, M.2    Chafitz, J.A.3    Habener, J.F.4
  • 28
    • 0026710736 scopus 로고
    • The promoter of the CD19 gene is a target for the B-cell-specific transcription factor RSAP
    • Kozmik, Z., S. Wang, P. Dorfler, B. Adams, and M. Busslinger. 1992. The promoter of the CD19 gene is a target for the B-cell-specific transcription factor RSAP. Mol. Cell. Biol. 12: 2662-2672.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 2662-2672
    • Kozmik, Z.1    Wang, S.2    Dorfler, P.3    Adams, B.4    Busslinger, M.5
  • 29
    • 0027373441 scopus 로고
    • Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells
    • Leonard, J., B. Peers, T. Johnson, K. Ferreri, S. Lee, and M.R. Montminy. 1993. Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells. Mol. Endocrinol. 7: 1275-1283.
    • (1993) Mol. Endocrinol. , vol.7 , pp. 1275-1283
    • Leonard, J.1    Peers, B.2    Johnson, T.3    Ferreri, K.4    Lee, S.5    Montminy, M.R.6
  • 30
    • 0030560994 scopus 로고    scopus 로고
    • Pax genes and their roles in cell differentiation and development
    • Mansouri, A., M. Hallonet, and P. Gruss. 1996. Pax genes and their roles in cell differentiation and development. Curr. Opin. Cell Biol. 8: 851-857.
    • (1996) Curr. Opin. Cell Biol. , vol.8 , pp. 851-857
    • Mansouri, A.1    Hallonet, M.2    Gruss, P.3
  • 32
    • 0028314969 scopus 로고
    • IDX-1: A new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene
    • Miller, C.P., R.E. McGehee, Jr., and J.F. Hahener. 1994. IDX-1: A new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. EMBO J. 13: 1145-1156.
    • (1994) EMBO J. , vol.13 , pp. 1145-1156
    • Miller, C.P.1    McGehee Jr., R.E.2    Hahener, J.F.3
  • 33
    • 0026698987 scopus 로고
    • Differential expression of neural cell adhesion molecule and cadherins in pancreatic islets, glucagonomas, and insulinomas
    • Moller, C.J., S. Christgau, M.R. Williamson, O.D. Madsen, Z.P. Niu, E. Bock, and S. Baekkeskov. 1992. Differential expression of neural cell adhesion molecule and cadherins in pancreatic islets, glucagonomas, and insulinomas. Mol. Endocrinol. 6: 1332-1342.
    • (1992) Mol. Endocrinol. , vol.6 , pp. 1332-1342
    • Moller, C.J.1    Christgau, S.2    Williamson, M.R.3    Madsen, O.D.4    Niu, Z.P.5    Bock, E.6    Baekkeskov, S.7
  • 34
    • 0030587617 scopus 로고    scopus 로고
    • Expression of avian Pax1 and Pax9 is intrinsically regulated in the pharyngeal endoderm, but depends on environmental influences in the paraxial mesoderm
    • Muller, T.S., C. Ebensperger, A. Neubuser, H. Koseki, R. Balling, B. Christ, and J. Wilting. 1996. Expression of avian Pax1 and Pax9 is intrinsically regulated in the pharyngeal endoderm, but depends on environmental influences in the paraxial mesoderm. Dev. Biol. 178: 403-417.
    • (1996) Dev. Biol. , vol.178 , pp. 403-417
    • Muller, T.S.1    Ebensperger, C.2    Neubuser, A.3    Koseki, H.4    Balling, R.5    Christ, B.6    Wilting, J.7
  • 35
    • 0028674214 scopus 로고
    • Insulin-like growth factor II is focally up-regulated and functionally involved as a second signal for oncogene-induced tumorigenesis
    • Naik, P., G. Christofori, and D. Hanahan. 1994. Insulin-like growth factor II is focally up-regulated and functionally involved as a second signal for oncogene-induced tumorigenesis. Cold Spring Harb. Symp. Quant. Biol. 59: 459-470.
    • (1994) Cold Spring Harb. Symp. Quant. Biol. , vol.59 , pp. 459-470
    • Naik, P.1    Christofori, G.2    Hanahan, D.3
  • 36
    • 0028941181 scopus 로고
    • Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor
    • Naya, F.J., C.M. Stellrecht, and M.J. Tsai. 1995. Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. Genes & Dev. 9: 1009-1019.
    • (1995) Genes & Dev. , vol.9 , pp. 1009-1019
    • Naya, F.J.1    Stellrecht, C.M.2    Tsai, M.J.3
  • 37
    • 0030070145 scopus 로고    scopus 로고
    • Function of the human insulin promoter in primary cultured islet cells
    • Odagiri, H., J. Wang, and M.S. German. 1996. Function of the human insulin promoter in primary cultured islet cells. J. Biol. Chem. 271: 1909-1915.
    • (1996) J. Biol. Chem. , vol.271 , pp. 1909-1915
    • Odagiri, H.1    Wang, J.2    German, M.S.3
  • 39
    • 0027384997 scopus 로고
    • IPF1, a homeodomain-containing transactivator of the insulin gene
    • Ohlsson, H., K. Karlsson, and T. Edlund. 1993. IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J. 12: 4251-4259.
    • (1993) EMBO J. , vol.12 , pp. 4251-4259
    • Ohlsson, H.1    Karlsson, K.2    Edlund, T.3
  • 40
    • 0028567837 scopus 로고
    • Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1
    • Peers, B., J. Leonard, S. Sharma, G. Teitelman, and M.R. Montminy. 1994. Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1. Mol. Endocrinol. 8: 1798-1806.
    • (1994) Mol. Endocrinol. , vol.8 , pp. 1798-1806
    • Peers, B.1    Leonard, J.2    Sharma, S.3    Teitelman, G.4    Montminy, M.R.5
  • 41
    • 0024334030 scopus 로고
    • Glucagon gene transcription is negatively regulated by insulin in a hamster islet cell line
    • Philippe, J. 1989. Glucagon gene transcription is negatively regulated by insulin in a hamster islet cell line. J. Clin. Invest. 84: 672-677.
    • (1989) J. Clin. Invest. , vol.84 , pp. 672-677
    • Philippe, J.1
  • 42
    • 0028873948 scopus 로고
    • Islet-specific proteins interact with the insulin-response element of the glucagon gene
    • Philippe, J., C. Morel, and M. Cordier-Bussat. 1995. Islet-specific proteins interact with the insulin-response element of the glucagon gene. J. Biol. Chem. 270: 3039-3045.
    • (1995) J. Biol. Chem. , vol.270 , pp. 3039-3045
    • Philippe, J.1    Morel, C.2    Cordier-Bussat, M.3
  • 43
    • 0027965633 scopus 로고
    • Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans
    • Quiring, R., U. Walldorf, U. Kloter, and W.J. Gehring. 1994. Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans. Science 265: 785-789.
    • (1994) Science , vol.265 , pp. 785-789
    • Quiring, R.1    Walldorf, U.2    Kloter, U.3    Gehring, W.J.4
  • 45
    • 0030927342 scopus 로고    scopus 로고
    • The beta-cell transcription factors and development of the pancreas
    • Sander, M. and M.S. German. 1997. The beta-cell transcription factors and development of the pancreas. J. Mol. Med. 75: 327-340.
    • (1997) J. Mol. Med. , vol.75 , pp. 327-340
    • Sander, M.1    German, M.S.2
  • 46
    • 0027279692 scopus 로고
    • Defects of neuronal migration and the pathogenesis of cortical malformations are associated with Small eye (Sey) in the mouse, a point mutation at the Pax-6-locus
    • Schmahl, W., M. Knoedlseder, J. Favor, and D. Davidson. 1993. Defects of neuronal migration and the pathogenesis of cortical malformations are associated with Small eye (Sey) in the mouse, a point mutation at the Pax-6-locus. Acta Neuropathol. 86: 126-135.
    • (1993) Acta Neuropathol. , vol.86 , pp. 126-135
    • Schmahl, W.1    Knoedlseder, M.2    Favor, J.3    Davidson, D.4
  • 47
    • 0027316156 scopus 로고
    • NF-HB (BSAP) is a repressor of the murine immunoglobulin heavy-chain 3′ alpha enhancer at early stages of B-cell differentiation
    • Singh, M. and B.K. Birshtein. 1993. NF-HB (BSAP) is a repressor of the murine immunoglobulin heavy-chain 3′ alpha enhancer at early stages of B-cell differentiation. Mol. Cell. Biol. 13: 3611-3622.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 3611-3622
    • Singh, M.1    Birshtein, B.K.2
  • 48
    • 0029027780 scopus 로고
    • Developmental biology of the pancreas
    • Slack, J.M. 1995. Developmental biology of the pancreas. Development 121: 1569-1580.
    • (1995) Development , vol.121 , pp. 1569-1580
    • Slack, J.M.1
  • 49
    • 0030897629 scopus 로고    scopus 로고
    • The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammilian pancreas
    • Sosa-Pineda, B., K. Chowdhury, M. Torres, G. Oliver, and P. Gruss. 1997. The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammilian pancreas. Nature 386: 399-402.
    • (1997) Nature , vol.386 , pp. 399-402
    • Sosa-Pineda, B.1    Chowdhury, K.2    Torres, M.3    Oliver, G.4    Gruss, P.5
  • 50
    • 0030914931 scopus 로고    scopus 로고
    • Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas
    • St-Onge, L., B. Sosa-Peneda, K. Chowdhury, A. Mansouri, and P. Gruss. 1997. Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas. Nature 387: 406-409.
    • (1997) Nature , vol.387 , pp. 406-409
    • St-Onge, L.1    Sosa-Peneda, B.2    Chowdhury, K.3    Mansouri, A.4    Gruss, P.5
  • 51
    • 0029855582 scopus 로고    scopus 로고
    • Forebrain patterning defects in Small eye mutant mice
    • Stoykova, A., R. Fritsch, C. Walther, and P. Gruss. 1996. Forebrain patterning defects in Small eye mutant mice. Development 122: 3453-3465.
    • (1996) Development , vol.122 , pp. 3453-3465
    • Stoykova, A.1    Fritsch, R.2    Walther, C.3    Gruss, P.4
  • 52
    • 84995839584 scopus 로고
    • Pax-QNR/Pax-6, a paired box- and homeobox-containing gene expressed in neurons, is also expressed in pancreatic endocrine cells
    • Turque, N., S. Plaza, F. Radvanyi, C. Carriere, and S. Saule. 1994. Pax-QNR/Pax-6, a paired box- and homeobox-containing gene expressed in neurons, is also expressed in pancreatic endocrine cells. Mol. Endocrinol. 8: 929-938.
    • (1994) Mol. Endocrinol. , vol.8 , pp. 929-938
    • Turque, N.1    Plaza, S.2    Radvanyi, F.3    Carriere, C.4    Saule, S.5
  • 53
    • 0027997502 scopus 로고
    • Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP
    • Urbanek, P., Z.Q. Wang, I. Fetka, E.F. Wagner, and M. Busslinger. 1994. Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP [see Comments]. Cell 79: 901-912.
    • (1994) Cell , vol.79 , pp. 901-912
    • Urbanek, P.1    Wang, Z.Q.2    Fetka, I.3    Wagner, E.F.4    Busslinger, M.5
  • 54
    • 0028196601 scopus 로고
    • The B cell-specific transcription factor BSAP regulates B cell proliferation
    • Wakatsuki, Y., M.F. Neurath, E.E. Max, and W. Strober. 1994. The B cell-specific transcription factor BSAP regulates B cell proliferation. J. Exp. Med. 179: 1099-1108.
    • (1994) J. Exp. Med. , vol.179 , pp. 1099-1108
    • Wakatsuki, Y.1    Neurath, M.F.2    Max, E.E.3    Strober, W.4
  • 55
    • 0026340588 scopus 로고
    • Pax-6, a murine paired box gene, is expressed in the developing CNS
    • Walther, C. and P. Gruss. 1991. Pax-6, a murine paired box gene, is expressed in the developing CNS. Development 113: 1435-1449.
    • (1991) Development , vol.113 , pp. 1435-1449
    • Walther, C.1    Gruss, P.2
  • 58
    • 0029047865 scopus 로고
    • The LIM domain homeobox gene isl-1 is a positive regulator of islet cell-specific proglucagon gene transcription
    • Wang, M. and D.J. Drucker. 1995. The LIM domain homeobox gene isl-1 is a positive regulator of islet cell-specific proglucagon gene transcription. J. Biol. Chem. 270: 12646-12652.
    • (1995) J. Biol. Chem. , vol.270 , pp. 12646-12652
    • Wang, M.1    Drucker, D.J.2
  • 59
    • 0022595271 scopus 로고
    • Structure of the human glucagon gene
    • White, J.W. and G.F. Saunders. 1986. Structure of the human glucagon gene. Nucleic Acids Res. 14: 4719-4730.
    • (1986) Nucleic Acids Res. , vol.14 , pp. 4719-4730
    • White, J.W.1    Saunders, G.F.2
  • 62
    • 0026738482 scopus 로고
    • Pax-8, a paired domain-containing protein, hinds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters
    • Zannini, M., H. Francis-Lang, D. Plachov, and R. Di Lauro. 1992. Pax-8, a paired domain-containing protein, hinds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters. Mol. Cell. Biol. 12: 4230-4241.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 4230-4241
    • Zannini, M.1    Francis-Lang, H.2    Plachov, D.3    Di Lauro, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.