Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of β-cell formation in the pancreas

Development

Volumn 127, Issue 24, 2000, Pages 5533-5540

  Sander, N ^a   Sussel, L ^a   Conners, J ^a   Scheel, D ^a   Kalamaras, J ^a   Dela Cruz, F ^a   Schwitzgebel, V ^a   Hayes Jordan, A ^a   German, M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

cell; Insulin; Islet; Mouse; Transcription factor

Indexed keywords

HOMEODOMAIN PROTEIN; INSULIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL SURVIVAL; CONTROL SYSTEM; CONTROLLED STUDY; DNA FLANKING REGION; EMBRYO; EMBRYO DEVELOPMENT; FETUS; GENE DISRUPTION; GENE MUTATION; HOMEOBOX; INSULIN SYNTHESIS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; REGULATORY MECHANISM; STEM CELL;

ANIMALS; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, HOMEOBOX; HOMEODOMAIN PROTEINS; ISLETS OF LANGERHANS; MICE; MICE, KNOCKOUT; MUTATION; PANCREAS; TRANSCRIPTION FACTORS;

ANIMALIA; MAMMALIA;

EID: 0034524101     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

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14. Insulin-promoter-factor 1 is required for pancreas development in mice
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25. Pancreatic beta cells express a diverse set of homeobox genes
26. The β-cell transcription factors and development of the pancreas
27. Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development
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34. Expression of peptide YY in all four islet cell types in the developing mouse pancreas suggests a common peptide YY-producing progenitor