Profound defects in pancreatic β-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1α, and Hnf-3β

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 6, 2002, Pages 3818-3823

  Shih, David Q ^a   Heimesaat, Markus ^a   Kuwajima, Satoru ^a   Stein, Roland ^b   Wright, Christopher V E ^b   Stoffel, Markus ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Diabetes mellitus; Hepatocyte nuclear factors; Insulin secretion; Pancreatic islets

Indexed keywords

FRUCTOSE BISPHOSPHATE ALDOLASE; GLUCOKINASE; GLUCOSE; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HEPATOCYTE NUCLEAR FACTOR 3; HEPATOCYTE NUCLEAR FACTOR 3BETA; INSULIN; ISOENZYME; NUCLEAR FACTOR I; PYRUVATE KINASE; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG; UVOMORULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CELL MATURATION; CELL STRUCTURE; CONTROLLED STUDY; GENE MUTATION; GLUCAGON RELEASE; HETEROZYGOTE; IMMUNOHISTOCHEMISTRY; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; MOUSE; MOUSE MUTANT; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NULL ALLELE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM;

ANIMALS; BLOOD GLUCOSE; CELL SIZE; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION; GLUCOSE; GLUCOSE TOLERANCE TEST; HEPATOCYTE NUCLEAR FACTOR 1; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HEPATOCYTE NUCLEAR FACTOR 1-BETA; HEPATOCYTE NUCLEAR FACTOR 3-BETA; HETEROZYGOTE; HOMEODOMAIN PROTEINS; HOMEOSTASIS; INSULIN; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED C57BL; MUTATION; NUCLEAR PROTEINS; RNA, MESSENGER; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0037133691     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.062605899     Document Type: Article

References (27)