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Volumn 26, Issue 56, 2007, Pages 7799-7808

DNA double-strand break repair and development

Author keywords

ATM; Development; DNA repair; Double strand breaks; NHEJ

Indexed keywords

ATM PROTEIN; BRCA2 PROTEIN; CHLOROQUINE; DNA DEPENDENT PROTEIN KINASE; DNA LIGASE4; DOUBLE STRANDED DNA; HISTONE DEACETYLASE INHIBITOR; HISTONE H2AX; MRE11 PROTEIN; NIBRIN; PROTEIN P53; PROTEIN XRCC4; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

EID: 36949016233     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210877     Document Type: Review
Times cited : (42)

References (147)
  • 1
    • 31044432090 scopus 로고    scopus 로고
    • XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining
    • Ahnesorg P, Smith P, Jackson SP. (2006). XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. Cell 124: 301-313.
    • (2006) Cell , vol.124 , pp. 301-313
    • Ahnesorg, P.1    Smith, P.2    Jackson, S.P.3
  • 2
    • 11244280890 scopus 로고    scopus 로고
    • Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining
    • Audebert M, Salles B, Calsou P. (2004). Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining. J Biol Chem 279: 55117-55126.
    • (2004) J Biol Chem , vol.279 , pp. 55117-55126
    • Audebert, M.1    Salles, B.2    Calsou, P.3
  • 3
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • Bakkenist CJ, Kastan MB. (2003). DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421: 499-506.
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 4
    • 3142534591 scopus 로고    scopus 로고
    • Initiating cellular stress responses
    • Bakkenist CJ, Kastan MB. (2004). Initiating cellular stress responses. Cell 118: 9-17.
    • (2004) Cell , vol.118 , pp. 9-17
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 6
    • 0032585526 scopus 로고    scopus 로고
    • Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice
    • Barnes DE, Stamp G, Rosewell I, Denzel A, Lindahl T. (1998). Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice. Curr Biol 8: 1395-1398.
    • (1998) Curr Biol , vol.8 , pp. 1395-1398
    • Barnes, D.E.1    Stamp, G.2    Rosewell, I.3    Denzel, A.4    Lindahl, T.5
  • 7
    • 17244367849 scopus 로고    scopus 로고
    • DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
    • Bartkova J, Horejsi Z, Koed K, Kramer A, Tort F, Zieger K et al. (2005). DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434: 864-870.
    • (2005) Nature , vol.434 , pp. 864-870
    • Bartkova, J.1    Horejsi, Z.2    Koed, K.3    Kramer, A.4    Tort, F.5    Zieger, K.6
  • 8
    • 33845235459 scopus 로고    scopus 로고
    • Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
    • Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N et al. (2006). Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 444: 633-637.
    • (2006) Nature , vol.444 , pp. 633-637
    • Bartkova, J.1    Rezaei, N.2    Liontos, M.3    Karakaidos, P.4    Kletsas, D.5    Issaeva, N.6
  • 9
    • 3242881500 scopus 로고    scopus 로고
    • The cellular response to general and programmed DNA double strand breaks
    • Bassing CH, Alt FW. (2004). The cellular response to general and programmed DNA double strand breaks. DNA Repair (Amst) 3: 781-796.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 781-796
    • Bassing, C.H.1    Alt, F.W.2
  • 10
    • 22944462083 scopus 로고    scopus 로고
    • Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1
    • Bekker-Jensen S, Lukas C, Melander F, Bartek J, Lukas J. (2005). Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1. J Cell Biol 170: 201-211.
    • (2005) J Cell Biol , vol.170 , pp. 201-211
    • Bekker-Jensen, S.1    Lukas, C.2    Melander, F.3    Bartek, J.4    Lukas, J.5
  • 11
    • 34447551681 scopus 로고    scopus 로고
    • Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair
    • Berkovich E, Monnat Jr RJ, Kastan MB. (2007). Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. Nat Cell Biol 9: 683-690.
    • (2007) Nat Cell Biol , vol.9 , pp. 683-690
    • Berkovich, E.1    Monnat Jr, R.J.2    Kastan, M.B.3
  • 14
    • 0034102337 scopus 로고    scopus 로고
    • ATR disruption leads to chromosomal fragmentation and early embryonic lethality
    • Brown EJ, Baltimore D. (2000). ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev 14: 397-402.
    • (2000) Genes Dev , vol.14 , pp. 397-402
    • Brown, E.J.1    Baltimore, D.2
  • 15
    • 31044440630 scopus 로고    scopus 로고
    • Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly
    • Buck D, Malivert L, de Chasseval R, Barraud A, Fondaneche MC, Sanal O et al. (2006a). Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly. Cell 124: 287-299.
    • (2006) Cell , vol.124 , pp. 287-299
    • Buck, D.1    Malivert, L.2    de Chasseval, R.3    Barraud, A.4    Fondaneche, M.C.5    Sanal, O.6
  • 16
    • 30944455282 scopus 로고    scopus 로고
    • Severe combined immunodeficiency and microcephaly in siblings with hypomorphic mutations in DNA ligase IV
    • Buck D, Moshous D, de Chasseval R, Ma Y, le Deist F, Cavazzana-Calvo M et al. (2006b). Severe combined immunodeficiency and microcephaly in siblings with hypomorphic mutations in DNA ligase IV. Eur J Immunol 36: 224-235.
    • (2006) Eur J Immunol , vol.36 , pp. 224-235
    • Buck, D.1    Moshous, D.2    de Chasseval, R.3    Ma, Y.4    le Deist, F.5    Cavazzana-Calvo, M.6
  • 17
    • 3242886503 scopus 로고    scopus 로고
    • Role of DNA-PK in the cellular response to DNA double-strand breaks
    • Burma S, Chen DJ. (2004). Role of DNA-PK in the cellular response to DNA double-strand breaks. DNA Repair (Amst) 3: 909-918.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 909-918
    • Burma, S.1    Chen, D.J.2
  • 18
    • 34447093903 scopus 로고    scopus 로고
    • ATM prevents the persistence and propagation of chromosome breaks in lymphocytes
    • Callen E, Jankovic M, Difilippantonio S, Daniel JA, Chen HT, Celeste A et al. (2007). ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Cell 130: 63-75.
    • (2007) Cell , vol.130 , pp. 63-75
    • Callen, E.1    Jankovic, M.2    Difilippantonio, S.3    Daniel, J.A.4    Chen, H.T.5    Celeste, A.6
  • 19
    • 0032076248 scopus 로고    scopus 로고
    • The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response
    • Carney JP, Maser RS, Olivares H, Davis EM, Le Beau M, Yates III JR et al. (1998). The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell 93: 477-486.
    • (1998) Cell , vol.93 , pp. 477-486
    • Carney, J.P.1    Maser, R.S.2    Olivares, H.3    Davis, E.M.4    Le Beau, M.5    Yates III, J.R.6
  • 23
    • 1542510620 scopus 로고    scopus 로고
    • Brca2 deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-) mutant mice
    • Cheung AM, Elia A, Tsao MS, Done S, Wagner KU, Hennighausen L et al. (2004). Brca2 deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-) mutant mice. Cancer Res 64: 1959-1965.
    • (2004) Cancer Res , vol.64 , pp. 1959-1965
    • Cheung, A.M.1    Elia, A.2    Tsao, M.S.3    Done, S.4    Wagner, K.U.5    Hennighausen, L.6
  • 25
    • 3242876404 scopus 로고    scopus 로고
    • Ataxia-telangiectasia, an evolving phenotype
    • Chun HH, Gatti RA. (2004). Ataxia-telangiectasia, an evolving phenotype. DNA Repair (Amst) 3: 1187-1196.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 1187-1196
    • Chun, H.H.1    Gatti, R.A.2
  • 26
    • 21744452376 scopus 로고    scopus 로고
    • Cancer in xeroderma pigmentosum and related disorders of DNA repair
    • Cleaver JE. (2005). Cancer in xeroderma pigmentosum and related disorders of DNA repair. Nat Rev Cancer 5: 564-573.
    • (2005) Nat Rev Cancer , vol.5 , pp. 564-573
    • Cleaver, J.E.1
  • 27
    • 0030659153 scopus 로고    scopus 로고
    • Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation
    • Connor F, Bertwistle D, Mee PJ, Ross GM, Swift S, Grigorieva E et al. (1997). Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation. Nat Genet 17: 423-430.
    • (1997) Nat Genet , vol.17 , pp. 423-430
    • Connor, F.1    Bertwistle, D.2    Mee, P.J.3    Ross, G.M.4    Swift, S.5    Grigorieva, E.6
  • 28
    • 2642573591 scopus 로고    scopus 로고
    • Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells
    • Couedel C, Mills KD, Barchi M, Shen L, Olshen A, Johnson RD et al. (2004). Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells. Genes Dev 18: 1293-1304.
    • (2004) Genes Dev , vol.18 , pp. 1293-1304
    • Couedel, C.1    Mills, K.D.2    Barchi, M.3    Shen, L.4    Olshen, A.5    Johnson, R.D.6
  • 29
    • 0031214080 scopus 로고    scopus 로고
    • Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV
    • Critchlow SE, Bowater RP, Jackson SP. (1997). Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV. Curr Biol 7: 588-598.
    • (1997) Curr Biol , vol.7 , pp. 588-598
    • Critchlow, S.E.1    Bowater, R.P.2    Jackson, S.P.3
  • 30
    • 0042161939 scopus 로고    scopus 로고
    • The Fanconi road to cancer
    • D'Andrea AD. (2003). The Fanconi road to cancer. Genes Dev 17: 1933-1936.
    • (2003) Genes Dev , vol.17 , pp. 1933-1936
    • D'Andrea, A.D.1
  • 31
    • 0037268338 scopus 로고    scopus 로고
    • The Fanconi anaemia/BRCA pathway
    • D'Andrea AD, Grompe M. (2003). The Fanconi anaemia/BRCA pathway. Nat Rev Cancer 3: 23-34.
    • (2003) Nat Rev Cancer , vol.3 , pp. 23-34
    • D'Andrea, A.D.1    Grompe, M.2
  • 32
    • 33845269825 scopus 로고    scopus 로고
    • Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
    • Di Micco R, Fumagalli M, Cicalese A, Piccinin S, Gasparini P, Luise C et al. (2006). Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 444: 638-642.
    • (2006) Nature , vol.444 , pp. 638-642
    • Di Micco, R.1    Fumagalli, M.2    Cicalese, A.3    Piccinin, S.4    Gasparini, P.5    Luise, C.6
  • 33
    • 0034162719 scopus 로고    scopus 로고
    • DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus
    • DiBiase SJ, Zeng Z-C, Chen R, Hyslop T, Curran Jr WJ, Iliakis G. (2000). DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus. Cancer Res 60: 1245-1253.
    • (2000) Cancer Res , vol.60 , pp. 1245-1253
    • DiBiase, S.J.1    Zeng, Z.-C.2    Chen, R.3    Hyslop, T.4    Curran Jr, W.J.5    Iliakis, G.6
  • 34
    • 22144462810 scopus 로고    scopus 로고
    • Difilippantonio S, Celeste A, Fernandez-Capetillo O, Chen HT, Reina San Martin B, Van Laethem F et al. (2005). Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models. Nat Cell Biol 7: 675-685.
    • Difilippantonio S, Celeste A, Fernandez-Capetillo O, Chen HT, Reina San Martin B, Van Laethem F et al. (2005). Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models. Nat Cell Biol 7: 675-685.
  • 36
    • 3242892589 scopus 로고    scopus 로고
    • Nijmegen breakage syndrome: Clinical manifestation of defective response to DNA double-strand breaks
    • Digweed M, Sperling K. (2004). Nijmegen breakage syndrome: clinical manifestation of defective response to DNA double-strand breaks. DNA Repair (Amst) 3: 1207-1217.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 1207-1217
    • Digweed, M.1    Sperling, K.2
  • 37
    • 33748054298 scopus 로고    scopus 로고
    • ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage
    • Dornan D, Shimizu H, Mah A, Dudhela T, Eby M, O'Rourke K et al. (2006). ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage. Science 313: 1122-1126.
    • (2006) Science , vol.313 , pp. 1122-1126
    • Dornan, D.1    Shimizu, H.2    Mah, A.3    Dudhela, T.4    Eby, M.5    O'Rourke, K.6
  • 39
    • 15844394846 scopus 로고    scopus 로고
    • Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
    • Falck J, Coates J, Jackson SP. (2005). Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 434: 605-611.
    • (2005) Nature , vol.434 , pp. 605-611
    • Falck, J.1    Coates, J.2    Jackson, S.P.3
  • 41
    • 0032511976 scopus 로고    scopus 로고
    • Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV
    • Frank KM, Sekiguchi JM, Seidl KJ, Swat W, Rathbun GA, Cheng HL et al. (1998). Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature 396: 173-177.
    • (1998) Nature , vol.396 , pp. 173-177
    • Frank, K.M.1    Sekiguchi, J.M.2    Seidl, K.J.3    Swat, W.4    Rathbun, G.A.5    Cheng, H.L.6
  • 42
    • 0033634973 scopus 로고    scopus 로고
    • DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway
    • Frank KM, Sharpless NE, Gao Y, Sekiguchi JM, Ferguson DO, Zhu C et al. (2000). DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol Cell 5: 993-1002.
    • (2000) Mol Cell , vol.5 , pp. 993-1002
    • Frank, K.M.1    Sharpless, N.E.2    Gao, Y.3    Sekiguchi, J.M.4    Ferguson, D.O.5    Zhu, C.6
  • 43
    • 34250001115 scopus 로고    scopus 로고
    • BRCA2 is required for neurogenesis and suppression of medulloblastoma
    • Frappart PO, Lee Y, Lamont J, McKinnon PJ. (2007). BRCA2 is required for neurogenesis and suppression of medulloblastoma. EMBO J 26: 2732-2742.
    • (2007) EMBO J , vol.26 , pp. 2732-2742
    • Frappart, P.O.1    Lee, Y.2    Lamont, J.3    McKinnon, P.J.4
  • 44
    • 33749678963 scopus 로고    scopus 로고
    • Ataxia-telangiectasia and related diseases
    • Frappart PO, McKinnon PJ. (2006). Ataxia-telangiectasia and related diseases. Neuromolecular Med 8: 495-512.
    • (2006) Neuromolecular Med , vol.8 , pp. 495-512
    • Frappart, P.O.1    McKinnon, P.J.2
  • 45
    • 18844394291 scopus 로고    scopus 로고
    • An essential function for NBS1 in the prevention of ataxia and cerebellar defects
    • Frappart PO, Tong WM, Demuth I, Radovanovic I, Herceg Z, Aguzzi A et al. (2005). An essential function for NBS1 in the prevention of ataxia and cerebellar defects. Nat Med 11: 538-544.
    • (2005) Nat Med , vol.11 , pp. 538-544
    • Frappart, P.O.1    Tong, W.M.2    Demuth, I.3    Radovanovic, I.4    Herceg, Z.5    Aguzzi, A.6
  • 46
    • 30344455023 scopus 로고    scopus 로고
    • Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage version 7
    • Friedberg EC, Meira LB. (2006). Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage version 7. DNA Repair (Amst) 5: 189-209.
    • (2006) DNA Repair (Amst) , vol.5 , pp. 189-209
    • Friedberg, E.C.1    Meira, L.B.2
  • 47
    • 0032167446 scopus 로고    scopus 로고
    • A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination
    • Gao Y, Chaudhuri J, Zhu C, Davidson L, Weaver DT, Alt FW. (1998a). A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. Immunity 9: 367-376.
    • (1998) Immunity , vol.9 , pp. 367-376
    • Gao, Y.1    Chaudhuri, J.2    Zhu, C.3    Davidson, L.4    Weaver, D.T.5    Alt, F.W.6
  • 48
    • 0034690249 scopus 로고    scopus 로고
    • Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development
    • Gao Y, Ferguson DO, Xie W, Manis JP, Sekiguchi J, Frank KM et al. (2000). Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Nature 404: 897-900.
    • (2000) Nature , vol.404 , pp. 897-900
    • Gao, Y.1    Ferguson, D.O.2    Xie, W.3    Manis, J.P.4    Sekiguchi, J.5    Frank, K.M.6
  • 49
    • 0032417640 scopus 로고    scopus 로고
    • A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis
    • Gao Y, Sun Y, Frank KM, Dikkes P, Fujiwara Y, Seidl KJ et al. (1998b). A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell 95: 891-902.
    • (1998) Cell , vol.95 , pp. 891-902
    • Gao, Y.1    Sun, Y.2    Frank, K.M.3    Dikkes, P.4    Fujiwara, Y.5    Seidl, K.J.6
  • 50
    • 19544379326 scopus 로고    scopus 로고
    • Analysis of DNA ligase IV mutations found in LIG4 syndrome patients: The impact of two linked polymorphisms
    • Girard PM, Kysela B, Harer CJ, Doherty AJ, Jeggo PA. (2004). Analysis of DNA ligase IV mutations found in LIG4 syndrome patients: the impact of two linked polymorphisms. Hum Mol Genet 13: 2369-2376.
    • (2004) Hum Mol Genet , vol.13 , pp. 2369-2376
    • Girard, P.M.1    Kysela, B.2    Harer, C.J.3    Doherty, A.J.4    Jeggo, P.A.5
  • 52
    • 0030743386 scopus 로고    scopus 로고
    • Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells [see comments]
    • Grawunder U, Wilm M, Wu X, Kulesza P, Wilson TE, Mann M et al. (1997). Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells [see comments]. Nature 388: 492-495.
    • (1997) Nature , vol.388 , pp. 492-495
    • Grawunder, U.1    Wilm, M.2    Wu, X.3    Kulesza, P.4    Wilson, T.E.5    Mann, M.6
  • 53
    • 0032544413 scopus 로고    scopus 로고
    • Requirement for an interaction of XRCC4 with DNA ligase IV for wild-type V(D)J recombination and DNA double-strand break repair in vivo
    • Grawunder U, Zimmer D, Kulesza P, Lieber MR. (1998a). Requirement for an interaction of XRCC4 with DNA ligase IV for wild-type V(D)J recombination and DNA double-strand break repair in vivo. J Biol Chem 273: 24708-24714.
    • (1998) J Biol Chem , vol.273 , pp. 24708-24714
    • Grawunder, U.1    Zimmer, D.2    Kulesza, P.3    Lieber, M.R.4
  • 54
    • 0032537803 scopus 로고    scopus 로고
    • DNA ligase IV binds to XRCC4 via a motif located between rather than within its BRCT domains
    • Grawunder U, Zimmer D, Leiber MR. (1998b). DNA ligase IV binds to XRCC4 via a motif located between rather than within its BRCT domains. Curr Biol 8: 873-876.
    • (1998) Curr Biol , vol.8 , pp. 873-876
    • Grawunder, U.1    Zimmer, D.2    Leiber, M.R.3
  • 56
    • 0034646304 scopus 로고    scopus 로고
    • Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice
    • Gu Y, Sekiguchi J, Gao Y, Dikkes P, Frank K, Ferguson D et al. (2000). Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice. Proc Natl Acad Sci USA 97: 2668-2673.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 2668-2673
    • Gu, Y.1    Sekiguchi, J.2    Gao, Y.3    Dikkes, P.4    Frank, K.5    Ferguson, D.6
  • 57
    • 0029858143 scopus 로고    scopus 로고
    • V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors
    • Guidos CJ, Williams CJ, Grandal I, Knowles G, Huang MT, Danska JS. (1996). V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors. Genes Dev 10: 2038-2054.
    • (1996) Genes Dev , vol.10 , pp. 2038-2054
    • Guidos, C.J.1    Williams, C.J.2    Grandal, I.3    Knowles, G.4    Huang, M.T.5    Danska, J.S.6
  • 58
    • 34249945536 scopus 로고    scopus 로고
    • DNA double-strand break repair: From mechanistic understanding to cancer treatment
    • Helleday T, Lo J, van Gent DC, Engelward BP. (2007). DNA double-strand break repair: from mechanistic understanding to cancer treatment. DNA Repair (Amst) 6: 923-935.
    • (2007) DNA Repair (Amst) , vol.6 , pp. 923-935
    • Helleday, T.1    Lo, J.2    van Gent, D.C.3    Engelward, B.P.4
  • 59
    • 0032524070 scopus 로고    scopus 로고
    • Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system
    • Herzog KH, Chong MJ, Kapsetaki M, Morgan JI, McKinnon PJ. (1998). Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system. Science 280: 1089-1091.
    • (1998) Science , vol.280 , pp. 1089-1091
    • Herzog, K.H.1    Chong, M.J.2    Kapsetaki, M.3    Morgan, J.I.4    McKinnon, P.J.5
  • 60
    • 33748713412 scopus 로고    scopus 로고
    • Rad54: The Swiss Army knife of homologous recombination?
    • Heyer WD, Li X, Rolfsmeier M, Zhang XP. (2006). Rad54: the Swiss Army knife of homologous recombination? Nucleic Acids Res 34: 4115-4125.
    • (2006) Nucleic Acids Res , vol.34 , pp. 4115-4125
    • Heyer, W.D.1    Li, X.2    Rolfsmeier, M.3    Zhang, X.P.4
  • 61
    • 0035902108 scopus 로고    scopus 로고
    • Genome maintenance mechanisms for preventing cancer
    • Hoeijmakers JH. (2001). Genome maintenance mechanisms for preventing cancer. Nature 411: 366-374.
    • (2001) Nature , vol.411 , pp. 366-374
    • Hoeijmakers, J.H.1
  • 62
    • 33751116534 scopus 로고    scopus 로고
    • Ku80 and p53 suppress medulloblastoma that arise independent of Rag-1-induced DSBs
    • Holcomb VB, Vogel H, Marple T, Kornegay RW, Hasty P. (2006). Ku80 and p53 suppress medulloblastoma that arise independent of Rag-1-induced DSBs. Oncogene 25: 7159-7165.
    • (2006) Oncogene , vol.25 , pp. 7159-7165
    • Holcomb, V.B.1    Vogel, H.2    Marple, T.3    Kornegay, R.W.4    Hasty, P.5
  • 64
    • 10744233204 scopus 로고    scopus 로고
    • EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer
    • Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF et al. (2003). EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. Cell 115: 523-535.
    • (2003) Cell , vol.115 , pp. 523-535
    • Hughes-Davies, L.1    Huntsman, D.2    Ruas, M.3    Fuks, F.4    Bye, J.5    Chin, S.F.6
  • 65
    • 30344463835 scopus 로고    scopus 로고
    • ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
    • Jazayeri A, Falck J, Lukas C, Bartek J, Smith GC, Lukas J et al. (2006). ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol 8: 37-45.
    • (2006) Nat Cell Biol , vol.8 , pp. 37-45
    • Jazayeri, A.1    Falck, J.2    Lukas, C.3    Bartek, J.4    Smith, G.C.5    Lukas, J.6
  • 66
    • 10744228800 scopus 로고    scopus 로고
    • Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
    • Jeffers JR, Parganas E, Lee Y, Yang C, Wang J, Brennan J et al. (2003). Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 4: 321-328.
    • (2003) Cancer Cell , vol.4 , pp. 321-328
    • Jeffers, J.R.1    Parganas, E.2    Lee, Y.3    Yang, C.4    Wang, J.5    Brennan, J.6
  • 67
    • 0037019597 scopus 로고    scopus 로고
    • The greek goddess, Artemis, reveals the secrets of her cleavage
    • Jeggo P, O'Neill P. (2002). The greek goddess, Artemis, reveals the secrets of her cleavage. DNA Repair (Amst) 1: 771-777.
    • (2002) DNA Repair (Amst) , vol.1 , pp. 771-777
    • Jeggo, P.1    O'Neill, P.2
  • 68
    • 0035734285 scopus 로고    scopus 로고
    • Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer
    • Jonkers J, Meuwissen R, van der Gulden H, Peterse H, van der Valk M, Berns A. (2001). Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat Genet 29: 418-425.
    • (2001) Nat Genet , vol.29 , pp. 418-425
    • Jonkers, J.1    Meuwissen, R.2    van der Gulden, H.3    Peterse, H.4    van der Valk, M.5    Berns, A.6
  • 69
    • 0037086702 scopus 로고    scopus 로고
    • Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair
    • Kang J, Bronson RT, Xu Y. (2002). Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair. EMBO J 21: 1447-1455.
    • (2002) EMBO J , vol.21 , pp. 1447-1455
    • Kang, J.1    Bronson, R.T.2    Xu, Y.3
  • 70
    • 0034576494 scopus 로고    scopus 로고
    • The many substrates and functions of ATM
    • Kastan MB, Lim DS. (2000). The many substrates and functions of ATM. Nat Rev Mol Cell Biol 1: 179-186.
    • (2000) Nat Rev Mol Cell Biol , vol.1 , pp. 179-186
    • Kastan, M.B.1    Lim, D.S.2
  • 71
    • 29144506137 scopus 로고    scopus 로고
    • The Fanconi anemia/BRCA pathway: New faces in the crowd
    • Kennedy RD, D'Andrea AD. (2005). The Fanconi anemia/BRCA pathway: new faces in the crowd. Genes Dev 19: 2925-2940.
    • (2005) Genes Dev , vol.19 , pp. 2925-2940
    • Kennedy, R.D.1    D'Andrea, A.D.2
  • 72
    • 0033592868 scopus 로고    scopus 로고
    • Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage
    • Khosravi R, Maya R, Gottlieb T, Oren M, Shiloh Y, Shkedy D. (1999). Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. Proc Natl Acad Sci USA 96: 14973-14977.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 14973-14977
    • Khosravi, R.1    Maya, R.2    Gottlieb, T.3    Oren, M.4    Shiloh, Y.5    Shkedy, D.6
  • 73
    • 2942687831 scopus 로고    scopus 로고
    • Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway
    • Kitagawa R, Bakkenist CJ, McKinnon PJ, Kastan MB. (2004). Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev 18: 1423-1438.
    • (2004) Genes Dev , vol.18 , pp. 1423-1438
    • Kitagawa, R.1    Bakkenist, C.J.2    McKinnon, P.J.3    Kastan, M.B.4
  • 75
    • 0034668060 scopus 로고    scopus 로고
    • Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm
    • Lee Y, Barnes DE, Lindahl T, McKinnon PJ. (2000). Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm. Genes Dev 14: 2576-2580.
    • (2000) Genes Dev , vol.14 , pp. 2576-2580
    • Lee, Y.1    Barnes, D.E.2    Lindahl, T.3    McKinnon, P.J.4
  • 76
    • 0035448927 scopus 로고    scopus 로고
    • Ataxia telangiectasia mutated-dependent apoptosis after genotoxic stress in the developing nervous system is determined by cellular differentiation status
    • Lee Y, Chong MJ, McKinnon PJ. (2001). Ataxia telangiectasia mutated-dependent apoptosis after genotoxic stress in the developing nervous system is determined by cellular differentiation status. J Neurosci 21: 6687-6693.
    • (2001) J Neurosci , vol.21 , pp. 6687-6693
    • Lee, Y.1    Chong, M.J.2    McKinnon, P.J.3
  • 77
    • 0037112505 scopus 로고    scopus 로고
    • DNA ligase IV suppresses medulloblastoma formation
    • Lee Y, McKinnon PJ. (2002). DNA ligase IV suppresses medulloblastoma formation. Cancer Res 62: 6395-6399.
    • (2002) Cancer Res , vol.62 , pp. 6395-6399
    • Lee, Y.1    McKinnon, P.J.2
  • 78
    • 34247159940 scopus 로고    scopus 로고
    • Responding to DNA double strand breaks in the nervous system
    • Lee Y, McKinnon PJ. (2007). Responding to DNA double strand breaks in the nervous system. Neuroscience 145: 1365-1374.
    • (2007) Neuroscience , vol.145 , pp. 1365-1374
    • Lee, Y.1    McKinnon, P.J.2
  • 79
    • 0942268167 scopus 로고    scopus 로고
    • Repair of DNA double strand breaks by non-homologous end joining
    • Lees-Miller SP, Meek K. (2003). Repair of DNA double strand breaks by non-homologous end joining. Biochimie 85: 1161-1173.
    • (2003) Biochimie , vol.85 , pp. 1161-1173
    • Lees-Miller, S.P.1    Meek, K.2
  • 80
    • 0042839614 scopus 로고    scopus 로고
    • Mechanism and regulation of human non-homologous DNA end-joining
    • Lieber MR, Ma Y, Pannicke U, Schwarz K. (2003). Mechanism and regulation of human non-homologous DNA end-joining. Nat Rev Mol Cell Biol 4: 712-720.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 712-720
    • Lieber, M.R.1    Ma, Y.2    Pannicke, U.3    Schwarz, K.4
  • 81
    • 30744465308 scopus 로고    scopus 로고
    • MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals
    • Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, Celeste A et al. (2006). MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell 21: 187-200.
    • (2006) Mol Cell , vol.21 , pp. 187-200
    • Lou, Z.1    Minter-Dykhouse, K.2    Franco, S.3    Gostissa, M.4    Rivera, M.A.5    Celeste, A.6
  • 82
    • 0037468232 scopus 로고    scopus 로고
    • MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways
    • Lou Z, Minter-Dykhouse K, Wu X, Chen J. (2003). MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature 421: 957-961.
    • (2003) Nature , vol.421 , pp. 957-961
    • Lou, Z.1    Minter-Dykhouse, K.2    Wu, X.3    Chen, J.4
  • 83
    • 0035811590 scopus 로고    scopus 로고
    • Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice
    • Ludwig T, Fisher P, Murty V, Efstratiadis A. (2001). Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice. Oncogene 20: 3937-3948.
    • (2001) Oncogene , vol.20 , pp. 3937-3948
    • Ludwig, T.1    Fisher, P.2    Murty, V.3    Efstratiadis, A.4
  • 84
    • 34249947699 scopus 로고    scopus 로고
    • ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    • Matsuoka S, Ballif BA, Smogorzewska A, McDonald III ER, Hurov KE, Luo J et al. (2007). ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316: 1160-1166.
    • (2007) Science , vol.316 , pp. 1160-1166
    • Matsuoka, S.1    Ballif, B.A.2    Smogorzewska, A.3    McDonald III, E.R.4    Hurov, K.E.5    Luo, J.6
  • 85
    • 0035339357 scopus 로고    scopus 로고
    • ATM-dependent phosphorylation of Mdm2 on serine 395: Role in p53 activation by DNA damage
    • Maya R, Balass M, Kim ST, Shkedy D, Leal JF, Shifman O et al. (2001). ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Genes Dev 15: 1067-1077.
    • (2001) Genes Dev , vol.15 , pp. 1067-1077
    • Maya, R.1    Balass, M.2    Kim, S.T.3    Shkedy, D.4    Leal, J.F.5    Shifman, O.6
  • 86
    • 0023148873 scopus 로고
    • Ataxia-telangiectasia: An inherited disorder of ionizing-radiation sensitivity in man. Progress in the elucidation of the underlying biochemical defect
    • McKinnon PJ. (1987). Ataxia-telangiectasia: an inherited disorder of ionizing-radiation sensitivity in man. Progress in the elucidation of the underlying biochemical defect. Hum Genet 75: 197-208.
    • (1987) Hum Genet , vol.75 , pp. 197-208
    • McKinnon, P.J.1
  • 87
    • 4444339751 scopus 로고    scopus 로고
    • ATM and ataxia telangiectasia
    • McKinnon PJ. (2004). ATM and ataxia telangiectasia. EMBO Rep 5: 772-776.
    • (2004) EMBO Rep , vol.5 , pp. 772-776
    • McKinnon, P.J.1
  • 90
    • 0035917489 scopus 로고    scopus 로고
    • Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency
    • Moshous D, Callebaut I, de Chasseval R, Corneo B, Cavazzana-Calvo M, Le Deist F et al. (2001). Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency. Cell 105: 177-186.
    • (2001) Cell , vol.105 , pp. 177-186
    • Moshous, D.1    Callebaut, I.2    de Chasseval, R.3    Corneo, B.4    Cavazzana-Calvo, M.5    Le Deist, F.6
  • 91
    • 34250001450 scopus 로고    scopus 로고
    • DNA repair is limiting for haematopoietic stem cells during ageing
    • Nijnik A, Woodbine L, Marchetti C, Dawson S, Lambe T, Liu C et al. (2007). DNA repair is limiting for haematopoietic stem cells during ageing. Nature 447: 686-690.
    • (2007) Nature , vol.447 , pp. 686-690
    • Nijnik, A.1    Woodbine, L.2    Marchetti, C.3    Dawson, S.4    Lambe, T.5    Liu, C.6
  • 93
    • 18244362081 scopus 로고    scopus 로고
    • DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency
    • O'Driscoll M, Cerosaletti KM, Girard PM, Dai Y, Stumm M, Kysela B et al. (2001). DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency. Mol Cell 8: 1175-1185.
    • (2001) Mol Cell , vol.8 , pp. 1175-1185
    • O'Driscoll, M.1    Cerosaletti, K.M.2    Girard, P.M.3    Dai, Y.4    Stumm, M.5    Kysela, B.6
  • 94
    • 3242881897 scopus 로고    scopus 로고
    • An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome
    • O'Driscoll M, Gennery AR, Seidel J, Concannon P, Jeggo PA. (2004). An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome. DNA Repair (Amst) 3: 1227-1235.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 1227-1235
    • O'Driscoll, M.1    Gennery, A.R.2    Seidel, J.3    Concannon, P.4    Jeggo, P.A.5
  • 95
    • 0142054687 scopus 로고    scopus 로고
    • Shared genetic susceptibility to breast cancer, brain tumors, and Fanconi anemia
    • Offit K, Levran O, Mullaney B, Mah K, Nafa K, Batish SD et al. (2003). Shared genetic susceptibility to breast cancer, brain tumors, and Fanconi anemia. J Natl Cancer Inst 95: 1548-1551.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 1548-1551
    • Offit, K.1    Levran, O.2    Mullaney, B.3    Mah, K.4    Nafa, K.5    Batish, S.D.6
  • 96
    • 33745628782 scopus 로고    scopus 로고
    • Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development
    • Orii KE, Lee Y, Kondo N, McKinnon PJ. (2006). Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development. Proc Natl Acad Sci USA 103: 10017-10022.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 10017-10022
    • Orii, K.E.1    Lee, Y.2    Kondo, N.3    McKinnon, P.J.4
  • 97
    • 0030885974 scopus 로고    scopus 로고
    • Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination in vivo
    • Ouyang H, Nussenzweig A, Kurimasa A, Soares VC, Li X, Cordon-Cardo C et al. (1997). Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination in vivo. J Exp Med 186: 921-929.
    • (1997) J Exp Med , vol.186 , pp. 921-929
    • Ouyang, H.1    Nussenzweig, A.2    Kurimasa, A.3    Soares, V.C.4    Li, X.5    Cordon-Cardo, C.6
  • 98
    • 33748648775 scopus 로고    scopus 로고
    • Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo
    • Pellegrini M, Celeste A, Difilippantonio S, Guo R, Wang W, Feigenbaum L et al. (2006). Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo. Nature 443: 222-225.
    • (2006) Nature , vol.443 , pp. 222-225
    • Pellegrini, M.1    Celeste, A.2    Difilippantonio, S.3    Guo, R.4    Wang, W.5    Feigenbaum, L.6
  • 100
    • 33846569450 scopus 로고    scopus 로고
    • Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer
    • Reid S, Schindler D, Hanenberg H, Barker K, Hanks S, Kalb R et al. (2007). Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer. Nat Genet 39: 162-164.
    • (2007) Nat Genet , vol.39 , pp. 162-164
    • Reid, S.1    Schindler, D.2    Hanenberg, H.3    Barker, K.4    Hanks, S.5    Kalb, R.6
  • 101
    • 33750809977 scopus 로고    scopus 로고
    • Cernunnos-XLF, a recently identified non-homologous end-joining factor required for the development of the immune system
    • Revy P, Malivert L, de Villartay JP. (2006). Cernunnos-XLF, a recently identified non-homologous end-joining factor required for the development of the immune system. Curr Opin Allergy Clin Immunol 6: 416-420.
    • (2006) Curr Opin Allergy Clin Immunol , vol.6 , pp. 416-420
    • Revy, P.1    Malivert, L.2    de Villartay, J.P.3
  • 103
    • 0035903103 scopus 로고    scopus 로고
    • Cellular and biochemical impact of a mutation in DNA ligase IV conferring clinical radiosensitivity
    • Riballo E, Doherty AJ, Dai Y, Stiff T, Oettinger MA, Jeggo PA et al. (2001). Cellular and biochemical impact of a mutation in DNA ligase IV conferring clinical radiosensitivity. J Biol Chem 276: 31124-31132.
    • (2001) J Biol Chem , vol.276 , pp. 31124-31132
    • Riballo, E.1    Doherty, A.J.2    Dai, Y.3    Stiff, T.4    Oettinger, M.A.5    Jeggo, P.A.6
  • 104
    • 9744220428 scopus 로고    scopus 로고
    • A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci
    • Riballo E, Kuhne M, Rief N, Doherty A, Smith GC, Recio MJ et al. (2004). A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Mol Cell 16: 715-724.
    • (2004) Mol Cell , vol.16 , pp. 715-724
    • Riballo, E.1    Kuhne, M.2    Rief, N.3    Doherty, A.4    Smith, G.C.5    Recio, M.J.6
  • 105
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. (1998). DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 273: 5858-5868.
    • (1998) J Biol Chem , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 106
    • 0037416138 scopus 로고    scopus 로고
    • Defective DNA repair and increased genomic instability in Artemis-deficient murine cells
    • Rooney S, Alt FW, Lombard D, Whitlow S, Eckersdorff M, Fleming J et al. (2003). Defective DNA repair and increased genomic instability in Artemis-deficient murine cells. J Exp Med 197: 553-565.
    • (2003) J Exp Med , vol.197 , pp. 553-565
    • Rooney, S.1    Alt, F.W.2    Lombard, D.3    Whitlow, S.4    Eckersdorff, M.5    Fleming, J.6
  • 107
    • 0036932453 scopus 로고    scopus 로고
    • Leaky scid associated with defective V(D)J coding end processing in Artemis-deficient mice
    • Rooney S, Sekiguchi J, Zhu C, Cheng HL, Manis J, Whitlow S et al. (2002). Leaky scid associated with defective V(D)J coding end processing in Artemis-deficient mice. Mol Cell 10: 1379-1390.
    • (2002) Mol Cell , vol.10 , pp. 1379-1390
    • Rooney, S.1    Sekiguchi, J.2    Zhu, C.3    Cheng, H.L.4    Manis, J.5    Whitlow, S.6
  • 108
    • 34548348780 scopus 로고    scopus 로고
    • The mouse ascending: Perspectives for human-disease models
    • Rosenthal N, Brown S. (2007). The mouse ascending: perspectives for human-disease models. Nat Cell Biol 9: 993-999.
    • (2007) Nat Cell Biol , vol.9 , pp. 993-999
    • Rosenthal, N.1    Brown, S.2
  • 109
    • 34250007142 scopus 로고    scopus 로고
    • Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
    • Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL. (2007). Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 447: 725-729.
    • (2007) Nature , vol.447 , pp. 725-729
    • Rossi, D.J.1    Bryder, D.2    Seita, J.3    Nussenzweig, A.4    Hoeijmakers, J.5    Weissman, I.L.6
  • 110
    • 0042632901 scopus 로고    scopus 로고
    • Pathways of DNA double-strand break repair during the mammalian cell cycle
    • Rothkamm K, Kruger I, Thompson LH, Lobrich M. (2003). Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol Cell Biol 23: 5706-5715.
    • (2003) Mol Cell Biol , vol.23 , pp. 5706-5715
    • Rothkamm, K.1    Kruger, I.2    Thompson, L.H.3    Lobrich, M.4
  • 112
    • 0035853127 scopus 로고    scopus 로고
    • Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development
    • Sekiguchi J, Ferguson DO, Chen HT, Yang EM, Earle J, Frank K et al. (2001). Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development. Proc Natl Acad Sci USA 98: 3243-3248.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 3243-3248
    • Sekiguchi, J.1    Ferguson, D.O.2    Chen, H.T.3    Yang, E.M.4    Earle, J.5    Frank, K.6
  • 113
    • 0037365789 scopus 로고    scopus 로고
    • ATM and related protein kinases: Safeguarding genome integrity
    • Shiloh Y. (2003). ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 3: 155-168.
    • (2003) Nat Rev Cancer , vol.3 , pp. 155-168
    • Shiloh, Y.1
  • 114
    • 33745823159 scopus 로고    scopus 로고
    • The ATM-mediated DNA-damage response: Taking shape
    • Shiloh Y. (2006). The ATM-mediated DNA-damage response: taking shape. Trends Biochem Sci 31: 402-410.
    • (2006) Trends Biochem Sci , vol.31 , pp. 402-410
    • Shiloh, Y.1
  • 115
    • 3242878504 scopus 로고    scopus 로고
    • DNA recombination, chromosomal stability and carcinogenesis: Insights into the role of BRCA2
    • Shivji MK, Venkitaraman AR. (2004). DNA recombination, chromosomal stability and carcinogenesis: insights into the role of BRCA2. DNA Repair (Amst) 3: 835-843.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 835-843
    • Shivji, M.K.1    Venkitaraman, A.R.2
  • 116
    • 0033544724 scopus 로고    scopus 로고
    • The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder
    • Stewart GS, Maser RS, Stankovic T, Bressan DA, Kaplan MI, Jaspers NG et al. (1999). The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder. Cell 99: 577-587.
    • (1999) Cell , vol.99 , pp. 577-587
    • Stewart, G.S.1    Maser, R.S.2    Stankovic, T.3    Bressan, D.A.4    Kaplan, M.I.5    Jaspers, N.G.6
  • 119
    • 34248579748 scopus 로고    scopus 로고
    • The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex
    • Stracker TH, Morales M, Couto SS, Hussein H, Petrini JH. (2007). The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex. Nature 447: 218-221.
    • (2007) Nature , vol.447 , pp. 218-221
    • Stracker, T.H.1    Morales, M.2    Couto, S.S.3    Hussein, H.4    Petrini, J.H.5
  • 120
    • 29244434544 scopus 로고    scopus 로고
    • MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
    • Stucki M, Clapperton JA, Mohammad D, Yaffe MB, Smerdon SJ, Jackson SP. (2005). MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell 123: 1213-1226.
    • (2005) Cell , vol.123 , pp. 1213-1226
    • Stucki, M.1    Clapperton, J.A.2    Mohammad, D.3    Yaffe, M.B.4    Smerdon, S.J.5    Jackson, S.P.6
  • 121
    • 33646106590 scopus 로고    scopus 로고
    • gammaH2AX and MDC1: Anchoring the DNA-damage-response machinery to broken chromosomes
    • Stucki M, Jackson SP. (2006). gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes. DNA Repair (Amst) 5: 534-543.
    • (2006) DNA Repair (Amst) , vol.5 , pp. 534-543
    • Stucki, M.1    Jackson, S.P.2
  • 122
    • 14444277477 scopus 로고    scopus 로고
    • Brca2 is required for embryonic cellular proliferation in the mouse
    • Suzuki A, de la Pompa JL, Hakem R, Elia A, Yoshida R, Mo R et al. (1997). Brca2 is required for embryonic cellular proliferation in the mouse. Genes Dev 11: 1242-1252.
    • (1997) Genes Dev , vol.11 , pp. 1242-1252
    • Suzuki, A.1    de la Pompa, J.L.2    Hakem, R.3    Elia, A.4    Yoshida, R.5    Mo, R.6
  • 123
    • 0032167545 scopus 로고    scopus 로고
    • Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity
    • Taccioli GE, Amatucci AG, Beamish HJ, Gell D, Xiang XH, Torres Arzayus MI et al. (1998). Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity. Immunity 9: 355-366.
    • (1998) Immunity , vol.9 , pp. 355-366
    • Taccioli, G.E.1    Amatucci, A.G.2    Beamish, H.J.3    Gell, D.4    Xiang, X.H.5    Torres Arzayus, M.I.6
  • 124
    • 18644375649 scopus 로고    scopus 로고
    • Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription
    • Takai H, Naka K, Okada Y, Watanabe M, Harada N, Saito S et al. (2002). Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO J 21: 5195-5205.
    • (2002) EMBO J , vol.21 , pp. 5195-5205
    • Takai, H.1    Naka, K.2    Okada, Y.3    Watanabe, M.4    Harada, N.5    Saito, S.6
  • 125
    • 0038740579 scopus 로고    scopus 로고
    • The mammalian XRCC genes: Their roles in DNA repair and genetic stability
    • Thacker J, Zdzienicka MZ. (2003). The mammalian XRCC genes: their roles in DNA repair and genetic stability. DNA Repair (Amst) 2: 655-672.
    • (2003) DNA Repair (Amst) , vol.2 , pp. 655-672
    • Thacker, J.1    Zdzienicka, M.Z.2
  • 126
    • 3242881692 scopus 로고    scopus 로고
    • The XRCC genes: Expanding roles in DNA double-strand break repair
    • Thacker J, Zdzienicka MZ. (2004). The XRCC genes: expanding roles in DNA double-strand break repair. DNA Repair (Amst) 3: 1081-1090.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 1081-1090
    • Thacker, J.1    Zdzienicka, M.Z.2
  • 127
    • 0346156075 scopus 로고    scopus 로고
    • Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice
    • Theunissen JW, Kaplan MI, Hunt PA, Williams BR, Ferguson DO, Alt FW et al. (2003). Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice. Mol Cell 12: 1511-1523.
    • (2003) Mol Cell , vol.12 , pp. 1511-1523
    • Theunissen, J.W.1    Kaplan, M.I.2    Hunt, P.A.3    Williams, B.R.4    Ferguson, D.O.5    Alt, F.W.6
  • 130
    • 0032076190 scopus 로고    scopus 로고
    • Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome
    • Varon R, Vissinga C, Platzer M, Cerosaletti KM, Chrzanowska KH, Saar K et al. (1998). Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. Cell 93: 467-476.
    • (1998) Cell , vol.93 , pp. 467-476
    • Varon, R.1    Vissinga, C.2    Platzer, M.3    Cerosaletti, K.M.4    Chrzanowska, K.H.5    Saar, K.6
  • 131
    • 20144363082 scopus 로고    scopus 로고
    • DNA ligase III as a candidate component of backup pathways of nonhomologous end joining
    • Wang H, Rosidi B, Perrault R, Wang M, Zhang L, Windhofer F et al. (2005a). DNA ligase III as a candidate component of backup pathways of nonhomologous end joining. Cancer Res 65: 4020-4030.
    • (2005) Cancer Res , vol.65 , pp. 4020-4030
    • Wang, H.1    Rosidi, B.2    Perrault, R.3    Wang, M.4    Zhang, L.5    Windhofer, F.6
  • 132
    • 16244401671 scopus 로고    scopus 로고
    • Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression
    • Wang J, Pluth JM, Cooper PK, Cowan MJ, Chen DJ, Yannone SM. (2005b). Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression. DNA Repair (Amst) 4: 556-570.
    • (2005) DNA Repair (Amst) , vol.4 , pp. 556-570
    • Wang, J.1    Pluth, J.M.2    Cooper, P.K.3    Cowan, M.J.4    Chen, D.J.5    Yannone, S.M.6
  • 133
    • 16644380896 scopus 로고    scopus 로고
    • Early events in the DNA damage response
    • Ward I, Chen J. (2004). Early events in the DNA damage response. Curr Top Dev Biol 63: 1-35.
    • (2004) Curr Top Dev Biol , vol.63 , pp. 1-35
    • Ward, I.1    Chen, J.2
  • 134
    • 0038700698 scopus 로고    scopus 로고
    • Molecular views of recombination proteins and their control
    • West SC. (2003). Molecular views of recombination proteins and their control. Nat Rev Mol Cell Biol 4: 435-445.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 435-445
    • West, S.C.1
  • 137
    • 3242886313 scopus 로고    scopus 로고
    • Homologous recombination-mediated double-strand break repair
    • Wyman C, Ristic D, Kanaar R. (2004). Homologous recombination-mediated double-strand break repair. DNA Repair (Amst) 3: 827-833.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 827-833
    • Wyman, C.1    Ristic, D.2    Kanaar, R.3
  • 139
    • 0029844048 scopus 로고    scopus 로고
    • Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
    • Xu Y, Ashley T, Brainerd EE, Bronson RT, Meyn MS, Baltimore D. (1996). Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev 10: 2411-2422.
    • (1996) Genes Dev , vol.10 , pp. 2411-2422
    • Xu, Y.1    Ashley, T.2    Brainerd, E.E.3    Bronson, R.T.4    Meyn, M.S.5    Baltimore, D.6
  • 140
    • 0029821651 scopus 로고    scopus 로고
    • Dual roles of ATM in the cellular response to radiation and in cell growth control
    • Xu Y, Baltimore D. (1996). Dual roles of ATM in the cellular response to radiation and in cell growth control. Genes Dev 10: 2401-2410.
    • (1996) Genes Dev , vol.10 , pp. 2401-2410
    • Xu, Y.1    Baltimore, D.2
  • 141
    • 0031806910 scopus 로고    scopus 로고
    • Involvement of p53 and p21 in cellular defects and tumorigenesis in atm-/- mice
    • Xu Y, Yang EM, Brugarolas J, Jacks T, Baltimore D. (1998). Involvement of p53 and p21 in cellular defects and tumorigenesis in atm-/- mice. Mol Cell Biol 18: 4385-4390.
    • (1998) Mol Cell Biol , vol.18 , pp. 4385-4390
    • Xu, Y.1    Yang, E.M.2    Brugarolas, J.3    Jacks, T.4    Baltimore, D.5
  • 142
    • 33646550838 scopus 로고    scopus 로고
    • XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice
    • Yan CT, Kaushal D, Murphy M, Zhang Y, Datta A, Chen C et al. (2006). XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice. Proc Natl Acad Sci USA 103: 7378-7383.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 7378-7383
    • Yan, C.T.1    Kaushal, D.2    Murphy, M.3    Zhang, Y.4    Datta, A.5    Chen, C.6
  • 143
    • 34547115962 scopus 로고    scopus 로고
    • Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through Phosphorylation of TopBP1 by ATM
    • Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG. (2007). Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through Phosphorylation of TopBP1 by ATM. J Biol Chem 282: 17501-17506.
    • (2007) J Biol Chem , vol.282 , pp. 17501-17506
    • Yoo, H.Y.1    Kumagai, A.2    Shevchenko, A.3    Shevchenko, A.4    Dunphy, W.G.5
  • 144
    • 20744436198 scopus 로고    scopus 로고
    • ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1
    • You Z, Chahwan C, Bailis J, Hunter T, Russell P. (2005). ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol Cell Biol 25: 5363-5379.
    • (2005) Mol Cell Biol , vol.25 , pp. 5363-5379
    • You, Z.1    Chahwan, C.2    Bailis, J.3    Hunter, T.4    Russell, P.5
  • 145
    • 4744373121 scopus 로고    scopus 로고
    • Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response
    • Zhang X, Succi J, Feng Z, Prithivirajsingh S, Story MD, Legerski RJ. (2004). Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response. Mol Cell Biol 24: 9207-9220.
    • (2004) Mol Cell Biol , vol.24 , pp. 9207-9220
    • Zhang, X.1    Succi, J.2    Feng, Z.3    Prithivirajsingh, S.4    Story, M.D.5    Legerski, R.J.6
  • 146
    • 0035936554 scopus 로고    scopus 로고
    • Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice
    • Zhu J, Petersen S, Tessarollo L, Nussenzweig A. (2001). Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice. Curr Biol 11: 105-109.
    • (2001) Curr Biol , vol.11 , pp. 105-109
    • Zhu, J.1    Petersen, S.2    Tessarollo, L.3    Nussenzweig, A.4
  • 147
    • 33746601439 scopus 로고    scopus 로고
    • Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway
    • Ziv Y, Bielopolski D, Galanty Y, Lukas C, Taya Y, Schultz DC et al. (2006). Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway. Nat Cell Biol 8: 870-876.
    • (2006) Nat Cell Biol , vol.8 , pp. 870-876
    • Ziv, Y.1    Bielopolski, D.2    Galanty, Y.3    Lukas, C.4    Taya, Y.5    Schultz, D.C.6


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