Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient

Current Biology

Volumn 9, Issue 13, 1999, Pages 699-702

  Riballo, E ^a   Critchlow, S E ^b   Teo, S H ^b   Doherty, A J ^c   Priestley, A ^a   Broughton, B ^a   Kysela, B ^a   Beamish, H ^a   Plowman, N ^d   Arlett, C F ^a   Lehmann, A R ^a   Jackson, S P ^b   Jeggo, P A ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA LIGASE IV; DNA RECOMBINATION; DNA REPAIR; ENZYME ANALYSIS;

MAMMALIA; RODENTIA;

EID: 0033166623     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(99)80311-X     Document Type: Article

References (21)

1. Jeggo PA, Taccioli GE, Jackson SP: Menage à trois: Double strand break repair, V(D)J recombination and DNA-PK. BioEssays 1995, 17:949-957.
2. Critchlow SE, Jackson SP: DNA end-joining: From yeast to man. Trends Biochem Sci 1998, 23:394-398.
3. Li Z, Otevrel T, Gao Y, Cheng H-L, Seed B, Stamato TD, et al.: The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. Cell 1995, 83:1079-1089.
4. Critchlow SE, Bowater RP, Jackson SP: Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV. Curr Biol 1997, 7:588-598.
5. Grawunder U, Wilm M, Wu X, Kulesza P, Wilson TE, Mann M, et al.: Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature 1997, 388:492-495.
6. Grawunder U, Zimmer D, Fugmann S, Schwarz K, Lieber MR: DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes. Mol Cell 1998, 2:477-484.
7. Smith GEM, Jackson SP: The DNA-dependent protein kinase. Genes Dev 1999, 13:916-934.
8. Frank KM, Sekiguchi JM, Seidl KJ, Swat W, Rathbun GA, Cheng HL, et al.: Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature 1998, 396:173-177.
9. Plowman PN, Bridges BA, Arlett CF, Hinney A, Kingston JE: An instance of clinical radiation morbidity and cellular radiosensitivity, not associated with ataxia-telangiectasia. Br J Radiol 1990, 63:624-628.
10. Badie C, Iliakis G, Foray N, Alsbeih G, Pantellias GE, Okayasu R, et al.: Defective repair of DNA double-strand breaks and chromosome damage in fibroblasts from a radiosensitive leukemia patient. Cancer Res 1995, 55:1232-1234.
11. Badie C, Goodhardt M, Waugh A, Doyen N, Foray N, Calsou P, et al.: A DNA double-strand break defective fibroblast cell line, (180BR), derived from a radiosensitive patient represents a new mutant phenotype. Cancer Res 1997, 57:4600-4607.
12. Shuman S: Closing the gap on DNA ligase. Structure 1996, 4:653-656.
13. Subramanya HS, Doherty AJ, Ashford SR, Wigley DB: Crystal structure of an ATP-dependent DNA ligase from bacteriophage T7. Cell 1996, 85:607-615.
14. Håkansson K, Doherty AJ, Shuman S, Wigley DB: X-ray crystallography reveals a large conformational change during guanyl transfer by mRNA capping enzymes. Cell 1997, 89:545-553.
15. Schar P, Herrmann G, Daly G, Lindahl T: A newly identified DNA ligase of Saccharomyces cerevisiae involved in RAD52-independent repair of DNA double-strand breaks. Genes Dev 1997, 11:1912-1924.
16. Teo S-H, Jackson SP: Identification of Saccharomyces cerevisiae DNA ligase IV: Involvement in DNA double-strand break repair. EMBO J 1997, 16:4788-4795.
17. Wilson TE, Grawunder U, Lieber MR: Yeast DNA ligase IV mediates non-homologous DNA end joining. Nature 1997, 388:495-498.
18. Herrmann G, Lindahl T, Schar P: Saccharomyces cerevisiae LIF1: A function involved in DNA double-strand break repair related to mammalian XRCC4. EMBO J 1998, 17:4188-4198.
19. Barnes DE, Stamp G, Rosewell I, Denzel A, Lindahl T: Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice. Curr Biol 1998, 8:1395-1398.
20. Scholer H, Haslinger A, Heguy A, Holtgreve H, Karin M: In vivo competition between a metallothionein regulatory element and the SV40 enhancer. Science 1986, 232:76-80.
21. Robins P, Lindahl T: DNA ligase IV from HeLa cell nuclei. J Biol Chem 1996, 271:24257-24261.