Cellular and Biochemical Impact of a Mutation in DNA Ligase IV Conferring Clinical Radiosensitivity

Journal of Biological Chemistry

Volumn 276, Issue 33, 2001, Pages 31124-31132

  Riballo, Enriqueta ^a   Doherty, Aidan J ^b   Dai, Yan ^c   Stiff, Thomas ^a   Oettinger, Marjorie A ^c   Jeggo, Penny A ^a   Kysela, Boris ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CELLS; DNA; ENZYMES; MUTAGENESIS; RADIOTHERAPY;

MUTATIONS; RADIOSENSITIVITY;

BIOCHEMISTRY;

ADENOSINE PHOSPHATE; DNA; DNA LIGASE IV; DNA LIGASE IV XRCC4; LIGASE; MUTANT PROTEIN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; UNCLASSIFIED DRUG; POLYDEOXYRIBONUCLEOTIDE SYNTHASE (ATP);

ANIMAL CELL; ARTICLE; BRAIN DEVELOPMENT; CANCER RADIOTHERAPY; CONTROLLED STUDY; DNA CONFORMATION; DNA RECOMBINATION; GENE MUTATION; HOMOZYGOSITY; HOMOZYGOUS MUTATION; IMMUNOGLOBULIN V(D)J RECOMBINATION; LEUKEMIA; MOLECULAR MODEL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN STABILITY; PROTEIN STRUCTURE; RADIOSENSITIVITY; STRUCTURAL MODEL; TEMPERATURE SENSITIVITY; AUDIOVISUAL EQUIPMENT; CELL LINE; CHEMISTRY; DNA REPAIR; GENETIC RECOMBINATION; GENETICS; HUMAN; METABOLISM; MUTATION; RADIATION DOSE; STRUCTURE ACTIVITY RELATION; TEMPERATURE;

ANIMALIA;

ADENOSINE MONOPHOSPHATE; CELL LINE; DNA; DNA LIGASES; DNA REPAIR; HUMANS; MODELS, STRUCTURAL; MUTATION; RADIATION TOLERANCE; RECOMBINATION, GENETIC; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE;

EID: 0035903103     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M103866200     Document Type: Article

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