Brca2 is required for embryonic cellular proliferation in the mouse

Genes and Development

Volumn 11, Issue 10, 1997, Pages 1242-1252

  Suzuki, Akira ^a,b   De La Pompa, José Luis ^a,b   Hakem, Razqallah ^a,b   Elia, Andrew ^a,b   Yoshida, Ritsuko ^a,b   Mo, Kong ^c,d   Nishina, Hiroshi ^a,b   Chuang, Tony ^a,b   Wakeham, Andrew ^a,b   Itie, Annick ^a,b   Koo, Wilson ^a,b   Billia, Phyllis ^a,b   Ho, Alexandra ^a,b   Fukumoto, Manabu ^e   Hui, Chi Chung ^c,d   Mak, Tak W ^a,b  

^a AMGEN INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

^e KYOTO UNIVERSITY   (Japan)

Author keywords

Brca2 mutant mice; embryogenesis; p21; proliferation

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER SUSCEPTIBILITY; CELL PROLIFERATION; CONTROLLED STUDY; DNA REPAIR; EMBRYO DEVELOPMENT; ENZYME INHIBITION; GASTRULATION; GENETIC PREDISPOSITION; GROWTH REGULATION; MESODERM; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 14444277477     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.11.10.1242     Document Type: Article

References (49)

1. Baumann, P., F.E. Benson, and S.C. West. 1996. Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro. Cell 87: 757-766.
2. Church, G.M. and W. Gilbert. 1984. Genomic sequencing. Proc. Natl. Acad. Sci. 81: 1991-1995.
3. Collins, N., R. McManus, R. Wooster, J. Mangion, S. Seal, S.R. Lakhani, W. Ormiston, P.A. Daly, D. Ford, D.F. Easton, and M.R. Stratton. 1995. Consistent loss of the wild-type allele in breast cancers from a family linked to the BRCA2 gene on chromosome 13q12-13. Oncogene 10: 1673-1675.
4. Coucovanis, E. and G.R. Martin. 1995. Signals for death and survival: A two step mechanism for cavitation in the vertebrate embryo. Cell 83: 279-287.
5. Cox, L.S. and D.P. Lane. 1995. Tumor supressors, kinases and clamps - How p53 regulates the cell-cycle in response to DNA-damage. BioEssays 17: 501-508.
6. Donehower, L.A., M. Harvey, B.L. Slagle, M.J. McArthur, C.A. Montgomery, Jr, J.S. Butel, and A. Bradley. 1992. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature 356: 215-221.
7. El-Deiry, W.S., T. Tokina, V.E. Velculescu, D.B. Levy, R. Parsons, J.M. Trent, D. Lin, E. Mercer, K.W. Kinzler, and B. Vogelstein. 1993. WAF1, a potential mediator of p53 tumor suppression. Cell 75: 817-825.
8. Futreal, P.A., Q. Liu, D. Shattuck-Eidens, C. Cochran, K. Harshman, S. Tavtigan, L.M. Bennett, A. Haugen-Strano, J. Swensen, Y. Miki et al. 1994. BRCA1 mutations in primary breast and ovarian carcinomas. Science 266: 120-122.
9. Gessler, M., A. Poustka, W. Cavenee, R.L. Neve, S.H. Orkin, and G.A.P. Bruns. 1990. Homozygous deletion in Wilms tumors of a zinc-finger gene identified by chromosome jumping. Nature 343: 774-778.
10. Gayther, S.A., J. Mangion, P. Russel, S. Seal, R. Barfoot, B.A.J. Ponder, M.R. Stratton, and D. Easton. 1997. Variation of risks of breast and ovarian cancer associated with different germline mutations of the BRCA2 gene. Nature Genet. 15: 103-105.
11. Gowen, L.C., B.L. Johnson, A.M. Latour, K.K. Sulik, and B.H. Koller. 1996. Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nature Genet. 12: 191-194.
12. Gu, Y., C.W. Turek, and D.O. Morgan. 1993. Inhibition of CDK2 activity in vivo by an associated 20k regulatory subunit. Nature 366: 707-710.
13. Gudmundsson, J., G. Johannesdottir, J.T. Bergthorsson, A. Arason, S. Ingvarsson, V. Egilsson, and R.B. Barkardottir. 1995. Different tumor types from BRCA2 carriers show wild-type chromosome deletions on 13q12q13. Cancer Res. 55: 4830-4832.
14. Guillemot, F., A. Nagy, A. Auerbach, J. Rossan, and A.L. Joyner. 1994. Essential role of Mash-2 in extraembryonic development. Nature 371: 333-336.
15. Hakem, R., J.L. de la Pompa, C. Sirard, R. Mo, M. Woo, A. Hakem, A. Wakeham, J. Potter, A. Reitmair, F. Billia, E. Firpo, C.C. Hui, J. Roberts, J. Rossant, and T.W. Mak. 1996. The tumor-suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell 85: 1009-1023.
16. Harper, J.W., G.R. Adami, N. Wei, K. Keyomarsi, and S.J. Elledge. 1993. The p21-cdk interacting protein Cip is a potent inhibitor of G1 cyclin-dependem kinases. Cell 75: 805-816.
17. Hansen, M.F., A. Koufos, B.L. Gallie, R.A. Phillips, O. Fodstad, A. Brogger, T. Gedde-Dahl, and W.K. Cavenee. 1985. Osteoscarcoma and retinoblastoma: A shared chromosomal mechanism revealing recessive predisposition. Proc. Natl. Acad. Sci. 82: 6216-6220.
18. Hayashi, Y., M. Koike, M. Matsunami, and T. Hoshino. 1988. Effects of fixation time and enzymatic digestion on immunohistochemical demonstration of bromodeoxyuridine in formalin-fixed, paraffin-embedded tissue. J. Histochem. Cytochem. 36: 511-514.
19. Hui, C.C. and A. Joyner. 1993. A mouse model for the Greig cephalopolysyndactyly syndrome: The extra-toes' mutation contains an intragenic deletion of the G1i3 gene. Nature Genet. 3: 241-246.
20. Hunter, T. 1997. Oncoprotein networks. Cell 88: 333-346.
21. Keegan, K.S., D.A. Holtzman, A.W. Plug, E.R. Christenson, E.E. Brainerd, G. Flaggs, N.J. Bentley, E.M. Taylor, M.S. Meyn, S.B. Moss, A.M. Carr, T. Ashley, and M.F. Hoekstra. 1996. The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes. Genes & Dev. 10: 2423-2437.
22. Kispert, A. and B.G. Herrmann. 1993. The Brachyury gene encodes a novel DNA binding protein. EMBO J. 12: 3211-3220.
23. Kleinberg, D. L. and C.B. Newman. 1986. The pituitary gland in primate mammary development: Evidence that prolactin is not essential. Ann. N.Y. Acad. Sci 464: 37-43.
24. Kolodner, R. 1996. Biochemistry and genetics of eukaryotic mismatch repair. Genes & Dev. 10: 1433-1442.
25. Kowalczykowski, S.C. 1991. Biochemistry of genetic recombination: Energetics and mechanism of DNA strand exchange. Annu. Rev. Biophys. Chem. 20: 539-575.
26. Kreidberg, J.A., H. Sariola, J.M. Loring, M. Maeda, J. Pelletier, D. Housman, and R. Jaenisch. 1993. WT-1 is required for early kidney development. Cell 74: 679-691.
27. Lee, E.Y.H.P., C.Y. Chang, N. Hu, Y.C.J. Wang, C.C. Lai, K. Herrup, W.H. Lee, and A. Bradley. 1992. Mice deficient for Rb are nonviable and show detects in neurogenesis and haematopoiesis. Nature 359: 288-294.
28. Levine, A. 1977. p53, the cellular gatekeeper for growth and division. Cell 88: 323-331.
29. Lim, D.S. and P. Hasty. 1996. A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53. Mol. Cell. Biol. 16: 7133-7143.
30. Liu, C.Y., A. Fleskennikin, S. Li, Y.Y. Zeng, and W.H. Lee. 1996. Inactivation of the mouse brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development. Genes & Dev. 10: 1835-1843.
31. Markin, D., F.P. Li, L.C. Strong, J.F. Fraumeni, Jr., C.E. Nelson, D.H. Kim, J. Kassel, M.A. Gryka, F.Z. Bischoff, M.A. Tainsky, and S.H. Freind. 1990. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasm. Science 250: 1233-1238.
32. Miki, Y., J. Swensen, D. Shattuckeidens, P.A. Futreal, K. Harshman, S. Tavtigian, Q.Y. Liu, C. Cochran, L.M. Bennett, W. Ding, R. Bell, J. Rosenthal, C. Hussey, T. Tran, M. Mcclure, C. Frye, T. Hattier, R. Phelps, A. Haugenstrano, H. Katcher, K. Yakumo, Z. Gholami, D. Shaffer, S. Stone, S. Bayer, C. Wray, R. Bogden, P. Dayananth, J. Ward, P. Tonin, S. Narod, P.K. Bristow, F.H. Norris, L. Helvering, P. Morrison, P. Rosteck, M. Lai, J.C. Barrett, C. Lewis, S. Neuhausen, L. Cannonalbright, D. Goldgar, R. Wiseman, A. Kamb, and M.H. Skolnick. 1994. A strong candidate for the breast and ovarian-cancer susceptibility gene BRCA1. Science 266: 66-71.
33. Miki, Y., T. Katagiri, F. Kasumi, T. Yoshimoto, and Y. Nakamura. 1996. Mutation analysis in the BRCA2 gene in primary breast cancers. Nature Genet. 13: 245-247.
34. Mishina, Y., A. Suzuki, N. Veno, and R.R. Behringer. 1995. BMPR encodes a type I bone morphogenetic protein-receptor that is essential for gastrulation during mouse embryogenesis. Genes & Dev. 9: 3027-3037.
35. Phelan, C.M., J.M. Lancaster, P. Tonin, C. Gumbs, C. Cochran, R. Carter, P. Ghadirian, C. Perret, R. Moslehi, F. Dion, M.C. Faucher, K. Dole, S. Karimi, W. Foulkes, H. Lounis, E. Warner, P. Goss, D. Anderson, C. Larsson, S.A. Narod, and P.A. Futreal. 1996. Mutation analysis of the BRCA2 gene in 49 site-specific breast-cancer families. Nature Genet. 13: 120-122.
36. Power, M.A. and P.P.L. Tam. 1993. Oncet of gastrulation, morphogenesis and somitogenesis in mouse embryos displaying compensatory growth. Anat. Embryol. 187: 493-504.
37. Radding, C.M. 1991. Helical interactions in homologous pairing and strand exchange driven by RecA protein. J. Biol. Chem. 266: 5355-5358.
38. Rajan, J.V., M. Wang, S.T. Marquis, and L.A. Chodosh, 1996. Brca2 is coordinately regulated with brca1 during proliferation and differentiation in mammary epithelial-cells. Proc. Natl. Acad. Sci. 93: 13078-13083.
39. Scully, R., J. Chen, A. Plug, Y. Xiao, D. Weaver, J. Feunteun, T. Ashley, and D.M. Livingston. 1977. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88: 265-275.
40. Siiteri, P.K., N. Simberg, and J. Murai. 1986. Estrogens and breast cancer. Ann. N. Y. Acad. Sci 464: 100-105.
41. Snow, M.H.L. 1977. Gastrulation in the mouse: Growth and regionalization of the epiblast. J. Embryol. Exp. Morphol. 42: 293-303.
42. Srivastava, S., Z. Zou, K. Pirollo, W. Blattner, and E.H. Chang. 1990. Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome. Nature 348: 747-749.
43. Sung, P. 1994. Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast Rad51 protein. Science 265: 1241-1243.
44. Sung, P. and D.L. Robberson. 1995. DNA strand exchange mediated by a Rad51-ssDNA nucleoprotein filament with polarity opposite to that of RecA. Cell 82: 453-461.
45. Tavtigian, S.V., J. Simard, J. Rommens, F. Couch, D. Shattuckeidens, S. Neuhausen, S. Merajver, S. Thorlacius, K. Offit, D. Stoppalyonnet, C. Belanger, R. Bell, S. Berry, R. Bogden, Q. Chen, T. Davis, M. Dumot, C. Frye, T. Hattier, S. Jammulapati, T. Janecki, P. Jiang, R. Kehrer, J.F. Leblanc, J.T. Mitchell, J. Mcarthurmorrison, K. Nguyn, Y. Peng, C. Samson, M. Schroeder, S.C. Snyder, L. Steele, M. Stringfellow, C. Stroup, B. Swedlund, J. Swensen, D. Teng, A. Thomas, T. Tran, T. Tran, M. Tranchant, J. Weaverfeldhaus, A. Wong, H. Shizuya, J.E. Eyfiord, L. Cannonalbright, F. Labrie, M.H. Skolnick, B. Weber, A. Kamb, and D.E. Goldgar. 1996. The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds. Nature Genet. 12: 333-337.
46. Thorlacius, S., L. Tryggbadottir, G.H. Olafsdottir, J.G. Jonasson, H.M. Ogmundsdottir, H. Tulinius, and J.E. Eyfjord. 1995. Linkage to BRCA2 region in hereditary male breast-cancer. Lancet 346: 544-545.
47. Thorlacius, S., G. Olafsdottir, L. Tryggvadottir, S. Neuhausen, J.G. Jonasson, S.V. Tavtigian, H. Tulinius, H.M. Ogmundsdottir, and J.E. Eyfjord. 1996. A single BRCA2 mutation in male and female breast-cancer families from Iceland with varied cancer phenotypes. Nature Genet. 13: 117-119.
48. Vaughn, J.P., F.D. Cirisano, G. Huper, A. Berchuck, P.A. Futreal, I.R. Marks, and J.D. Iglehart. 1996. Cell-cycle control of BRCA2. Cancer Res. 56: 4590-4594.
49. Wooster, R., G. Bignell, J. Lancaster, S. Swift, S. Seal, J. Mangion, N. Collins, S. Gregory, C. Gumbs, G. Micklem, R. Barfoot, R. Hamoudi, S. Patel, C. Rice, P. Biggs, Y. Hashim, A. Smith, F. Connor, A. Arason, J. Gudmundsson, D. Ficenec, D. Kelsell, D. Ford, P. Tonin, D.T. Bishop, N.K. Spurr, B. Ponder, R. Eeles, J. Peto, P. Devilee, C. Cornelisse, H. Lynch, S. Narod, G. Lenoir, V. Egilsson, R.B. Barkadottir, D.F. Easton, D.R. Bentley, P.A. Futreal, A. Ashworth, and M.R. Stratton. 1995. Identification of the breast-cancer susceptibility gene BRCA2. Nature 378: 789-792.