Hydrogen peroxide supports human and rat cytochrome P450 1A2-catalyzed 2-amino-3-methylimidazo[4,5-f]quinoline bioactivation to mutagenic metabolites: Significance of cytochrome P450 peroxygenase

Chemical Research in Toxicology

Volumn 10, Issue 5, 1997, Pages 582-588

  Anari, M Reza ^a   Josephy, P David ^b   Henry, Tracey ^b   O'Brien, Peter J ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF GUELPH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 METHYLIMIDAZO[4,5 F]QUINOLINE; 3 METHYLCHOLANTHRENE; AROMATIC AMINE; CYTOCHROME C PEROXIDASE; CYTOCHROME P450; CYTOCHROME P450 INHIBITOR; FLAVONE DERIVATIVE; HETEROCYCLIC AMINE; HYDROGEN PEROXIDE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FOOD COMPOSITION; GENOTOXICITY; HUMAN; HUMAN TISSUE; LIVER MICROSOME; MUTAGENICITY; NONHUMAN; OXIDATIVE STRESS; RAT; SALMONELLA TYPHIMURIUM;

ANIMALS; BIOTRANSFORMATION; CATALYSIS; CYTOCHROME P-450 CYP1A2; ENZYME ACTIVATION; HUMANS; HYDROGEN PEROXIDE; MALE; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; MUTAGENICITY TESTS; MUTAGENS; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; SALMONELLA TYPHIMURIUM;

ANIMALIA; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0030917089     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx960144k     Document Type: Article

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