Competition between cytochrome P-450 isozymes for NADPH-cytochrome P- 450 oxidoreductase affects drug metabolism

Journal of Pharmacology and Experimental Therapeutics

Volumn 289, Issue 2, 1999, Pages 661-667

  Li, Dongtao N ^a   Pritchard, Michael P ^a   Hanlon, Steven P ^a   Burchell, Brian ^a   Wolf, C Roland ^a   Friedberg, Thomas ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHOXYRESORUFIN O DEALKYLASE; BUFURALOL; BUFURALOL 1' HYDROXYLASE; COUMARIN 7 HYDROXYLASE; CYTOCHROME P450; CYTOCHROME P450 3A4; CYTOCHROME P450 ISOENZYME; DEBRISOQUINE 4 HYDROXYLASE; DRUG METABOLIZING ENZYME; LIVER ENZYME; NADPH CYTOCHROME P450 OXIDOREDUCTASE; TESTOSTERONE; UNCLASSIFIED DRUG;

COMPETITIVE INHIBITION; CONFERENCE PAPER; CONTROLLED STUDY; DRUG INHIBITION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME MECHANISM; ESCHERICHIA COLI; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIMULATION; STOICHIOMETRY;

ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; ENZYME INHIBITORS; ESCHERICHIA COLI; ETHANOLAMINES; HUMANS; ISOENZYMES; MEMBRANES; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; NADPH-FERRIHEMOPROTEIN REDUCTASE; PLASMIDS; RECOMBINANT PROTEINS; STEROID HYDROXYLASES; TESTOSTERONE;

EID: 0032954374     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

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