Peroxidases

Chemico-Biological Interactions

Volumn 129, Issue 1-2, 2000, Pages 113-139

  O'Brien, Peter J ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Chemical carcinogenesis; Hypochlorite; Idiosyncratic drug reactions; Peroxidase

Indexed keywords

4 AMINOQUINOLINE; CARBAMAZEPINE; CLOZAPINE; INDOMETACIN; LACTOPEROXIDASE; LOW DENSITY LIPOPROTEIN; MESALAZINE; MYELOPEROXIDASE; OXYGEN; PARACETAMOL; PEROXIDASE; PIPERANOMETOZINE; PROPYLTHIOURACIL; PROSTAGLANDIN SYNTHASE; TRIMETHOPRIM; XENOBIOTIC AGENT;

AGRANULOCYTOSIS; ARTICLE; ATHEROSCLEROSIS; CARCINOGENESIS; CATALYSIS; CHROMOSOMAL LOCALIZATION; DISEASE PREDISPOSITION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME POLYMORPHISM; GENE MUTATION; GENETIC POLYMORPHISM; HUMAN; INFLAMMATION; LIVER NECROSIS; MOLECULAR EVOLUTION; NONHUMAN; OXIDATION; PROTEIN FAMILY; REDUCTION; TERATOGENICITY;

ANIMALS; CHROMOSOME MAPPING; EVOLUTION, MOLECULAR; HUMANS; MAMMALS; METABOLIC DETOXICATION, DRUG; PEROXIDASES; SUBSTRATE SPECIFICITY; XENOBIOTICS;

EID: 0034527729     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(00)00201-5     Document Type: Article

References (139)

1. Peroxidases and catalases
2. Structure and evolution of peroxidases
3. Tyrosyl radicals and their role in hydroperoxide-dependent activation and inactivation of prostaglandin endoperoxidase synthase
4. Site-specific spin trapping of tyrosine radicals in the oxidation of metmyoglobin by hydrogen peroxide
5. Heme protein radicals: Formation, fate and biological consequences
6. Mechanisms of simultaneous iodination and coupling catalyzed by thyroid peroxidase
7. Mutational analysis of the role of the distal histidine and glutamate residues of prostaglandin- endoperoxide synthase-2 in peroxidase catalysis, hydroperoxide reduction and cyclooxygenase activation
8. X-ray crystal structure of canine myeloperoxidase at 3 Å resolution
9. Site-directed mutagenesis of human myeloperoxidase
10. Molecular evolution of thyroid peroxidase
11. Molecular cloning and characterization of a chromosome gene for human eosinophil peroxidase
12. Molecular cloning and characterization of the chromosomal gene for human lactoperoxidase
13. The murine eosinophil peroxidase maps to chromosome 11
14. An Alu element in the myeloperoxidase promoter contains a composite SPI-thyroid hormone-retinoic acid response element
15. Uterine peroxidases
16. Molecular genetics of peroxidase deficiency
17. Myeloperoxidase polymorphism is associated with gender specific risk of Alzheimer's disease
18. Substantially reduced risk of cancer of the aerodigestive tract in subjects with variant 463A of the myeloperoxidase gene
19. Cloning and sequence analysis of the human salivary peroxidase-encoding cDNA
20. Transcriptional regulation of thyroperoxydase gene
21. Immunoaffinity purification and cDNA cloning of human platelet prostaglandin endoperoxide synthase (cyclooxygenase)
22. Characterisation of the human gene (PTGS2) encoding prostaglandin-endoperoxide synthase 2
23. Characterisation of the genomic structure, chromosomal location and promoter of human prostaglandin H synthase-2 gene
24. Fish macrophages express a cyclo-oxygenase-2 homologue after activation
25. X-ray absorption and resonance raman spectroscopy of human myeloperoxidase at neutral and acid pH
26. Biochemical evidence for heme linkage through esters with Asp-93 and Glu-241 in human eosinophil peroxidase
27. The sulphonium ion linkage in myeloperoxidase
28. Kinetics and mechanism of the peroxidase-catalyzed iodination of tyrosine
29. Tyrosine 130 is an important outer ring donor for thyroxine formation in thyroglobulin
30. Purification of a novel flavoprotein involved in the thyroid NADPH oxidase
31. 2+-dependent and NADPH-dependent ferricyanide reductase
32. Thiocyanate and chloride as competing substrates for myeloperoxidase
33. Thiocyanate, a plausible physiological electron donor of gastric peroxidase
34. Reaction of myeloperoxidase compound I with chloride, bromide, iodide and thiocyanate
35. Thiocyanate and chloride as competing substrates for myeloperoxidase
36. The peroxidase system in human secretions
37. Oxidation of neutrophil glutathione and protein thiols by myeloperoxidase-derived hypochlorous acid
38. Peroxidase mediated bromination of unsaturated fatty acids to form bromohydrins
39. Molecular chlorine generated by the myeloperoxidase-hydrogen peroxide-chloride system of phagocytes converts low density lipoprotein cholesterol into a family of chlorinated sterols
40. Chlorination of tyrosyl residues in peptides by myeloperoxidase and human neutrophils
41. Human neutrophils employ chlorine gas as an oxidant during phagocytosis
42. Nutrition and metabolism of proteins
43. Mechanisms of oxidative damage by myeloperoxidase in atherosclerosis and other inflammatory disorders
44. Human phagocytes employ the myeloperoxidase-hydrogen peroxide system to synthesise dityrosine, trityrosine, pulcherosine and isodityrosine by a tyrosyl radical-dependent pathway
45. Myeloperoxidase-dependent generation of a tyrosine peroxide by neutrophils
46. p-Hydroxyphenylacetaldehyde is the major product of L-tyrosine oxidation by activated human phagocytes
47. Pathways for oxidation of low density lipoprotein by myeloperoxidase
48. Mechanism-based chemopreventive strategies against etoposide-induced acute myeloid leukemia
49. Myeloperoxidase-catalysed redox cycling of phenol promotes lipid peroxidation and thiol oxidation in HL-60 cells
50. Radical formation during the peroxidase catalysed metabolism of carcinogens and xenobiotics: The reactivity of these radicals with GSH, DNA and unsaturated lipid
51. Benzene and its phenolic metabolites produced oxidative DNA damage in HL-60 cells in vitro and in the bone marrow in vivo
52. An interaction of benzene metabolites reproduces the myelotoxicity associated with benzene exposure
53. Genotoxicity of two metabolites of benzene: Phenol and hydroquinone show strong synergistic effects in vivo
54. Peroxidase activation of hydroquinone results in the formation of DNA adducts in HL-60 cells and human bone marrow
55. The DNA adduct formed in HL-60 cells treated with hydroquinone
56. 2 in the formation of DNA adducts in HL-60 cells treated with benzene metabolites
57. Microsomal and peroxidase activation of 4-hydroxy-tamoxifen to form DNA adducts
58. Peroxidase-catalysed pro- versus antioxidant effects of 4-hydroxytamoxifen
59. Peroxidase-mediated irreversible binding of arylamine carcinogens to DNA in intact polymorphonuclear leukocytes activated by a tumor promoter
60. Generation of free radical intermediates from foreign compounds by neutrophil-derived oxidants
61. In vitro formation, disposition and toxicity of N-acetoxy-sulfamethoxazole, a potential mediator of sulfamethoxazole toxicity
62. N-Chlorination of sulfamethoxazole and dapsone by the myeloperoxidase system
63. Possible role of free radical formation in clozapine induced agranulocytosis
64. Clozapine is oxidised by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to the cells
65. Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine
66. A comparison of the covalent binding of clozapine and olanzapine to human neutrophils in vitro and in vivo
67. The metabolic formation of reactive intermediates from clozapine
68. Idiosyncratic drug reactions
69. Oxidation of aminopyrine by hypochlorite to a reactive dication: Possible implications for aminopyrine-induced agranulocytosis
70. Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalerial drugs
71. Oxidation of 5-aminosalicylic acid by hypochlorous acid to a reactive iminoquinone
72. Oxidation of a metabolite of indomethacin to reactive intermediates by activated neutrophils, hypochlorous acid and the myeloperoxidase system
73. Oxidation of diclofenac to reactive intermediates by neutrophils, myeloperoxidase and hypochlorous acid
74. Metabolism of trimethoprim to a reactive iminoquinone methide by activated human neutrophils and hepatic microsomes
75. Metabolism of vesnarinone by activated neutrophils
76. Oxidation of propylthiouracil to reactive metabolites by activated neutrophils: Implications for agranulocytosis
77. Antibodies to myeloperoxidase in propylthiouracil-induced autoimmune disease in the cat
78. Myeloperoxidase catalysed cooxidative metabolism of methimazole: Oxidation of glutathione and NADH by free radical intermediates
79. Covalent binding of carbamazepine oxidative metabolites to neutrophils
80. Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species
81. Acetaminophen hepatoxicity in tumor necrosis factor/lymphotoxin-alpha gene knockout mice
82. Formation of biological reactive intermediates by peroxidases: Halide mediated acetaminophen oxidation and cytotoxicity
83. Molecular mechanisms for the peroxidase catalysed activation of arylamine carcinogens to cytotoxic metabolites
84. Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice
85. Cytochrome P450 and peroxidase-dependent activation of procarbazine and iproniazid in mammalian cells
86. Assay of the human leukocyte enzymes myeloperoxidase and eosinophil peroxidase
87. Eosinophil peroxidase dependent hydroxyl radical generation by human eosinophils
88. Pulmonary immune cells in health and disease: The eosinophil leukocyte
89. Cytotoxic properties of human eosinophil peroxidase plus major basic protein
90. 3-bromotyrosine and 3,5-dibromotyrosine are major products of protein oxidation by eosinophil peroxidase: Potential markers for eosinophil-dependent tissue injury in vivo
91. Localization and origin of the intestinal peroxidase-effect of adrenal glucocorticoids
92. Ontogeny of peroxidase activity in epithelium and eosinophils of the mouse uterus
93. Activation of 4-hydroxytamoxifen and the tamoxifen derivative metabolite E, by uterine peroxidase to form DNA adducts
94. Nature of macromolecular binding of diethylstilbestrol to DNA and protein following oxidation by peroxidase/hydrogen peroxide
95. Molecular events in neutrophil transepithelial migration
96. Carcinogen-DNA adducts in human breast tissue
97. Aromatic DNA adducts in adjacent tissues of breast cancer patients: Clues to breast cancer etiology
98. Hemolytic anemia induced by dapsone transmitted through breast milk
99. Induction of repair synthesis of DNA in mammary and urinary bladder epithelial cells by N-hydroxy derivatives of carcinogenic arylamines
100. Genotoxicity of environmental agents in human mammary epithelial cells
101. Peroxidative metabolism of carcinogenic N-arylhydroxamic acids: Implications for tumorigenesis
102. Determination of benzo(a)pyrene and 7,12-dimethylbenzy(a)anthracene-DNA adducts formed in rat mammary glands
103. The metabolism of 17 beta-estradiol by lactoperoxidase: A possible source of oxidative stress in breast milk
104. The approach to understanding aromatic hydrocarbon carcinogenesis: The central role of radical cations in metabolic activation
105. Current concepts: Neutrophils and the activation of carcinogens in the breast and other organs
106. Possible mechanisms for PhlP-DNA formation in the mammary gland of female Sprague-Dawley rats
107. Lactoperoxidase-catalysed oxidation of indomethacin
108. Inhibition of thyroid peroxidase by dietary flavonoids
109. Porphyrin π-cation and protein radicals in peroxidase catalysis and inhibition by anti-thyroid chemicals
110. Mechanism for inhibition of thyroid peroxidase by leucomalachite green
111. Mechanism for the antithyroid action of minocyclin
112. Anti-thyroid isoflavones from soybean
113. Interaction between peroxidase and cyclooxygenase activities in prostaglandin-endoperoxide synthase
114. Coupling of the peroxidase and cyclooxygenase reactions of prostaglandin H synthase
115. The role of cyclooxygenase in inflammation, cancer and development
116. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
117. Localisation of prostaglandin H synthase isoenzymes in murine epidermal tumors
118. Aspirin-like molecules that covalently inactivate cyclooxygenase-2
119. Mechanism of action of nonsteroidal anti-inflammatory drugs
120. Co-oxygenation of organic substrates by the prostaglandin synthetase of sheep vesicular gland
121. The possible involvement of a peroxidase in prostaglandin biosynthesis
122. Reactions of prostaglandin endoperoxide synthase and its compound I with hydroperoxides
123. Prostaglandin H synthase and xenobiotic oxidation
124. The relationship between ionisation potential and prostaglandin H synthase-catalysed binding of aromatic hydrocarbons to DNA
125. The approach to understanding aromatic hydrocarbon carcinogenesis: The central role of radical cations in metabolic activation
126. Oxidation of (+)7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene by mouse keratinocytes
127. Peroxyl radical and cytochrome P450 metabolic activation in mouse skin in vitro and in vivo
128. Prostaglandin synthase-mediated metabolism of carcinogens and a potential role for peroxyl radicals as reactive intermediates
129. N′-(3′-monophospho-deoxyguanosin-8-yl)-N-acetylbenzid ine formation by peroxidative metabolism
130. Aspirin inhibition of N-(4-(5-nitro-2-furyl)-2-thiazolyl) formamide-induced lesions of the urinary bladder
131. DNA adducts formed by ring-oxidation of the carcinogen 2-naphthylamine with prostaglandin H synthase
132. Postlabelling analysis of adducts generated by peroxidase-mediated binding of N-hydroxy-4-acetylaminobiphenyl to DNA
133. Free radical intermediates of phenytion and related teratogens
134. Oxidative damage in chemical teratogenesis
135. Redox cycling of phenol induced oxidative stress in human epidermal keratinocytes
136. Detection of glutathione thiyl free radical catalysed by prostaglandin H synthase present in keratinocytes