In vitro biotransformation of the selective serotonin reuptake inhibitor citalopram, its enantiomers and demethylated metabolites by monoamine oxidase in rat and human brain preparations

Molecular Psychiatry

Volumn 7, Issue 2, 2002, Pages 181-188

  Kosel, M ^a,b   Gnerre, C ^c,d   Voirol, P ^a,e   Amey, M ^a   Rochat, B ^a,f   Bouras, C ^g   Testa, B ^c   Baumann, P ^a  

^a DEPT UNIV DE PSYCHIATRIE ADULTE   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

^d UNIVERSITY OF BASEL   (Switzerland)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f NOVARTIS PHARMA AG   (Switzerland)

^g GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Citalopram; Cytochrome P 450; Drug metabolism; Human brain; In vitro; Monoamine oxidase; Rat brain

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ACENOCOUMAROL; AMINE OXIDASE (FLAVIN CONTAINING); AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; ANTIDEPRESSANT AGENT; BUDESONIDE; CITALOPRAM; CITALOPRAM PROPIONATE; CLOMIPRAMINE; CYTOCHROME P450; DIAZEPAM; DOPAMINE; DRUG METABOLITE; ENALAPRIL; FLUOXETINE; FLURBIPROFEN; GLYCERYL TRINITRATE; HALOPERIDOL; HYDROGEN PEROXIDE; LORAZEPAM; MAPROTILINE; MONOAMINE OXIDASE INHIBITOR; NADROPARIN; PROPYLTHIOURACIL; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZOLPIDEM;

ANIMAL TISSUE; ARTICLE; BRAIN METABOLISM; BRAIN MICROSOME; BRAIN MITOCHONDRION; BRAIN REGION; BRAIN TISSUE; CEREBELLUM; CONTROLLED STUDY; DEMETHYLATION; DEPRESSION; DOSE RESPONSE; DRUG METABOLISM; DRUG TRANSFORMATION; ENANTIOMER; ENZYME ACTIVITY; ENZYME MECHANISM; FRONTAL CORTEX; HUMAN; HUMAN TISSUE; NONHUMAN; PRIORITY JOURNAL; PUTAMEN; RAT; STEREOCHEMISTRY; WHITE MATTER;

ANIMALS; BRAIN; CITALOPRAM; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; HYDROGEN PEROXIDE; METHYLATION; MITOCHONDRIA; MONOAMINE OXIDASE; RATS; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; STEREOISOMERISM;

EID: 85047695626     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000946     Document Type: Article

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