NADH cytochrome b5 reductase and cytochrome b5 catalyze the microsomal reduction of xenobiotic hydroxylamines and amidoximes in humans

Journal of Pharmacology and Experimental Therapeutics

Volumn 311, Issue 3, 2004, Pages 1171-1178

  Kurian, Joseph R ^a   Bajad, Sunil U ^a   Miller, Jackie L ^a   Chin, Nathaniel A ^a   Trepanier, Lauren A ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDOXIME DERIVATIVE; CYTOCHROME B5; CYTOCHROME B5 REDUCTASE; HYDROXYLAMINE; N HYDROXYDAPSONE; OXIME DERIVATIVE; SULFAMETHOXAZOLE; SULFAMETHOXAZOLE HYDROXYLAMINE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT; AMIDE; BLOCKING ANTIBODY; COMPLEMENTARY DNA; OXIME;

ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ELECTRON TRANSPORT; ENZYME ACTIVITY; ENZYME MECHANISM; FIBROBLAST; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; LIVER MICROSOME; METHEMOGLOBINEMIA; PHARMACOGENETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; REDUCTION KINETICS; STOICHIOMETRY; XENOBIOTIC METABOLISM; BIOSYNTHESIS; DRUG ANTAGONISM; GENETICS; IMMUNOHISTOCHEMISTRY; KINETICS; METABOLISM; OXIDATION REDUCTION REACTION;

AMIDES; ANTIBODIES, BLOCKING; CYTOCHROME-B(5) REDUCTASE; CYTOCHROMES B5; DNA, COMPLEMENTARY; FIBROBLASTS; HUMANS; HYDROXYLAMINES; IMMUNOHISTOCHEMISTRY; KINETICS; MICROSOMES, LIVER; OXIDATION-REDUCTION; OXIMES; XENOBIOTICS;

EID: 10044230408     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.072389     Document Type: Article

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