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Volumn 5, Issue 5, 1999, Pages 582-585

Free radical-mediated oxidative dna damage in the mechanism of thalidomide teratogenicity

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; FREE RADICAL; HORSERADISH PEROXIDASE; N TERT BUTYL ALPHA PHENYLNITRONE; PROSTAGLANDIN SYNTHASE; THALIDOMIDE;

EID: 0032920883     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/8466     Document Type: Article
Times cited : (441)

References (25)
  • 1
    • 0023789803 scopus 로고
    • A short history of thalidomide embryopathy
    • Lenz, W. A short history of thalidomide embryopathy. Teratology 38, 203-15 (1988).
    • (1988) Teratology , vol.38 , pp. 203-215
    • Lenz, W.1
  • 2
    • 0030299068 scopus 로고    scopus 로고
    • Thalidomide, a current teratogen in South America
    • Castilla, E.E. et al. Thalidomide, a current teratogen in South America. Teratology 54, 273-7 (1996).
    • (1996) Teratology , vol.54 , pp. 273-277
    • Castilla, E.E.1
  • 3
    • 0023729816 scopus 로고
    • Proposed mechanisms of action in thalidomide embryopathy
    • Stephens, T.D. Proposed mechanisms of action in thalidomide embryopathy. Teratology 38, 229-39 (1988).
    • (1988) Teratology , vol.38 , pp. 229-239
    • Stephens, T.D.1
  • 4
    • 0029968112 scopus 로고    scopus 로고
    • Biochemical toxicology of chemical teratogenesis
    • Wells, P.G. & Winn, L.M. Biochemical toxicology of chemical teratogenesis. Crit. Rev. Biochem. Mol. Biol. 31, 1-40 (1996).
    • (1996) Crit. Rev. Biochem. Mol. Biol. , vol.31 , pp. 1-40
    • Wells, P.G.1    Winn, L.M.2
  • 5
    • 0032566524 scopus 로고    scopus 로고
    • Free radical intermediates of phenytoin and related teratogens. Prostaglandin H synthase-catalyzed bioactivation, electron paramagnetic resonance spectrometry, and photochemical product analysis
    • Parman, T., Chen, G. & Wells, P.G. Free radical intermediates of phenytoin and related teratogens. Prostaglandin H synthase-catalyzed bioactivation, electron paramagnetic resonance spectrometry, and photochemical product analysis. J. Biol. Chem. 273, 25079-88 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 25079-25088
    • Parman, T.1    Chen, G.2    Wells, P.G.3
  • 6
    • 0028980410 scopus 로고
    • DNA oxidation as a potential molecular mechanism mediating drug-induced birth defects: Phenytoin and structurally related teratogens initiate the formation of 8-hydroxy-2′-deoxyguanosine in vitro and in vivo in murine maternal hepatic and embryonic tissues
    • Liu, L. & Wells, P.G. DNA oxidation as a potential molecular mechanism mediating drug-induced birth defects: phenytoin and structurally related teratogens initiate the formation of 8-hydroxy-2′-deoxyguanosine in vitro and in vivo in murine maternal hepatic and embryonic tissues. Free Radic. Biol. Med. 19, 639-48 (1995).
    • (1995) Free Radic. Biol. Med. , vol.19 , pp. 639-648
    • Liu, L.1    Wells, P.G.2
  • 7
    • 0000754891 scopus 로고
    • Extracellular thiol-disulfide status reflecting chemical toxicity mediated via oxidative stress: Validation with paraquat and t-butylhydroperoxide, and implications for phenytoin and thalidomide teratogenicity
    • Arlen, R.R. & Wells, P.G. Extracellular thiol-disulfide status reflecting chemical toxicity mediated via oxidative stress: Validation with paraquat and t-butylhydroperoxide, and implications for phenytoin and thalidomide teratogenicity. FASEB J. 4, A608 (1990).
    • (1990) FASEB J. , vol.4
    • Arlen, R.R.1    Wells, P.G.2
  • 8
    • 0030434509 scopus 로고    scopus 로고
    • Inhibition of thalidomide teratogenicity by acetylsalicylic acid: Evidence for prostaglandin H synthase-catalyzed bioactivation of thalidomide to a teratogenic reactive intermediate
    • Arlen, R.R. & Wells, P.G. Inhibition of thalidomide teratogenicity by acetylsalicylic acid: evidence for prostaglandin H synthase-catalyzed bioactivation of thalidomide to a teratogenic reactive intermediate. J. Pharm. Exp. Ther. 277, 1649-58 (1996).
    • (1996) J. Pharm. Exp. Ther. , vol.277 , pp. 1649-1658
    • Arlen, R.R.1    Wells, P.G.2
  • 10
    • 0031036750 scopus 로고    scopus 로고
    • Evidence for embryonic prostaglandin H synthase-catalyzed bioactivation and reactive oxygen species-mediated oxidation of cellular macromolecules in phenytoin and benzo[a]pyrene teratogenesis
    • Winn, L.M. & Wells, P.G. Evidence for embryonic prostaglandin H synthase-catalyzed bioactivation and reactive oxygen species-mediated oxidation of cellular macromolecules in phenytoin and benzo[a]pyrene teratogenesis. Free Radic. Biol. Med. 22, 607-21 (1997).
    • (1997) Free Radic. Biol. Med. , vol.22 , pp. 607-621
    • Winn, L.M.1    Wells, P.G.2
  • 11
    • 0030047170 scopus 로고    scopus 로고
    • Phenytoin-initiated hydroxyl radical formation: Characterization by enhanced salicylate hydroxylation
    • Kim, P.M. & Wells, P.G. Phenytoin-initiated hydroxyl radical formation: characterization by enhanced salicylate hydroxylation. Mol. Pharm. 49, 172-81 (1996)
    • (1996) Mol. Pharm. , vol.49 , pp. 172-181
    • Kim, P.M.1    Wells, P.G.2
  • 12
    • 0026592966 scopus 로고
    • 8-hydroxyguanine, an abundant form of oxidative DNA damage, causes G - T and A - C substitutions
    • Cheng, K.C., Cahill, D.S., Kasai, H., Nishimura, S. & Loeb, L.A. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G - T and A - C substitutions. J. Biol. Chem. 267, 166-72 (1992).
    • (1992) J. Biol. Chem. , vol.267 , pp. 166-172
    • Cheng, K.C.1    Cahill, D.S.2    Kasai, H.3    Nishimura, S.4    Loeb, L.A.5
  • 13
    • 17644432448 scopus 로고    scopus 로고
    • Thalidomide: Lack of mutagenic activity across phyla and genetic endpoints
    • Ashby, J. et al. Thalidomide: lack of mutagenic activity across phyla and genetic endpoints. Mutat. Res. 396, 45-46 (1997).
    • (1997) Mutat. Res. , vol.396 , pp. 45-46
    • Ashby, J.1
  • 14
    • 0013809449 scopus 로고
    • The metabolism of thalidomide: The fate of thalidomide and some of its hydrolysis products in various species
    • Schumacher, H., Smith, R.L. & Williams, R.T. The metabolism of thalidomide: The fate of thalidomide and some of its hydrolysis products in various species. Br. J. Phamacol. 25, 338-351 (1965).
    • (1965) Br. J. Phamacol. , vol.25 , pp. 338-351
    • Schumacher, H.1    Smith, R.L.2    Williams, R.T.3
  • 16
    • 0030819981 scopus 로고    scopus 로고
    • Interaction of [glutarimide-2-14C]-thalidomide with rat embryonic DNA in vivo
    • Huang, P.H. & McBride, W.G. Interaction of [glutarimide-2-14C]-thalidomide with rat embryonic DNA in vivo [see comments]. Teratogen. Carcinogen. Mutagen. 17, 1-5 (1997).
    • (1997) Teratogen. Carcinogen. Mutagen. , vol.17 , pp. 1-5
    • Huang, P.H.1    McBride, W.G.2
  • 17
    • 0030610287 scopus 로고    scopus 로고
    • Never-ending tales of the mode of the teratogenic action of thalidomide
    • Neubert, D. Never-ending tales of the mode of the teratogenic action of thalidomide. Teratogen. Carcinogen. Mutagen. 17, i-ii (1997).
    • (1997) Teratogen. Carcinogen. Mutagen. , vol.17
    • Neubert, D.1
  • 18
    • 0022625689 scopus 로고
    • Teratogen metabolism: Thalidomide activation is mediated by cytochrome P-450
    • Braun, A.G., Harding, F.A. & Weinreb, S.L. Teratogen metabolism: thalidomide activation is mediated by cytochrome P-450. Toxicol. Appl. Pharm. 82, 175-9 (1986).
    • (1986) Toxicol. Appl. Pharm. , vol.82 , pp. 175-179
    • Braun, A.G.1    Harding, F.A.2    Weinreb, S.L.3
  • 19
    • 0025903898 scopus 로고
    • Induction of morphological differentiation in the human leukemic cell line K562 by exposure to thalidomide metabolites
    • Hatfill, S.J., Fester, E.D., de Beer, D.P. & Bohm, L. Induction of morphological differentiation in the human leukemic cell line K562 by exposure to thalidomide metabolites. Leukemia Res. 15, 129-36 (1991).
    • (1991) Leukemia Res. , vol.15 , pp. 129-136
    • Hatfill, S.J.1    Fester, E.D.2    De Beer, D.P.3    Bohm, L.4
  • 20
    • 0015463570 scopus 로고
    • Chemical structure and teratogenic properties 3. A review of available data on structure-activity relationships and mechanism of action of thalidomide analogues
    • Jonsson, N.A. Chemical structure and teratogenic properties 3. A review of available data on structure-activity relationships and mechanism of action of thalidomide analogues. Acta Pharma. Suec. 9, 521-42 (1972).
    • (1972) Acta Pharma. Suec. , vol.9 , pp. 521-542
    • Jonsson, N.A.1
  • 21
    • 0014418488 scopus 로고
    • Relationship between teratogenicity and structure in the thalidomide field
    • Wuest, H.M., Fox, R.R. & Crary, D.D. Relationship between teratogenicity and structure in the thalidomide field. Experientia 24, 993-4 (1968).
    • (1968) Experientia , vol.24 , pp. 993-994
    • Wuest, H.M.1    Fox, R.R.2    Crary, D.D.3
  • 22
    • 0028270821 scopus 로고
    • Cytochrome P450 in human fetal liver: Significance and fetal-specific expression
    • Kitada, M. & Kamataki, T. Cytochrome P450 in human fetal liver: significance and fetal-specific expression. Drug Metab. Rev. 26, 305-23 (1994).
    • (1994) Drug Metab. Rev. , vol.26 , pp. 305-323
    • Kitada, M.1    Kamataki, T.2
  • 23
    • 0025139365 scopus 로고
    • Characterization of a novel cytochrome P450 from the transformable cell line, C3H/10T1/2
    • Pottenger, L.H. & Jefcoate, C.R. Characterization of a novel cytochrome P450 from the transformable cell line, C3H/10T1/2. Carcinogenesis 11, 321-7 (1990).
    • (1990) Carcinogenesis , vol.11 , pp. 321-327
    • Pottenger, L.H.1    Jefcoate, C.R.2
  • 24
    • 0028149573 scopus 로고
    • Functional cytochrome P4503A isoforms in human embryonic tissues: Expression during organogenesis
    • Yang, H.Y., Lee, Q.P., Rettie, A.E. & Juchau, M.R. Functional cytochrome P4503A isoforms in human embryonic tissues: expression during organogenesis. Mol. Pharmacol. 46, 922-8 (1994).
    • (1994) Mol. Pharmacol. , vol.46 , pp. 922-928
    • Yang, H.Y.1    Lee, Q.P.2    Rettie, A.E.3    Juchau, M.R.4
  • 25
    • 0032899624 scopus 로고    scopus 로고
    • Maternal administration of superoxide dismutase and catalase in phenytoin teratogenicity
    • Winn, L.M. & Wells, P.G. Maternal administration of superoxide dismutase and catalase in phenytoin teratogenicity. Free Radic. Biol. Med. 26, 266-74 (1999).
    • (1999) Free Radic. Biol. Med. , vol.26 , pp. 266-274
    • Winn, L.M.1    Wells, P.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.