Role of NAD(P)H:quinone oxidoreductase 1 (DT diaphorase) in protection against quinone toxicity

Biochemical Pharmacology

Volumn 60, Issue 2, 2000, Pages 207-214

  Joseph, Pius ^a   Long II, Delwin J ^a   Klein Szanto, Andres J P ^b   Jaiswal, Anil K ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b FOX CHASE CANCER CENTER   (United States)

Author keywords

6 quinone; Benzo a pyrene 3; Benzoquinone; Carcinogenicity; CHO cells; Menadione; NAD(P)H:quinone oxidoreductase 1; NQO1 mice; Toxicity

Indexed keywords

BENZO[A]PYRENE 3,6 DIONE; BENZO[A]PYRENE DERIVATIVE; BENZOQUINONE; COMPLEMENTARY DNA; CYTOCHROME P450 REDUCTASE; MENADIONE; OXIDOREDUCTASE; PHORBOL 13 ACETATE 12 MYRISTATE; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENICITY; CELL PROTECTION; CHO CELL; CONTROLLED STUDY; CYTOTOXICITY; DNA ADDUCT; DNA DAMAGE; KNOCKOUT MOUSE; LIPID PEROXIDATION; LIVER; MEMBRANE DAMAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN CARCINOGENESIS; SKIN PAPILLOMA;

ANIMALS; BENZOPYRENES; BENZOQUINONES; CARCINOGENICITY TESTS; CELL SURVIVAL; CHO CELLS; CRICETINAE; FEMALE; MALE; MICE; MICE, INBRED C57BL; NAD(P)H DEHYDROGENASE (QUINONE); PROTECTIVE AGENTS; VITAMIN K;

EID: 0034662467     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00321-X     Document Type: Article

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