메뉴 건너뛰기




Volumn 32, Issue 3-4, 2000, Pages 339-361

The human CYP3A subfamily: Practical considerations

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A; DRUG;

EID: 0034541821     PISSN: 03602532     EISSN: None     Source Type: Journal    
DOI: 10.1081/DMR-100102338     Document Type: Conference Paper
Times cited : (207)

References (105)
  • 1
    • 0026750647 scopus 로고
    • The human hepatic cytochromes P450 involved in drug metabolism
    • S. A. Wrighton and J. C. Stevens, The human hepatic cytochromes P450 involved in drug metabolism, Crit. Rev. Toxicol., 22, 1-21 (1992).
    • (1992) Crit. Rev. Toxicol. , vol.22 , pp. 1-21
    • Wrighton, S.A.1    Stevens, J.C.2
  • 2
    • 0002888510 scopus 로고
    • Human cytochrome P450 enzymes
    • (P. R. Ortiz de Montellano, ed.), Plenum Press, New York
    • F. P. Guengerich, Human cytochrome P450 enzymes, in Cytochrome P450, 2nd ed. (P. R. Ortiz de Montellano, ed.), Plenum Press, New York, 1995, pp. 473-535.
    • (1995) Cytochrome P450, 2nd Ed. , pp. 473-535
    • Guengerich, F.P.1
  • 3
    • 0029584276 scopus 로고
    • Substrates of human hepatic cytochrome P450 3A4
    • A. P. Li, D. L. Kaminski, and A. Rasmussen, Substrates of human hepatic cytochrome P450 3A4, Toxicology, 104, 1-8 (1995).
    • (1995) Toxicology , vol.104 , pp. 1-8
    • Li, A.P.1    Kaminski, D.L.2    Rasmussen, A.3
  • 4
    • 0030022629 scopus 로고    scopus 로고
    • An overview of current cytochrome P450 technology for assessing the safety and efficacy of new materials
    • A. Parkinson, An overview of current cytochrome P450 technology for assessing the safety and efficacy of new materials, Toxicol. Pathol., 24, 45-57 (1996).
    • (1996) Toxicol. Pathol. , vol.24 , pp. 45-57
    • Parkinson, A.1
  • 5
    • 0002769936 scopus 로고    scopus 로고
    • Pharmacokinetics
    • (J. G. Hardman, L. E. Limbird, P. B. Molinoff, R. W. Ruddon, and A. G. Gilman, eds.), McGraw-Hill, New York
    • L. Z. Benet, Pharmacokinetics, in Goodman and Gilman's: The Pharmacological Basis of Therapeutics, 9th ed. (J. G. Hardman, L. E. Limbird, P. B. Molinoff, R. W. Ruddon, and A. G. Gilman, eds.), McGraw-Hill, New York, 1996, p. 14.
    • (1996) Goodman and Gilman's: The Pharmacological Basis of Therapeutics, 9th Ed. , pp. 14
    • Benet, L.Z.1
  • 8
    • 0022998708 scopus 로고
    • Characterization of rat and human liver microsomal cytochrome P450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism
    • F. P. Guengerich, M. V. Martin. P. H. Beaune, P. Kremers, T. Wolff, and D. J. Waxman, Characterization of rat and human liver microsomal cytochrome P450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism, J. Biol. Chem., 26, 5051-5060 (1986).
    • (1986) J. Biol. Chem. , vol.26 , pp. 5051-5060
    • Guengerich, F.P.1    Martin, M.V.2    Beaune, P.H.3    Kremers, P.4    Wolff, T.5    Waxman, D.J.6
  • 11
    • 0001313948 scopus 로고
    • Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase
    • P. H. Beaune, D. R. Umbenhauer, R. W. Bork, R. S. Lloyd, and F. P. Guengerich, Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase, Proc. Natl. Acad. Sci. USA, 83, 8064-8068 (1986).
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 8064-8068
    • Beaune, P.H.1    Umbenhauer, D.R.2    Bork, R.W.3    Lloyd, R.S.4    Guengerich, F.P.5
  • 13
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • T. Shimada, H. Yamazaki, M. Mimura, Y. Inui, and F. P. Guengerich, Interindividual variations in human liver cytochrome P450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians, J. Pharmacol. Exp. Ther., 270, 414-423 (1994).
    • (1994) J. Pharmacol. Exp. Ther. , vol.270 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3    Inui, Y.4    Guengerich, F.P.5
  • 14
    • 0025184340 scopus 로고
    • Mechanism-based inactivation of human liver cytochrome P450 IIIA4 by gestodene
    • F. P. Guengerich, Mechanism-based inactivation of human liver cytochrome P450 IIIA4 by gestodene, Chem. Res. Toxicol., 3, 363-371 (1990).
    • (1990) Chem. Res. Toxicol. , vol.3 , pp. 363-371
    • Guengerich, F.P.1
  • 15
    • 0021355534 scopus 로고
    • Induction of cytochrome P-450 by glucocorticoids in rat liver. I. Evidence
    • E. G. Schuetz, S. A. Wrighton, J. L. Barwick, and P. S. Guzelian, Induction of cytochrome P-450 by glucocorticoids in rat liver. I. Evidence, J. Biol. Chem., 259, 1999-2006 (1984).
    • (1984) J. Biol. Chem. , vol.259 , pp. 1999-2006
    • Schuetz, E.G.1    Wrighton, S.A.2    Barwick, J.L.3    Guzelian, P.S.4
  • 16
    • 0021361026 scopus 로고
    • Induction of cytochrome P-450 by glucocorticoids in rat liver. II. Evidence that glucocorticoids regulate induction of cytochrome P-450 by a non-classical mechanism
    • E. G. Scheutz and P. S. Guzelian, Induction of cytochrome P-450 by glucocorticoids in rat liver. II. Evidence that glucocorticoids regulate induction of cytochrome P-450 by a non-classical mechanism, J. Biol. Chem., 259, 2007-2012 (1984).
    • (1984) J. Biol. Chem. , vol.259 , pp. 2007-2012
    • Scheutz, E.G.1    Guzelian, P.S.2
  • 17
    • 0028917364 scopus 로고
    • Transcriptional elements directing a liver-specific expression of P450/6betaA (CYP3A2) gene-encoding testosterone 6beta-hydroxylase
    • M. Miyata, K. Nagata, Y. Yamazoe, and R. Kato, Transcriptional elements directing a liver-specific expression of P450/6betaA (CYP3A2) gene-encoding testosterone 6beta-hydroxylase, Arch. Biochem. Biophys., 318, 71-79 (1995).
    • (1995) Arch. Biochem. Biophys. , vol.318 , pp. 71-79
    • Miyata, M.1    Nagata, K.2    Yamazoe, Y.3    Kato, R.4
  • 18
    • 0028789188 scopus 로고
    • A novel cis-element in a liver cytochrome P450 3A gene confers synergistic induction by glucocorticoids plus antiglucocorticoids
    • L. C. Quattrochi, A. S. Mills, J. L. Barwick, C. B. Yockey, and P. S. Guzelian, A novel cis-element in a liver cytochrome P450 3A gene confers synergistic induction by glucocorticoids plus antiglucocorticoids, J. Biol. Chem., 270, 28,917-28,923 (1995).
    • (1995) J. Biol. Chem. , vol.270
    • Quattrochi, L.C.1    Mills, A.S.2    Barwick, J.L.3    Yockey, C.B.4    Guzelian, P.S.5
  • 19
    • 0029906308 scopus 로고    scopus 로고
    • Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif
    • J. M. Huss, S. I. Wang, A. Astrom, P. McQuiddy, and C. B. Kasper, Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif. Proc. Natl. Acad. Sci. USA, 93, 4666-4670 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 4666-4670
    • Huss, J.M.1    Wang, S.I.2    Astrom, A.3    McQuiddy, P.4    Kasper, C.B.5
  • 21
    • 0031914323 scopus 로고    scopus 로고
    • The antibiotic rifampicin is a nonsteroidal ligand and activator of the human glucocorticoid receptor
    • C. Calleja, J. M. Pascussi, J. C. Mani, P. Maurel, and M. J. Vilaren, The antibiotic rifampicin is a nonsteroidal ligand and activator of the human glucocorticoid receptor, Nature Med., 4, 92-96 (1998).
    • (1998) Nature Med. , vol.4 , pp. 92-96
    • Calleja, C.1    Pascussi, J.M.2    Mani, J.C.3    Maurel, P.4    Vilaren, M.J.5
  • 22
    • 0024400702 scopus 로고
    • Identification of a polymorphically expressed member of the human cytochrome P450III family
    • S. A. Wrighton, B. J. Ring, P. B. Watkins, and M. VandenBranden, Identification of a polymorphically expressed member of the human cytochrome P450III family, Molec. Pharmacol., 36, 97-105 (1989).
    • (1989) Molec. Pharmacol. , vol.36 , pp. 97-105
    • Wrighton, S.A.1    Ring, B.J.2    Watkins, P.B.3    VandenBranden, M.4
  • 23
    • 0024430299 scopus 로고
    • Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver
    • J. D. Schuetz, D. T. Molowa, and P. S. Guzelian, Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver, Arch. Biochem. Biophys., 274, 355-365 (1989).
    • (1989) Arch. Biochem. Biophys. , vol.274 , pp. 355-365
    • Schuetz, J.D.1    Molowa, D.T.2    Guzelian, P.S.3
  • 24
    • 0342468270 scopus 로고    scopus 로고
    • Detection of a CYP3A5 allelic variant: A candidate for the polymorphic expression of the protein?
    • Y. Jounaidi, V. Hyrailles, L. Gervot, and P. Maurel, Detection of a CYP3A5 allelic variant: A candidate for the polymorphic expression of the protein? Biochem. Biophys. Res. Commun., 221, 466-470 (1996).
    • (1996) Biochem. Biophys. Res. Commun. , vol.221 , pp. 466-470
    • Jounaidi, Y.1    Hyrailles, V.2    Gervot, L.3    Maurel, P.4
  • 25
    • 0030059885 scopus 로고    scopus 로고
    • Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells
    • J. D. Schuetz, E. G. Schuetz, J. V. Thottassery, P. S. Guzelian, S. Strom, and D. Sun, Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells, Molec. Pharmacol., 49, 63-72 (1996).
    • (1996) Molec. Pharmacol. , vol.49 , pp. 63-72
    • Schuetz, J.D.1    Schuetz, E.G.2    Thottassery, J.V.3    Guzelian, P.S.4    Strom, S.5    Sun, D.6
  • 27
    • 0028234586 scopus 로고
    • Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A subfamily
    • J. C. Gorski, S. D. Hall, D. R. Jones, M. VandenBranden, and S. A. Wrighton, Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A subfamily, Biochem. Pharmacol., 47, 1643-1653 (1994).
    • (1994) Biochem. Pharmacol. , vol.47 , pp. 1643-1653
    • Gorski, J.C.1    Hall, S.D.2    Jones, D.R.3    Vandenbranden, M.4    Wrighton, S.A.5
  • 28
    • 0028270821 scopus 로고
    • Cytochrome P450 in human fetal liver: Significance and fetal-specific expression
    • M. Kitada and T. Kamataki, Cytochrome P450 in human fetal liver: Significance and fetal-specific expression, Drug Metab. Rev., 26, 305-323 (1994).
    • (1994) Drug Metab. Rev. , vol.26 , pp. 305-323
    • Kitada, M.1    Kamataki, T.2
  • 30
    • 0024534194 scopus 로고
    • Isolation and characterization of human fetal liver cytochrome P450HLp2: A third member of the P450III gene family
    • S. A. Wrighton and M. VandenBranden, Isolation and characterization of human fetal liver cytochrome P450HLp2: A third member of the P450III gene family, Arch. Biochem. Biophys., 268, 144-151 (1989).
    • (1989) Arch. Biochem. Biophys. , vol.268 , pp. 144-151
    • Wrighton, S.A.1    VandenBranden, M.2
  • 31
    • 0025903396 scopus 로고
    • Four forms of cytochrome P-450 in human fetal liver: Purification and their capacity of activate promutagens
    • K. Kitada, M. Taneda, K. Itahashi, and T. Kamataki, Four forms of cytochrome P-450 in human fetal liver: Purification and their capacity of activate promutagens, Jpn. J. Cancer Res., 82, 426-432 (1991).
    • (1991) Jpn. J. Cancer Res. , vol.82 , pp. 426-432
    • Kitada, K.1    Taneda, M.2    Itahashi, K.3    Kamataki, T.4
  • 32
    • 0024535542 scopus 로고
    • Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450
    • M. Komori, K. Nishio, H. Ohi, M. Kitada, and T. Kamataki, Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450, J. Biochem., 105, 161-163 (1989).
    • (1989) J. Biochem. , vol.105 , pp. 161-163
    • Komori, M.1    Nishio, K.2    Ohi, H.3    Kitada, M.4    Kamataki, T.5
  • 33
    • 0023896017 scopus 로고
    • Identification of a cytochrome P-450 in human fetal liver related to glucocorticoid-inducible cytochrome P450HLp in the adult
    • S. A. Wrighton, D. T. Molowa, and P. S. Guzelian, Identification of a cytochrome P-450 in human fetal liver related to glucocorticoid-inducible cytochrome P450HLp in the adult, Biochem. Pharmacol., 37, 3053-3055 (1988).
    • (1988) Biochem. Pharmacol. , vol.37 , pp. 3053-3055
    • Wrighton, S.A.1    Molowa, D.T.2    Guzelian, P.S.3
  • 34
    • 0023200455 scopus 로고
    • P-450 HFLa, a form of cytochrome P-450 purified from human fetal livers, is the 16alpha-hydroxylase of dehydroepiandrosterone 3-sulfate
    • M. Kitada, T. Kamataki, K. Itahashi, T. Rikihisa, and Y. Kanakubo, P-450 HFLa, a form of cytochrome P-450 purified from human fetal livers, is the 16alpha-hydroxylase of dehydroepiandrosterone 3-sulfate, J. Biol. Chem., 262, 13,534-13,537 (1987).
    • (1987) J. Biol. Chem. , vol.262
    • Kitada, M.1    Kamataki, T.2    Itahashi, K.3    Rikihisa, T.4    Kanakubo, Y.5
  • 35
    • 0026520777 scopus 로고
    • Paradoxical transcriptional activation of rat liver cytochrome P450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: Analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes
    • H-J. Burger, J. D. Schuetz, E. G. Schuetz, and P. S. Guzelian, Paradoxical transcriptional activation of rat liver cytochrome P450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: Analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes, Proc. Natl. Acad. Sci. USA, 89, 2145-2149 (1992).
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 2145-2149
    • Burger, H.-J.1    Schuetz, J.D.2    Schuetz, E.G.3    Guzelian, P.S.4
  • 36
    • 0029906308 scopus 로고    scopus 로고
    • Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif
    • J. M. Hus, S. I. Wang, A. Astrom, P. McQuiddy, and C. B. Kasper, Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif, Proc. Natl. Acad. Sci. USA, 93, 4666-4670 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 4666-4670
    • Hus, J.M.1    Wang, S.I.2    Astrom, A.3    McQuiddy, P.4    Kasper, C.B.5
  • 37
    • 0032169485 scopus 로고    scopus 로고
    • The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
    • J. M. Lehmann, D. D. McKee, M. A. Watson, T. M. Wilson, J. T. Moore, and S. A. Kliewer, The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions, J. Clin. Invest., 102, 1-8 (1998).
    • (1998) J. Clin. Invest. , vol.102 , pp. 1-8
    • Lehmann, J.M.1    McKee, D.D.2    Watson, M.A.3    Wilson, T.M.4    Moore, J.T.5    Kliewer, S.A.6
  • 39
    • 13144260727 scopus 로고    scopus 로고
    • Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction
    • G. Bertilsson, J. Heidrich, K. Svensson, et al., Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction, Proc. Natl. Acad. Sci. USA, 95, 12,208-12,213 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95
    • Bertilsson, G.1    Heidrich, J.2    Svensson, K.3
  • 40
    • 0032437889 scopus 로고    scopus 로고
    • Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone utilize the nuclear hormone receptor PXR to activate the cytochrome P4503A23 hormone response element
    • E. G. Schuetz, C. Brimer, and J. D. Schuetz, Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone utilize the nuclear hormone receptor PXR to activate the cytochrome P4503A23 hormone response element, Molec. Pharm., 54, 1113-1117 (1998).
    • (1998) Molec. Pharm. , vol.54 , pp. 1113-1117
    • Schuetz, E.G.1    Brimer, C.2    Schuetz, J.D.3
  • 42
    • 0029562554 scopus 로고
    • The RXR heterodimers and orphan receptors
    • D. J. Mangelsdorf and R. M. Evans, The RXR heterodimers and orphan receptors, Cell, 83, 841-850 (1995).
    • (1995) Cell , vol.83 , pp. 841-850
    • Mangelsdorf, D.J.1    Evans, R.M.2
  • 43
    • 0030945754 scopus 로고    scopus 로고
    • Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1,2,5-dihydroxyvitamin D3
    • P. Schmiedlin-Ren, K. E. Thummel, J. M. Fisher, M. F. Paine, K. S. Lown, and P. B. Watkins, Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1,2,5-dihydroxyvitamin D3, Molec. Pharm., 51, 741-754 (1997).
    • (1997) Molec. Pharm. , vol.51 , pp. 741-754
    • Schmiedlin-Ren, P.1    Thummel, K.E.2    Fisher, J.M.3    Paine, M.F.4    Lown, K.S.5    Watkins, P.B.6
  • 44
    • 0033199499 scopus 로고    scopus 로고
    • P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR, and PPAR
    • D. J. Waxman, P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR, and PPAR, Arch. Biochem. Biophys., 369, 11-23 (1999).
    • (1999) Arch. Biochem. Biophys. , vol.369 , pp. 11-23
    • Waxman, D.J.1
  • 45
    • 0032707445 scopus 로고    scopus 로고
    • Moleclar mechanisms of cytochrome P-450 induction by xenobiotics: An expanded role for nuclear hormone receptors
    • U. Savas, K. J. Griffin, and E. F. Johnson, Moleclar mechanisms of cytochrome P-450 induction by xenobiotics: An expanded role for nuclear hormone receptors, Molec. Pharm., 56, 851-857 (1999).
    • (1999) Molec. Pharm. , vol.56 , pp. 851-857
    • Savas, U.1    Griffin, K.J.2    Johnson, E.F.3
  • 46
    • 0034012654 scopus 로고    scopus 로고
    • The glucocorticoid receptor is essential for induction of Cytochrome P4502B by steroids by not for drug or steroid induction of CYP3A or P450 reductase in mouse liver
    • E. G. Schuetz, W. Schmid, G. Schutz, et al., The glucocorticoid receptor is essential for induction of Cytochrome P4502B by steroids by not for drug or steroid induction of CYP3A or P450 reductase in mouse liver, Drug Metab., Dispos., 28, 268-278 (2000).
    • (2000) Drug Metab., Dispos. , vol.28 , pp. 268-278
    • Schuetz, E.G.1    Schmid, W.2    Schutz, G.3
  • 47
    • 0032547341 scopus 로고    scopus 로고
    • Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4
    • T. R. Rebbeck, J. A. Jaffe, A. H. Walker, A. J. Wein, and S. B. Malkowicz, Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4, J. Natl. Cancer Inst., 90, 1225-1229 (1998).
    • (1998) J. Natl. Cancer Inst. , vol.90 , pp. 1225-1229
    • Rebbeck, T.R.1    Jaffe, J.A.2    Walker, A.H.3    Wein, A.J.4    Malkowicz, S.B.5
  • 48
    • 0027137429 scopus 로고
    • Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control
    • H. Hashimoto, K. Toide, R. Kitamura, M. Fugita, S. Tagawa, S. Itoh, and T. Kamataki, Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control, Eur. J. Biochem., 218, 585-595 (1993).
    • (1993) Eur. J. Biochem. , vol.218 , pp. 585-595
    • Hashimoto, H.1    Toide, K.2    Kitamura, R.3    Fugita, M.4    Tagawa, S.5    Itoh, S.6    Kamataki, T.7
  • 49
    • 13144282667 scopus 로고    scopus 로고
    • Association of CYP3A4 genotype with treatment-related leukemia
    • C. A. Felix, A. H. Walker, B. J. Lange, et al., Association of CYP3A4 genotype with treatment-related leukemia, Proc. Natl. Acad. Sci. USA, 95, 13,176-13,181 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95
    • Felix, C.A.1    Walker, A.H.2    Lange, B.J.3
  • 50
    • 0345643389 scopus 로고    scopus 로고
    • Interindividual differences in hepatic expression of CYP3A4: Relationship to genetic polymorphism in the 5′-upstream regulatory region
    • A. Westlind, L. Lofberg, N. Tindberg, T. B. Andersson, and M. Ingelman-Sundberg, Interindividual differences in hepatic expression of CYP3A4: Relationship to genetic polymorphism in the 5′-upstream regulatory region, Biochem. Biophys. Res. Commun., 259, 201-205 (1999).
    • (1999) Biochem. Biophys. Res. Commun. , vol.259 , pp. 201-205
    • Westlind, A.1    Lofberg, L.2    Tindberg, N.3    Andersson, T.B.4    Ingelman-Sundberg, M.5
  • 51
    • 0032825907 scopus 로고    scopus 로고
    • Population distribution and effects on drug metabolism of a genetic variant in the 5′ promoter region of CYP3A4
    • S. E. Ball, J. Scatina, J. Kao, et al., Population distribution and effects on drug metabolism of a genetic variant in the 5′ promoter region of CYP3A4, Clin. Pharmacol. Ther., 66, 288-294 (1999).
    • (1999) Clin. Pharmacol. Ther. , vol.66 , pp. 288-294
    • Ball, S.E.1    Scatina, J.2    Kao, J.3
  • 52
    • 0029013333 scopus 로고
    • LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid hormones
    • A. Kralli, S. P. Bohen, and K. R. Yamamoto, LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid hormones, Proc. Natl. Acad. Sci. USA, 92, 4701-4705 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 4701-4705
    • Kralli, A.1    Bohen, S.P.2    Yamamoto, K.R.3
  • 53
    • 0030589989 scopus 로고    scopus 로고
    • Steroid transport, accumulation, and antagonism of P-glycoprotein in multidrug-resistant cells
    • K. M. Barnes, B. Dickstein, G. B. Cutler, T. Fojo, and S. E. Bates, Steroid transport, accumulation, and antagonism of P-glycoprotein in multidrug-resistant cells, Biochemistry, 35, 4820-4827 (1996).
    • (1996) Biochemistry , vol.35 , pp. 4820-4827
    • Barnes, K.M.1    Dickstein, B.2    Cutler, G.B.3    Fojo, T.4    Bates, S.E.5
  • 54
    • 0031732606 scopus 로고    scopus 로고
    • Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdrla P-glycoprotein knockout mice
    • O. C. Meijer, E. C. M. de Lange, D. D. Breimer, A. G. de Boer, J. O. Workel, and E. R. de Kloet, Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdrla P-glycoprotein knockout mice, Endocrinology, 139, 1789-1793 (1998).
    • (1998) Endocrinology , vol.139 , pp. 1789-1793
    • Meijer, O.C.1    De Lange, E.C.M.2    Breimer, D.D.3    De Boer, A.G.4    Workel, J.O.5    De Kloet, E.R.6
  • 55
    • 0030059953 scopus 로고    scopus 로고
    • Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells
    • E. G. Schuetz, W. T. Beck, and J. D. Schuetz, Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells, Molec. Pharm., 49, 311-318 (1996).
    • (1996) Molec. Pharm. , vol.49 , pp. 311-318
    • Schuetz, E.G.1    Beck, W.T.2    Schuetz, J.D.3
  • 56
    • 0029916534 scopus 로고    scopus 로고
    • P-glycoprotein: A major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans
    • E. G. Schuetz, A. H. Schinkel, M. V. Relling, and J. D. Schuetz, P-glycoprotein: A major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans, Proc. Natl. Acad. Sci. USA, 93, 4001-4005 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 4001-4005
    • Schuetz, E.G.1    Schinkel, A.H.2    Relling, M.V.3    Schuetz, J.D.4
  • 57
    • 0031748173 scopus 로고    scopus 로고
    • In vitro and in vivo drug interactions involving human CYP3A
    • K. E. Thummel and G. R. Wilkinson, In vitro and in vivo drug interactions involving human CYP3A, Annu. Rev. Pharmacol. Toxicol., 38, 389-430 (1998).
    • (1998) Annu. Rev. Pharmacol. Toxicol. , vol.38 , pp. 389-430
    • Thummel, K.E.1    Wilkinson, G.R.2
  • 58
    • 0000574406 scopus 로고    scopus 로고
    • Evaluation of atypical cytochrome P450 kinetics with two-substrate-models: Evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites
    • K. R. Korzekwa, N. Krishnamachary, M. Shou, A. Ogai, R. A. Parise, A. E. Rettie, F. J. Gonzalez, and T. S. Tracy, Evaluation of atypical cytochrome P450 kinetics with two-substrate-models: Evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites, Biochemistry, 37, 4137-4147 (1998).
    • (1998) Biochemistry , vol.37 , pp. 4137-4147
    • Korzekwa, K.R.1    Krishnamachary, N.2    Shou, M.3    Ogai, A.4    Parise, R.A.5    Rettie, A.E.6    Gonzalez, F.J.7    Tracy, T.S.8
  • 59
    • 0028071759 scopus 로고
    • Noninvasive tests of CYP3A enzymes
    • P. B. Watkins, Noninvasive tests of CYP3A enzymes, Pharmacogenetics, 4, 171-184 (1994).
    • (1994) Pharmacogenetics , vol.4 , pp. 171-184
    • Watkins, P.B.1
  • 61
    • 0030696112 scopus 로고    scopus 로고
    • Predicting drug interactions in vivo from experiments in vitro. Human studies with paclitaxel and ketoconazole
    • C. A. Jamis-Dow, M. L. Pearl, P. B. Watkins, D. S. Blake, R. W. Klecker, and J. M. Collins, Predicting drug interactions in vivo from experiments in vitro. Human studies with paclitaxel and ketoconazole, Am. J. Clin. Oncol., 20, 592-599 (1997).
    • (1997) Am. J. Clin. Oncol. , vol.20 , pp. 592-599
    • Jamis-Dow, C.A.1    Pearl, M.L.2    Watkins, P.B.3    Blake, D.S.4    Klecker, R.W.5    Collins, J.M.6
  • 65
    • 0032956839 scopus 로고    scopus 로고
    • Inhibition of CYP3A in human intestinal and liver microsomes: Comparison of Ki values and impact of CYP3A5 expression
    • M. A. Gibbs, K. E. Thummel, D. D. Shen, and K. L. Kunze, Inhibition of CYP3A in human intestinal and liver microsomes: Comparison of Ki values and impact of CYP3A5 expression, Drug Metab. Dispos., 27, 180-187, (1999).
    • (1999) Drug Metab. Dispos. , vol.27 , pp. 180-187
    • Gibbs, M.A.1    Thummel, K.E.2    Shen, D.D.3    Kunze, K.L.4
  • 66
    • 0029743080 scopus 로고    scopus 로고
    • Midazolam hydroxylation by liver microsomes in vitro: Inhibition by fluoxetine, norfluoxetine, and by azole antifungal agents
    • L. L. v. Moltke, D. J. Greenblatt, J. Schmider, S. X. Duan, C. E. Wright, J. S. Harmatz, and R. I. Shader, Midazolam hydroxylation by liver microsomes in vitro: Inhibition by fluoxetine, norfluoxetine, and by azole antifungal agents, J. Clin. Pharmacol., 36, 783-791 (1996).
    • (1996) J. Clin. Pharmacol. , vol.36 , pp. 783-791
    • Moltke, L.L.V.1    Greenblatt, D.J.2    Schmider, J.3    Duan, S.X.4    Wright, C.E.5    Harmatz, J.S.6    Shader, R.I.7
  • 67
    • 0027996327 scopus 로고
    • Terfenadine metabolism in human liver. In vitro inhibition by macrolide antibiotics and azole antifungals
    • M. Jurima-Romet, K. Crawford, T. Cyr, and T. Inaba, Terfenadine metabolism in human liver. In vitro inhibition by macrolide antibiotics and azole antifungals, Drug Metab. Dispos., 22, 849-857 (1994).
    • (1994) Drug Metab. Dispos. , vol.22 , pp. 849-857
    • Jurima-Romet, M.1    Crawford, K.2    Cyr, T.3    Inaba, T.4
  • 68
    • 0030903839 scopus 로고    scopus 로고
    • Metabolism of rifabutin in human enterocyte and liver microsomes: Kinetic parameters, identification of enzyme systems, and drug interactions with macrolides and antifungal agents
    • E. Iatsimirskaia, S. Tulebaev, E. Storozhuk, I. Utkin, D. Smith, N. Gerber, and T. Koudriakova, Metabolism of rifabutin in human enterocyte and liver microsomes: Kinetic parameters, identification of enzyme systems, and drug interactions with macrolides and antifungal agents, Clin. Pharmacol. Ther., 61, 554-562 (1997).
    • (1997) Clin. Pharmacol. Ther. , vol.61 , pp. 554-562
    • Iatsimirskaia, E.1    Tulebaev, S.2    Storozhuk, E.3    Utkin, I.4    Smith, D.5    Gerber, N.6    Koudriakova, T.7
  • 69
    • 0028361593 scopus 로고
    • Inhibition of human CYP3A catalyzed 1′-hydroxymidazolam formation by ketoconzole, nifedipine, erythromycin, cimetidine, and nizatidine
    • S. A. Wrighton and B. J. Ring, Inhibition of human CYP3A catalyzed 1′-hydroxymidazolam formation by ketoconzole, nifedipine, erythromycin, cimetidine, and nizatidine, Pharm. Res., 11, 921-923 (1994).
    • (1994) Pharm. Res. , vol.11 , pp. 921-923
    • Wrighton, S.A.1    Ring, B.J.2
  • 70
    • 0029664974 scopus 로고    scopus 로고
    • The effect of systemic antimycotics, itraconazole and fluconazole, on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam
    • K. T. Olkkola, J. Ahonen, and P. J. Neuvonen, The effect of systemic antimycotics, itraconazole and fluconazole, on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam, Anesthes. Analges., 82, 511-516 (1996).
    • (1996) Anesthes. Analges. , vol.82 , pp. 511-516
    • Olkkola, K.T.1    Ahonen, J.2    Neuvonen, P.J.3
  • 71
    • 0028357256 scopus 로고
    • Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole
    • K. T. Olkkola, J. T. Backman, and P. J. Neuoven, Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole, Clin. Pharmacol. Ther., 55, 481-485 (1994).
    • (1994) Clin. Pharmacol. Ther. , vol.55 , pp. 481-485
    • Olkkola, K.T.1    Backman, J.T.2    Neuoven, P.J.3
  • 75
    • 0027447395 scopus 로고
    • Cytochrome P-450 complex formation by dirithromycin and other macrolides in rats and human livers
    • T. D. Lindstrom, B. R. Hanssen, and S. A. Wrighton, Cytochrome P-450 complex formation by dirithromycin and other macrolides in rats and human livers, Antimicrob. Agent Chemother., 37, 265-269 (1993).
    • (1993) Antimicrob. Agent Chemother. , vol.37 , pp. 265-269
    • Lindstrom, T.D.1    Hanssen, B.R.2    Wrighton, S.A.3
  • 78
    • 0030868233 scopus 로고    scopus 로고
    • The role of cytochrome P450 3A4 in alfentanil clearance. Implications for interindividual variability in disposition and perioperative drug interactions
    • E. D. Kharasch, M. Russell, D. Mautz, K. E. Thummel, K. L. Kunze, A. T. Bowdle, and K. Cox, The role of cytochrome P450 3A4 in alfentanil clearance. Implications for interindividual variability in disposition and perioperative drug interactions, Anesthesiology, 87, 36-50 (1997).
    • (1997) Anesthesiology , vol.87 , pp. 36-50
    • Kharasch, E.D.1    Russell, M.2    Mautz, D.3    Thummel, K.E.4    Kunze, K.L.5    Bowdle, A.T.6    Cox, K.7
  • 79
    • 0026719283 scopus 로고
    • A pharmacokinetic evaluation of the combined administration of triazolam and fluoxetine
    • C. E. Wright, T. A. Lasher-Sisson, R. C. Steenwyk, and C. N. Swanson, A pharmacokinetic evaluation of the combined administration of triazolam and fluoxetine, Pharmacothcrapy, 12, 103-106 (1992).
    • (1992) Pharmacothcrapy , vol.12 , pp. 103-106
    • Wright, C.E.1    Lasher-Sisson, T.A.2    Steenwyk, R.C.3    Swanson, C.N.4
  • 80
    • 0031417358 scopus 로고    scopus 로고
    • Assessment of the potential for a pharmacokinetic interaction between fluoxetine and terfenadine
    • R. F. Bergstrom, M. J. Goldberg, B. J. Cerimele, and B. L. Hatcher, Assessment of the potential for a pharmacokinetic interaction between fluoxetine and terfenadine, Clin. Pharmacol. Ther., 62, 643-651 (1997).
    • (1997) Clin. Pharmacol. Ther. , vol.62 , pp. 643-651
    • Bergstrom, R.F.1    Goldberg, M.J.2    Cerimele, B.J.3    Hatcher, B.L.4
  • 81
    • 0000497670 scopus 로고
    • Isotopically sensitive branching and its effect on the observed intramolecular isotope effects in cytochrome P-450 catalyzed reactions: A new method for the estimation of intrinsic isotope effects
    • J. P. Jones, K. R. Korzekwa, A. E. Rettie, and W. F. Trager, Isotopically sensitive branching and its effect on the observed intramolecular isotope effects in cytochrome P-450 catalyzed reactions: A new method for the estimation of intrinsic isotope effects, J. Am. Chem. Soc., 108, 7074-7078 (1986).
    • (1986) J. Am. Chem. Soc. , vol.108 , pp. 7074-7078
    • Jones, J.P.1    Korzekwa, K.R.2    Rettie, A.E.3    Trager, W.F.4
  • 82
    • 0024451771 scopus 로고
    • Theory for the observed isotope effects from enzymatic systems that form multiple products via branched reaction pathways: Cytochrome P-450
    • K. R. Korzekwa, W. F. Trager, and J. R. Gillette, Theory for the observed isotope effects from enzymatic systems that form multiple products via branched reaction pathways: Cytochrome P-450, Biochemistry, 28, 9012-9018 (1989).
    • (1989) Biochemistry , vol.28 , pp. 9012-9018
    • Korzekwa, K.R.1    Trager, W.F.2    Gillette, J.R.3
  • 83
    • 0030910832 scopus 로고    scopus 로고
    • Intramolecular isotope effects for benzylic hydroxylation of isomeric xylenes and 4,4′-dimethylbiphenyl by cytochrome P450: Relationship between distance of methyl groups and masking of the intrinsic isotope effect
    • K. R. Iyer, J. P. Jones, J. F. Darbyshire, and W. F. Trager, Intramolecular isotope effects for benzylic hydroxylation of isomeric xylenes and 4,4′-dimethylbiphenyl by cytochrome P450: Relationship between distance of methyl groups and masking of the intrinsic isotope effect, Biochemistry, 36, 7136-7143 (1997).
    • (1997) Biochemistry , vol.36 , pp. 7136-7143
    • Iyer, K.R.1    Jones, J.P.2    Darbyshire, J.F.3    Trager, W.F.4
  • 84
    • 0028999257 scopus 로고
    • Isotope effects studies on the cytochrome P450 enzymes
    • K. R. Korzekwa, W. F. Trager, and J. R. Gillette, Isotope effects studies on the cytochrome P450 enzymes, Drug Metab. Rev., 27, 45-59 (1995).
    • (1995) Drug Metab. Rev. , vol.27 , pp. 45-59
    • Korzekwa, K.R.1    Trager, W.F.2    Gillette, J.R.3
  • 85
    • 0001894312 scopus 로고
    • Deuterium isotope effects in the metabolism of drugs and xenobiotics: Implications for drug design
    • A. B. Foster, Deuterium isotope effects in the metabolism of drugs and xenobiotics: Implications for drug design, Adv. Drug Res., 14, 1-40 (1985).
    • (1985) Adv. Drug Res. , vol.14 , pp. 1-40
    • Foster, A.B.1
  • 86
    • 0024991656 scopus 로고
    • Active site dynamics of toluene hydroxylation by cytochrome P450
    • R. P. Hanzlik and K.-H. J. Ling, Active site dynamics of toluene hydroxylation by cytochrome P450, J. Org. Chem., 55, 3392-3397 (1990).
    • (1990) J. Org. Chem. , vol.55 , pp. 3392-3397
    • Hanzlik, R.P.1    Ling, K.-H.J.2
  • 87
    • 0024434143 scopus 로고
    • Metabolism of the B-ring of testosterone by the rat cytochrome P-450 system
    • K. Korzekwa, K. Nagata, W. F. Trager, and J. R. Gillette, Metabolism of the B-ring of testosterone by the rat cytochrome P-450 system, Drug Metab. Rev., 20, 535-539 (1989).
    • (1989) Drug Metab. Rev. , vol.20 , pp. 535-539
    • Korzekwa, K.1    Nagata, K.2    Trager, W.F.3    Gillette, J.R.4
  • 88
    • 0025150366 scopus 로고
    • Theoretical studies on cytochrome P-450 mediated hydroxylation: A predictive model for hydrogen atom abstractions
    • K. R. Korzekwa, J. P. Jones, and J. R. Gillette, Theoretical studies on cytochrome P-450 mediated hydroxylation: A predictive model for hydrogen atom abstractions, J. Am. Chem. Soc., 112, 7042-7046 (1990).
    • (1990) J. Am. Chem. Soc. , vol.112 , pp. 7042-7046
    • Korzekwa, K.R.1    Jones, J.P.2    Gillette, J.R.3
  • 90
    • 0028307539 scopus 로고
    • Activation of CYP3A4: Evidence for the simultaneous binding of two substrates in a cytochrome P450 active site
    • M. Shou, J. Grogan, J. A. Mancewicz, K. W. Krausz, F. J. Gonzalez, H. V. Gelboin, and K. R. Korzekwa, Activation of CYP3A4: Evidence for the simultaneous binding of two substrates in a cytochrome P450 active site, Biochemistry, 33, 6450-6455 (1994).
    • (1994) Biochemistry , vol.33 , pp. 6450-6455
    • Shou, M.1    Grogan, J.2    Mancewicz, J.A.3    Krausz, K.W.4    Gonzalez, F.J.5    Gelboin, H.V.6    Korzekwa, K.R.7
  • 91
    • 0023949862 scopus 로고
    • Modulation of rabbit and human hepatic cytochrome P-450-catalyzed steroid hydroxylations by alpha-naphthoflavone
    • G. E. Schwab, J. L. Raucy, and E. F. Johnson, Modulation of rabbit and human hepatic cytochrome P-450-catalyzed steroid hydroxylations by alpha-naphthoflavone, Molec. Pharmacol., 33, 493-499 (1988).
    • (1988) Molec. Pharmacol. , vol.33 , pp. 493-499
    • Schwab, G.E.1    Raucy, J.L.2    Johnson, E.F.3
  • 92
    • 0031028518 scopus 로고    scopus 로고
    • Cooperativity in oxidations catalyzed by cytochrome P450 3A4
    • Y.-F. Ueng, T. Kuwabara, Y.-J. Chun, and F. P. Guengerich, Cooperativity in oxidations catalyzed by cytochrome P450 3A4, Biochemistry, 36, 370-381 (1997).
    • (1997) Biochemistry , vol.36 , pp. 370-381
    • Ueng, Y.-F.1    Kuwabara, T.2    Chun, Y.-J.3    Guengerich, F.P.4
  • 94
    • 0030444902 scopus 로고    scopus 로고
    • Cytochrome P450 conformation and substrate interactions as probed by CO binding kinetics
    • A. P. Koley, R. C. Robinson, and F. K. Friedman, Cytochrome P450 conformation and substrate interactions as probed by CO binding kinetics, Biochimie, 78, 706-713 (1996).
    • (1996) Biochimie , vol.78 , pp. 706-713
    • Koley, A.P.1    Robinson, R.C.2    Friedman, F.K.3
  • 95
    • 0019505397 scopus 로고
    • Ascorbic acid inhibition of aromatase activity in human placenta tissue
    • L. Milewich, G. T. Chen, P. C. MacDonald, and J. A. Peterson, Ascorbic acid inhibition of aromatase activity in human placenta tissue, J. Steroid Biochem., 14, 185-193 (1981).
    • (1981) J. Steroid Biochem. , vol.14 , pp. 185-193
    • Milewich, L.1    Chen, G.T.2    MacDonald, P.C.3    Peterson, J.A.4
  • 96
    • 0031022331 scopus 로고    scopus 로고
    • Differential mechanisms of cytochrome P450 inhibition and activation by alpha-naphthoflavone
    • A. P. Koley, J. T. M. Buters, R. C. Robinson, A. Markowitz, and F. K. Friedman, Differential mechanisms of cytochrome P450 inhibition and activation by alpha-naphthoflavone, J. Biol. Chem., 272, 3149-3152 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 3149-3152
    • Koley, A.P.1    Buters, J.T.M.2    Robinson, R.C.3    Markowitz, A.4    Friedman, F.K.5
  • 99
    • 0026440394 scopus 로고
    • When is cortisol a mineralocorticoid?
    • J. Clore, A. Schoolwerth, and C. O. Watlington, When is cortisol a mineralocorticoid? [editorial], Kidney Int., 42, 1297-1308 (1992).
    • (1992) Kidney Int. , vol.42 , pp. 1297-1308
    • Clore, J.1    Schoolwerth, A.2    Watlington, C.O.3
  • 100
    • 0026464616 scopus 로고
    • Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes
    • J. C. Kolars, P. Schmiedlin-Ren, J. D. Schuetz, C. Fang, and P. B. Watkins, Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes, J. Clin. Invest., 90, 1871-1878 (1992).
    • (1992) J. Clin. Invest. , vol.90 , pp. 1871-1878
    • Kolars, J.C.1    Schmiedlin-Ren, P.2    Schuetz, J.D.3    Fang, C.4    Watkins, P.B.5
  • 101
    • 0030982634 scopus 로고    scopus 로고
    • Grapefruit juice increases felodipine oral availability in man by decreasing intestinal CYP3A protein expression
    • M. B. Brown, W. Guo, and P. B. Watkins, Grapefruit juice increases felodipine oral availability in man by decreasing intestinal CYP3A protein expression. J. Clin. Invest. 99, 2545-2553 (1997).
    • (1997) J. Clin. Invest. , vol.99 , pp. 2545-2553
    • Brown, M.B.1    Guo, W.2    Watkins, P.B.3
  • 102
    • 0030696487 scopus 로고    scopus 로고
    • Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents: Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins
    • P. Schmiedlin-Ren, D. J. Edwards, M. E. Fitzsimmons, et al., Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents: Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins. Drug Metab. Dispos., 25, 1228-1233 (1997).
    • (1997) Drug Metab. Dispos. , vol.25 , pp. 1228-1233
    • Schmiedlin-Ren, P.1    Edwards, D.J.2    Fitzsimmons, M.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.