-
1
-
-
0026750647
-
The human hepatic cytochromes P450 involved in drug metabolism
-
S. A. Wrighton and J. C. Stevens, The human hepatic cytochromes P450 involved in drug metabolism, Crit. Rev. Toxicol., 22, 1-21 (1992).
-
(1992)
Crit. Rev. Toxicol.
, vol.22
, pp. 1-21
-
-
Wrighton, S.A.1
Stevens, J.C.2
-
2
-
-
0002888510
-
Human cytochrome P450 enzymes
-
(P. R. Ortiz de Montellano, ed.), Plenum Press, New York
-
F. P. Guengerich, Human cytochrome P450 enzymes, in Cytochrome P450, 2nd ed. (P. R. Ortiz de Montellano, ed.), Plenum Press, New York, 1995, pp. 473-535.
-
(1995)
Cytochrome P450, 2nd Ed.
, pp. 473-535
-
-
Guengerich, F.P.1
-
3
-
-
0029584276
-
Substrates of human hepatic cytochrome P450 3A4
-
A. P. Li, D. L. Kaminski, and A. Rasmussen, Substrates of human hepatic cytochrome P450 3A4, Toxicology, 104, 1-8 (1995).
-
(1995)
Toxicology
, vol.104
, pp. 1-8
-
-
Li, A.P.1
Kaminski, D.L.2
Rasmussen, A.3
-
4
-
-
0030022629
-
An overview of current cytochrome P450 technology for assessing the safety and efficacy of new materials
-
A. Parkinson, An overview of current cytochrome P450 technology for assessing the safety and efficacy of new materials, Toxicol. Pathol., 24, 45-57 (1996).
-
(1996)
Toxicol. Pathol.
, vol.24
, pp. 45-57
-
-
Parkinson, A.1
-
5
-
-
0002769936
-
Pharmacokinetics
-
(J. G. Hardman, L. E. Limbird, P. B. Molinoff, R. W. Ruddon, and A. G. Gilman, eds.), McGraw-Hill, New York
-
L. Z. Benet, Pharmacokinetics, in Goodman and Gilman's: The Pharmacological Basis of Therapeutics, 9th ed. (J. G. Hardman, L. E. Limbird, P. B. Molinoff, R. W. Ruddon, and A. G. Gilman, eds.), McGraw-Hill, New York, 1996, p. 14.
-
(1996)
Goodman and Gilman's: The Pharmacological Basis of Therapeutics, 9th Ed.
, pp. 14
-
-
Benet, L.Z.1
-
6
-
-
0021098075
-
Purification and characterization of six cytochrome P450 isozymes from human liver microsomes
-
P. P. Wang, P. Beaune, L. S. Kaminsky, G. A. Dannan, F. F. Kadlubar, D. Larrey, and F. P. Guengerich, Purification and characterization of six cytochrome P450 isozymes from human liver microsomes, Biochemistry, 22, 5375-5383 (1983).
-
(1983)
Biochemistry
, vol.22
, pp. 5375-5383
-
-
Wang, P.P.1
Beaune, P.2
Kaminsky, L.S.3
Dannan, G.A.4
Kadlubar, F.F.5
Larrey, D.6
Guengerich, F.P.7
-
7
-
-
0041301863
-
Identification of an inducible form of cytochrome P-450 in human liver
-
P. B. Watkins, S. A. Wrighton, P. Maurel, E. G. Schuetz, G. Mendez-Picon, G. A. Parker, and P. S. Guzelian, Identification of an inducible form of cytochrome P-450 in human liver, Proc. Natl. Acad. Sci. USA, 82, 6310-6314 (1985).
-
(1985)
Proc. Natl. Acad. Sci. USA
, vol.82
, pp. 6310-6314
-
-
Watkins, P.B.1
Wrighton, S.A.2
Maurel, P.3
Schuetz, E.G.4
Mendez-Picon, G.5
Parker, G.A.6
Guzelian, P.S.7
-
8
-
-
0022998708
-
Characterization of rat and human liver microsomal cytochrome P450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism
-
F. P. Guengerich, M. V. Martin. P. H. Beaune, P. Kremers, T. Wolff, and D. J. Waxman, Characterization of rat and human liver microsomal cytochrome P450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism, J. Biol. Chem., 26, 5051-5060 (1986).
-
(1986)
J. Biol. Chem.
, vol.26
, pp. 5051-5060
-
-
Guengerich, F.P.1
Martin, M.V.2
Beaune, P.H.3
Kremers, P.4
Wolff, T.5
Waxman, D.J.6
-
9
-
-
0345638660
-
Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver
-
D. T. Molowa, E. G. Schuetz, S. A. Wrighton, P. B. Watkins, P. Kremers, G. Mendez-Picon, G. A. Parker, and P. S. Guzelian, Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver, Proc. Natl. Acad. Sci. USA, 83, 5311-5315 (1986).
-
(1986)
Proc. Natl. Acad. Sci. USA
, vol.83
, pp. 5311-5315
-
-
Molowa, D.T.1
Schuetz, E.G.2
Wrighton, S.A.3
Watkins, P.B.4
Kremers, P.5
Mendez-Picon, G.6
Parker, G.A.7
Guzelian, P.S.8
-
10
-
-
9044254525
-
P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature
-
D. R. Nelson, L. Koymans, T. Kamataki, J. J. Stegeman, R. Feyereisen, D. J. Waxman, M. R. Waterman, O. Gotoh, M. J. Coon, R. W. Estabrook, I. C. Gunsalus, and D. W. Nebert, P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature, Pharmacogenetics, 6, 1-42 (1996).
-
(1996)
Pharmacogenetics
, vol.6
, pp. 1-42
-
-
Nelson, D.R.1
Koymans, L.2
Kamataki, T.3
Stegeman, J.J.4
Feyereisen, R.5
Waxman, D.J.6
Waterman, M.R.7
Gotoh, O.8
Coon, M.J.9
Estabrook, R.W.10
Gunsalus, I.C.11
Nebert, D.W.12
-
11
-
-
0001313948
-
Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase
-
P. H. Beaune, D. R. Umbenhauer, R. W. Bork, R. S. Lloyd, and F. P. Guengerich, Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase, Proc. Natl. Acad. Sci. USA, 83, 8064-8068 (1986).
-
(1986)
Proc. Natl. Acad. Sci. USA
, vol.83
, pp. 8064-8068
-
-
Beaune, P.H.1
Umbenhauer, D.R.2
Bork, R.W.3
Lloyd, R.S.4
Guengerich, F.P.5
-
12
-
-
0028063131
-
CYP3A gene expression in human gut epithelium
-
J. C. Kolars, K. S. Lown, P. Schmiedlin-Ren, M. Ghosh, C. Fang, S. A. Wrighton, R. M. Merion, and P. B. Watkins, CYP3A gene expression in human gut epithelium, Pharmacogenetics, 4, 247-259 (1994).
-
(1994)
Pharmacogenetics
, vol.4
, pp. 247-259
-
-
Kolars, J.C.1
Lown, K.S.2
Schmiedlin-Ren, P.3
Ghosh, M.4
Fang, C.5
Wrighton, S.A.6
Merion, R.M.7
Watkins, P.B.8
-
13
-
-
0028237729
-
Interindividual variations in human liver cytochrome P450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
-
T. Shimada, H. Yamazaki, M. Mimura, Y. Inui, and F. P. Guengerich, Interindividual variations in human liver cytochrome P450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians, J. Pharmacol. Exp. Ther., 270, 414-423 (1994).
-
(1994)
J. Pharmacol. Exp. Ther.
, vol.270
, pp. 414-423
-
-
Shimada, T.1
Yamazaki, H.2
Mimura, M.3
Inui, Y.4
Guengerich, F.P.5
-
14
-
-
0025184340
-
Mechanism-based inactivation of human liver cytochrome P450 IIIA4 by gestodene
-
F. P. Guengerich, Mechanism-based inactivation of human liver cytochrome P450 IIIA4 by gestodene, Chem. Res. Toxicol., 3, 363-371 (1990).
-
(1990)
Chem. Res. Toxicol.
, vol.3
, pp. 363-371
-
-
Guengerich, F.P.1
-
15
-
-
0021355534
-
Induction of cytochrome P-450 by glucocorticoids in rat liver. I. Evidence
-
E. G. Schuetz, S. A. Wrighton, J. L. Barwick, and P. S. Guzelian, Induction of cytochrome P-450 by glucocorticoids in rat liver. I. Evidence, J. Biol. Chem., 259, 1999-2006 (1984).
-
(1984)
J. Biol. Chem.
, vol.259
, pp. 1999-2006
-
-
Schuetz, E.G.1
Wrighton, S.A.2
Barwick, J.L.3
Guzelian, P.S.4
-
16
-
-
0021361026
-
Induction of cytochrome P-450 by glucocorticoids in rat liver. II. Evidence that glucocorticoids regulate induction of cytochrome P-450 by a non-classical mechanism
-
E. G. Scheutz and P. S. Guzelian, Induction of cytochrome P-450 by glucocorticoids in rat liver. II. Evidence that glucocorticoids regulate induction of cytochrome P-450 by a non-classical mechanism, J. Biol. Chem., 259, 2007-2012 (1984).
-
(1984)
J. Biol. Chem.
, vol.259
, pp. 2007-2012
-
-
Scheutz, E.G.1
Guzelian, P.S.2
-
17
-
-
0028917364
-
Transcriptional elements directing a liver-specific expression of P450/6betaA (CYP3A2) gene-encoding testosterone 6beta-hydroxylase
-
M. Miyata, K. Nagata, Y. Yamazoe, and R. Kato, Transcriptional elements directing a liver-specific expression of P450/6betaA (CYP3A2) gene-encoding testosterone 6beta-hydroxylase, Arch. Biochem. Biophys., 318, 71-79 (1995).
-
(1995)
Arch. Biochem. Biophys.
, vol.318
, pp. 71-79
-
-
Miyata, M.1
Nagata, K.2
Yamazoe, Y.3
Kato, R.4
-
18
-
-
0028789188
-
A novel cis-element in a liver cytochrome P450 3A gene confers synergistic induction by glucocorticoids plus antiglucocorticoids
-
L. C. Quattrochi, A. S. Mills, J. L. Barwick, C. B. Yockey, and P. S. Guzelian, A novel cis-element in a liver cytochrome P450 3A gene confers synergistic induction by glucocorticoids plus antiglucocorticoids, J. Biol. Chem., 270, 28,917-28,923 (1995).
-
(1995)
J. Biol. Chem.
, vol.270
-
-
Quattrochi, L.C.1
Mills, A.S.2
Barwick, J.L.3
Yockey, C.B.4
Guzelian, P.S.5
-
19
-
-
0029906308
-
Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif
-
J. M. Huss, S. I. Wang, A. Astrom, P. McQuiddy, and C. B. Kasper, Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif. Proc. Natl. Acad. Sci. USA, 93, 4666-4670 (1996).
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 4666-4670
-
-
Huss, J.M.1
Wang, S.I.2
Astrom, A.3
McQuiddy, P.4
Kasper, C.B.5
-
20
-
-
0032498303
-
An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
-
S. A. Kliewer, J. T. Moore, L. Wade, J. L. Staudinger, M. A. Watson, S. A. Jones, D. D. McKee, B. B. Oliver, T. M. Willson, R. H. Zetterstrom, T. Perlmann, and J. M. Lehmann, An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway, Cell, 92, 73-82 (1998).
-
(1998)
Cell
, vol.92
, pp. 73-82
-
-
Kliewer, S.A.1
Moore, J.T.2
Wade, L.3
Staudinger, J.L.4
Watson, M.A.5
Jones, S.A.6
McKee, D.D.7
Oliver, B.B.8
Willson, T.M.9
Zetterstrom, R.H.10
Perlmann, T.11
Lehmann, J.M.12
-
21
-
-
0031914323
-
The antibiotic rifampicin is a nonsteroidal ligand and activator of the human glucocorticoid receptor
-
C. Calleja, J. M. Pascussi, J. C. Mani, P. Maurel, and M. J. Vilaren, The antibiotic rifampicin is a nonsteroidal ligand and activator of the human glucocorticoid receptor, Nature Med., 4, 92-96 (1998).
-
(1998)
Nature Med.
, vol.4
, pp. 92-96
-
-
Calleja, C.1
Pascussi, J.M.2
Mani, J.C.3
Maurel, P.4
Vilaren, M.J.5
-
22
-
-
0024400702
-
Identification of a polymorphically expressed member of the human cytochrome P450III family
-
S. A. Wrighton, B. J. Ring, P. B. Watkins, and M. VandenBranden, Identification of a polymorphically expressed member of the human cytochrome P450III family, Molec. Pharmacol., 36, 97-105 (1989).
-
(1989)
Molec. Pharmacol.
, vol.36
, pp. 97-105
-
-
Wrighton, S.A.1
Ring, B.J.2
Watkins, P.B.3
VandenBranden, M.4
-
23
-
-
0024430299
-
Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver
-
J. D. Schuetz, D. T. Molowa, and P. S. Guzelian, Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver, Arch. Biochem. Biophys., 274, 355-365 (1989).
-
(1989)
Arch. Biochem. Biophys.
, vol.274
, pp. 355-365
-
-
Schuetz, J.D.1
Molowa, D.T.2
Guzelian, P.S.3
-
24
-
-
0342468270
-
Detection of a CYP3A5 allelic variant: A candidate for the polymorphic expression of the protein?
-
Y. Jounaidi, V. Hyrailles, L. Gervot, and P. Maurel, Detection of a CYP3A5 allelic variant: A candidate for the polymorphic expression of the protein? Biochem. Biophys. Res. Commun., 221, 466-470 (1996).
-
(1996)
Biochem. Biophys. Res. Commun.
, vol.221
, pp. 466-470
-
-
Jounaidi, Y.1
Hyrailles, V.2
Gervot, L.3
Maurel, P.4
-
25
-
-
0030059885
-
Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells
-
J. D. Schuetz, E. G. Schuetz, J. V. Thottassery, P. S. Guzelian, S. Strom, and D. Sun, Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells, Molec. Pharmacol., 49, 63-72 (1996).
-
(1996)
Molec. Pharmacol.
, vol.49
, pp. 63-72
-
-
Schuetz, J.D.1
Schuetz, E.G.2
Thottassery, J.V.3
Guzelian, P.S.4
Strom, S.5
Sun, D.6
-
26
-
-
0025161416
-
Studies on the expression and metabolic capabilities of human liver cytochrome P450 IIIA
-
S. A. Wrighton, W. R. Brian, M. A. Sari, M. Iwasaki, F. P. Guengerich, J. L. Raucy, D. T. Molowa, and M. VandenBranden, Studies on the expression and metabolic capabilities of human liver cytochrome P450 IIIA, Molec. Pharmacol., 38, 207-213 (1990).
-
(1990)
Molec. Pharmacol.
, vol.38
, pp. 207-213
-
-
Wrighton, S.A.1
Brian, W.R.2
Sari, M.A.3
Iwasaki, M.4
Guengerich, F.P.5
Raucy, J.L.6
Molowa, D.T.7
VandenBranden, M.8
-
27
-
-
0028234586
-
Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A subfamily
-
J. C. Gorski, S. D. Hall, D. R. Jones, M. VandenBranden, and S. A. Wrighton, Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A subfamily, Biochem. Pharmacol., 47, 1643-1653 (1994).
-
(1994)
Biochem. Pharmacol.
, vol.47
, pp. 1643-1653
-
-
Gorski, J.C.1
Hall, S.D.2
Jones, D.R.3
Vandenbranden, M.4
Wrighton, S.A.5
-
28
-
-
0028270821
-
Cytochrome P450 in human fetal liver: Significance and fetal-specific expression
-
M. Kitada and T. Kamataki, Cytochrome P450 in human fetal liver: Significance and fetal-specific expression, Drug Metab. Rev., 26, 305-323 (1994).
-
(1994)
Drug Metab. Rev.
, vol.26
, pp. 305-323
-
-
Kitada, M.1
Kamataki, T.2
-
29
-
-
0022255668
-
Purification and properties of cytochrome P-450 from homogenates of human fetal livers
-
K. Kitada, T. Kamataki, K. Itahashi, T. Rikihisa, R. Kato, and Y. Kanakubo, Purification and properties of cytochrome P-450 from homogenates of human fetal livers, Arch. Biochem. Biophys., 241, 275-280 (1985).
-
(1985)
Arch. Biochem. Biophys.
, vol.241
, pp. 275-280
-
-
Kitada, K.1
Kamataki, T.2
Itahashi, K.3
Rikihisa, T.4
Kato, R.5
Kanakubo, Y.6
-
30
-
-
0024534194
-
Isolation and characterization of human fetal liver cytochrome P450HLp2: A third member of the P450III gene family
-
S. A. Wrighton and M. VandenBranden, Isolation and characterization of human fetal liver cytochrome P450HLp2: A third member of the P450III gene family, Arch. Biochem. Biophys., 268, 144-151 (1989).
-
(1989)
Arch. Biochem. Biophys.
, vol.268
, pp. 144-151
-
-
Wrighton, S.A.1
VandenBranden, M.2
-
31
-
-
0025903396
-
Four forms of cytochrome P-450 in human fetal liver: Purification and their capacity of activate promutagens
-
K. Kitada, M. Taneda, K. Itahashi, and T. Kamataki, Four forms of cytochrome P-450 in human fetal liver: Purification and their capacity of activate promutagens, Jpn. J. Cancer Res., 82, 426-432 (1991).
-
(1991)
Jpn. J. Cancer Res.
, vol.82
, pp. 426-432
-
-
Kitada, K.1
Taneda, M.2
Itahashi, K.3
Kamataki, T.4
-
32
-
-
0024535542
-
Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450
-
M. Komori, K. Nishio, H. Ohi, M. Kitada, and T. Kamataki, Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450, J. Biochem., 105, 161-163 (1989).
-
(1989)
J. Biochem.
, vol.105
, pp. 161-163
-
-
Komori, M.1
Nishio, K.2
Ohi, H.3
Kitada, M.4
Kamataki, T.5
-
33
-
-
0023896017
-
Identification of a cytochrome P-450 in human fetal liver related to glucocorticoid-inducible cytochrome P450HLp in the adult
-
S. A. Wrighton, D. T. Molowa, and P. S. Guzelian, Identification of a cytochrome P-450 in human fetal liver related to glucocorticoid-inducible cytochrome P450HLp in the adult, Biochem. Pharmacol., 37, 3053-3055 (1988).
-
(1988)
Biochem. Pharmacol.
, vol.37
, pp. 3053-3055
-
-
Wrighton, S.A.1
Molowa, D.T.2
Guzelian, P.S.3
-
34
-
-
0023200455
-
P-450 HFLa, a form of cytochrome P-450 purified from human fetal livers, is the 16alpha-hydroxylase of dehydroepiandrosterone 3-sulfate
-
M. Kitada, T. Kamataki, K. Itahashi, T. Rikihisa, and Y. Kanakubo, P-450 HFLa, a form of cytochrome P-450 purified from human fetal livers, is the 16alpha-hydroxylase of dehydroepiandrosterone 3-sulfate, J. Biol. Chem., 262, 13,534-13,537 (1987).
-
(1987)
J. Biol. Chem.
, vol.262
-
-
Kitada, M.1
Kamataki, T.2
Itahashi, K.3
Rikihisa, T.4
Kanakubo, Y.5
-
35
-
-
0026520777
-
Paradoxical transcriptional activation of rat liver cytochrome P450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: Analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes
-
H-J. Burger, J. D. Schuetz, E. G. Schuetz, and P. S. Guzelian, Paradoxical transcriptional activation of rat liver cytochrome P450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: Analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes, Proc. Natl. Acad. Sci. USA, 89, 2145-2149 (1992).
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 2145-2149
-
-
Burger, H.-J.1
Schuetz, J.D.2
Schuetz, E.G.3
Guzelian, P.S.4
-
36
-
-
0029906308
-
Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif
-
J. M. Hus, S. I. Wang, A. Astrom, P. McQuiddy, and C. B. Kasper, Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif, Proc. Natl. Acad. Sci. USA, 93, 4666-4670 (1996).
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 4666-4670
-
-
Hus, J.M.1
Wang, S.I.2
Astrom, A.3
McQuiddy, P.4
Kasper, C.B.5
-
37
-
-
0032169485
-
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
-
J. M. Lehmann, D. D. McKee, M. A. Watson, T. M. Wilson, J. T. Moore, and S. A. Kliewer, The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions, J. Clin. Invest., 102, 1-8 (1998).
-
(1998)
J. Clin. Invest.
, vol.102
, pp. 1-8
-
-
Lehmann, J.M.1
McKee, D.D.2
Watson, M.A.3
Wilson, T.M.4
Moore, J.T.5
Kliewer, S.A.6
-
38
-
-
0032532134
-
SXR, a novel steroid and xenobiotic sensing nuclear receptor
-
B. Blumberg, W. Sabbagh, H. Juguilon, J. Bolado, and C. M. van Matel, SXR, a novel steroid and xenobiotic sensing nuclear receptor, Genes Dev., 12, 3195-3205 (1998).
-
(1998)
Genes Dev.
, vol.12
, pp. 3195-3205
-
-
Blumberg, B.1
Sabbagh, W.2
Juguilon, H.3
Bolado, J.4
Van Matel, C.M.5
-
39
-
-
13144260727
-
Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction
-
G. Bertilsson, J. Heidrich, K. Svensson, et al., Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction, Proc. Natl. Acad. Sci. USA, 95, 12,208-12,213 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
-
-
Bertilsson, G.1
Heidrich, J.2
Svensson, K.3
-
40
-
-
0032437889
-
Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone utilize the nuclear hormone receptor PXR to activate the cytochrome P4503A23 hormone response element
-
E. G. Schuetz, C. Brimer, and J. D. Schuetz, Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone utilize the nuclear hormone receptor PXR to activate the cytochrome P4503A23 hormone response element, Molec. Pharm., 54, 1113-1117 (1998).
-
(1998)
Molec. Pharm.
, vol.54
, pp. 1113-1117
-
-
Schuetz, E.G.1
Brimer, C.2
Schuetz, J.D.3
-
41
-
-
0033526864
-
Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene
-
J-M. Pascussi, Y. Jounaidi, L. Drocourt, J. Domergu, C. Balakaud, P. Maurel, and M. J. Vileram, Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene, Biochem. Biophys. Res. Commun., 260, 377-381 (1999).
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.260
, pp. 377-381
-
-
Pascussi, J.-M.1
Jounaidi, Y.2
Drocourt, L.3
Domergu, J.4
Balakaud, C.5
Maurel, P.6
Vileram, M.J.7
-
42
-
-
0029562554
-
The RXR heterodimers and orphan receptors
-
D. J. Mangelsdorf and R. M. Evans, The RXR heterodimers and orphan receptors, Cell, 83, 841-850 (1995).
-
(1995)
Cell
, vol.83
, pp. 841-850
-
-
Mangelsdorf, D.J.1
Evans, R.M.2
-
43
-
-
0030945754
-
Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1,2,5-dihydroxyvitamin D3
-
P. Schmiedlin-Ren, K. E. Thummel, J. M. Fisher, M. F. Paine, K. S. Lown, and P. B. Watkins, Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1,2,5-dihydroxyvitamin D3, Molec. Pharm., 51, 741-754 (1997).
-
(1997)
Molec. Pharm.
, vol.51
, pp. 741-754
-
-
Schmiedlin-Ren, P.1
Thummel, K.E.2
Fisher, J.M.3
Paine, M.F.4
Lown, K.S.5
Watkins, P.B.6
-
44
-
-
0033199499
-
P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR, and PPAR
-
D. J. Waxman, P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR, and PPAR, Arch. Biochem. Biophys., 369, 11-23 (1999).
-
(1999)
Arch. Biochem. Biophys.
, vol.369
, pp. 11-23
-
-
Waxman, D.J.1
-
45
-
-
0032707445
-
Moleclar mechanisms of cytochrome P-450 induction by xenobiotics: An expanded role for nuclear hormone receptors
-
U. Savas, K. J. Griffin, and E. F. Johnson, Moleclar mechanisms of cytochrome P-450 induction by xenobiotics: An expanded role for nuclear hormone receptors, Molec. Pharm., 56, 851-857 (1999).
-
(1999)
Molec. Pharm.
, vol.56
, pp. 851-857
-
-
Savas, U.1
Griffin, K.J.2
Johnson, E.F.3
-
46
-
-
0034012654
-
The glucocorticoid receptor is essential for induction of Cytochrome P4502B by steroids by not for drug or steroid induction of CYP3A or P450 reductase in mouse liver
-
E. G. Schuetz, W. Schmid, G. Schutz, et al., The glucocorticoid receptor is essential for induction of Cytochrome P4502B by steroids by not for drug or steroid induction of CYP3A or P450 reductase in mouse liver, Drug Metab., Dispos., 28, 268-278 (2000).
-
(2000)
Drug Metab., Dispos.
, vol.28
, pp. 268-278
-
-
Schuetz, E.G.1
Schmid, W.2
Schutz, G.3
-
47
-
-
0032547341
-
Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4
-
T. R. Rebbeck, J. A. Jaffe, A. H. Walker, A. J. Wein, and S. B. Malkowicz, Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4, J. Natl. Cancer Inst., 90, 1225-1229 (1998).
-
(1998)
J. Natl. Cancer Inst.
, vol.90
, pp. 1225-1229
-
-
Rebbeck, T.R.1
Jaffe, J.A.2
Walker, A.H.3
Wein, A.J.4
Malkowicz, S.B.5
-
48
-
-
0027137429
-
Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control
-
H. Hashimoto, K. Toide, R. Kitamura, M. Fugita, S. Tagawa, S. Itoh, and T. Kamataki, Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control, Eur. J. Biochem., 218, 585-595 (1993).
-
(1993)
Eur. J. Biochem.
, vol.218
, pp. 585-595
-
-
Hashimoto, H.1
Toide, K.2
Kitamura, R.3
Fugita, M.4
Tagawa, S.5
Itoh, S.6
Kamataki, T.7
-
49
-
-
13144282667
-
Association of CYP3A4 genotype with treatment-related leukemia
-
C. A. Felix, A. H. Walker, B. J. Lange, et al., Association of CYP3A4 genotype with treatment-related leukemia, Proc. Natl. Acad. Sci. USA, 95, 13,176-13,181 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
-
-
Felix, C.A.1
Walker, A.H.2
Lange, B.J.3
-
50
-
-
0345643389
-
Interindividual differences in hepatic expression of CYP3A4: Relationship to genetic polymorphism in the 5′-upstream regulatory region
-
A. Westlind, L. Lofberg, N. Tindberg, T. B. Andersson, and M. Ingelman-Sundberg, Interindividual differences in hepatic expression of CYP3A4: Relationship to genetic polymorphism in the 5′-upstream regulatory region, Biochem. Biophys. Res. Commun., 259, 201-205 (1999).
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.259
, pp. 201-205
-
-
Westlind, A.1
Lofberg, L.2
Tindberg, N.3
Andersson, T.B.4
Ingelman-Sundberg, M.5
-
51
-
-
0032825907
-
Population distribution and effects on drug metabolism of a genetic variant in the 5′ promoter region of CYP3A4
-
S. E. Ball, J. Scatina, J. Kao, et al., Population distribution and effects on drug metabolism of a genetic variant in the 5′ promoter region of CYP3A4, Clin. Pharmacol. Ther., 66, 288-294 (1999).
-
(1999)
Clin. Pharmacol. Ther.
, vol.66
, pp. 288-294
-
-
Ball, S.E.1
Scatina, J.2
Kao, J.3
-
52
-
-
0029013333
-
LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid hormones
-
A. Kralli, S. P. Bohen, and K. R. Yamamoto, LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid hormones, Proc. Natl. Acad. Sci. USA, 92, 4701-4705 (1995).
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 4701-4705
-
-
Kralli, A.1
Bohen, S.P.2
Yamamoto, K.R.3
-
53
-
-
0030589989
-
Steroid transport, accumulation, and antagonism of P-glycoprotein in multidrug-resistant cells
-
K. M. Barnes, B. Dickstein, G. B. Cutler, T. Fojo, and S. E. Bates, Steroid transport, accumulation, and antagonism of P-glycoprotein in multidrug-resistant cells, Biochemistry, 35, 4820-4827 (1996).
-
(1996)
Biochemistry
, vol.35
, pp. 4820-4827
-
-
Barnes, K.M.1
Dickstein, B.2
Cutler, G.B.3
Fojo, T.4
Bates, S.E.5
-
54
-
-
0031732606
-
Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdrla P-glycoprotein knockout mice
-
O. C. Meijer, E. C. M. de Lange, D. D. Breimer, A. G. de Boer, J. O. Workel, and E. R. de Kloet, Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdrla P-glycoprotein knockout mice, Endocrinology, 139, 1789-1793 (1998).
-
(1998)
Endocrinology
, vol.139
, pp. 1789-1793
-
-
Meijer, O.C.1
De Lange, E.C.M.2
Breimer, D.D.3
De Boer, A.G.4
Workel, J.O.5
De Kloet, E.R.6
-
55
-
-
0030059953
-
Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells
-
E. G. Schuetz, W. T. Beck, and J. D. Schuetz, Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells, Molec. Pharm., 49, 311-318 (1996).
-
(1996)
Molec. Pharm.
, vol.49
, pp. 311-318
-
-
Schuetz, E.G.1
Beck, W.T.2
Schuetz, J.D.3
-
56
-
-
0029916534
-
P-glycoprotein: A major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans
-
E. G. Schuetz, A. H. Schinkel, M. V. Relling, and J. D. Schuetz, P-glycoprotein: A major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans, Proc. Natl. Acad. Sci. USA, 93, 4001-4005 (1996).
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 4001-4005
-
-
Schuetz, E.G.1
Schinkel, A.H.2
Relling, M.V.3
Schuetz, J.D.4
-
57
-
-
0031748173
-
In vitro and in vivo drug interactions involving human CYP3A
-
K. E. Thummel and G. R. Wilkinson, In vitro and in vivo drug interactions involving human CYP3A, Annu. Rev. Pharmacol. Toxicol., 38, 389-430 (1998).
-
(1998)
Annu. Rev. Pharmacol. Toxicol.
, vol.38
, pp. 389-430
-
-
Thummel, K.E.1
Wilkinson, G.R.2
-
58
-
-
0000574406
-
Evaluation of atypical cytochrome P450 kinetics with two-substrate-models: Evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites
-
K. R. Korzekwa, N. Krishnamachary, M. Shou, A. Ogai, R. A. Parise, A. E. Rettie, F. J. Gonzalez, and T. S. Tracy, Evaluation of atypical cytochrome P450 kinetics with two-substrate-models: Evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites, Biochemistry, 37, 4137-4147 (1998).
-
(1998)
Biochemistry
, vol.37
, pp. 4137-4147
-
-
Korzekwa, K.R.1
Krishnamachary, N.2
Shou, M.3
Ogai, A.4
Parise, R.A.5
Rettie, A.E.6
Gonzalez, F.J.7
Tracy, T.S.8
-
59
-
-
0028071759
-
Noninvasive tests of CYP3A enzymes
-
P. B. Watkins, Noninvasive tests of CYP3A enzymes, Pharmacogenetics, 4, 171-184 (1994).
-
(1994)
Pharmacogenetics
, vol.4
, pp. 171-184
-
-
Watkins, P.B.1
-
60
-
-
12644270207
-
Steady-state pharmacokinetics of delavirdine in HIV-positive patients: Effect on erythromycin breath test
-
C.-L. Cheng, D. E. Smith, P. L. Carver, S. R. Cox, P. B. Watkins, D. S. Blake, C. A. Kauffman, K. M. Meyer, G. L. Amidon, and P. L. Stetson, Steady-state pharmacokinetics of delavirdine in HIV-positive patients: Effect on erythromycin breath test, Clin. Pharmacol. Ther., 61, 531-543 (1997).
-
(1997)
Clin. Pharmacol. Ther.
, vol.61
, pp. 531-543
-
-
Cheng, C.-L.1
Smith, D.E.2
Carver, P.L.3
Cox, S.R.4
Watkins, P.B.5
Blake, D.S.6
Kauffman, C.A.7
Meyer, K.M.8
Amidon, G.L.9
Stetson, P.L.10
-
61
-
-
0030696112
-
Predicting drug interactions in vivo from experiments in vitro. Human studies with paclitaxel and ketoconazole
-
C. A. Jamis-Dow, M. L. Pearl, P. B. Watkins, D. S. Blake, R. W. Klecker, and J. M. Collins, Predicting drug interactions in vivo from experiments in vitro. Human studies with paclitaxel and ketoconazole, Am. J. Clin. Oncol., 20, 592-599 (1997).
-
(1997)
Am. J. Clin. Oncol.
, vol.20
, pp. 592-599
-
-
Jamis-Dow, C.A.1
Pearl, M.L.2
Watkins, P.B.3
Blake, D.S.4
Klecker, R.W.5
Collins, J.M.6
-
62
-
-
0029738490
-
First-pass metabolism of midazolam by the human intestine
-
M. F. Paine, D. D. Shen, K. L. Kunze, J. D. Perkins, C. L. Marsh, J. P. McVicar, D. M. Barr, B. S. Gillies, and K. E. Thummel, First-pass metabolism of midazolam by the human intestine, Clin. Pharmacol. Ther., 60, 14-24 (1996).
-
(1996)
Clin. Pharmacol. Ther.
, vol.60
, pp. 14-24
-
-
Paine, M.F.1
Shen, D.D.2
Kunze, K.L.3
Perkins, J.D.4
Marsh, C.L.5
McVicar, J.P.6
Barr, D.M.7
Gillies, B.S.8
Thummel, K.E.9
-
63
-
-
0031445547
-
Characterization of inter- and intra-intestinal differences in human CYP3A-dependent metabolism
-
M. F. Paine, M. Khalighi, J. M. Fisher, D. D. Shen, K. L. Kunze, C. L. Marsh, J. D. Perkins, and K. E. Thummel, Characterization of inter- and intra-intestinal differences in human CYP3A-dependent metabolism, J. Pharmacol. Exp. Ther., 283, 1552-1562 (1997).
-
(1997)
J. Pharmacol. Exp. Ther.
, vol.283
, pp. 1552-1562
-
-
Paine, M.F.1
Khalighi, M.2
Fisher, J.M.3
Shen, D.D.4
Kunze, K.L.5
Marsh, C.L.6
Perkins, J.D.7
Thummel, K.E.8
-
65
-
-
0032956839
-
Inhibition of CYP3A in human intestinal and liver microsomes: Comparison of Ki values and impact of CYP3A5 expression
-
M. A. Gibbs, K. E. Thummel, D. D. Shen, and K. L. Kunze, Inhibition of CYP3A in human intestinal and liver microsomes: Comparison of Ki values and impact of CYP3A5 expression, Drug Metab. Dispos., 27, 180-187, (1999).
-
(1999)
Drug Metab. Dispos.
, vol.27
, pp. 180-187
-
-
Gibbs, M.A.1
Thummel, K.E.2
Shen, D.D.3
Kunze, K.L.4
-
66
-
-
0029743080
-
Midazolam hydroxylation by liver microsomes in vitro: Inhibition by fluoxetine, norfluoxetine, and by azole antifungal agents
-
L. L. v. Moltke, D. J. Greenblatt, J. Schmider, S. X. Duan, C. E. Wright, J. S. Harmatz, and R. I. Shader, Midazolam hydroxylation by liver microsomes in vitro: Inhibition by fluoxetine, norfluoxetine, and by azole antifungal agents, J. Clin. Pharmacol., 36, 783-791 (1996).
-
(1996)
J. Clin. Pharmacol.
, vol.36
, pp. 783-791
-
-
Moltke, L.L.V.1
Greenblatt, D.J.2
Schmider, J.3
Duan, S.X.4
Wright, C.E.5
Harmatz, J.S.6
Shader, R.I.7
-
67
-
-
0027996327
-
Terfenadine metabolism in human liver. In vitro inhibition by macrolide antibiotics and azole antifungals
-
M. Jurima-Romet, K. Crawford, T. Cyr, and T. Inaba, Terfenadine metabolism in human liver. In vitro inhibition by macrolide antibiotics and azole antifungals, Drug Metab. Dispos., 22, 849-857 (1994).
-
(1994)
Drug Metab. Dispos.
, vol.22
, pp. 849-857
-
-
Jurima-Romet, M.1
Crawford, K.2
Cyr, T.3
Inaba, T.4
-
68
-
-
0030903839
-
Metabolism of rifabutin in human enterocyte and liver microsomes: Kinetic parameters, identification of enzyme systems, and drug interactions with macrolides and antifungal agents
-
E. Iatsimirskaia, S. Tulebaev, E. Storozhuk, I. Utkin, D. Smith, N. Gerber, and T. Koudriakova, Metabolism of rifabutin in human enterocyte and liver microsomes: Kinetic parameters, identification of enzyme systems, and drug interactions with macrolides and antifungal agents, Clin. Pharmacol. Ther., 61, 554-562 (1997).
-
(1997)
Clin. Pharmacol. Ther.
, vol.61
, pp. 554-562
-
-
Iatsimirskaia, E.1
Tulebaev, S.2
Storozhuk, E.3
Utkin, I.4
Smith, D.5
Gerber, N.6
Koudriakova, T.7
-
69
-
-
0028361593
-
Inhibition of human CYP3A catalyzed 1′-hydroxymidazolam formation by ketoconzole, nifedipine, erythromycin, cimetidine, and nizatidine
-
S. A. Wrighton and B. J. Ring, Inhibition of human CYP3A catalyzed 1′-hydroxymidazolam formation by ketoconzole, nifedipine, erythromycin, cimetidine, and nizatidine, Pharm. Res., 11, 921-923 (1994).
-
(1994)
Pharm. Res.
, vol.11
, pp. 921-923
-
-
Wrighton, S.A.1
Ring, B.J.2
-
70
-
-
0029664974
-
The effect of systemic antimycotics, itraconazole and fluconazole, on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam
-
K. T. Olkkola, J. Ahonen, and P. J. Neuvonen, The effect of systemic antimycotics, itraconazole and fluconazole, on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam, Anesthes. Analges., 82, 511-516 (1996).
-
(1996)
Anesthes. Analges.
, vol.82
, pp. 511-516
-
-
Olkkola, K.T.1
Ahonen, J.2
Neuvonen, P.J.3
-
71
-
-
0028357256
-
Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole
-
K. T. Olkkola, J. T. Backman, and P. J. Neuoven, Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole, Clin. Pharmacol. Ther., 55, 481-485 (1994).
-
(1994)
Clin. Pharmacol. Ther.
, vol.55
, pp. 481-485
-
-
Olkkola, K.T.1
Backman, J.T.2
Neuoven, P.J.3
-
72
-
-
0028359701
-
Dose of midazolam should be reduced during diltiazem and verapamil treatments
-
J. T. Backman, K. T. Olkkola, K. Aranko, J.-J. Himberg, and P. J. Neuvonen, Dose of midazolam should be reduced during diltiazem and verapamil treatments, Br. J. Clin. Pharmacol., 37, 221-225 (1994).
-
(1994)
Br. J. Clin. Pharmacol.
, vol.37
, pp. 221-225
-
-
Backman, J.T.1
Olkkola, K.T.2
Aranko, K.3
Himberg, J.-J.4
Neuvonen, P.J.5
-
73
-
-
0027477751
-
A potentially hazardous interaction between erythromycin and midazolam
-
K. T. Olkkola, K. Aranko, H. Luuila, A. Hiller, L. Saarnivaara, J.-J. Himberg, and P. J. Neuvonen, A potentially hazardous interaction between erythromycin and midazolam, Clin. Pharmacol. Ther., 53, 298-305 (1993).
-
(1993)
Clin. Pharmacol. Ther.
, vol.53
, pp. 298-305
-
-
Olkkola, K.T.1
Aranko, K.2
Luuila, H.3
Hiller, A.4
Saarnivaara, L.5
Himberg, J.-J.6
Neuvonen, P.J.7
-
74
-
-
0031696409
-
The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin
-
J. C. Gorski, D. R. Jones, B. D. Haehner-Daniels, M. A. Hamman, E. M. O'Mara, and S. D. Hall, The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin, Clin. Pharmacol. Ther., 64, 133-143 (1998).
-
(1998)
Clin. Pharmacol. Ther.
, vol.64
, pp. 133-143
-
-
Gorski, J.C.1
Jones, D.R.2
Haehner-Daniels, B.D.3
Hamman, M.A.4
O'Mara, E.M.5
Hall, S.D.6
-
75
-
-
0027447395
-
Cytochrome P-450 complex formation by dirithromycin and other macrolides in rats and human livers
-
T. D. Lindstrom, B. R. Hanssen, and S. A. Wrighton, Cytochrome P-450 complex formation by dirithromycin and other macrolides in rats and human livers, Antimicrob. Agent Chemother., 37, 265-269 (1993).
-
(1993)
Antimicrob. Agent Chemother.
, vol.37
, pp. 265-269
-
-
Lindstrom, T.D.1
Hanssen, B.R.2
Wrighton, S.A.3
-
76
-
-
0027483266
-
Effects of clarithromycin and its metabolites on the mixed function oxidase system in hepatic microsomes of rats
-
S. Ohmori, I. Ishii, S. I. Kuriya, T. Taniguchi, T. Rikihisa, S. Hirose, Y. Kanakubo, and M. Kitada, Effects of clarithromycin and its metabolites on the mixed function oxidase system in hepatic microsomes of rats, Drug Metab. Dispos., 21, 358-363 (1993).
-
(1993)
Drug Metab. Dispos.
, vol.21
, pp. 358-363
-
-
Ohmori, S.1
Ishii, I.2
Kuriya, S.I.3
Taniguchi, T.4
Rikihisa, T.5
Hirose, S.6
Kanakubo, Y.7
Kitada, M.8
-
77
-
-
0024359587
-
Inhibition of alfentanil metabolism by erythromycin
-
R. R. Bartkowski, M. E. Goldberg, G. E. Larijani, and T. Boerner, Inhibition of alfentanil metabolism by erythromycin, Clin. Pharmacol. Ther., 46, 99-102 (1989).
-
(1989)
Clin. Pharmacol. Ther.
, vol.46
, pp. 99-102
-
-
Bartkowski, R.R.1
Goldberg, M.E.2
Larijani, G.E.3
Boerner, T.4
-
78
-
-
0030868233
-
The role of cytochrome P450 3A4 in alfentanil clearance. Implications for interindividual variability in disposition and perioperative drug interactions
-
E. D. Kharasch, M. Russell, D. Mautz, K. E. Thummel, K. L. Kunze, A. T. Bowdle, and K. Cox, The role of cytochrome P450 3A4 in alfentanil clearance. Implications for interindividual variability in disposition and perioperative drug interactions, Anesthesiology, 87, 36-50 (1997).
-
(1997)
Anesthesiology
, vol.87
, pp. 36-50
-
-
Kharasch, E.D.1
Russell, M.2
Mautz, D.3
Thummel, K.E.4
Kunze, K.L.5
Bowdle, A.T.6
Cox, K.7
-
79
-
-
0026719283
-
A pharmacokinetic evaluation of the combined administration of triazolam and fluoxetine
-
C. E. Wright, T. A. Lasher-Sisson, R. C. Steenwyk, and C. N. Swanson, A pharmacokinetic evaluation of the combined administration of triazolam and fluoxetine, Pharmacothcrapy, 12, 103-106 (1992).
-
(1992)
Pharmacothcrapy
, vol.12
, pp. 103-106
-
-
Wright, C.E.1
Lasher-Sisson, T.A.2
Steenwyk, R.C.3
Swanson, C.N.4
-
80
-
-
0031417358
-
Assessment of the potential for a pharmacokinetic interaction between fluoxetine and terfenadine
-
R. F. Bergstrom, M. J. Goldberg, B. J. Cerimele, and B. L. Hatcher, Assessment of the potential for a pharmacokinetic interaction between fluoxetine and terfenadine, Clin. Pharmacol. Ther., 62, 643-651 (1997).
-
(1997)
Clin. Pharmacol. Ther.
, vol.62
, pp. 643-651
-
-
Bergstrom, R.F.1
Goldberg, M.J.2
Cerimele, B.J.3
Hatcher, B.L.4
-
81
-
-
0000497670
-
Isotopically sensitive branching and its effect on the observed intramolecular isotope effects in cytochrome P-450 catalyzed reactions: A new method for the estimation of intrinsic isotope effects
-
J. P. Jones, K. R. Korzekwa, A. E. Rettie, and W. F. Trager, Isotopically sensitive branching and its effect on the observed intramolecular isotope effects in cytochrome P-450 catalyzed reactions: A new method for the estimation of intrinsic isotope effects, J. Am. Chem. Soc., 108, 7074-7078 (1986).
-
(1986)
J. Am. Chem. Soc.
, vol.108
, pp. 7074-7078
-
-
Jones, J.P.1
Korzekwa, K.R.2
Rettie, A.E.3
Trager, W.F.4
-
82
-
-
0024451771
-
Theory for the observed isotope effects from enzymatic systems that form multiple products via branched reaction pathways: Cytochrome P-450
-
K. R. Korzekwa, W. F. Trager, and J. R. Gillette, Theory for the observed isotope effects from enzymatic systems that form multiple products via branched reaction pathways: Cytochrome P-450, Biochemistry, 28, 9012-9018 (1989).
-
(1989)
Biochemistry
, vol.28
, pp. 9012-9018
-
-
Korzekwa, K.R.1
Trager, W.F.2
Gillette, J.R.3
-
83
-
-
0030910832
-
Intramolecular isotope effects for benzylic hydroxylation of isomeric xylenes and 4,4′-dimethylbiphenyl by cytochrome P450: Relationship between distance of methyl groups and masking of the intrinsic isotope effect
-
K. R. Iyer, J. P. Jones, J. F. Darbyshire, and W. F. Trager, Intramolecular isotope effects for benzylic hydroxylation of isomeric xylenes and 4,4′-dimethylbiphenyl by cytochrome P450: Relationship between distance of methyl groups and masking of the intrinsic isotope effect, Biochemistry, 36, 7136-7143 (1997).
-
(1997)
Biochemistry
, vol.36
, pp. 7136-7143
-
-
Iyer, K.R.1
Jones, J.P.2
Darbyshire, J.F.3
Trager, W.F.4
-
84
-
-
0028999257
-
Isotope effects studies on the cytochrome P450 enzymes
-
K. R. Korzekwa, W. F. Trager, and J. R. Gillette, Isotope effects studies on the cytochrome P450 enzymes, Drug Metab. Rev., 27, 45-59 (1995).
-
(1995)
Drug Metab. Rev.
, vol.27
, pp. 45-59
-
-
Korzekwa, K.R.1
Trager, W.F.2
Gillette, J.R.3
-
85
-
-
0001894312
-
Deuterium isotope effects in the metabolism of drugs and xenobiotics: Implications for drug design
-
A. B. Foster, Deuterium isotope effects in the metabolism of drugs and xenobiotics: Implications for drug design, Adv. Drug Res., 14, 1-40 (1985).
-
(1985)
Adv. Drug Res.
, vol.14
, pp. 1-40
-
-
Foster, A.B.1
-
86
-
-
0024991656
-
Active site dynamics of toluene hydroxylation by cytochrome P450
-
R. P. Hanzlik and K.-H. J. Ling, Active site dynamics of toluene hydroxylation by cytochrome P450, J. Org. Chem., 55, 3392-3397 (1990).
-
(1990)
J. Org. Chem.
, vol.55
, pp. 3392-3397
-
-
Hanzlik, R.P.1
Ling, K.-H.J.2
-
87
-
-
0024434143
-
Metabolism of the B-ring of testosterone by the rat cytochrome P-450 system
-
K. Korzekwa, K. Nagata, W. F. Trager, and J. R. Gillette, Metabolism of the B-ring of testosterone by the rat cytochrome P-450 system, Drug Metab. Rev., 20, 535-539 (1989).
-
(1989)
Drug Metab. Rev.
, vol.20
, pp. 535-539
-
-
Korzekwa, K.1
Nagata, K.2
Trager, W.F.3
Gillette, J.R.4
-
88
-
-
0025150366
-
Theoretical studies on cytochrome P-450 mediated hydroxylation: A predictive model for hydrogen atom abstractions
-
K. R. Korzekwa, J. P. Jones, and J. R. Gillette, Theoretical studies on cytochrome P-450 mediated hydroxylation: A predictive model for hydrogen atom abstractions, J. Am. Chem. Soc., 112, 7042-7046 (1990).
-
(1990)
J. Am. Chem. Soc.
, vol.112
, pp. 7042-7046
-
-
Korzekwa, K.R.1
Jones, J.P.2
Gillette, J.R.3
-
89
-
-
0029741968
-
Electronic models for cytochrome P450 oxidations
-
K. R. Korzekwa, J. Grogan, S. DeVito, and J. P. Jones, Electronic models for cytochrome P450 oxidations, Adv. Exp. Med. Biol., 387, 361-369 (1996).
-
(1996)
Adv. Exp. Med. Biol.
, vol.387
, pp. 361-369
-
-
Korzekwa, K.R.1
Grogan, J.2
DeVito, S.3
Jones, J.P.4
-
90
-
-
0028307539
-
Activation of CYP3A4: Evidence for the simultaneous binding of two substrates in a cytochrome P450 active site
-
M. Shou, J. Grogan, J. A. Mancewicz, K. W. Krausz, F. J. Gonzalez, H. V. Gelboin, and K. R. Korzekwa, Activation of CYP3A4: Evidence for the simultaneous binding of two substrates in a cytochrome P450 active site, Biochemistry, 33, 6450-6455 (1994).
-
(1994)
Biochemistry
, vol.33
, pp. 6450-6455
-
-
Shou, M.1
Grogan, J.2
Mancewicz, J.A.3
Krausz, K.W.4
Gonzalez, F.J.5
Gelboin, H.V.6
Korzekwa, K.R.7
-
91
-
-
0023949862
-
Modulation of rabbit and human hepatic cytochrome P-450-catalyzed steroid hydroxylations by alpha-naphthoflavone
-
G. E. Schwab, J. L. Raucy, and E. F. Johnson, Modulation of rabbit and human hepatic cytochrome P-450-catalyzed steroid hydroxylations by alpha-naphthoflavone, Molec. Pharmacol., 33, 493-499 (1988).
-
(1988)
Molec. Pharmacol.
, vol.33
, pp. 493-499
-
-
Schwab, G.E.1
Raucy, J.L.2
Johnson, E.F.3
-
92
-
-
0031028518
-
Cooperativity in oxidations catalyzed by cytochrome P450 3A4
-
Y.-F. Ueng, T. Kuwabara, Y.-J. Chun, and F. P. Guengerich, Cooperativity in oxidations catalyzed by cytochrome P450 3A4, Biochemistry, 36, 370-381 (1997).
-
(1997)
Biochemistry
, vol.36
, pp. 370-381
-
-
Ueng, Y.-F.1
Kuwabara, T.2
Chun, Y.-J.3
Guengerich, F.P.4
-
93
-
-
0032735988
-
CYP3A4 drug interactions: Correlation of 10 in vitro prove substrates
-
K. E. Kenworthy, J. C. Bloomer, S. E. Clarke, and J. B. Houston, CYP3A4 drug interactions: Correlation of 10 in vitro prove substrates, Br. J. Clin. Pharmacol., 48, 716-727 (1999).
-
(1999)
Br. J. Clin. Pharmacol.
, vol.48
, pp. 716-727
-
-
Kenworthy, K.E.1
Bloomer, J.C.2
Clarke, S.E.3
Houston, J.B.4
-
94
-
-
0030444902
-
Cytochrome P450 conformation and substrate interactions as probed by CO binding kinetics
-
A. P. Koley, R. C. Robinson, and F. K. Friedman, Cytochrome P450 conformation and substrate interactions as probed by CO binding kinetics, Biochimie, 78, 706-713 (1996).
-
(1996)
Biochimie
, vol.78
, pp. 706-713
-
-
Koley, A.P.1
Robinson, R.C.2
Friedman, F.K.3
-
95
-
-
0019505397
-
Ascorbic acid inhibition of aromatase activity in human placenta tissue
-
L. Milewich, G. T. Chen, P. C. MacDonald, and J. A. Peterson, Ascorbic acid inhibition of aromatase activity in human placenta tissue, J. Steroid Biochem., 14, 185-193 (1981).
-
(1981)
J. Steroid Biochem.
, vol.14
, pp. 185-193
-
-
Milewich, L.1
Chen, G.T.2
MacDonald, P.C.3
Peterson, J.A.4
-
96
-
-
0031022331
-
Differential mechanisms of cytochrome P450 inhibition and activation by alpha-naphthoflavone
-
A. P. Koley, J. T. M. Buters, R. C. Robinson, A. Markowitz, and F. K. Friedman, Differential mechanisms of cytochrome P450 inhibition and activation by alpha-naphthoflavone, J. Biol. Chem., 272, 3149-3152 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 3149-3152
-
-
Koley, A.P.1
Buters, J.T.M.2
Robinson, R.C.3
Markowitz, A.4
Friedman, F.K.5
-
97
-
-
0006761706
-
Expression of CYP3A enzymes in human kidney
-
B. Haehner, S. A. Wrighton, S. K. Janardan, P. B. Watkins, and S. A. Hall, Expression of CYP3A enzymes in human kidney. Molec. Pharmacol., 50, 52-59 (1996).
-
(1996)
Molec. Pharmacol.
, vol.50
, pp. 52-59
-
-
Haehner, B.1
Wrighton, S.A.2
Janardan, S.K.3
Watkins, P.B.4
Hall, S.A.5
-
98
-
-
0029051491
-
Renal and hepatic family 3A cytochromes P450 (CYP3A) in spontaneously hypertensive rats
-
S. S. Gosh, A. K. Basu, S. Gosh, R. Hagley, L. Kramer, J. Schuetz, W. M. Grogan, P. S. Guzelian, and C. O. Watlington, Renal and hepatic family 3A cytochromes P450 (CYP3A) in spontaneously hypertensive rats, Biochem. Pharmacol., 50, 49-54 (1995).
-
(1995)
Biochem. Pharmacol.
, vol.50
, pp. 49-54
-
-
Gosh, S.S.1
Basu, A.K.2
Gosh, S.3
Hagley, R.4
Kramer, L.5
Schuetz, J.6
Grogan, W.M.7
Guzelian, P.S.8
Watlington, C.O.9
-
99
-
-
0026440394
-
When is cortisol a mineralocorticoid?
-
J. Clore, A. Schoolwerth, and C. O. Watlington, When is cortisol a mineralocorticoid? [editorial], Kidney Int., 42, 1297-1308 (1992).
-
(1992)
Kidney Int.
, vol.42
, pp. 1297-1308
-
-
Clore, J.1
Schoolwerth, A.2
Watlington, C.O.3
-
100
-
-
0026464616
-
Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes
-
J. C. Kolars, P. Schmiedlin-Ren, J. D. Schuetz, C. Fang, and P. B. Watkins, Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes, J. Clin. Invest., 90, 1871-1878 (1992).
-
(1992)
J. Clin. Invest.
, vol.90
, pp. 1871-1878
-
-
Kolars, J.C.1
Schmiedlin-Ren, P.2
Schuetz, J.D.3
Fang, C.4
Watkins, P.B.5
-
101
-
-
0030982634
-
Grapefruit juice increases felodipine oral availability in man by decreasing intestinal CYP3A protein expression
-
M. B. Brown, W. Guo, and P. B. Watkins, Grapefruit juice increases felodipine oral availability in man by decreasing intestinal CYP3A protein expression. J. Clin. Invest. 99, 2545-2553 (1997).
-
(1997)
J. Clin. Invest.
, vol.99
, pp. 2545-2553
-
-
Brown, M.B.1
Guo, W.2
Watkins, P.B.3
-
102
-
-
0030696487
-
Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents: Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins
-
P. Schmiedlin-Ren, D. J. Edwards, M. E. Fitzsimmons, et al., Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents: Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins. Drug Metab. Dispos., 25, 1228-1233 (1997).
-
(1997)
Drug Metab. Dispos.
, vol.25
, pp. 1228-1233
-
-
Schmiedlin-Ren, P.1
Edwards, D.J.2
Fitzsimmons, M.E.3
-
103
-
-
0032949332
-
Molecular and physical mechanisms of first-pass extraction
-
S. D. Hall, K. E. Thummel, P. B. Watkins, K. S. Lown, L. Z. Benet, M. F. Paine, R. R. Mayo, K. Turgeon, D. G. Bailey, R. J. Fontana, and S. A. Wrighton, Molecular and physical mechanisms of first-pass extraction, Drug Metab. Dispos., 27 161-166 (1999).
-
(1999)
Drug Metab. Dispos.
, vol.27
, pp. 161-166
-
-
Hall, S.D.1
Thummel, K.E.2
Watkins, P.B.3
Lown, K.S.4
Benet, L.Z.5
Paine, M.F.6
Mayo, R.R.7
Turgeon, K.8
Bailey, D.G.9
Fontana, R.J.10
Wrighton, S.A.11
-
104
-
-
0032904977
-
Grapefruit juice activates p-glycoprotein-mediated drug transport
-
A. Soldner, U. Christians, M. Susanto, V. J. Wacher, J. A. Silverman, and L. Z. Benet, Grapefruit juice activates p-glycoprotein-mediated drug transport, Pharm. Res., 16, 4768-4785 (1999).
-
(1999)
Pharm. Res.
, vol.16
, pp. 4768-4785
-
-
Soldner, A.1
Christians, U.2
Susanto, M.3
Wacher, V.J.4
Silverman, J.A.5
Benet, L.Z.6
-
105
-
-
1442321728
-
6,7-dihydroxybergamottin in grapefruit juice and Seville orange juice: Effects on cyclosporine disposition, enterocyte CYP3A4 and P-glycoprotein
-
D. Edwards, M. E. Fitzsimmons, E. G. Schuetz, K. Yasuda, M. P. Ducharme, L. H. Warbasse, P. M. Woster, J. D. Schuetz, and P. B. Watkins, 6,7-dihydroxybergamottin in grapefruit juice and Seville orange juice: Effects on cyclosporine disposition, enterocyte CYP3A4 and P-glycoprotein, Clin. Pharmacol. Ther., 65, 237-244 (1999).
-
(1999)
Clin. Pharmacol. Ther.
, vol.65
, pp. 237-244
-
-
Edwards, D.1
Fitzsimmons, M.E.2
Schuetz, E.G.3
Yasuda, K.4
Ducharme, M.P.5
Warbasse, L.H.6
Woster, P.M.7
Schuetz, J.D.8
Watkins, P.B.9
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