Molecular and structural aspects of xenobiotic carbonyl metabolizing enzymes. Role of reductases and dehydrogenases in xenobiotic phase I reactions

Toxicology

Volumn 144, Issue 1-3, 2000, Pages 71-81

  Oppermann, Udo C T ^a   Maser, Edmund ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Alcohol dehydrogenase; Aldehyde dehydrogenase; Aldo keto reductases; Carbonyl reduction; Hydroxysteroid dehydrogenase; Quinone reductase; Short chain dehydrogenases reductases; Xenobiotic carbonyl metabolism

Indexed keywords

1,4 BENZOQUINONE; AFLATOXIN B1; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; AROMATIC HYDROCARBON; DIMETHYLNITROSAMINE DEMETHYLASE; FORMALDEHYDE; GLUTATHIONE; HYDROXYSTEROID DEHYDROGENASE; MITOMYCIN C; NITROSAMINE; OXIDOREDUCTASE; PHENOBARBITAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); RETINOIC ACID;

BINDING SITE; BIOTRANSFORMATION; DRUG METABOLISM; DRUG OXIDATION; ENZYME ACTIVITY; ENZYME SPECIFICITY; HUMAN; LIVER MICROSOME METABOLISM; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; REVIEW; XENOBIOTIC METABOLISM;

EID: 0034600004     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(99)00192-4     Document Type: Article

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