메뉴 건너뛰기




Volumn 38, Issue , 1998, Pages 97-120

Cyclooxygenases 1 and 2

Author keywords

Inflammation; Nonsteroidal anti inflammatory drugs; Prostaglandins; Selective inhibitors

Indexed keywords

5 (4 FLUOROPHENYL) 1 [(4 METHYLSULFONYL)PHENYL] 3 TRIFLUOROMETHYLPYRAZOLE; 6 (2,4 DIFLUOROPHENYLTHIO) 5 METHANESULFONAMIDO 1 INDANONE; 6 METHOXY 2 NAPHTHYLACETIC ACID; ACETYLSALICYLIC ACID; BACTERIUM LIPOPOLYSACCHARIDE; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; CYTOKINE; DICLOFENAC; ETODOLAC; INDOMETACIN; MELOXICAM; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PIROXICAM; PROSTAGLANDIN; PROSTAGLANDIN E2; ROFECOXIB; RS 57067000; SULINDAC; UNCLASSIFIED DRUG;

EID: 0031777185     PISSN: 00664251     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.pharmtox.38.1.97     Document Type: Review
Times cited : (2691)

References (127)
  • 1
    • 0023968630 scopus 로고
    • Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence
    • DeWitt DL, Smith WL. 1988. Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence. Proc. Natl. Acad. Sci. USA 85:1412-16
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 1412-1416
    • DeWitt, D.L.1    Smith, W.L.2
  • 2
    • 0023855416 scopus 로고
    • Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase)
    • Merlie JP, Fagan D, Mudd J, Needleman P. 1988. Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase). J. Biol. Chem. 263:3550-53
    • (1988) J. Biol. Chem. , vol.263 , pp. 3550-3553
    • Merlie, J.P.1    Fagan, D.2    Mudd, J.3    Needleman, P.4
  • 3
    • 0023915232 scopus 로고
    • Primary structure of sheep prostaglandin endoperoxide synthase deduced from cDNA sequence
    • Yokoyama C, Takai T, Tanabe T. 1988. Primary structure of sheep prostaglandin endoperoxide synthase deduced from cDNA sequence. FEBS Lett. 231:347-51
    • (1988) FEBS Lett. , vol.231 , pp. 347-351
    • Yokoyama, C.1    Takai, T.2    Tanabe, T.3
  • 6
    • 0029904828 scopus 로고    scopus 로고
    • Cyclooxygenase-2 and its regulation in inflammation
    • Bakhle YS, Botting RM. 1996. Cyclooxygenase-2 and its regulation in inflammation. Mediat. Inflamm. 5:305-23
    • (1996) Mediat. Inflamm. , vol.5 , pp. 305-323
    • Bakhle, Y.S.1    Botting, R.M.2
  • 7
    • 0030911815 scopus 로고    scopus 로고
    • Cyclo-oxygenase isoenzymes. How recent findings affect thinking about nonsteroidal anti-inflammatory drugs
    • Jouzeau J-Y, Terlain B, Abid A, Nedelec E, Netter P. 1997. Cyclo-oxygenase isoenzymes. How recent findings affect thinking about nonsteroidal anti-inflammatory drugs. Drugs 53:563-82
    • (1997) Drugs , vol.53 , pp. 563-582
    • Jouzeau, J.-Y.1    Terlain, B.2    Abid, A.3    Nedelec, E.4    Netter, P.5
  • 8
    • 0015237292 scopus 로고
    • Inhibition of prostaglandin synthesis as a mechanism of action for the aspirin-like drugs
    • Vane JR. 1971. Inhibition of prostaglandin synthesis as a mechanism of action for the aspirin-like drugs. Nature 231:232-35
    • (1971) Nature , vol.231 , pp. 232-235
    • Vane, J.R.1
  • 9
    • 0029911267 scopus 로고    scopus 로고
    • Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2
    • Luong C, Miller A, Barnett J, Chow J, Ramesha C, et al. 1996. Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2. Nat. Struct. Biol. 3:927-33
    • (1996) Nat. Struct. Biol. , vol.3 , pp. 927-933
    • Luong, C.1    Miller, A.2    Barnett, J.3    Chow, J.4    Ramesha, C.5
  • 10
    • 0030461132 scopus 로고    scopus 로고
    • Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
    • Kurumbail RG, Stevens AM, Gierse JK, McDonald JJ, Stegeman RA, et al. 1996. Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents. Nature 384:644-48
    • (1996) Nature , vol.384 , pp. 644-648
    • Kurumbail, R.G.1    Stevens, A.M.2    Gierse, J.K.3    McDonald, J.J.4    Stegeman, R.A.5
  • 12
    • 0028295135 scopus 로고
    • Mutation of serine-516 in human prostaglandin G/H synthase-2 to methionine or aspirin acetylation of this residue stimulates 15-R-HETE synthesis
    • Mancini JA, O'Neill GP, Bayly C, Vickers PJ. 1994. Mutation of serine-516 in human prostaglandin G/H synthase-2 to methionine or aspirin acetylation of this residue stimulates 15-R-HETE synthesis. FEBS Lett. 342:33-37
    • (1994) FEBS Lett. , vol.342 , pp. 33-37
    • Mancini, J.A.1    O'Neill, G.P.2    Bayly, C.3    Vickers, P.J.4
  • 13
    • 0028339780 scopus 로고
    • Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin
    • Lecomte M, Laneuville O, Ji C, DeWitt DL, Smith WL. 1994. Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin. J. Biol. Chem. 269:13207-15
    • (1994) J. Biol. Chem. , vol.269 , pp. 13207-13215
    • Lecomte, M.1    Laneuville, O.2    Ji, C.3    DeWitt, D.L.4    Smith, W.L.5
  • 14
    • 0028123502 scopus 로고
    • Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: Inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid
    • O'Neill GP, Mancini JA, Kargman S, Yergey J, Kwan MY, et al. 1994. Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid. Mol. Pharmacol. 45:245-54
    • (1994) Mol. Pharmacol. , vol.45 , pp. 245-254
    • O'Neill, G.P.1    Mancini, J.A.2    Kargman, S.3    Yergey, J.4    Kwan, M.Y.5
  • 15
    • 0029983843 scopus 로고    scopus 로고
    • Constitutive cyclooxygenase (COX-1) and inducible cyclooxygenase (COX-2): Rationale for selective inhibition and progress to date
    • Griswold DE, Adams JL. 1996. Constitutive cyclooxygenase (COX-1) and inducible cyclooxygenase (COX-2): rationale for selective inhibition and progress to date. Med. Res. Rev. 16:181-206
    • (1996) Med. Res. Rev. , vol.16 , pp. 181-206
    • De Griswold1    Adams, J.L.2
  • 17
    • 0029899186 scopus 로고    scopus 로고
    • A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors
    • Gierse JK, McDonald JJ, Hauser SD, Rangwala SH, Koboldt CM, et al. 1996. A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors. J. Biol. Chem. 271: 15810-14
    • (1996) J. Biol. Chem. , vol.271 , pp. 15810-15814
    • Gierse, J.K.1    McDonald, J.J.2    Hauser, S.D.3    Rangwala, S.H.4    Koboldt, C.M.5
  • 18
    • 0029666486 scopus 로고    scopus 로고
    • 509 in time-dependent inhibition of human prostaglandin H synthase-2 cyclooxygenase activity by isoform-selective agents
    • 509 in time-dependent inhibition of human prostaglandin H synthase-2 cyclooxygenase activity by isoform-selective agents. J. Biol. Chem. 271:19134-39
    • (1996) J. Biol. Chem. , vol.271 , pp. 19134-19139
    • Guo, Q.1    Wang, L.2    Ruan, K.3    Kulmacz, R.J.4
  • 19
    • 0028783912 scopus 로고
    • Arginine 120 of prostaglandin G/H synthase-1 is required for the inhibition by nonsteroidal anti-inflammatory drugs containing a carboxylic acid moiety
    • Mancini JA, Riendeau D, Falgueyret JP, Vickers PJ, O'Neill GP. 1995. Arginine 120 of prostaglandin G/H synthase-1 is required for the inhibition by nonsteroidal anti-inflammatory drugs containing a carboxylic acid moiety. J. Biol. Chem. 270:29372-77
    • (1995) J. Biol. Chem. , vol.270 , pp. 29372-29377
    • Mancini, J.A.1    Riendeau, D.2    Falgueyret, J.P.3    Vickers, P.J.4    O'Neill, G.P.5
  • 20
    • 0030068054 scopus 로고    scopus 로고
    • Involvement of arginine 120, glutamate 524 and tyrosine 355 in the binding of arachidonate and 2-phenylpropionic acid inhibitors to the cyclooxygenase active site of ovine prostaglandin endoperoxide H synthase-1
    • Bhattacharyya DK, Lecomte M, Rieke CJ, Garavito RM, Smith WL. 1996. Involvement of arginine 120, glutamate 524 and tyrosine 355 in the binding of arachidonate and 2-phenylpropionic acid inhibitors to the cyclooxygenase active site of ovine prostaglandin endoperoxide H synthase-1. J. Biol. Chem. 271:2179-84
    • (1996) J. Biol. Chem. , vol.271 , pp. 2179-2184
    • Bhattacharyya, D.K.1    Lecomte, M.2    Rieke, C.J.3    Garavito, R.M.4    Smith, W.L.5
  • 23
    • 0027200551 scopus 로고
    • Subcellular localization of prostaglandin endoperoxide synthase-2 in murine 3T3 cells
    • Regier MK, DeWitt DL, Schindler MS, Smith WL. 1993. Subcellular localization of prostaglandin endoperoxide synthase-2 in murine 3T3 cells. Arch. Biochem. Biophys. 301:439-44
    • (1993) Arch. Biochem. Biophys. , vol.301 , pp. 439-444
    • Regier, M.K.1    DeWitt, D.L.2    Schindler, M.S.3    Smith, W.L.4
  • 24
    • 0028969527 scopus 로고
    • Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2
    • Monta I, Schindler MS, Regier MK, Otto JC, Hori T, et al. 1995. Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2. J. Biol. Chem. 270:10902-8
    • (1995) J. Biol. Chem. , vol.270 , pp. 10902-10908
    • Monta, I.1    Schindler, M.S.2    Regier, M.K.3    Otto, J.C.4    Hori, T.5
  • 25
    • 0028037571 scopus 로고
    • The orientation of prostaglandin endoperoxide synthases-1 and -2 in the endoplasmic reticulum
    • Otto JC, Smith WL. 1994. The orientation of prostaglandin endoperoxide synthases-1 and -2 in the endoplasmic reticulum. J. Biol. Chem. 269:19868-75
    • (1994) J. Biol. Chem. , vol.269 , pp. 19868-19875
    • Otto, J.C.1    Smith, W.L.2
  • 26
    • 0030033449 scopus 로고    scopus 로고
    • IL-13 and IL-4 inhibit bone resorption by suppressing cyclooxygenase-2-dependent prostaglandin synthesis in osteoblasts
    • Onoe Y, Miyaura C, Kaminakayashiki T, Nagai Y, Noguchi K, et al. 1996. IL-13 and IL-4 inhibit bone resorption by suppressing cyclooxygenase-2-dependent prostaglandin synthesis in osteoblasts. J. Immunol. 156:758-64
    • (1996) J. Immunol. , vol.156 , pp. 758-764
    • Onoe, Y.1    Miyaura, C.2    Kaminakayashiki, T.3    Nagai, Y.4    Noguchi, K.5
  • 27
    • 0030017042 scopus 로고    scopus 로고
    • Characterization of prostaglandin G/H synthase 1 and 2 in rat, dog, monkey and human gastrointestinal tracts
    • Kargman S, Charleson S, Cartwright M, Frank J, Riendeau D, et al. 1996. Characterization of prostaglandin G/H synthase 1 and 2 in rat, dog, monkey and human gastrointestinal tracts. Gastroenterology 111:445-54
    • (1996) Gastroenterology , vol.111 , pp. 445-454
    • Kargman, S.1    Charleson, S.2    Cartwright, M.3    Frank, J.4    Riendeau, D.5
  • 28
    • 0030895087 scopus 로고    scopus 로고
    • Crypt stem cell survival in the mouse intestinal epithelium is regulated by prostaglandins synthesized through cyclooxygenase-1
    • Cohn SM, Schloemann S, Tessner T, Seibert K, Stenson WF. 1997. Crypt stem cell survival in the mouse intestinal epithelium is regulated by prostaglandins synthesized through cyclooxygenase-1. J. Clin. Invest. 99:1367-79
    • (1997) J. Clin. Invest. , vol.99 , pp. 1367-1379
    • Cohn, S.M.1    Schloemann, S.2    Tessner, T.3    Seibert, K.4    Stenson, W.F.5
  • 30
    • 0004456598 scopus 로고
    • Biological properties of cyclooxygenase products
    • ed. F Cunningham, London: Academic
    • Vane JR, Botting RM. 1994. Biological properties of cyclooxygenase products. In Lipid Mediators, ed. F Cunningham, pp. 61-97. London: Academic
    • (1994) Lipid Mediators , pp. 61-97
    • Vane, J.R.1    Botting, R.M.2
  • 31
    • 0028034970 scopus 로고
    • Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction
    • Harris RC, McKanna JA, Akai Y, Jacobson HR, Dubois RN, et al. 1994. Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction. J. Clin. Invest. 94:2504-10
    • (1994) J. Clin. Invest. , vol.94 , pp. 2504-2510
    • Harris, R.C.1    McKanna, J.A.2    Akai, Y.3    Jacobson, H.R.4    Dubois, R.N.5
  • 32
    • 0030061641 scopus 로고    scopus 로고
    • 2 on the induction of nitric oxide- and prostanoid-forming pathways in cultured rat mesangial cells
    • 2 on the induction of nitric oxide- and prostanoid-forming pathways in cultured rat mesangial cells. Biochem. J. 313:617-23
    • (1996) Biochem. J. , vol.313 , pp. 617-623
    • Nüsing, R.M.1    Klein, T.2    Pfeilschifter, J.3    Ullrich, V.4
  • 33
    • 0028120906 scopus 로고
    • Collaborative overview of randomised trials of antiplatelet therapy-I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients
    • Antiplatelet Trialists' Collaboration. 1994. Collaborative overview of randomised trials of antiplatelet therapy-I: prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Br. Med. J. 308:81-106
    • (1994) Br. Med. J. , vol.308 , pp. 81-106
  • 34
    • 0030894130 scopus 로고    scopus 로고
    • The case for low-dose aspirin for the prevention of myocardial infarction: But how low is low?
    • Förster W, Parratt JR. 1996. The case for low-dose aspirin for the prevention of myocardial infarction: But how low is low? Cardiovasc. Drugs Ther. 10:727-34
    • (1996) Cardiovasc. Drugs Ther. , vol.10 , pp. 727-734
    • Förster, W.1    Parratt, J.R.2
  • 35
    • 0030860088 scopus 로고    scopus 로고
    • Use of a cyclo-oxygenase type-2-selective nonsteroidal anti-inflammatory agent to prevent preterm delivery
    • Sawdy R, Slater D, Fisk N, Edmonds DK, Bennett P. 1997. Use of a cyclo-oxygenase type-2-selective nonsteroidal anti-inflammatory agent to prevent preterm delivery. Lancet 350:265-66
    • (1997) Lancet , vol.350 , pp. 265-266
    • Sawdy, R.1    Slater, D.2    Fisk, N.3    Edmonds, D.K.4    Bennett, P.5
  • 36
    • 0029740064 scopus 로고    scopus 로고
    • Localization of prostaglandin H synthase type 2 protein and mRNA in term human fetal membranes and decidua
    • Gibb W, Sun M. 1996. Localization of prostaglandin H synthase type 2 protein and mRNA in term human fetal membranes and decidua. J. Endocrinol. 150:497-503
    • (1996) J. Endocrinol. , vol.150 , pp. 497-503
    • Gibb, W.1    Sun, M.2
  • 38
    • 0029917190 scopus 로고    scopus 로고
    • Expression of human chorionic gonadotropin (hCG)/luteinizing hormone receptors and regulation of the cyclooxygenase-1 gene by exogenous hCG in human fetal membranes
    • Toth P, Li X, Lei ZM, Rao CV. 1996. Expression of human chorionic gonadotropin (hCG)/luteinizing hormone receptors and regulation of the cyclooxygenase-1 gene by exogenous hCG in human fetal membranes. J. Clin. Endocrinol. Metab. 81:1283-88
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 1283-1288
    • Toth, P.1    Li, X.2    Lei, Z.M.3    Rao, C.V.4
  • 39
    • 0029949756 scopus 로고    scopus 로고
    • Developmental expression of the cyclo-oxygenase-1 and cyclo-oxygenase-2 genes in the peri-implantation mouse uterus and their differential regulation by the blastocyst and ovarian steroids
    • Chakraborty I, Das SK, Wang J, Dey SK. 1996. Developmental expression of the cyclo-oxygenase-1 and cyclo-oxygenase-2 genes in the peri-implantation mouse uterus and their differential regulation by the blastocyst and ovarian steroids. J. Mol. Endocrinol. 16:107-22
    • (1996) J. Mol. Endocrinol. , vol.16 , pp. 107-122
    • Chakraborty, I.1    Das, S.K.2    Wang, J.3    Dey, S.K.4
  • 40
    • 0028922530 scopus 로고
    • Glucocorticoids stimulate the expression of prostaglandin endoperoxide H synthase-2 in amnion cells
    • Zakar T, Hirst JJ, Milovic JE, Olson DM. 1995. Glucocorticoids stimulate the expression of prostaglandin endoperoxide H synthase-2 in amnion cells. Endocrinology 136:1610-19
    • (1995) Endocrinology , vol.136 , pp. 1610-1619
    • Zakar, T.1    Hirst, J.J.2    Milovic, J.E.3    Olson, D.M.4
  • 41
    • 0042540024 scopus 로고    scopus 로고
    • The induction of cyclooxygenase-2 (COX-2) in intact human amnion tissue by interleukin-4
    • Spaziani EP, Lantz ME, Benoit RR, O'Brien WF. 1996. The induction of cyclooxygenase-2 (COX-2) in intact human amnion tissue by interleukin-4. Prostaglandins 51:215-23
    • (1996) Prostaglandins , vol.51 , pp. 215-223
    • Spaziani, E.P.1    Lantz, M.E.2    Benoit, R.R.3    O'Brien, W.F.4
  • 42
    • 0029824156 scopus 로고    scopus 로고
    • Expression of prostaglandin G/H synthase-1 and -2 in ovine amnion and placenta following glucocorticoid-induced labour onset
    • McLaren WJ, Young IR, Wong MH, Rice GE. 1996. Expression of prostaglandin G/H synthase-1 and -2 in ovine amnion and placenta following glucocorticoid-induced labour onset. J. Endocrinol. 151:125-35
    • (1996) J. Endocrinol. , vol.151 , pp. 125-135
    • McLaren, W.J.1    Young, I.R.2    Wong, M.H.3    Rice, G.E.4
  • 43
    • 0028843881 scopus 로고
    • Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
    • Langenbach R, Morham SG, Tiano HF, Loftin CD, Ghanayem BI, et al. 1995. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell 83:483-92
    • (1995) Cell , vol.83 , pp. 483-492
    • Langenbach, R.1    Morham, S.G.2    Tiano, H.F.3    Loftin, C.D.4    Ghanayem, B.I.5
  • 44
    • 0028807498 scopus 로고
    • Prostaglandin synthase 2 gene disruption casuses severe renal pathology in the mouse
    • Morham SG, Langenbach R, Loftin CD, Tiano HF, Vouloumanos N, et al. 1995. Prostaglandin synthase 2 gene disruption casuses severe renal pathology in the mouse. Cell 83:473-82
    • (1995) Cell , vol.83 , pp. 473-482
    • Morham, S.G.1    Langenbach, R.2    Loftin, C.D.3    Tiano, H.F.4    Vouloumanos, N.5
  • 45
    • 0028818913 scopus 로고
    • Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II
    • Dinchuk JE, Car BD, Focht RJ, Johnston JJ, Jaffee BD, et al. 1995. Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. Nature 378:406-9
    • (1995) Nature , vol.378 , pp. 406-409
    • Dinchuk, J.E.1    Car, B.D.2    Focht, R.J.3    Johnston, J.J.4    Jaffee, B.D.5
  • 46
    • 0029202298 scopus 로고
    • Ovarian cell differentiation: A cascade of multiple hormones, cellular signals, and regulated genes
    • Richards JS, Fitzpatrick SL, Clemens JW, Morris JK, Alliston T, et al. 1995. Ovarian cell differentiation: a cascade of multiple hormones, cellular signals, and regulated genes. [Review]. Rec. Prog. Hormone Res. 50:223-54
    • (1995) Rec. Prog. Hormone Res. , vol.50 , pp. 223-254
    • Richards, J.S.1    Fitzpatrick, S.L.2    Clemens, J.W.3    Morris, J.K.4    Alliston, T.5
  • 47
    • 0028892425 scopus 로고
    • Yes, but do they still get headaches?
    • DeWitt DL, Smith WL. 1995. Yes, but do they still get headaches? Cell 83:345-48
    • (1995) Cell , vol.83 , pp. 345-348
    • DeWitt, D.L.1    Smith, W.L.2
  • 49
    • 0027290813 scopus 로고
    • Expression of a mitogen-inducible cyclooxygenase in brain neurons; regulation by synaptic activity and glucocorticoids
    • Yamagata K, Andreassson KI, Kaufman WE, Barnes CA, Worley PF. 1993. Expression of a mitogen-inducible cyclooxygenase in brain neurons; regulation by synaptic activity and glucocorticoids. Neuron 11:371-86
    • (1993) Neuron , vol.11 , pp. 371-386
    • Yamagata, K.1    Andreassson, K.I.2    Kaufman, W.E.3    Barnes, C.A.4    Worley, P.F.5
  • 50
    • 0028902109 scopus 로고
    • Characterization of inducible cyclooxygenase in rat brain
    • Breder CD, Dewitt D, Kraig RP. 1995. Characterization of inducible cyclooxygenase in rat brain. J. Comp. Neurol. 355:296-315
    • (1995) J. Comp. Neurol. , vol.355 , pp. 296-315
    • Breder, C.D.1    Dewitt, D.2    Kraig, R.P.3
  • 51
    • 0029866955 scopus 로고    scopus 로고
    • Expression of inducible cyclooxygenase mRNA in the mouse brain after systemic administration of bacterial lipopolysaccharide
    • Breder CD, Saper CB. 1996. Expression of inducible cyclooxygenase mRNA in the mouse brain after systemic administration of bacterial lipopolysaccharide. Brain Res. 713:64-69
    • (1996) Brain Res. , vol.713 , pp. 64-69
    • Breder, C.D.1    Saper, C.B.2
  • 53
    • 0030597962 scopus 로고    scopus 로고
    • Up-regulation of cyclooxygenase-2 mRNA in the rat spinal cord following peripheral inflammation
    • Beiche F, Scheuerer S, Brune K, Geisslinger G, Goppelt-Struebe M. 1996. Up-regulation of cyclooxygenase-2 mRNA in the rat spinal cord following peripheral inflammation. FEBS Lett. 390:165-69
    • (1996) FEBS Lett. , vol.390 , pp. 165-169
    • Beiche, F.1    Scheuerer, S.2    Brune, K.3    Geisslinger, G.4    Goppelt-Struebe, M.5
  • 54
    • 0027293391 scopus 로고
    • Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues
    • O'Neill GP, Ford-Hutchinson AW. 1993. Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues. FEBS Lett. 330:156-60
    • (1993) FEBS Lett. , vol.330 , pp. 156-160
    • O'Neill, G.P.1    Ford-Hutchinson, A.W.2
  • 55
    • 0027525156 scopus 로고
    • Dominant expression of mRNA for prostaglandin D synthase in leptomeninges, choroid plexus and oligodendrocytes of the adult rat brain
    • Urade Y, Kitahama K, Ohishi H, Kaneko T, Mizuno N, et al. 1993. Dominant expression of mRNA for prostaglandin D synthase in leptomeninges, choroid plexus and oligodendrocytes of the adult rat brain. Proc. Natl. Acad. Sci. USA 90:9070-74
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 9070-9074
    • Urade, Y.1    Kitahama, K.2    Ohishi, H.3    Kaneko, T.4    Mizuno, N.5
  • 56
    • 0013640871 scopus 로고    scopus 로고
    • Fever: How may circulating pyrogens signal the brain?
    • Blatteis CM, Sehic E. 1997. Fever: How may circulating pyrogens signal the brain? News Physiol. Sci. 12:1-8
    • (1997) News Physiol. Sci. , vol.12 , pp. 1-8
    • Blatteis, C.M.1    Sehic, E.2
  • 57
    • 0030590429 scopus 로고    scopus 로고
    • Endothelial cells of the brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1β: A possible site of prostaglandin synthesis responsible for fever
    • Cao C, Matsumura K, Yamagata K, Watanabe Y. 1996. Endothelial cells of the brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1β: a possible site of prostaglandin synthesis responsible for fever. Brain Res. 733:263-72
    • (1996) Brain Res. , vol.733 , pp. 263-272
    • Cao, C.1    Matsumura, K.2    Yamagata, K.3    Watanabe, Y.4
  • 58
    • 0030989111 scopus 로고    scopus 로고
    • Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages
    • Elmquist JK, Breder CD, Sherin JE, Scammell TE, Hickey WF, et al. 1997. Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages. J. Comp. Neurol. 382:119-29
    • (1997) J. Comp. Neurol. , vol.382 , pp. 119-129
    • Elmquist, J.K.1    Breder, C.D.2    Sherin, J.E.3    Scammell, T.E.4    Hickey, W.F.5
  • 59
    • 0030787985 scopus 로고    scopus 로고
    • Involvement of cyclooxygenase-2 in LPS-induced fever and regulation of its mRNA by LPS in rat brain
    • Cao C, Matsumura K, Yamagata K, Watanabe Y. 1997. Involvement of cyclooxygenase-2 in LPS-induced fever and regulation of its mRNA by LPS in rat brain. Am. J. Physiol. 272:R1712-25
    • (1997) Am. J. Physiol. , vol.272
    • Cao, C.1    Matsumura, K.2    Yamagata, K.3    Watanabe, Y.4
  • 60
    • 0015505169 scopus 로고
    • Prostaglandins, aspirin-like drugs and hyperalgesia
    • Ferreira SH. 1972. Prostaglandins, aspirin-like drugs and hyperalgesia. Nature 240:200-3
    • (1972) Nature , vol.240 , pp. 200-203
    • Ferreira, S.H.1
  • 61
    • 0030913028 scopus 로고    scopus 로고
    • Cytokines, nerve growth factor and inflammatory hyperalgesia: The contribution of tumour necrosis factor α
    • Woolf CJ, Allchorne A, Safieh-Garabedian B, Poole S. 1997. Cytokines, nerve growth factor and inflammatory hyperalgesia: the contribution of tumour necrosis factor α. Br. J. Pharmacol. 121: 417-24
    • (1997) Br. J. Pharmacol. , vol.121 , pp. 417-424
    • Woolf, C.J.1    Allchorne, A.2    Safieh-Garabedian, B.3    Poole, S.4
  • 63
    • 0026787367 scopus 로고
    • The pivotal role of tumour necrosis factor α in the development of inflammatory hyperalgesia
    • Cunha FQ, Poole S, Lorenzetti BB, Ferreira SH. 1992. The pivotal role of tumour necrosis factor α in the development of inflammatory hyperalgesia. Br. J. Pharmacol. 107:660-64
    • (1992) Br. J. Pharmacol. , vol.107 , pp. 660-664
    • Cunha, F.Q.1    Poole, S.2    Lorenzetti, B.B.3    Ferreira, S.H.4
  • 65
    • 0029823291 scopus 로고    scopus 로고
    • 2 causes sensitization of the primary afferent neuron via the spinal release of glutamate
    • 2 causes sensitization of the primary afferent neuron via the spinal release of glutamate. Inflamm. Res. 45:499-502
    • (1996) Inflamm. Res. , vol.45 , pp. 499-502
    • Ferreira, S.H.1    Lorenzetti, B.B.2
  • 66
    • 0026795636 scopus 로고
    • Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition
    • Malmberg AB, Yaksh TL. 1992. Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition. Science 257:1276-79
    • (1992) Science , vol.257 , pp. 1276-1279
    • Malmberg, A.B.1    Yaksh, T.L.2
  • 67
    • 0030580417 scopus 로고    scopus 로고
    • Analysis of the effects of cyclooxygenase (COX)-1 and COX-2 in spinal nociceptive transmission using indomethacin, a non-selective COX inhibitor, and NS-398, a COX-2 selective inhibitor
    • Yamamoto T, Nozaki-Taguchi N. 1996. Analysis of the effects of cyclooxygenase (COX)-1 and COX-2 in spinal nociceptive transmission using indomethacin, a non-selective COX inhibitor, and NS-398, a COX-2 selective inhibitor. Brain Res. 739:104-10
    • (1996) Brain Res. , vol.739 , pp. 104-110
    • Yamamoto, T.1    Nozaki-Taguchi, N.2
  • 68
    • 0002841625 scopus 로고    scopus 로고
    • Cyclooxygenases in rat spinal cord: Selective induction of COX-2 during peripheral inflammation
    • Abstr.
    • Gardiner NJ, Giblett S, Grubb BD. 1997. Cyclooxygenases in rat spinal cord: selective induction of COX-2 during peripheral inflammation. Br. J. Pharmacol, 120:71P (Abstr.)
    • (1997) Br. J. Pharmacol , vol.120
    • Gardiner, N.J.1    Giblett, S.2    Grubb, B.D.3
  • 69
    • 0031463351 scopus 로고    scopus 로고
    • Prostanoids synthesized by cyclooxygenase isoforms in rat spinal cord and their contribution to the development of neuronal hyperexcitability
    • In press
    • Willingale HL, Gardiner NJ, McLymont N, Giblett S, Grubb BD. 1997. Prostanoids synthesized by cyclooxygenase isoforms in rat spinal cord and their contribution to the development of neuronal hyperexcitability. Br. J. Pharmacol. In press
    • (1997) Br. J. Pharmacol.
    • Willingale, H.L.1    Gardiner, N.J.2    McLymont, N.3    Giblett, S.4    Grubb, B.D.5
  • 71
    • 0028972026 scopus 로고
    • 2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation
    • 2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell 83:813-19
    • (1995) Cell , vol.83 , pp. 813-819
    • Kliewer, S.A.1    Lenhard, J.M.2    Willson, T.M.3    Patel, I.4    Morris, D.C.5
  • 73
    • 0029562554 scopus 로고
    • The RXR heterodimers and orphan receptors
    • Mangelsdorf DJ, Evans RM. 1995. The RXR heterodimers and orphan receptors. Cell 83:841-50
    • (1995) Cell , vol.83 , pp. 841-850
    • Mangelsdorf, D.J.1    Evans, R.M.2
  • 75
    • 0030606276 scopus 로고    scopus 로고
    • Self-promotion? Intimate connections between APC and prostaglandin H synthase-2
    • Prescott SM, White RL. 1996. Self-promotion? Intimate connections between APC and prostaglandin H synthase-2. Cell 87:783-86
    • (1996) Cell , vol.87 , pp. 783-786
    • Prescott, S.M.1    White, R.L.2
  • 76
    • 0028803728 scopus 로고
    • Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2
    • Tsujii M, Dubois RN. 1995. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell 83:493-501
    • (1995) Cell , vol.83 , pp. 493-501
    • Tsujii, M.1    Dubois, R.N.2
  • 77
    • 0029117289 scopus 로고
    • Nonsteroidal antiinflammatory drugs cause apoptosis and induce cyclooxygenases in chicken embryo fibroblasts
    • Lu X, Xie W, Reed D, Bradshaw WS, Simmons DL. 1995. Nonsteroidal antiinflammatory drugs cause apoptosis and induce cyclooxygenases in chicken embryo fibroblasts. Proc. Natl. Acad. Sci. USA 92:7961-65
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 7961-7965
    • Lu, X.1    Xie, W.2    Reed, D.3    Bradshaw, W.S.4    Simmons, D.L.5
  • 78
    • 17544388790 scopus 로고
    • Nimesulide; a multifactorial therapeutic approach to the inflammatory process?; a 7-year clinical experience
    • Bennett A, Berti F, Ferreira SH. 1993. Nimesulide; a multifactorial therapeutic approach to the inflammatory process?; a 7-year clinical experience. Drugs 46:1-283
    • (1993) Drugs , vol.46 , pp. 1-283
    • Bennett, A.1    Berti, F.2    Ferreira, S.H.3
  • 79
  • 80
    • 13444266910 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: Identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, celecoxib)
    • Penning TD, Talley JJ, Bertenshaw SR, Carter JS, Collins PW, et al. 1997. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, celecoxib). J Med. Chem. 40:1347-65
    • (1997) J Med. Chem. , vol.40 , pp. 1347-1365
    • Penning, T.D.1    Talley, J.J.2    Bertenshaw, S.R.3    Carter, J.S.4    Collins, P.W.5
  • 81
    • 8244255009 scopus 로고    scopus 로고
    • Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor
    • Riendeau D, Percival MD, Boyce S, Brideau C, Charleson S, et al. 1997. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br. J. Pharmacol. 121:105-17
    • (1997) Br. J. Pharmacol. , vol.121 , pp. 105-117
    • Riendeau, D.1    Percival, M.D.2    Boyce, S.3    Brideau, C.4    Charleson, S.5
  • 82
    • 0000036055 scopus 로고    scopus 로고
    • Selective inhibition of cyclooxygenase-2 (COX-2) with MK-0966 (250 mg q.d.) is associated with less gastroduodenal damage than aspirin (ASA) 650 mg q.i.d. or ibuprofen (IBU) 800 mg t.i.d.
    • Abstr.
    • Lanza F, Simon T, Quan H, Bolognese J, Rack MF, et al. 1997. Selective inhibition of cyclooxygenase-2 (COX-2) with MK-0966 (250 mg q.d.) is associated with less gastroduodenal damage than aspirin (ASA) 650 mg q.i.d. or ibuprofen (IBU) 800 mg t.i.d. Gastroenterology 112:A194 (Abstr.)
    • (1997) Gastroenterology , vol.112
    • Lanza, F.1    Simon, T.2    Quan, H.3    Bolognese, J.4    Rack, M.F.5
  • 83
    • 0000036055 scopus 로고    scopus 로고
    • A pilot endoscopic study of the gastroduodenal effects of SC-58635, a novel COX-2 selective inhibitor
    • Abstr.
    • Lanza FL, Rack MF, Callison DA, Hubbard RC, Yu SS, et al. 1997. A pilot endoscopic study of the gastroduodenal effects of SC-58635, a novel COX-2 selective inhibitor. Gastroenterology 112:A194 (Abstr.)
    • (1997) Gastroenterology , vol.112
    • Lanza, F.L.1    Rack, M.F.2    Callison, D.A.3    Hubbard, R.C.4    Yu, S.S.5
  • 84
    • 33646124789 scopus 로고    scopus 로고
    • SC-58635, a highly selective inhibitor of COX-2, is an effective analgesic in an acute post-surgical pain model
    • Abstr.
    • Hubbard RC, Mehlisch DR, Jasper DR, Nugent MJ, Yu S, et al. 1996. SC-58635, a highly selective inhibitor of COX-2, is an effective analgesic in an acute post-surgical pain model. J. Invest. Med. 44:293A (Abstr.)
    • (1996) J. Invest. Med. , vol.44
    • Hubbard, R.C.1    Mehlisch, D.R.2    Jasper, D.R.3    Nugent, M.J.4    Yu, S.5
  • 85
    • 0001867832 scopus 로고    scopus 로고
    • Efficacy of MK-966, a highly selective inhibitor of COX-2, in the treatment of postoperative dental pain
    • Abstr.
    • Ehrich E, Mehlisch D, Perkins S, Brown P, Wittreich J, et al. 1996. Efficacy of MK-966, a highly selective inhibitor of COX-2, in the treatment of postoperative dental pain. Arthritis Rheum. 39(Suppl. 9):S81 (Abstr.)
    • (1996) Arthritis Rheum. , vol.39 , Issue.9 SUPPL.
    • Ehrich, E.1    Mehlisch, D.2    Perkins, S.3    Brown, P.4    Wittreich, J.5
  • 86
    • 0029033219 scopus 로고
    • Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: A novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and non-human primate stomach
    • Chan C-C, Boyce S, Brideau C, Ford-Hutchinson AW, Gordon R, et al. 1995. Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and non-human primate stomach. J. Pharmacol. Exp. Ther. 274:1531-37
    • (1995) J. Pharmacol. Exp. Ther. , vol.274 , pp. 1531-1537
    • Chan, C.-C.1    Boyce, S.2    Brideau, C.3    Ford-Hutchinson, A.W.4    Gordon, R.5
  • 87
    • 0031052054 scopus 로고    scopus 로고
    • Cyclooxygenase 2 and wound healing in the stomach
    • Stenson WF. 1997. Cyclooxygenase 2 and wound healing in the stomach. Gastroenterology 112:645-48
    • (1997) Gastroenterology , vol.112 , pp. 645-648
    • Stenson, W.F.1
  • 88
    • 0031052116 scopus 로고    scopus 로고
    • Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice
    • Mizuno H, Sakamoto C, Matsuda K, Wada K, Uchida T, et al. 1997. Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice. Gastroenterology 112:387-97
    • (1997) Gastroenterology , vol.112 , pp. 387-397
    • Mizuno, H.1    Sakamoto, C.2    Matsuda, K.3    Wada, K.4    Uchida, T.5
  • 89
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler KW, Vogelstein B. 1996. Lessons from hereditary colorectal cancer. Cell 87:159-70
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 92
    • 0028556801 scopus 로고
    • Aspirin use and the risk for colorectal cancer and adenoma in male health professionals
    • Giovanucci E, Rimm EB, Stampfer MJ, Colditz GA, Ascherio A, et al. 1994. Aspirin use and the risk for colorectal cancer and adenoma in male health professionals. Ann. Intern. Med. 121:241-46
    • (1994) Ann. Intern. Med. , vol.121 , pp. 241-246
    • Giovanucci, E.1    Rimm, E.B.2    Stampfer, M.J.3    Colditz, G.A.4    Ascherio, A.5
  • 93
  • 94
    • 0027993458 scopus 로고
    • Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas
    • Eberhart CE, Coffey RJ, Radhika A, Giardiello FM, Ferrenbach S, et al. 1994. Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 107:1183-88
    • (1994) Gastroenterology , vol.107 , pp. 1183-1188
    • Eberhart, C.E.1    Coffey, R.J.2    Radhika, A.3    Giardiello, F.M.4    Ferrenbach, S.5
  • 96
    • 0031000902 scopus 로고    scopus 로고
    • Modulation of apoptosis by sulindac, curcumin, phenylethyl-3-methylcaffeate and 6-phenylhexyl isothiocyanate: Apoptotic index as a biomarker in colon cancer chemoprevention and promotion
    • Samaha HS, Kelloff GJ, Steele V, Rao CV, Reddy BS. 1997. Modulation of apoptosis by sulindac, curcumin, phenylethyl-3-methylcaffeate and 6-phenylhexyl isothiocyanate: apoptotic index as a biomarker in colon cancer chemoprevention and promotion. Cancer Res. 57:1301-5
    • (1997) Cancer Res. , vol.57 , pp. 1301-1305
    • Samaha, H.S.1    Kelloff, G.J.2    Steele, V.3    Rao, C.V.4    Reddy, B.S.5
  • 97
    • 0030992045 scopus 로고    scopus 로고
    • Effects of sulindac on sporadic colorectal adenomatous polyps
    • Matsuhashi N, Nakajima A, Fukushima Y, Yazaki Y, Oka T. 1997. Effects of sulindac on sporadic colorectal adenomatous polyps. Gut 40:344-49
    • (1997) Gut , vol.40 , pp. 344-349
    • Matsuhashi, N.1    Nakajima, A.2    Fukushima, Y.3    Yazaki, Y.4    Oka, T.5
  • 101
    • 0031035593 scopus 로고    scopus 로고
    • Sulfone metabolite of sulindac inhibits mammary carcinogenesis
    • Thompson HJ, Jiang C, Lu J, Mehta RG, Piazza GA, et al. 1997. Sulfone metabolite of sulindac inhibits mammary carcinogenesis. Cancer Res. 57:267-71
    • (1997) Cancer Res. , vol.57 , pp. 267-271
    • Thompson, H.J.1    Jiang, C.2    Lu, J.3    Mehta, R.G.4    Piazza, G.A.5
  • 102
    • 0029879704 scopus 로고    scopus 로고
    • Neuroinflammatory mechanisms in Alzheimer's disease: New opportunities for drug discovery
    • Cochran FR, Vitek MP. 1996. Neuroinflammatory mechanisms in Alzheimer's disease: new opportunities for drug discovery. Expert Opin. Invest. Drugs 5:449-55
    • (1996) Expert Opin. Invest. Drugs , vol.5 , pp. 449-455
    • Cochran, F.R.1    Vitek, M.P.2
  • 103
    • 0030000385 scopus 로고    scopus 로고
    • The role of anti-inflammatory drugs in the prevention and treatment of Alzheimer's disease
    • Breitner JCS. 1996. The role of anti-inflammatory drugs in the prevention and treatment of Alzheimer's disease. Annu. Rev. Med. 47:401-11
    • (1996) Annu. Rev. Med. , vol.47 , pp. 401-411
    • Breitner, J.C.S.1
  • 104
    • 0029610011 scopus 로고
    • The inflammatory response system of brain: Implications for therapy of Alzheimer and other neurodegenerative diseases
    • McGeer PL, McGeer EG. 1995. The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res. Rev. 21:195-218
    • (1995) Brain Res. Rev. , vol.21 , pp. 195-218
    • McGeer, P.L.1    McGeer, E.G.2
  • 105
    • 0030897133 scopus 로고    scopus 로고
    • Risk of Alzheimer's disease and duration of NSAID use
    • Stewart WF, Kawas C, Corrada M, Metter EJ. 1997. Risk of Alzheimer's disease and duration of NSAID use. Neurology 48:626-32
    • (1997) Neurology , vol.48 , pp. 626-632
    • Stewart, W.F.1    Kawas, C.2    Corrada, M.3    Metter, E.J.4
  • 106
    • 0029587620 scopus 로고
    • Inflammatory and immunological mechanisms in Alzheimer's disease
    • Hampel H, Muller N. 1995. Inflammatory and immunological mechanisms in Alzheimer's disease. Drug News Perspect. 8:599-608
    • (1995) Drug News Perspect. , vol.8 , pp. 599-608
    • Hampel, H.1    Muller, N.2
  • 108
    • 0030250598 scopus 로고    scopus 로고
    • Prostaglandin G/H synthase-2 (cyclooxygenase-2) mRNA expression is decreased in Alzheimer's disease
    • Chang JW, Coleman PD, O'Banion MK. 1996. Prostaglandin G/H synthase-2 (cyclooxygenase-2) mRNA expression is decreased in Alzheimer's disease. Neurobiol. Aging. 17:801-8
    • (1996) Neurobiol. Aging. , vol.17 , pp. 801-808
    • Chang, J.W.1    Coleman, P.D.2    O'Banion, M.K.3
  • 110
  • 111
    • 0031456454 scopus 로고    scopus 로고
    • Differential inhibition of human prostaglandin endoperoxide synthase-1 and -2 by nonsteroidal anti-inflammatory drugs
    • In press
    • Patrignani P, Panara MR, Sciulli MG, Santini G, Renda G, Patrono C. 1997. Differential inhibition of human prostaglandin endoperoxide synthase-1 and -2 by nonsteroidal anti-inflammatory drugs. J. Physiol. Pharmacol. 48:In press
    • (1997) J. Physiol. Pharmacol. , vol.48
    • Patrignani, P.1    Panara, M.R.2    Sciulli, M.G.3    Santini, G.4    Renda, G.5    Patrono, C.6
  • 112
    • 0027480087 scopus 로고
    • Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other nonsteroidal anti-inflammatory drugs
    • Meade EA, Smith WL, DeWitt DL. 1993. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other nonsteroidal anti-inflammatory drugs. J. Biol. Chem. 268:6610-14
    • (1993) J. Biol. Chem. , vol.268 , pp. 6610-6614
    • Meade, E.A.1    Smith, W.L.2    DeWitt, D.L.3
  • 113
    • 0030030129 scopus 로고    scopus 로고
    • Meloxicam: Influence on arachidonic acid metabolism. Part 1. in vitro findings
    • Engelhardt G, Bögel R, Schnitzer Chr, Utzmann R. 1996 Meloxicam: influence on arachidonic acid metabolism. Part 1. In vitro findings. Biochem. Pharmacol. 51:21-28
    • (1996) Biochem. Pharmacol. , vol.51 , pp. 21-28
    • Engelhardt, G.1    Bögel, R.2    Schnitzer, Chr.3    Utzmann, R.4
  • 115
    • 0028089109 scopus 로고
    • NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro
    • Futaki N, Takahashi S, Yokoyama M, Arai S, Higuchi S, Otomo S. 1994. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins 47:55-59
    • (1994) Prostaglandins , vol.47 , pp. 55-59
    • Futaki, N.1    Takahashi, S.2    Yokoyama, M.3    Arai, S.4    Higuchi, S.5    Otomo, S.6
  • 116
    • 0027986841 scopus 로고
    • Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs
    • Laneuville O, Breuer DK, DeWitt DL, Hla T, Funk CD and Smith WL. 1994. Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J. Pharmacol. Exp. Ther. 271:927-34
    • (1994) J. Pharmacol. Exp. Ther. , vol.271 , pp. 927-934
    • Laneuville, O.1    Breuer, D.K.2    DeWitt, D.L.3    Hla, T.4    Funk, C.D.5    Smith, W.L.6
  • 117
    • 0028830109 scopus 로고
    • Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase
    • Gierse JK, Hauser SD, Creely DP, Koboldt C, Rangwala SH, et al. 1995. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem. J. 305:479-84
    • (1995) Biochem. J. , vol.305 , pp. 479-484
    • Gierse, J.K.1    Hauser, S.D.2    Creely, D.P.3    Koboldt, C.4    Rangwala, S.H.5
  • 119
    • 0027940487 scopus 로고
    • Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases
    • Patrignani P, Panara MR, Greco A, Fusco O, Natoli C, et al. 1994. Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases. J. Pharmacol. Exp. Ther. 271:1705-12
    • (1994) J. Pharmacol. Exp. Ther. , vol.271 , pp. 1705-1712
    • Patrignani, P.1    Panara, M.R.2    Greco, A.3    Fusco, O.4    Natoli, C.5
  • 121
    • 0030022032 scopus 로고
    • A human whole blood assay for clinical evaluation of biochemical efficacy of cyclooxygenase inhibitors
    • Brideau C, Kargman S, Liu S, Dallob AL, Ehrich EW, et al. 1995. A human whole blood assay for clinical evaluation of biochemical efficacy of cyclooxygenase inhibitors. Inflamm. Res. 45:68-74
    • (1995) Inflamm. Res. , vol.45 , pp. 68-74
    • Brideau, C.1    Kargman, S.2    Liu, S.3    Dallob, A.L.4    Ehrich, E.W.5
  • 122
    • 0345265516 scopus 로고
    • Nimesulide: Selectivity for cyclooxygenase 2 over cyclo-oxygenase 1
    • Abstr.
    • Warner TD, Amirmansour C, Vane JR. 1995. Nimesulide: selectivity for cyclooxygenase 2 over cyclo-oxygenase 1. Inflamm. Res. 44(Suppl 3):S274 (Abstr.)
    • (1995) Inflamm. Res. , vol.44 , Issue.3 SUPPL.
    • Warner, T.D.1    Amirmansour, C.2    Vane, J.R.3
  • 123
    • 0003111606 scopus 로고    scopus 로고
    • The history of anti-inflammatory drugs and their mechanism of action
    • ed. N Bazan, J Botting, JR Vane, London: Kluwer/William Harvey Press
    • Vane JR, Botting RM. 1996. The history of anti-inflammatory drugs and their mechanism of action. In New Targets in Inflammation - Inhibitors of COX-2 or Adhesion Molecules, ed. N Bazan, J Botting, JR Vane, pp. 1-12. London: Kluwer/William Harvey Press
    • (1996) New Targets in Inflammation - Inhibitors of COX-2 or Adhesion Molecules , pp. 1-12
    • Vane, J.R.1    Botting, R.M.2
  • 124
    • 0027992733 scopus 로고
    • Purification, characterzation and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system
    • Barnett J, Chow J, Ives D, Chiou M, Mackenzie R, et al. 1994. Purification, characterzation and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim. Biophys. Acta 1209:130-39
    • (1994) Biochim. Biophys. Acta , vol.1209 , pp. 130-139
    • Barnett, J.1    Chow, J.2    Ives, D.3    Chiou, M.4    Mackenzie, R.5
  • 125
    • 0030582843 scopus 로고    scopus 로고
    • Selective inhibition of cyclooxygenase-1 and -2 using intact insect cell assays
    • Cromlish WA, Kennedy BP. 1996. Selective inhibition of cyclooxygenase-1 and -2 using intact insect cell assays. Biochem. Pharmacol. 52:1777-85
    • (1996) Biochem. Pharmacol. , vol.52 , pp. 1777-1785
    • Cromlish, W.A.1    Kennedy, B.P.2
  • 126
    • 0344402580 scopus 로고    scopus 로고
    • Effect of COX-2 inhibitors on constitutive and inducible cyclooxygenase activity from different sources. Comparison with anti-inflammatory activity
    • Abstr.
    • Carabaza A, Cabre F, Rottlan E, Calvo L, Gutierrez M, Gomez M, et al. 1996. Effect of COX-2 inhibitors on constitutive and inducible cyclooxygenase activity from different sources. Comparison with anti-inflammatory activity. Prostaglandins Leukot. Essent. Fatty Acids 55(Suppl. 1):93 (Abstr.)
    • (1996) Prostaglandins Leukot. Essent. Fatty Acids , vol.55 , Issue.1 SUPPL. , pp. 93
    • Carabaza, A.1    Cabre, F.2    Rottlan, E.3    Calvo, L.4    Gutierrez, M.5    Gomez, M.6
  • 127
    • 0029088821 scopus 로고
    • Etodolac selectively inhibits human prostaglandin G/H synthase 2 (PGHS-2) versus human PGHS-1
    • Glaser K, Sung M-L, O'Neill K, Belfast M, Hartman D, et al. 1995. Etodolac selectively inhibits human prostaglandin G/H synthase 2 (PGHS-2) versus human PGHS-1. Eur. J. Pharmacol. 281:107-11
    • (1995) Eur. J. Pharmacol. , vol.281 , pp. 107-111
    • Glaser, K.1    Sung, M.-L.2    O'Neill, K.3    Belfast, M.4    Hartman, D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.