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Volumn 3, Issue 10, 2006, Pages 1053-1101

The biochemistry of drug metabolism - An introduction Part 1. Principles and overview

Author keywords

[No Author keywords available]

Indexed keywords

ACYLGLYCEROL; AGRICULTURAL CHEMICAL; AMINO ACID; ANABOLIC AGENT; CALCIUM; CARBAMAZEPINE; CENTRAL STIMULANT AGENT; CHLORDANE; CHLORIDE; CHLORPHENOTANE; DIMETHYL SULFOXIDE; FATTY ACID; FOOD ADDITIVE; GROWTH HORMONE; HYDROLASE; INSULIN; ISOMERASE; LEVODOPA; LIGASE; LIPID; LYASE; MINERAL; OXIDOREDUCTASE; POLYCHLORINATED BIPHENYL DERIVATIVE; PROPRANOLOL; PSYCHEDELIC AGENT; SODIUM; TRANSFERASE; UNINDEXED DRUG; XENOBIOTIC AGENT;

EID: 33750632169     PISSN: 16121872     EISSN: 16121880     Source Type: Journal    
DOI: 10.1002/cbdv.200690111     Document Type: Review
Times cited : (75)

References (122)
  • 1
    • 0017647042 scopus 로고
    • 'History of drug metabolism: Discoveries of the major pathways in the 19th century'
    • A. Conti, M. H. Bickel, 'History of drug metabolism: discoveries of the major pathways in the 19th century', Drug Metab. Rev. 1977, 6, 1-50
    • (1977) Drug Metab. Rev. , vol.6 , pp. 1-50
    • Conti, A.1    Bickel, M.H.2
  • 2
    • 0022366179 scopus 로고
    • 'History of drug metabolism: The first half of the 20th century'
    • C. Bachmann, M. H. Bickel, 'History of drug metabolism: the first half of the 20th century', Drug Metab. Rev. 1986, 16, 185-253.
    • (1986) Drug Metab. Rev. , vol.16 , pp. 185-253
    • Bachmann, C.1    Bickel, M.H.2
  • 3
    • 33750606675 scopus 로고    scopus 로고
    • International Society for the Study of Xenobiotics
    • International Society for the Study of Xenobiotics, www.issx.org.
  • 7
    • 33750611891 scopus 로고
    • 'The coming of age of drug metabolism'
    • B. Testa, P. Jenner, 'The coming of age of drug metabolism', Curr. Contents Life Sci. 1990, 33, 17.
    • (1990) Curr. Contents Life Sci. , vol.33 , pp. 17
    • Testa, B.1    Jenner, P.2
  • 8
    • 33750606825 scopus 로고
    • Eds. R Jenner, B. Testa, Dekker, New York
    • 'Concepts in Drug Metabolism', Eds. R Jenner, B. Testa, Dekker, New York, 1980 and 1981, Part A and Part B.
    • (1980) 'Concepts in Drug Metabolism' , Issue.PART A-B
  • 9
    • 0343622296 scopus 로고
    • Eds. D. J. Benford, J. W. Bridges, G. G. Gibson, Taylor & Francis, London
    • 'Drug Metabolism - from Molecules to Man', Eds. D. J. Benford, J. W. Bridges, G. G. Gibson, Taylor & Francis, London, 1987.
    • (1987) 'Drug Metabolism - From Molecules to Man'
  • 11
    • 84883456465 scopus 로고
    • Eds. P. G. Welling, L. P. Balant, Springer, Heidelberg
    • 'Pharmacokinetics of Drugs', Eds. P. G. Welling, L. P. Balant, Springer, Heidelberg, 1994.
    • (1994) 'Pharmacokinetics of Drugs'
  • 15
    • 0003909064 scopus 로고    scopus 로고
    • Ed. T. F. Woolf, Dekker, New York
    • 'Handbook of Drug Metabolism', Ed. T. F. Woolf, Dekker, New York, 1999.
    • (1999) 'Handbook of Drug Metabolism'
  • 18
    • 0038680170 scopus 로고    scopus 로고
    • Ed. A. D. Rodrigues, Dekker, New York
    • 'Drug-Drug Interactions', Ed. A. D. Rodrigues, Dekker, New York, 2002.
    • (2002) 'Drug-Drug Interactions'
  • 19
    • 20044363256 scopus 로고    scopus 로고
    • Eds. J. Boullata, V. T. Armenti, Humana Press, Totowa
    • 'Handbook of Drug-Nutrient Interactions', Eds. J. Boullata, V. T. Armenti, Humana Press, Totowa, 2004.
    • (2004) 'Handbook of Drug-Nutrient Interactions'
  • 20
    • 33750607415 scopus 로고    scopus 로고
    • Ed. L. H. Lash, Humana Press, Totowa
    • 'Drug Metabolism and Transport', Ed. L. H. Lash, Humana Press, Totowa, 2005.
    • (2005) 'Drug Metabolism and Transport'
  • 21
    • 0003555917 scopus 로고    scopus 로고
    • Eds. I. R. Phillips, E. A. Shephard, Humana Press, Totowa
    • 'Cytochrome P450 Protocols', Eds. I. R. Phillips, E. A. Shephard, Humana Press, Totowa, 2006.
    • (2006) 'Cytochrome P450 Protocols'
  • 23
    • 84909710478 scopus 로고
    • Chapman & Hall, London
    • A. Albert, 'Xenobiosis', Chapman & Hall, London, 1987.
    • (1987) 'Xenobiosis'
    • Albert, A.1
  • 30
    • 0019920384 scopus 로고
    • 'Metabolism, pharmacokinetics, and toxicokinetics defined'
    • F. J. Di Carlo, 'Metabolism, pharmacokinetics, and toxicokinetics defined', Drug Metab. Rev. 1982, 13, 1-4.
    • (1982) Drug Metab. Rev. , vol.13 , pp. 1-4
    • Di Carlo, F.J.1
  • 31
    • 2442601735 scopus 로고    scopus 로고
    • 'Principles of drug metabolism'
    • in 6th edn., Ed. D. J. Abraham, Wiley-Interscience, Hoboken
    • B. Testa, W. Soine, 'Principles of drug metabolism', in 'Burger's Medicinal Chemistry and Drug Discovery', 6th edn., Vol. 2, Ed. D. J. Abraham, Wiley-Interscience, Hoboken, 2003, p. 431-498.
    • (2003) 'Burger's Medicinal Chemistry and Drug Discovery' , vol.2 , pp. 431-498
    • Testa, B.1    Soine, W.2
  • 32
    • 38249036339 scopus 로고
    • 'The behaviour of foreign substances in the human body'
    • A. Albert, 'The behaviour of foreign substances in the human body', Trends Pharmacol. Sci. 1987, 8, 258-261.
    • (1987) Trends Pharmacol. Sci. , vol.8 , pp. 258-261
    • Albert, A.1
  • 33
    • 33750605879 scopus 로고
    • 'Xenobiotic and endobiotic metabolizing enzymes: An overstretched discrimination?'
    • P. Jenner, B. Testa, F. J. Di Carlo, 'Xenobiotic and endobiotic metabolizing enzymes: an overstretched discrimination?', Trends Pharmacol. Sci. 1981, 2, 135-137.
    • (1981) Trends Pharmacol. Sci. , vol.2 , pp. 135-137
    • Jenner, P.1    Testa, B.2    Di Carlo, F.J.3
  • 34
    • 0025611278 scopus 로고
    • 'The enzymes of detoxication'
    • W. B. Jakoby, D. M. Ziegler, 'The enzymes of detoxication', J. Biol. Chem. 1990, 265, 20715-20718.
    • (1990) J. Biol. Chem. , vol.265 , pp. 20715-20718
    • Jakoby, W.B.1    Ziegler, D.M.2
  • 35
    • 0026376260 scopus 로고
    • 'Proposed role of drug-metabolizing enzymes: Regulation of steady state levels of the ligands that effect growth, homeostasis, differentiation, and neuroendocrine functions'
    • D. W. Nebert, 'Proposed role of drug-metabolizing enzymes: Regulation of steady state levels of the ligands that effect growth, homeostasis, differentiation, and neuroendocrine functions', Mol. Endocrinol. 1991, 5, 1203-1214.
    • (1991) Mol. Endocrinol. , vol.5 , pp. 1203-1214
    • Nebert, D.W.1
  • 36
    • 0025333289 scopus 로고
    • 'Evolution of the P450 gene superfamily: Animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation'
    • F. J. Gonzalez, D. W. Nebert, 'Evolution of the P450 gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation', Trends Genet. 1990, 6, 182-186.
    • (1990) Trends Genet. , vol.6 , pp. 182-186
    • Gonzalez, F.J.1    Nebert, D.W.2
  • 37
    • 0027026497 scopus 로고
    • 'Nature's pesticides'
    • B. N. Ames, M. Profet, 'Nature's pesticides', Nat. Toxins 1992, 1, 2-3.
    • (1992) Nat. Toxins , vol.1 , pp. 2-3
    • Ames, B.N.1    Profet, M.2
  • 38
    • 27144524217 scopus 로고
    • 'Drug metabolism and drug toxicity: Some evolutionary considerations'
    • in Eds. P. Jenner, B. Testa, Dekker, New York
    • W. R. Jondorf, 'Drug metabolism and drug toxicity: Some evolutionary considerations', in 'Concepts in Drug Metabolism', Part B, Eds. P. Jenner, B. Testa, Dekker, New York, 1981, p. 305-376.
    • (1981) 'Concepts in Drug Metabolism' , Issue.PART B , pp. 305-376
    • Jondorf, W.R.1
  • 39
    • 0020697040 scopus 로고
    • 'The use of theoretical pharmacokinetic concepts in studies of the mechanisms of formation of chemically reactive metabolites in vitro and in vivo'
    • J. R. Gillette, 'The use of theoretical pharmacokinetic concepts in studies of the mechanisms of formation of chemically reactive metabolites in vitro and in vivo', Drug Metab. Rev. 1983, 14, 9-33.
    • (1983) Drug Metab. Rev. , vol.14 , pp. 9-33
    • Gillette, J.R.1
  • 40
    • 0023723401 scopus 로고
    • 'Reactive intermediates and their toxicological significance'
    • T. J. Monks, S. S. Lau, 'Reactive intermediates and their toxicological significance', Toxicology 1988, 52, 1-54.
    • (1988) Toxicology , vol.52 , pp. 1-54
    • Monks, T.J.1    Lau, S.S.2
  • 41
    • 0000302145 scopus 로고
    • 'Pharmacokinetic and pharmacodynamic events: Can they always be distinguished?'
    • B. Testa, 'Pharmacokinetic and pharmacodynamic events: can they always be distinguished?', Trends Pharmacol. Sci. 1987, 8, 381-383.
    • (1987) Trends Pharmacol. Sci. , vol.8 , pp. 381-383
    • Testa, B.1
  • 42
    • 33750605086 scopus 로고    scopus 로고
    • 'ADME-Tox: The Fate of Drugs in the Body'
    • Eds. B. Testa, H. van de Waterbeemd, in 2nd, edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford, in press
    • 'ADME-Tox: The Fate of Drugs in the Body, Eds. B. Testa, H. van de Waterbeemd, in 'Comprehensive Medicinal Chemistry, 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford, Vol. 5, in press.
    • 'Comprehensive Medicinal Chemistry' , vol.5
  • 43
    • 0018140231 scopus 로고
    • 'Novel metabolites produced by functionalization reactions: Chemistry and toxicology'
    • B. Testa, P. Jenner, 'Novel metabolites produced by functionalization reactions: Chemistry and toxicology', Drug Metab. Rev. 1978, 7, 325-369.
    • (1978) Drug Metab. Rev. , vol.7 , pp. 325-369
    • Testa, B.1    Jenner, P.2
  • 44
    • 0020415697 scopus 로고
    • 'Conjugation reactions in foreign-compound metabolism: Definition, consequences, and species variations'
    • J. Caldwell, 'Conjugation reactions in foreign-compound metabolism: definition, consequences, and species variations', Drug Metab. Rev. 1982, 13, 745-777.
    • (1982) Drug Metab. Rev. , vol.13 , pp. 745-777
    • Caldwell, J.1
  • 45
    • 0020313118 scopus 로고
    • 'Nonenzymatic contributions to xenobiotic metabolism'
    • B. Testa, 'Nonenzymatic contributions to xenobiotic metabolism', Drug Metab. Rev. 1982, 13, 25-50.
    • (1982) Drug Metab. Rev. , vol.13 , pp. 25-50
    • Testa, B.1
  • 46
    • 0021917028 scopus 로고
    • 'Quantitative account of propranolol metabolism in urine of normal man'
    • T. Walle, U. K. Walle, L. S. Olanoff, 'Quantitative account of propranolol metabolism in urine of normal man', Drug Metab. Dispos. 1985, 13, 204-209.
    • (1985) Drug Metab. Dispos. , vol.13 , pp. 204-209
    • Walle, T.1    Walle, U.K.2    Olanoff, L.S.3
  • 47
    • 0017192172 scopus 로고
    • 'The concept of regioselectivity in drug metabolism'
    • B. Testa, P. Jenner, 'The concept of regioselectivity in drug metabolism', J. Pharm. Pharmacol. 1976, 28, 731-744.
    • (1976) J. Pharm. Pharmacol. , vol.28 , pp. 731-744
    • Testa, B.1    Jenner, P.2
  • 48
    • 0003450992 scopus 로고    scopus 로고
    • Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB)
    • 'Enzyme Nomenclature', Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB), www.chem.qmul.ac.uk/iubmb/ enzyme.
    • 'Enzyme Nomenclature'
  • 49
    • 21344463534 scopus 로고    scopus 로고
    • 'Tissue distribution of basic drugs: Accounting for enantiomeric, compound and regional differences amongst β-blocking drugs in rat'
    • T. Rodgers, D. Leahy, M. Rowland, 'Tissue distribution of basic drugs: Accounting for enantiomeric, compound and regional differences amongst β-blocking drugs in rat', J. Pharm. Sci. 2005, 94, 1237-1248
    • (2005) J. Pharm. Sci. , vol.94 , pp. 1237-1248
    • Rodgers, T.1    Leahy, D.2    Rowland, M.3
  • 50
    • 33750608350 scopus 로고    scopus 로고
    • 'Drug absorption, distribution, and elimination'
    • in 6th edn., Ed. D. J. Abraham, Wiley-Interscience, Hoboken
    • L. Z. Benet, B. Y. T. Perotti, L. Hardy, 'Drug absorption, distribution, and elimination', in 'Burger's Medicinal Chemistry and Drug Discovery', 6th edn., Vol. 2, Ed. D. J. Abraham, Wiley-Interscience, Hoboken, 2003, p. 633-647
    • (2003) 'Burger's Medicinal Chemistry and Drug Discovery' , vol.2 , pp. 633-647
    • Benet, L.Z.1    Perotti, B.Y.T.2    Hardy, L.3
  • 51
    • 0025916671 scopus 로고
    • 'Tissue binding versus plasma binding of drugs: General principles and pharmacokinetic consequences'
    • in Ed. B. Testa, Academic Press, London
    • B. Fichtl, A. von Nieciecki, K. Walter, 'Tissue binding versus plasma binding of drugs: General principles and pharmacokinetic consequences', in 'Advances in Drug Research', Vol. 20, Ed. B. Testa, Academic Press, London, 1991, p. 117-166.
    • (1991) 'Advances in Drug Research' , vol.20 , pp. 117-166
    • Fichtl, B.1    von Nieciecki, A.2    Walter, K.3
  • 52
    • 1842607633 scopus 로고    scopus 로고
    • 'Neonatal exposure to drugs in breast milk'
    • P. J. McNamara, M. Abbassi, 'Neonatal exposure to drugs in breast milk', Pharm. Res. 2004, 21, 555-566.
    • (2004) Pharm. Res. , vol.21 , pp. 555-566
    • McNamara, P.J.1    Abbassi, M.2
  • 53
    • 17744363706 scopus 로고    scopus 로고
    • 'Interspecies scaling of biliary excreted drugs: A comparison of several methods'
    • I. Mahmood, 'Interspecies scaling of biliary excreted drugs: A comparison of several methods', J. Pharm. Sci. 2005, 94, 883-892.
    • (2005) J. Pharm. Sci. , vol.94 , pp. 883-892
    • Mahmood, I.1
  • 54
    • 26444529021 scopus 로고    scopus 로고
    • 'The endoplasmic reticulum in xenobiotic toxicity'
    • A. E. Cribb, M. Peyton, S. Muruganandan, 'The endoplasmic reticulum in xenobiotic toxicity', Drug Metab. Rev. 2005, 37, 405-442.
    • (2005) Drug Metab. Rev. , vol.37 , pp. 405-442
    • Cribb, A.E.1    Peyton, M.2    Muruganandan, S.3
  • 55
    • 0034837087 scopus 로고    scopus 로고
    • 'High-throughput screening approaches for investigating drug metabolism and pharmacokinetics'
    • S. A. Robert, 'High-throughput screening approaches for investigating drug metabolism and pharmacokinetics', Xenobiotics 2001, 31, 557-589.
    • (2001) Xenobiotics , vol.31 , pp. 557-589
    • Robert, S.A.1
  • 57
    • 33750617743 scopus 로고    scopus 로고
    • 'Antifungal agents'
    • in 6th edn., Ed. D. J. Abraham, Wiley-Interscience, Hoboken
    • W. J. Watkins, T. E. Renau, 'Antifungal agents', in 'Burger's Medicinal Chemistry and Drug Discovery', 6th edn., Vol. 5, Ed. D. J. Abraham, Wiley-Interscience, Hoboken, 2003, p. 981-918.
    • (2003) 'Burger's Medicinal Chemistry and Drug Discovery' , vol.5 , pp. 918-981
    • Watkins, W.J.1    Renau, T.E.2
  • 58
    • 0032796389 scopus 로고    scopus 로고
    • 'Metabolism-based drug interactions involving oral azole antifungals in humans'
    • M. Strolin Benedetti, M. Bani, 'Metabolism-based drug interactions involving oral azole antifungals in humans', Drug Metab. Rev. 1999, 31, 665-717.
    • (1999) Drug Metab. Rev. , vol.31 , pp. 665-717
    • Strolin Benedetti, M.1    Bani, M.2
  • 59
    • 0020438611 scopus 로고
    • 'Pharmacologically active metabolites of drugs and other foreign compounds. Clinical, pharmacological, therapeutic and toxicological considerations'
    • D. E. Drayer, 'Pharmacologically active metabolites of drugs and other foreign compounds. Clinical, pharmacological, therapeutic and toxicological considerations', Drugs 1982, 24, 519-542.
    • (1982) Drugs , vol.24 , pp. 519-542
    • Drayer, D.E.1
  • 60
    • 4143147349 scopus 로고    scopus 로고
    • 'Discovering drugs though biological transformation: Role of pharmacologically active metabolites in drug discovery'
    • A. Fura, Y. Z. Shu, M. Zhu, R. L. Hanson, V. Roongta, W. G. Humphreys, 'Discovering drugs though biological transformation: Role of pharmacologically active metabolites in drug discovery', J. Med. Chem. 2004, 47, 4339-4351.
    • (2004) J. Med. Chem. , vol.47 , pp. 4339-4351
    • Fura, A.1    Shu, Y.Z.2    Zhu, M.3    Hanson, R.L.4    Roongta, V.5    Humphreys, W.G.6
  • 61
    • 2342481809 scopus 로고    scopus 로고
    • 'Lessons learned from marketed and investigational prodrugs'
    • P. Ettmayer, G. Amidon, B. Clement, B. Testa, 'Lessons learned from marketed and investigational prodrugs', J. Med. Chem. 2004, 47, 2393-2404.
    • (2004) J. Med. Chem. , vol.47 , pp. 2393-2404
    • Ettmayer, P.1    Amidon, G.2    Clement, B.3    Testa, B.4
  • 62
    • 7444253306 scopus 로고    scopus 로고
    • 'Prodrug research: Futile or fertile?'
    • B. Testa, 'Prodrug research: Futile or fertile?', Biochem. Pharmacol. 2004, 68, 2097-2106.
    • (2004) Biochem. Pharmacol. , vol.68 , pp. 2097-2106
    • Testa, B.1
  • 63
    • 0036242414 scopus 로고    scopus 로고
    • 'Toxicophores: Groups and metabolic routes associated with increased safety risk'
    • D. P. Williams, D. J. Naisbitt, 'Toxicophores: Groups and metabolic routes associated with increased safety risk', Curr. Opin. Drug Discov. Dev. 2002, 5, 104-115.
    • (2002) Curr. Opin. Drug Discov. Dev. , vol.5 , pp. 104-115
    • Williams, D.P.1    Naisbitt, D.J.2
  • 65
    • 0028289107 scopus 로고
    • 'Factors affecting the storage of drugs and other xenobiotics in adipose tissue'
    • in Eds. B. Testa, U. A. Meyer, Academic Press, London
    • M. H. Bickel, 'Factors affecting the storage of drugs and other xenobiotics in adipose tissue', in 'Advances in Drug Research', Vol. 25, Eds. B. Testa, U. A. Meyer, Academic Press, London, 1994, p. 56-86.
    • (1994) 'Advances in Drug Research' , vol.25 , pp. 56-86
    • Bickel, M.H.1
  • 66
    • 3042530803 scopus 로고    scopus 로고
    • 'Pollution gets personal'
    • E. Stokstad, 'Pollution gets personal', Science 2004, 304, 1892-1894
    • (2004) Science , vol.304 , pp. 1892-1894
    • Stokstad, E.1
  • 67
    • 3142590781 scopus 로고    scopus 로고
    • 'Exposure to flame retardants on the rise'
    • P. Webster, 'Exposure to flame retardants on the rise', Science 2004, 304, 1730.
    • (2004) Science , vol.304 , pp. 1730
    • Webster, P.1
  • 68
    • 35348978666 scopus 로고    scopus 로고
    • 'Anticonvulsants'
    • in 6th edn., Ed. D. J. Abraham, Wiley-Interscience, Hoboken
    • K. R. Scott, 'Anticonvulsants', in 'Burger's Medicinal Chemistry and Drug Discovery', 6th edn., Vol. 6, Ed. D. J. Abraham, Wiley-Interscience, Hoboken, 2003, p. 263-328.
    • (2003) 'Burger's Medicinal Chemistry and Drug Discovery' , vol.6 , pp. 263-328
    • Scott, K.R.1
  • 69
    • 0032522873 scopus 로고    scopus 로고
    • 'Incidence of adverse drug reactions in hospitalized patients: A meta-analysis of prospective studies'
    • J. Lazarou, B. H. Pomeranz, P. N. Corey, 'Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies', J. Am. Med. Assoc. 1998, 279, 1200-1205.
    • (1998) J. Am. Med. Assoc. , vol.279 , pp. 1200-1205
    • Lazarou, J.1    Pomeranz, B.H.2    Corey, P.N.3
  • 70
    • 33750631707 scopus 로고    scopus 로고
    • 'Pharmacogenomics: How gene variants can ruin good drugs'
    • (March)
    • R. Bullingham, 'Pharmacogenomics: how gene variants can ruin good drugs', Curr. Drug Discov. 2001 (March), 17-20.
    • (2001) Curr. Drug Discov. , pp. 17-20
    • Bullingham, R.1
  • 71
    • 84906444652 scopus 로고    scopus 로고
    • 'Immunotoxicology'
    • in 'ADME-Tox: The Fate of Drugs in the Body', in Eds. B. Testa, H. van de Waterbeemd, in 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford in press
    • C. Esser, 'Immunotoxicology', in 'ADME-Tox: The Fate of Drugs in the Body, Eds. B. Testa, H. van de Waterbeemd, in 'Comprehensive Medicinal Chemistry', 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford, Vol. 5, in press.
    • 'Comprehensive Medicinal Chemistry' , vol.5
    • Esser, C.1
  • 72
    • 33750619073 scopus 로고    scopus 로고
    • 'The Why and How of ADMET Research'
    • in 'ADME-Tox: The Fate of Drugs in the Body', Eds. B. Testa, H. van de Waterbeemd, in 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford in press
    • H. van de Waterbeemd, B. Testa, 'The Why and How of ADMET Research', in 'ADME-Tox: The Fate of Drugs in the Body', Eds. B. Testa, H. van de Waterbeemd, in 'Comprehensive Medicinal Chemistry', 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford, Vol. 5, in press
    • 'Comprehensive Medicinal Chemistry' , vol.5
    • van de Waterbeemd, H.1    Testa, B.2
  • 76
    • 0036035509 scopus 로고    scopus 로고
    • 'Do drug metabolism and pharmacokinetic departments make any contribution to drug discovery?'
    • D. A. Smith, E. F. Schmid, B. Jones, 'Do drug metabolism and pharmacokinetic departments make any contribution to drug discovery?', Clin. Pharmacokin. 2002, 41, 1005-1019.
    • (2002) Clin. Pharmacokin. , vol.41 , pp. 1005-1019
    • Smith, D.A.1    Schmid, E.F.2    Jones, B.3
  • 77
    • 0034890106 scopus 로고    scopus 로고
    • 'Optimization of metabolic stability as a goal of modern drug design'
    • T. N. Thompson, 'Optimization of metabolic stability as a goal of modern drug design', Med. Res. Rev. 2001, 21, 412-449.
    • (2001) Med. Res. Rev. , vol.21 , pp. 412-449
    • Thompson, T.N.1
  • 78
    • 12244293377 scopus 로고    scopus 로고
    • 'In silico predictive toxicology: The state-of-the-art and strategies to predict human health effects'
    • C. Helma, 'In silico predictive toxicology: The state-of-the-art and strategies to predict human health effects', Curr. Opin. Drug Discov. Dev. 2005, 8, 27-31.
    • (2005) Curr. Opin. Drug Discov. Dev. , vol.8 , pp. 27-31
    • Helma, C.1
  • 79
    • 77957596837 scopus 로고    scopus 로고
    • 'Computational models to predict toxicity'
    • in 'ADME-Tox: The Fate of Drugs in the Body', Eds. B. Testa, H. van de Waterbeemd, in 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford, in press
    • N. Greene, 'Computational models to predict toxicity', in 'ADME-Tox: The Fate of Drugs in the Body', Eds. B. Testa, H. van de Waterbeemd, in 'Comprehensive Medicinal Chemistry', 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford, Vol. 5, in press.
    • 'Comprehensive Medicinal Chemistry', , vol.5
    • Greene, N.1
  • 80
    • 79956371416 scopus 로고    scopus 로고
    • 'In silico models to predict passage through the skin and other biological barriers'
    • in 'ADME-Tox: The Fate of Drugs in the Body', Eds. B. Testa, H. van de Waterbeemd, in 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford, in press
    • M. Cronin, 'In silico models to predict passage through the skin and other biological barriers', in 'ADME-Tox: The Fate of Drugs in the Body', Eds. B. Testa, H. van de Waterbeemd, in 'Comprehensive Medicinal Chemistry', 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford, Vol. 5, in press.
    • 'Comprehensive Medicinal Chemistry' , vol.5
    • Cronin, M.1
  • 81
    • 77957591166 scopus 로고    scopus 로고
    • 'In vitro studies of drug metabolism'
    • in 'ADME-Tox: The Fate of Drugs in the Body', Eds. B. Testa, H. van de Waterbeemd, in 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford, in press
    • Y. Parmentier, M. J. Bossant, M. Bertrand, B. Walther, 'In vitro studies of drug metabolism', in 'ADME-Tox: The Fate of Drugs in the Body', Eds. B. Testa, H. van de Waterbeemd, in 'Comprehensive Medicinal Chemistry', 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford, Vol. 5, in press.
    • 'Comprehensive Medicinal Chemistry' , vol.5
    • Parmentier, Y.1    Bossant, M.J.2    Bertrand, M.3    Walther, B.4
  • 82
    • 0036784476 scopus 로고    scopus 로고
    • 'Comparison of in vitro preparations for semi-quantitative prediction of in vivo drug metabolism'
    • I. A. M. De Graaf, C. E. Van Meijeren, F. Pektas, H. J. Koster, 'Comparison of in vitro preparations for semi-quantitative prediction of in vivo drug metabolism', Drug Metab. Dispos 2002, 30, 1129-1136.
    • (2002) Drug Metab. Dispos , vol.30 , pp. 1129-1136
    • De Graaf, I.A.M.1    Van Meijeren, C.E.2    Pektas, F.3    Koster, H.J.4
  • 83
    • 24144496026 scopus 로고    scopus 로고
    • 'Microsomal prediction of in vivo clearance and associated interindividual variability of six benzodiazepines in humans'
    • H. C. Rawden, D. J. Carlile, A. Tindall, D. Hallifax, A. Galetin, K. Ito, J. B. Houston, 'Microsomal prediction of in vivo clearance and associated interindividual variability of six benzodiazepines in humans', Xenobiotica 2005, 35, 603-625.
    • (2005) Xenobiotica , vol.35 , pp. 603-625
    • Rawden, H.C.1    Carlile, D.J.2    Tindall, A.3    Hallifax, D.4    Galetin, A.5    Ito, K.6    Houston, J.B.7
  • 84
    • 0034837148 scopus 로고    scopus 로고
    • 'Assessment of drug-drug interactions: Concepts and approaches'
    • R. J. Weaver, 'Assessment of drug-drug interactions: concepts and approaches', Xenobiotica 2001, 31, 499-538.
    • (2001) Xenobiotica , vol.31 , pp. 499-538
    • Weaver, R.J.1
  • 85
    • 2142802929 scopus 로고    scopus 로고
    • 'Chapter 31. Enzyme Induction - Mechanisms, Assays, and Relevance to Drug Discovery and Development'
    • D. C. Evans, D. P. Hartley, R. Evers, 'Chapter 31. Enzyme Induction - Mechanisms, Assays, and Relevance to Drug Discovery and Development', Annu. Rep. Med. Chem. 2003, 38, 315-331.
    • (2003) Annu. Rep. Med. Chem. , vol.38 , pp. 315-331
    • Evans, D.C.1    Hartley, D.P.2    Evers, R.3
  • 86
    • 0033852930 scopus 로고    scopus 로고
    • 'Induction and drug development'
    • D. A. Smith, 'Induction and drug development', Eur. J. Pharm. Sci. 2000, 11, 185-189.
    • (2000) Eur. J. Pharm. Sci. , vol.11 , pp. 185-189
    • Smith, D.A.1
  • 87
    • 0036771085 scopus 로고    scopus 로고
    • 'Inhibition-based metabolic drug-drug interactions: Predictions from in vitro data'
    • C. Yao, R. H. Levy, 'Inhibition-based metabolic drug-drug interactions: predictions from in vitro data', J. Pharm. Sci. 2002, 91, 1923-1935.
    • (2002) J. Pharm. Sci. , vol.91 , pp. 1923-1935
    • Yao, C.1    Levy, R.H.2
  • 88
    • 84906428924 scopus 로고    scopus 로고
    • 'Mechanisms of toxification and detoxification which challenge drug candidates and drugs'
    • in 'ADME-Tox: The Fate of Drugs in the Body', Eds. B. Testa, H. van de Waterbeemd, in 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford, in press
    • B. Oesch-Bartlomowicz, F. Oesch, 'Mechanisms of toxification and detoxification which challenge drug candidates and drugs', in'ADME-Tox: The Fate of Drugs in the Body', Eds. B. Testa, H. van de Waterbeemd, in 'Comprehensive Medicinal Chemistry', 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford, Vol. 5, in press.
    • 'Comprehensive Medicinal Chemistry' , vol.5
    • Oesch-Bartlomowicz, B.1    Oesch, F.2
  • 89
    • 0035062413 scopus 로고    scopus 로고
    • 'Implications of polymorphic cytochrome P450-dependent drug metabolism for drug development'
    • M. Ingelman-Sundberg, 'Implications of polymorphic cytochrome P450-dependent drug metabolism for drug development', Drug Metab. Dispos. 2001, 29, 570-573.
    • (2001) Drug Metab. Dispos. , vol.29 , pp. 570-573
    • Ingelman-Sundberg, M.1
  • 90
    • 33646442004 scopus 로고    scopus 로고
    • 'Pharmacogenetics and drug development'
    • H. Reiser, 'Pharmacogenetics and drug development', Annu. Rep. Med. Chem. 2005, 40, 414-427.
    • (2005) Annu. Rep. Med. Chem. , vol.40 , pp. 414-427
    • Reiser, H.1
  • 91
    • 84906476318 scopus 로고    scopus 로고
    • 'Prodrug objectives and design'
    • in 'ADME-Tox: The Fate of Drugs in the Body', Eds. B. Testa, H. van de Waterbeemd, in 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford, in press
    • B. Testa, 'Prodrug objectives and design', in 'ADME-Tox: The Fate of Drugs in the Body', Eds. B. Testa, H. van de Waterbeemd, in 'Comprehensive Medicinal Chemistry', 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford, Vol. 5, in press.
    • 'Comprehensive Medicinal Chemistry' , vol.5
    • Testa, B.1
  • 92
    • 3242722209 scopus 로고    scopus 로고
    • 'Predicting drug metabolism - Concepts and challenges'
    • B. Testa, A.-L. Balmat, A. Long, 'Predicting drug metabolism - Concepts and challenges', Pure Appl. Chem. 2004, 76, 907-914.
    • (2004) Pure Appl. Chem. , vol.76 , pp. 907-914
    • Testa, B.1    Balmat, A.-L.2    Long, A.3
  • 93
    • 84906471754 scopus 로고    scopus 로고
    • 'Comprehensive expert systems to predict drug metabolism'
    • in 'ADME-Tox: The Fate of Drugs in the Body', Eds, B. Testa, H. van de Waterbeemd, in 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford, in press
    • D. R. Hawkins, 'Comprehensive expert systems to predict drug metabolism', in 'ADME-Tox: The Fate of Drugs in the Body', Eds, B. Testa, H. van de Waterbeemd, in 'Comprehensive Medicinal Chemistry', 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford, Vol. 5, in press.
    • 'Comprehensive Medicinal Chemistry' , vol.5
    • Hawkins, D.R.1
  • 94
    • 77957561475 scopus 로고    scopus 로고
    • 'Principles of drug metabolism 1: Redox reactions'
    • in 'ADME-Tox: The Fate of Drugs in the Body', Eds. B. Testa, H. van de Waterbeemd, in 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford, in press
    • W. F. Trager, 'Principles of drug metabolism 1: Redox reactions', in 'ADME-Tox: The Fate of Drugs in the Body', Eds. B. Testa, H. van de Waterbeemd, in 'Comprehensive Medicinal Chemistry', 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford, Vol. 5, in press.
    • 'Comprehensive Medicinal Chemistry' , vol.5
    • Trager, W.F.1
  • 95
    • 77957557296 scopus 로고    scopus 로고
    • 'Principles of drug metabolism 2: Hydrolysis and conjugation reactions'
    • in 'ADME-Tox: The Fate of Drugs in the Body', Eds. B. Testa, H. van de Waterbeemd, in 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford, in press
    • B. Testa, 'Principles of drug metabolism 2: Hydrolysis and conjugation reactions', in 'ADME-Tox: The Fate of Drugs in the Body', Eds. B. Testa, H. van de Waterbeemd, in 'Comprehensive Medicinal Chemistry', 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford, Vol. 5, in press.
    • 'Comprehensive Medicinal Chemistry' , vol.5
    • Testa, B.1
  • 97
    • 33750609619 scopus 로고    scopus 로고
    • 'Overcoming the quantity-quality trade-off in preclinical profiling'
    • (April/May)
    • R. DeWitte, 'Overcoming the quantity-quality trade-off in preclinical profiling', DrugPlus Intern. 2006 (April/May), 16-19.
    • (2006) DrugPlus Intern. , pp. 16-19
    • DeWitte, R.1
  • 98
    • 32244447844 scopus 로고    scopus 로고
    • 'Evaluation of human liver slices and reporter gene assays as systems for predicting the cytochrome P450 induction potential of drugs in vivo in humans'
    • K. R Persson, S. Ekehed, C. Otter, E. S. M. Lutz, J. McPheat, C. M. Masimirembwa, T. B. Andersson, 'Evaluation of human liver slices and reporter gene assays as systems for predicting the cytochrome P450 induction potential of drugs in vivo in humans', Pharm. Res. 2006, 23, 56-69.
    • (2006) Pharm. Res. , vol.23 , pp. 56-69
    • Persson, K.R.1    Ekehed, S.2    Otter, C.3    Lutz, E.S.M.4    McPheat, J.5    Masimirembwa, C.M.6    Andersson, T.B.7
  • 99
    • 0034111854 scopus 로고    scopus 로고
    • 'A commentary on the use of hepatocytes in drug metabolism studies during drug discovery and development'
    • D. M. Cross, M. K. Bayliss, 'A commentary on the use of hepatocytes in drug metabolism studies during drug discovery and development', Drug Metab. Rev. 2000, 32, 219-240.
    • (2000) Drug Metab. Rev. , vol.32 , pp. 219-240
    • Cross, D.M.1    Bayliss, M.K.2
  • 100
    • 18744377988 scopus 로고    scopus 로고
    • 'Bioinformatics in drug development and assessment'
    • D. S. Wishart, 'Bioinformatics in drug development and assessment', Drug Metab. Rev. 2005, 37, 279-310.
    • (2005) Drug Metab. Rev. , vol.37 , pp. 279-310
    • Wishart, D.S.1
  • 101
    • 0002565849 scopus 로고    scopus 로고
    • 'Structure-metabolism relations, and the challenge of predicting biotransformation'
    • in Eds. B. Testa, H. van de Waterbeemd, G. Folkers, R. Guy, Verlag Helvetica Chimica Acta, Zurich, and Wiley-VCH, Weinheim
    • B. Testa, G. Cruciani, 'Structure-metabolism relations, and the challenge of predicting biotransformation', in 'Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical, and Computational Strategies', Eds. B. Testa, H. van de Waterbeemd, G. Folkers, R. Guy, Verlag Helvetica Chimica Acta, Zurich, and Wiley-VCH, Weinheim, 2001, p. 65-84.
    • (2001) 'Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical, and Computational Strategies' , pp. 65-84
    • Testa, B.1    Cruciani, G.2
  • 102
    • 0033820354 scopus 로고    scopus 로고
    • 'The influence of lipophilicity on the pharmacokinetic behavior of drugs: Concepts and examples'
    • B. Testa, P. Crivori, M. Reist, R A. Carrupt, 'The influence of lipophilicity on the pharmacokinetic behavior of drugs: Concepts and examples', Perspect. Drug Discov. Des. 2000, 19, 179-211.
    • (2000) Perspect. Drug Discov. Des. , vol.19 , pp. 179-211
    • Testa, B.1    Crivori, P.2    Reist, M.3    Carrupt, R.A.4
  • 104
    • 0036136527 scopus 로고    scopus 로고
    • 'Computational models for cytochrome P450: A predictive electronic model for aromatic oxidation and hydrogen atom abstraction'
    • J. P. Jones, M. Mysinger, K. R. Korzekwa, 'Computational models for cytochrome P450: A predictive electronic model for aromatic oxidation and hydrogen atom abstraction', Drug Metab. Dispos. 2002, 30, 7-12.
    • (2002) Drug Metab. Dispos. , vol.30 , pp. 7-12
    • Jones, J.P.1    Mysinger, M.2    Korzekwa, K.R.3
  • 105
    • 2942614915 scopus 로고    scopus 로고
    • 'In silico predictive metabolism: A structural/electronic filter method'
    • D. L. Harris, 'In silico predictive metabolism: A structural/electronic filter method', Curr. Opin. Drug Discov. Dev. 2004, 7, 43-48.
    • (2004) Curr. Opin. Drug Discov. Dev. , vol.7 , pp. 43-48
    • Harris, D.L.1
  • 106
    • 20144370197 scopus 로고    scopus 로고
    • 'Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors'
    • L. E. Korhonen, M. Rahnasto, N. J. Mähönen, C. Wittekindt, A. Poso, R. O. Juvonen, H. Raunio, 'Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors', J. Med. Chem. 2005, 48, 3808-3815.
    • (2005) J. Med. Chem. , vol.48 , pp. 3808-3815
    • Korhonen, L.E.1    Rahnasto, M.2    Mähönen, N.J.3    Wittekindt, C.4    Poso, A.5    Juvonen, R.O.6    Raunio, H.7
  • 107
    • 1642457197 scopus 로고    scopus 로고
    • 'Multiple pharmacophores for the investigation of human UDP-glucuronosyltransferase isoform substrate selectivity'
    • M. J. Sorich, J. O. Miners, R. A. McKinnon, P. A. Smith, 'Multiple pharmacophores for the investigation of human UDP-glucuronosyltransferase isoform substrate selectivity', Mol. Pharmacol. 2004, 65, 301-308.
    • (2004) Mol. Pharmacol. , vol.65 , pp. 301-308
    • Sorich, M.J.1    Miners, J.O.2    McKinnon, R.A.3    Smith, P.A.4
  • 108
    • 0036230192 scopus 로고    scopus 로고
    • 'Molecular modeling of human cytochrome P450-substrate interactions'
    • D. F. V. Lewis, 'Molecular modeling of human cytochrome P450-substrate interactions', Drug Metab. Rev. 2002, 34, 55-67.
    • (2002) Drug Metab. Rev. , vol.34 , pp. 55-67
    • Lewis, D.F.V.1
  • 109
    • 0036267032 scopus 로고    scopus 로고
    • 'Homology modelling of human CYP2 family enzymes based on the CYP2C5 crystal structure'
    • D. F. V. Lewis,'Homology modelling of human CYP2 family enzymes based on the CYP2C5 crystal structure', Xenobiotica 2002, 32, 305-323.
    • (2002) Xenobiotica , vol.32 , pp. 305-323
    • Lewis, D.F.V.1
  • 110
    • 0037046521 scopus 로고    scopus 로고
    • 'Development of a combined protein and pharmacophore model for cytochrome P450 2C9'
    • M. J. de Groot, A. A. Alex, B. C. Jones, 'Development of a combined protein and pharmacophore model for cytochrome P450 2C9', J. Med. Chem. 2002, 45, 1983-1993.
    • (2002) J. Med. Chem. , vol.45 , pp. 1983-1993
    • de Groot, M.J.1    Alex, A.A.2    Jones, B.C.3
  • 111
    • 17444411955 scopus 로고    scopus 로고
    • 'Cytochrome P450 in silico: An integrative modeling approach'
    • C. de Graaf, N. P. E. Vermeulen, K. A. Feenstra, 'Cytochrome P450 in silico: An integrative modeling approach', J. Med. Chem. 2005, 48, 2725-2755.
    • (2005) J. Med. Chem. , vol.48 , pp. 2725-2755
    • de Graaf, C.1    Vermeulen, N.P.E.2    Feenstra, K.A.3
  • 113
    • 27444434892 scopus 로고    scopus 로고
    • 'MetaSite: Understanding Metabolism in Human Cytochromes from the Perspective of the Chemist'
    • G. Cruciani, E. Carosati, B. DeBoeck, K. Ethirajulu, C. Mackie, T. Howe, R. Vianello, 'MetaSite: Understanding Metabolism in Human Cytochromes from the Perspective of the Chemist', J. Med. Chem. 2005, 48, 6970-6979; www.moldiscovery.com.
    • (2005) J. Med. Chem. , vol.48 , pp. 6970-6979
    • Cruciani, G.1    Carosati, E.2    DeBoeck, B.3    Ethirajulu, K.4    Mackie, C.5    Howe, T.6    Vianello, R.7
  • 115
    • 33750606674 scopus 로고    scopus 로고
    • MDL Information Systems Inc
    • MDL Information Systems Inc., www.mdl.com.
  • 116
    • 33750616691 scopus 로고    scopus 로고
    • Accelyrs Ltd
    • Accelyrs Ltd., www.accelrys.com.
  • 118
    • 30344455919 scopus 로고    scopus 로고
    • 'In silico techniques for the study and prediction of xenobiotic metabolism: A review'
    • S. A. Kulkarni, J. Zhu, S. Blechinger, 'In silico techniques for the study and prediction of xenobiotic metabolism: A review', Xenobiotica 2005, 35, 955-973.
    • (2005) Xenobiotica , vol.35 , pp. 955-973
    • Kulkarni, S.A.1    Zhu, J.2    Blechinger, S.3
  • 120
    • 0001376350 scopus 로고    scopus 로고
    • 'META: A program for the prediction of the products of mammal metabolism of xenobiotics'
    • in Ed. P. W Erhardt, International Union of Pure and Applied Chemistry and Blackwell Science, London
    • G. Klopman, M. Tu, 'META: A program for the prediction of the products of mammal metabolism of xenobiotics', in 'Drug Metabolism: Databases and High-Throughput Testing During Drug Design and Development', Ed. P. W Erhardt, International Union of Pure and Applied Chemistry and Blackwell Science, London, 1999, p. 271-276; www.multicase.com.
    • (1999) 'Drug Metabolism: Databases and High-Throughput Testing During Drug Design and Development' , pp. 271-276
    • Klopman, G.1    Tu, M.2
  • 121
    • 0037204551 scopus 로고    scopus 로고
    • 'Computer systems for the prediction of xenobiotic metabolism'
    • J. J. Langowski, A. Long, 'Computer systems for the prediction of xenobiotic metabolism', Adv. Drug Delivery Rev. 2002, 54, 407-415
    • (2002) Adv. Drug Delivery Rev. , vol.54 , pp. 407-415
    • Langowski, J.J.1    Long, A.2
  • 122
    • 23044488827 scopus 로고    scopus 로고
    • 'Predicting drug metabolism - An evaluation of the expert system METEOR'
    • B. Testa, A. L. Balmat, A. Long, P. Judson, 'Predicting drug metabolism - An evaluation of the expert system METEOR', Chem. Biodiv. 2005, 2, 872-885; www.lhasalimited.org.
    • (2005) Chem. Biodiv. , vol.2 , pp. 872-885
    • Testa, B.1    Balmat, A.L.2    Long, A.3    Judson, P.4


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