Metabolism, pharmacokinetics and excretion of a potent tachykinin NK1 receptor antagonist (CP-122,721) in rat: Characterization of a novel oxidative pathway

Xenobiotica

Volumn 36, Issue 2-3, 2006, Pages 235-258

  Kamel, A ^a,b   Davis, J ^a   Potchoiba, M J ^a   Prakash, C ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b PFIZER INC   (United States)

Author keywords

Biotransformation; CP 122,721; Metabolism; NK1 receptor antagonist; Rats; Trifluoromethoxy anisole

Indexed keywords

3 (2 METHOXY 5 TRIFLUOROMETHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; NEUROKININ 1 RECEPTOR ANTAGONIST; SUBSTANCE P ANTAGONIST; TACHYKININ RECEPTOR ANTAGONIST;

ANIMAL EXPERIMENT; ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; DEMETHYLATION; DRUG ABSORPTION; DRUG DISPOSITION; DRUG EFFECT; DRUG EFFICACY; DRUG ELIMINATION; DRUG EXCRETION; DRUG METABOLISM; DRUG POTENCY; FECES ANALYSIS; FEMALE; GLUCURONIDATION; HYDROXYLATION; MALE; NONHUMAN; RAT;

ADMINISTRATION, ORAL; ANIMALS; FECES; FEMALE; MALE; METABOLIC CLEARANCE RATE; OXIDATION-REDUCTION; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROKININ-1; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 33646539102     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250600594444     Document Type: Article

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