The crystal structure of xanthine oxidoreductase during catalysis: Implications for reaction mechanism and enzyme inhibition

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 21, 2004, Pages 7931-7936

  Okamoto, Ken ^a   Matsumoto, Koji ^a,b   Hille, Russ ^c   Eger, Bryan T ^d   Pai, Emil F ^d   Nishino, Takeshi ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b Fuji Yakuhin Co Ltd   (Japan)

^c OHIO STATE UNIVERSITY   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXIDE; MOLYBDENUM; MOLYBDENUM HYDROXYLASE; OXYGEN; UNCLASSIFIED DRUG; WATER; XANTHINE OXIDASE;

ARTICLE; CATALYSIS; COMPLEX FORMATION; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HYDROXYLATION; OXYGEN TRANSPORT; PRIORITY JOURNAL; PROTEIN STABILITY; PROTON TRANSPORT; REACTION ANALYSIS; REDUCTION;

ANIMALS; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HYDROXIDES; HYDROXYLATION; LIGANDS; MILK; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLYBDENUM; OXIDOREDUCTASES; OXYGEN; STRUCTURE-ACTIVITY RELATIONSHIP; SULFUR; XANTHINE; XANTHINE DEHYDROGENASE;

EID: 2542612969     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0400973101     Document Type: Article

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