Pharmacogenetics of alcohol response and alcoholism: The interplay of genes and environmental factors in thresholds for alcoholism

Drug Metabolism and Disposition

Volumn 29, Issue 4 II, 2001, Pages 489-494

  Radel, M ^a   Goldman, D ^a  

^a Park 5 Building ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; ALDEHYDE DEHYDROGENASE ISOENZYME 2; BENZODIAZEPINE; DOPAMINE RECEPTOR; NICOTINE; OPIATE RECEPTOR; SEROTONIN RECEPTOR;

ALCOHOL METABOLISM; ALCOHOL TOLERANCE; ALCOHOL WITHDRAWAL; ALCOHOLISM; AMINO ACID SUBSTITUTION; CHROMOSOME 11; CONFERENCE PAPER; ENVIRONMENTAL FACTOR; GENE CLUSTER; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; HEREDITY; HERITABILITY; HUMAN; NEUROSCIENCE; NEUROTRANSMISSION; PHARMACODYNAMICS; PHARMACOGENETICS; PRIORITY JOURNAL; PROTEIN VARIANT; REWARD;

ALCOHOLISM; ANIMALS; ETHANOL; GENETIC PREDISPOSITION TO DISEASE; HUMANS; PHARMACOGENETICS; QUANTITATIVE TRAIT, HERITABLE; RODENTIA;

RODENTIA;

EID: 0035060492     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (85)

1. Gamma-aminobutyric acid and alcohol actions: Neurochemical studies of long sleep and short sleep mice
2. Naltrexone reverses ethanol-induced dopamine release in the nucleus accumbens in awake, freely moving rats
3. Mu opioid receptor gene variants: Lack of association with alcohol dependence
4. Accumbal dopamine overflow after ethanol: Localization of the antagonizing effect of mecamylamine
5. Voluntary ethanol intake in the rat: Effects of nicotinic acetylcholine receptor blockade or subchronic nicotine treatment
6. Maternal inheritance of alcohol abuse. Cross-fostering analysis of adopted women
7. Genetic polymorphism of human liver alcoho and aldehyde dehydrogenase and their relationship to alcohol metabolism and alcoholism
8. Genetic factors in alcohol metabolism and alcoholism
9. The molecular biology of neuronal nicotinic acetylcholine receptors
10. Bidirectional effects of GABAergic agonists and antagonists on maintenance of voluntary ethanol intake in rats
11. A receptor-operated chloride channels. II. Chronic effects of ethanol
12. A receptor γ2 subunit variant with severity of acute physiological dependence on alcohol
13. Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice
14. Serotonin-3 receptor and ethanol-stimulated dopamine release in the nucleus accumbens
15. Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism
16. Alcohol metabolising genes and alcoholism among Taiwanese Han men: Independent effect of ADH2, ADH3 and ALDH2
17. Alcohol metabolism and cardiovascular response in an alcoholic patient homozygous for the ALDH2*2 variant gene allele
18. Inheritance of alcohol abuse: Crossfostering analysis of adopted men
19. Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice
20. Strategies for identifying genes underlying drug abuse susceptibility
21. Elevated alcohol consumption in null mutant mice lacking 5-HTIB serotonin receptors
22. The 5-HT3B subunit is a major determinant of serotonin-receptor function
23. Alcohol dehydrogenases
24. Genotyping of the aldehyde dehydrogenase 2 (ALDH2) gene using the polymerase chain reaction: Evidence for single point mutation in the ALDH2 gene of ALDH2 deficiency
25. Voluntary ethanol intake in the rat and the associated accumbal dopamine overflow are blocked by ventral tegmental mecamylamine
26. Distribution of ADH2 and ALDH2 genotypes in different populations
27. Genetic transmission
28. General and specific inheritance of substance abuse and alcoholism
29. A functionally deficient DRD2 variant [Ser31 ICys] is not linked to alcoholism and substance abuse
30. Psychopathology in adopted and nonadopted daughters of alcoholics
31. Aldehyde dehydrogenase deficiency as cause of facial flushing reaction to alcohol in Japanese
32. A responses in cells stably transfected with receptor subunits
33. Genetic and environmental contributions to alcohol dependence risk in a national twin sample: Consistency of findings in women and men
34. Effect of GABAergic drugs on motor impairment from ethanol, barbital, and lorazepam in rat lines selected for differential sensitivity to ethanol
35. A multivariate genetic analysis of the use of tobacco, alcohol, and caffeine in a population based sample of male and female twins
36. Alcohol and aldehyde dehydrogenase polymorphisms and the risk for alcoholism
37. Alcohol dependence: A commentary on mechanisms
38. Genomic structure of the human mitochondrial aldehyde dehydrogenase gene
39. Structural mutation in a major human aldehyde dehydrogenase gene results in loss of enzyme activity
40. Association study between the-141C Ins/Del and TaqI A polymorphisms of the dopamine D2 receptor gene and alcoholism
41. A Pro385Ser substitution in the GABAA receptor α6 subunit gene associates with benzodiazepine sensitivity
42. Attenuation of some alcohol-induced mood changes and the desire to drink by 5-HT3 receptor blockage: A preliminary study in health male volunteers
43. A population-based twin study of alcoholism in women
44. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States
45. Benzodiazepine-induced motor impairment linked to point mutation at cerebellar GABAA receptor
46. Linkage of antisocial alcoholism to the serotonin 5-HTIB receptor gene in 2 populations
47. Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from autosome-wide scan in an American Indian population
48. Ethanol potentiates 5-HT3 receptor-mediated ion current in NCB-20 neuroblastoma cells
49. Cerebellar GABAA-receptor selective for a behavioral alcohol antagonist
50. Localization of brain reinforcement mechanisms: Intracranial self-administration and intracranial place-conditioning studies
51. Selective breeding for ethanol sensitivity: Short-sleep and long-sleep mice
52. Familial transmission of substance use disorders
53. Differential modulation of benzodiazepine receptor binding by ethanol in LS and SS mice
54. High levels of sensitivity to alcohol in young adult Jewish men: A pilot study
55. Blocking GABA(A) receptors in the anterior ventral tegmental area attenuates ethanol intake of the alcohol-preferring P rat
56. Addiction: Brain mechanisms and their treatment implications
57. Naltrexone and coping skills therapy for alcohol dependence: A controlled study
58. Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism
59. Can psychiatric and chemical dependency treatment units be smoke free?
60. Relationship of binge drinking to alcohol dependence, other psychiatric disorders, and behavioral problems in an American Indian tribe
61. Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor
62. Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine and methamphetamine
63. Human mu-opioid receptor variation and alcohol dependence
64. Genotypes of alcohol-metabolizing enzymes in Japanese with alcohol liver diseases: A strong association of the usual Caucasian-type aldehyde dehydrogenase gene (ALDH2) with the disease
65. Ethanol-induced changes in body sway in men at high alcoholism risk
66. Low level of response to alcohol as a predictor of future alcoholism
67. Alcohol-related disorders
68. Selective genotyping for the role of 5-HT2A, 5-HT2C, and the GABAA α6 receptors and the serotonin transporter in the level of response to alcohol: A pilot study
69. Evidence for genetic correlation of hypnotic effects and cerebellar Purkinje neuron depression in response to ethanol in mice
70. Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes
71. Heavy consumption of cigarettes, alcohol and coffee in male twins
72. Determination of nucleotide sequence of active site for catalytic properties of ADH3 genes
73. Low frequency of the ADH2*2 allele among Atayal natives of Taiwan with alcohol use disorders
74. Common genetic vulnerability for nicotine and alcohol dependence in men
75. Alcohol consumption by Orientals in North America is predicted largely by a single gene
76. Identification of a novel polymorphism of the dopamine transporter (DAT1) gene and significant association with alcoholism
77. Naltrexone in the treatment of alcohol dependence
78. Genetic differences in the ethanol sensitivity of GABAA receptors expressed in Xenopus oocytes
79. A receptor expressed in Xenopus oocytes requires 8 amino acids contained in the gamma 2L subunit
80. Ethanol action on excitatory amino acid activated ion channels
81. Mutations of gamma-aminobutyric acid and glycine receptors change alcohol cutoff: Evidence for an alcohol receptor?
82. A receptors is essential for benzodiazepine agonist binding
83. The role of reward pathways in the development of drug dependence
84. Neurobiology of addiction
85. Genetics of human alcohol-metabolizing enzymes