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Volumn 178, Issue , 2007, Pages 73-105

Novel gene switches

Author keywords

Bioengineering; Biopharmaceuticals; Gene Switch; Gene therapy; Inducible expression

Indexed keywords

ANIMAL; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENETIC TRANSCRIPTION; GENETICS; GENOME; REGULATOR GENE; REVIEW;

EID: 33846910280     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-540-35109-2_4     Document Type: Article
Times cited : (17)

References (139)
  • 2
    • 0035866302 scopus 로고    scopus 로고
    • A novel tetracycline-dependent transactivator with E2F4 transcriptional activation domain
    • Akagi K, Kanai M, Saya H, Kozu T, Berns A (2001) A novel tetracycline-dependent transactivator with E2F4 transcriptional activation domain. Nucleic Acids Res 29:e23
    • (2001) Nucleic Acids Res , vol.29
    • Akagi, K.1    Kanai, M.2    Saya, H.3    Kozu, T.4    Berns, A.5
  • 3
    • 0036019191 scopus 로고    scopus 로고
    • Tetracycline-inducible interleukin-10 gene transfer mediated by an adeno-associated virus: Application to experimental arthritis
    • Apparailly F, Millet V, Noel D, Jacquet C, Sany J, Jorgensen C (2002) Tetracycline-inducible interleukin-10 gene transfer mediated by an adeno-associated virus: application to experimental arthritis. Hum Gene Ther 13:1179-1188
    • (2002) Hum Gene Ther , vol.13 , pp. 1179-1188
    • Apparailly, F.1    Millet, V.2    Noel, D.3    Jacquet, C.4    Sany, J.5    Jorgensen, C.6
  • 4
    • 0038241770 scopus 로고    scopus 로고
    • Development of genetic circuitry exhibiting toggle switch or oscillatory behavior in Escherichia coli
    • Atkinson MR, Savageau MA, Myers JT, Ninfa AJ (2003) Development of genetic circuitry exhibiting toggle switch or oscillatory behavior in Escherichia coli. Cell 113:597-607
    • (2003) Cell , vol.113 , pp. 597-607
    • Atkinson, M.R.1    Savageau, M.A.2    Myers, J.T.3    Ninfa, A.J.4
  • 6
    • 0029980179 scopus 로고    scopus 로고
    • Controlled gene expression in mammalian cells via a regulatory cascade involving the tetracycline transactivator and lac repressor
    • Aubrecht J, Manivasakam P, Schiestl RH (1996) Controlled gene expression in mammalian cells via a regulatory cascade involving the tetracycline transactivator and lac repressor. Gene 172:227-231
    • (1996) Gene , vol.172 , pp. 227-231
    • Aubrecht, J.1    Manivasakam, P.2    Schiestl, R.H.3
  • 8
    • 0026043945 scopus 로고
    • A chimeric mammalian transactivator based on the lac repressor that is regulated by temperature and isopropyl beta-Dthiogalactopyranoside
    • Baim SB, Labow MA, Levine AJ, Shenk T (1991) A chimeric mammalian transactivator based on the lac repressor that is regulated by temperature and isopropyl beta-Dthiogalactopyranoside. Proc Natl Acad Sci U S A 88:5072-5076
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 5072-5076
    • Baim, S.B.1    Labow, M.A.2    Levine, A.J.3    Shenk, T.4
  • 9
    • 0029075822 scopus 로고
    • Co-regulation of two gene activities by tetracycline via a bidirectional promoter
    • Baron U, Freundlieb S, Gossen M, Bujard H (1995) Co-regulation of two gene activities by tetracycline via a bidirectional promoter. Nucleic Acids Res 23:3605-3606
    • (1995) Nucleic Acids Res , vol.23 , pp. 3605-3606
    • Baron, U.1    Freundlieb, S.2    Gossen, M.3    Bujard, H.4
  • 10
    • 0030797223 scopus 로고    scopus 로고
    • Tetracycline-controlled transcription in eukaryotes: Novel transactivators with graded transactivation potential
    • Baron U, Gossen M, Bujard H (1997) Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential. Nucleic Acids Res 25:2723-2729
    • (1997) Nucleic Acids Res , vol.25 , pp. 2723-2729
    • Baron, U.1    Gossen, M.2    Bujard, H.3
  • 12
    • 0025920615 scopus 로고
    • The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins
    • Bellefroid EJ, Poncelet DA, Lecocq PJ, Revelant O,Martial JA (1991) The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. Proc Natl Acad Sci U S A 88:3608-3612
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 3608-3612
    • Bellefroid, E.J.1    Poncelet, D.A.2    Lecocq, P.J.3    Revelant, O.4    Martial, J.A.5
  • 13
    • 0037337299 scopus 로고    scopus 로고
    • Site-specific cassette exchange and germline transmission withmouse ES cells expressing phiC31 integrase
    • Belteki G, Gertsenstein M, Ow DW, Nagy A (2003) Site-specific cassette exchange and germline transmission withmouse ES cells expressing phiC31 integrase. Nat Biotechnol 21:321-324
    • (2003) Nat Biotechnol , vol.21 , pp. 321-324
    • Belteki, G.1    Gertsenstein, M.2    Ow, D.W.3    Nagy, A.4
  • 15
    • 1542410260 scopus 로고    scopus 로고
    • Uncoupling of cell growth and proliferation results in enhancement of productivity in p21CIP1-arrested CHO cells
    • Bi JX, Shuttleworth J, Al-Rubeai M (2004) Uncoupling of cell growth and proliferation results in enhancement of productivity in p21CIP1-arrested CHO cells. Biotechnol Bioeng 85:741-749
    • (2004) Biotechnol Bioeng , vol.85 , pp. 741-749
    • Bi, J.X.1    Shuttleworth, J.2    Al-Rubeai, M.3
  • 16
    • 21744459294 scopus 로고    scopus 로고
    • Chemical-based translational induction of luciferase expression: An efficient tool for in vivo screening of protein farnesylation inhibitors
    • Boijoux O, Boutonnet C, Giamarchi C, Favre G, Vagner S, Faye JC (2005) Chemical-based translational induction of luciferase expression: an efficient tool for in vivo screening of protein farnesylation inhibitors. Mol Pharmacol 67:1829-1833
    • (2005) Mol Pharmacol , vol.67 , pp. 1829-1833
    • Boijoux, O.1    Boutonnet, C.2    Giamarchi, C.3    Favre, G.4    Vagner, S.5    Faye, J.C.6
  • 20
    • 0346503889 scopus 로고    scopus 로고
    • Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice
    • Branda CS, Dymecki SM (2004) Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice. Dev Cell 6:7-28
    • (2004) Dev Cell , vol.6 , pp. 7-28
    • Branda, C.S.1    Dymecki, S.M.2
  • 21
    • 0141737064 scopus 로고    scopus 로고
    • A novel sensor of NADH/NAD+ redox poise in Streptomyces coelicolor A3 (2)
    • Brekasis D, Paget MS (2003) A novel sensor of NADH/NAD+ redox poise in Streptomyces coelicolor A3 (2) . Embo J 22:4856-4865
    • (2003) Embo J , vol.22 , pp. 4856-4865
    • Brekasis, D.1    Paget, M.S.2
  • 23
    • 0032167985 scopus 로고    scopus 로고
    • A chimeric Cre recombinase inducible by synthetic, but not by natural ligands of the glucocorticoid receptor
    • Brocard J, Feil R, Chambon P, Metzger D (1998) A chimeric Cre recombinase inducible by synthetic, but not by natural ligands of the glucocorticoid receptor. Nucleic Acids Res 26: 4086-4090
    • (1998) Nucleic Acids Res , vol.26 , pp. 4086-4090
    • Brocard, J.1    Feil, R.2    Chambon, P.3    Metzger, D.4
  • 24
    • 0031874849 scopus 로고    scopus 로고
    • Improved properties of FLP recombinase evolved by cycling mutagenesis
    • Buchholz F, Angrand PO, Stewart AF (1998) Improved properties of FLP recombinase evolved by cycling mutagenesis. Nat Biotechnol 16:657-662
    • (1998) Nat Biotechnol , vol.16 , pp. 657-662
    • Buchholz, F.1    Angrand, P.O.2    Stewart, A.F.3
  • 27
    • 0030911409 scopus 로고    scopus 로고
    • P-Cymene catabolic pathway in Pseudomonas putida F1: Cloning and characterization of DNA encoding conversion of p-cymene to p-cumate
    • Eaton RW (1997) p-Cymene catabolic pathway in Pseudomonas putida F1: cloning and characterization of DNA encoding conversion of p-cymene to p-cumate. J Bacteriol 179:3171-3180
    • (1997) J Bacteriol , vol.179 , pp. 3171-3180
    • Eaton, R.W.1
  • 28
    • 0034688173 scopus 로고    scopus 로고
    • A synthetic oscillatory network of transcriptional regulators
    • Elowitz MB, Leibler S (2000) A synthetic oscillatory network of transcriptional regulators. Nature 403:335-338
    • (2000) Nature , vol.403 , pp. 335-338
    • Elowitz, M.B.1    Leibler, S.2
  • 29
    • 0035230952 scopus 로고    scopus 로고
    • Ethanol catabolism inAspergillus nidulans: Amodel system for studying gene regulation
    • FelenbokB, FlipphiM,Nikolaev I (2001) Ethanol catabolism inAspergillus nidulans: amodel system for studying gene regulation. Prog Nucleic Acid Res Mol Biol 69:149-204
    • (2001) Prog Nucleic Acid Res Mol Biol , vol.69 , pp. 149-204
    • Felenbok, B.1    Flipphi, M.2    Nikolaev, I.3
  • 30
    • 0035121677 scopus 로고    scopus 로고
    • The impact of mammalian gene regulation concepts on functional genomic research, metabolic engineering, and advanced gene therapies
    • Fussenegger M (2001) The impact of mammalian gene regulation concepts on functional genomic research, metabolic engineering, and advanced gene therapies. Biotechnol Prog 17:1-51
    • (2001) Biotechnol Prog , vol.17 , pp. 1-51
    • Fussenegger, M.1
  • 31
    • 0032484706 scopus 로고    scopus 로고
    • PTRIDENT,Anovel vector family for tricistronic gene expression in mammalian cells
    • FusseneggerM,Mazur X, Bailey JE (1998a) pTRIDENT,Anovel vector family for tricistronic gene expression in mammalian cells. Biotechnol Bioeng 57:1-10
    • (1998) Biotechnol Bioeng , vol.57 , pp. 1-10
    • Fussenegger, M.1    Mazur, X.2    Bailey, J.E.3
  • 32
    • 0031945008 scopus 로고    scopus 로고
    • Controlled proliferation bymultigenemetabolic engineering enhances the productivity of Chinesehamster ovary cells
    • FusseneggerM, Schlatter S, Datwyler D,Mazur X, Bailey JE (1998b) Controlled proliferation bymultigenemetabolic engineering enhances the productivity of Chinesehamster ovary cells. Nat Biotechnol 16:468-472
    • (1998) Nat Biotechnol , vol.16 , pp. 468-472
    • Fussenegger, M.1    Schlatter, S.2    Datwyler, D.3    Mazur, X.4    Bailey, J.E.5
  • 34
    • 4644373748 scopus 로고    scopus 로고
    • Dual-regulated myoD-and msx1-based interventions in C2C12-derived cells enable precisemyogenic/osteogenic/adipogenic lineage control
    • Fux C, Langer D, Fussenegger M (2004a) Dual-regulated myoD-and msx1-based interventions in C2C12-derived cells enable precisemyogenic/osteogenic/ adipogenic lineage control. J Gene Med 6:1159-1169
    • (2004) J Gene Med , vol.6 , pp. 1159-1169
    • Fux, C.1    Langer, D.2    Fussenegger, M.3
  • 35
    • 14844334826 scopus 로고    scopus 로고
    • Dual-regulated expression of C/EBPalpha and BMP-2 enables differential differentiation of C2C12 cells into adipocytes and osteoblasts
    • Fux C, Mitta B, Kramer BP, Fussenegger M (2004b) Dual-regulated expression of C/EBPalpha and BMP-2 enables differential differentiation of C2C12 cells into adipocytes and osteoblasts. Nucleic Acids Res 32:e1
    • (2004) Nucleic Acids Res , vol.32
    • Fux, C.1    Mitta, B.2    Kramer, B.P.3    Fussenegger, M.4
  • 36
    • 0035866183 scopus 로고    scopus 로고
    • Streptograminand tetracycline-responsive dual regulated expression of p27 (Kip1) sense and antisense enables positive and negative growth control of Chinese hamster ovary cells
    • Fux C, Moser S, Schlatter S, Rimann M, Bailey JE, Fussenegger M (2001) Streptograminand tetracycline-responsive dual regulated expression of p27 (Kip1) sense and antisense enables positive and negative growth control of Chinese hamster ovary cells. Nucleic Acids Res 29:e19
    • (2001) Nucleic Acids Res , vol.29
    • Fux, C.1    Moser, S.2    Schlatter, S.3    Rimann, M.4    Bailey, J.E.5    Fussenegger, M.6
  • 37
    • 1942458116 scopus 로고    scopus 로고
    • Novel macrolide-adjustable bidirectional expression modules for coordinated expression of two different transgenes in mice
    • Fux C, Weber W, Daoud-El Baba M, Heinzen C, Aubel D, Fussenegger M (2003) Novel macrolide-adjustable bidirectional expression modules for coordinated expression of two different transgenes in mice. J Gene Med 5:1067-1079
    • (2003) J Gene Med , vol.5 , pp. 1067-1079
    • Fux, C.1    Weber, W.2    Daoud-El Baba, M.3    Heinzen, C.4    Aubel, D.5    Fussenegger, M.6
  • 39
    • 0034688174 scopus 로고    scopus 로고
    • Construction of a genetic toggle switch in Escherichia coli
    • Gardner TS, Cantor CR, Collins JJ (2000) Construction of a genetic toggle switch in Escherichia coli. Nature 403:339-342
    • (2000) Nature , vol.403 , pp. 339-342
    • Gardner, T.S.1    Cantor, C.R.2    Collins, J.J.3
  • 40
    • 25144432005 scopus 로고    scopus 로고
    • Site-specific integration with phiC31 integrase for prolonged expression of therapeutic genes
    • Ginsburg DS, Calos MP (2005) Site-specific integration with phiC31 integrase for prolonged expression of therapeutic genes. Adv Genet 54:179-187
    • (2005) Adv Genet , vol.54 , pp. 179-187
    • Ginsburg, D.S.1    Calos, M.P.2
  • 41
    • 29744462590 scopus 로고    scopus 로고
    • Anovel binary adenovirus-based dual-regulated expression system for independent transcription control of two different transgenes
    • Gonzalez-NicoliniV, FusseneggerM (2005) Anovel binary adenovirus-based dual-regulated expression system for independent transcription control of two different transgenes. J Gene Med 7:1573-1585
    • (2005) J Gene Med , vol.7 , pp. 1573-1585
    • Gonzalez-Nicolini, V.1    Fussenegger, M.2
  • 42
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • Gossen M, Bujard H (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci U S A 89:5547-5551
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 45
    • 25644458511 scopus 로고    scopus 로고
    • Autoregulated, bidirectional and multicistronic gasinducible mammalian as well as lentiviral expression vectors
    • Hartenbach S, Fussenegger M (2005) Autoregulated, bidirectional and multicistronic gasinducible mammalian as well as lentiviral expression vectors. J Biotechnol 120:83-98
    • (2005) J Biotechnol , vol.120 , pp. 83-98
    • Hartenbach, S.1    Fussenegger, M.2
  • 46
    • 17044404727 scopus 로고    scopus 로고
    • Ligand-activated Flpe for temporally regulated gene modifications
    • Hunter NL, Awatramani RB, Farley FW, Dymecki SM (2005) Ligand-activated Flpe for temporally regulated gene modifications. Genesis 41:99-109
    • (2005) Genesis , vol.41 , pp. 99-109
    • Hunter, N.L.1    Awatramani, R.B.2    Farley, F.W.3    Dymecki, S.M.4
  • 47
    • 0033571243 scopus 로고    scopus 로고
    • Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: Comparison of the recombinase activity of the tamoxifen-inducible Cre-ER (T) and Cre-ER (T2) recombinases
    • Indra AK, Warot X, Brocard J, Bornert JM, Xiao JH, Chambon P, Metzger D (1999) Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER (T) and Cre-ER (T2) recombinases. Nucleic Acids Res 27:4324-4327
    • (1999) Nucleic Acids Res , vol.27 , pp. 4324-4327
    • Indra, A.K.1    Warot, X.2    Brocard, J.3    Bornert, J.M.4    Xiao, J.H.5    Chambon, P.6    Metzger, D.7
  • 51
    • 1042288133 scopus 로고    scopus 로고
    • Synergies of microtissue design, viral transduction and adjustable transgene expression for regenerative medicine
    • Kelm JM, Kramer BP, Gonzalez-Nicolini V, Ley B, FusseneggerM (2004) Synergies of microtissue design, viral transduction and adjustable transgene expression for regenerative medicine. Biotechnol Appl Biochem 39:3-16
    • (2004) Biotechnol Appl Biochem , vol.39 , pp. 3-16
    • Kelm, J.M.1    Kramer, B.P.2    Gonzalez-Nicolini, V.3    Ley, B.4    Fussenegger, M.5
  • 53
    • 22144452865 scopus 로고    scopus 로고
    • Hysteresis in a synthetic mammalian gene network
    • Kramer BP, FusseneggerM (2005) Hysteresis in a synthetic mammalian gene network. Proc Natl Acad Sci U S A 102:9517-9522
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 9517-9522
    • Kramer, B.P.1    Fussenegger, M.2
  • 54
    • 0041930790 scopus 로고    scopus 로고
    • Artificial regulatory networks and cascades for discretemultilevel transgene control in mammalian cells
    • Kramer BP,WeberW, FusseneggerM (2003) Artificial regulatory networks and cascades for discretemultilevel transgene control in mammalian cells. Biotechnol Bioeng 83:810-820
    • (2003) Biotechnol Bioeng , vol.83 , pp. 810-820
    • Kramer, B.P.1    Weber, W.2    Fussenegger, M.3
  • 55
    • 4344703213 scopus 로고    scopus 로고
    • BioLogic gates enable logical transcription control in mammalian cells
    • Kramer BP, Fischer C, Fussenegger M (2004a) BioLogic gates enable logical transcription control in mammalian cells. Biotechnol Bioeng 87:478-484
    • (2004) Biotechnol Bioeng , vol.87 , pp. 478-484
    • Kramer, B.P.1    Fischer, C.2    Fussenegger, M.3
  • 57
    • 24044457608 scopus 로고    scopus 로고
    • Semi-synthetic mammalian gene regulatory networks
    • Kramer BP, Fischer M, Fussenegger M (2005) Semi-synthetic mammalian gene regulatory networks. Metab Eng 7:241-250
    • (2005) Metab Eng , vol.7 , pp. 241-250
    • Kramer, B.P.1    Fischer, M.2    Fussenegger, M.3
  • 58
    • 0033600167 scopus 로고    scopus 로고
    • A G-CSF receptorgyrase B fusion gene: A new type of molecular switch for expansion of genetically modified hematopoietic cells
    • Kume A, Ito K, Ueda Y, Hasegawa M, UrabeM,Mano H, Ozawa K (1999) A G-CSF receptorgyrase B fusion gene: A new type of molecular switch for expansion of genetically modified hematopoietic cells. Biochem Biophys Res Commun 260:9-12
    • (1999) Biochem Biophys Res Commun , vol.260 , pp. 9-12
    • Kume, A.1    Ito, K.2    Ueda, Y.3    Hasegawa, M.4    Urabe, M.5    Mano, H.6    Ozawa, K.7
  • 59
    • 11144224259 scopus 로고    scopus 로고
    • Gene disruption by regulated short interfering RNA expression, using a two-adenovirus system
    • Kuninger D, Stauffer D, Eftekhari S,Wilson E, Thayer M, Rotwein P (2004) Gene disruption by regulated short interfering RNA expression, using a two-adenovirus system. Hum Gene Ther 15:1287-1292
    • (2004) Hum Gene Ther , vol.15 , pp. 1287-1292
    • Kuninger, D.1    Stauffer, D.2    Eftekhari, S.3    Wilson, E.4    Thayer, M.5    Rotwein, P.6
  • 61
    • 0345044372 scopus 로고    scopus 로고
    • Stable and efficient cassette exchange under non-selectable conditions by combined use of two site-specific recombinases
    • Lauth M, Spreafico F, Dethleffsen K, Meyer M (2002) Stable and efficient cassette exchange under non-selectable conditions by combined use of two site-specific recombinases. Nucleic Acids Res 30:e115
    • (2002) Nucleic Acids Res , vol.30
    • Lauth, M.1    Spreafico, F.2    Dethleffsen, K.3    Meyer, M.4
  • 63
    • 4344656346 scopus 로고    scopus 로고
    • Kinetics of regulated protein-protein interactions revealedwith firefly luciferase complementation imaging in cells and living animals
    • Luker KE, Smith MC, Luker GD, Gammon ST, Piwnica-Worms H, Piwnica-Worms D (2004) Kinetics of regulated protein-protein interactions revealedwith firefly luciferase complementation imaging in cells and living animals. ProcNatl Acad SciUS A 101:12288-12293
    • (2004) ProcNatl Acad SciUS A , vol.101 , pp. 12288-12293
    • Luker, K.E.1    Smith, M.C.2    Luker, G.D.3    Gammon, S.T.4    Piwnica-Worms, H.5    Piwnica-Worms, D.6
  • 64
    • 1842631431 scopus 로고    scopus 로고
    • Small interfering RNA production by enzymatic engineering of DNA (SPEED)
    • Luo B, Heard AD, Lodish HF (2004) Small interfering RNA production by enzymatic engineering of DNA (SPEED) . Proc Natl Acad Sci U S A 101:5494-5499
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 5494-5499
    • Luo, B.1    Heard, A.D.2    Lodish, H.F.3
  • 66
    • 8844239146 scopus 로고    scopus 로고
    • Macrolide-andtetracycline-adjustable siRNA-mediated gene silencing in mammalian cells using polymerase II-dependent promoter derivatives
    • Malphettes L,FusseneggerM (2004) Macrolide-andtetracycline-adjustable siRNA-mediated gene silencing in mammalian cells using polymerase II-dependent promoter derivatives. Biotechnol Bioeng 88:417-425
    • (2004) Biotechnol Bioeng , vol.88 , pp. 417-425
    • Malphettes, L.1    Fussenegger, M.2
  • 68
    • 0037144084 scopus 로고    scopus 로고
    • P27Kip1-mediated controlled proliferation technology increases constitutive sICAM production in CHO-DUKX adapted for growth in suspension and serum-free media
    • Meents H, Enenkel B,Werner RG, FusseneggerM (2002) p27Kip1-mediated controlled proliferation technology increases constitutive sICAM production in CHO-DUKX adapted for growth in suspension and serum-free media. Biotechnol Bioeng 79:619-627
    • (2002) Biotechnol Bioeng , vol.79 , pp. 619-627
    • Meents, H.1    Enenkel, B.2    Werner, R.G.3    Fussenegger, M.4
  • 69
    • 3142761399 scopus 로고    scopus 로고
    • Design and in vivo characterization of self-inactivating human and non-human lentiviral expression vectors engineered for streptogramin-adjustable transgene expression
    • Mitta B, Weber CC, Rimann M, Fussenegger M (2004) Design and in vivo characterization of self-inactivating human and non-human lentiviral expression vectors engineered for streptogramin-adjustable transgene expression. Nucleic Acids Res 32:e106
    • (2004) Nucleic Acids Res , vol.32
    • Mitta, B.1    Weber, C.C.2    Rimann, M.3    Fussenegger, M.4
  • 70
    • 27944453080 scopus 로고    scopus 로고
    • Vivo transduction of HIV-1-derived lentiviral particles engineered formacrolide-adjustable transgene expression
    • Mitta B,Weber CC, Fussenegger M (2005) In vivo transduction of HIV-1-derived lentiviral particles engineered formacrolide-adjustable transgene expression. J GeneMed 7:1400-1408
    • (2005) J GeneMed , vol.7 , pp. 1400-1408
    • Mitta, B.1    Weber, C.C.2    Fussenegger, M.3
  • 71
    • 14844359840 scopus 로고    scopus 로고
    • Development of cellular models for ribosomal protein S19 (RPS19)-Deficient diamond-blackfan anemia using inducible expression of siRNA against RPS19
    • Miyake K, Flygare J, Kiefer T, Utsugisawa T, Richter J, Ma Z, Wiznerowicz M, Trono D, Karlsson S (2005) Development of cellular models for ribosomal protein S19 (RPS19)-deficient diamond-blackfan anemia using inducible expression of siRNA against RPS19. Mol Ther 11:627-637
    • (2005) Mol Ther , vol.11 , pp. 627-637
    • Miyake, K.1    Flygare, J.2    Kiefer, T.3    Utsugisawa, T.4    Richter, J.5    Ma, Z.6    Wiznerowicz, M.7    Trono, D.8    Karlsson, S.9
  • 72
    • 0034281609 scopus 로고    scopus 로고
    • An update of pTRIDENT multicistronic expression vectors: PTRIDENTs containing novel streptograminresponsive promoters
    • Moser S, Schlatter S, Fux C, Rimann M, Bailey JE, FusseneggerM (2000) An update of pTRIDENT multicistronic expression vectors: pTRIDENTs containing novel streptograminresponsive promoters. Biotechnol Prog 16:724-735
    • (2000) Biotechnol Prog , vol.16 , pp. 724-735
    • Moser, S.1    Schlatter, S.2    Fux, C.3    Rimann, M.4    Bailey, J.E.5    Fussenegger, M.6
  • 73
    • 0035523704 scopus 로고    scopus 로고
    • Dual-regulated expression technology: A new era in the adjustment of heterologous gene expression in mammalian cells
    • Moser S, Rimann M, Fux C, Schlatter S, Bailey JE, Fussenegger M (2001) Dual-regulated expression technology: a new era in the adjustment of heterologous gene expression in mammalian cells. J Gene Med 3:529-549
    • (2001) J Gene Med , vol.3 , pp. 529-549
    • Moser, S.1    Rimann, M.2    Fux, C.3    Schlatter, S.4    Bailey, J.E.5    Fussenegger, M.6
  • 76
    • 0034028901 scopus 로고    scopus 로고
    • Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
    • Niwa H, Miyazaki J, Smith AG (2000) Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 24:372-376
    • (2000) Nat Genet , vol.24 , pp. 372-376
    • Niwa, H.1    Miyazaki, J.2    Smith, A.G.3
  • 77
    • 85047697543 scopus 로고    scopus 로고
    • Ablation of microvessels in vivo upon dimerization of iCaspase-9
    • Nor JE, Hu Y, Song W, Spencer DM, Nunez G (2002) Ablation of microvessels in vivo upon dimerization of iCaspase-9. Gene Ther 9:444-451
    • (2002) Gene Ther , vol.9 , pp. 444-451
    • Nor, J.E.1    Hu, Y.2    Song, W.3    Spencer, D.M.4    Nunez, G.5
  • 80
    • 0037352451 scopus 로고    scopus 로고
    • Improved ecdysone receptor-based inducible gene regulation system
    • Palli SR, Kapitskaya MZ, Kumar MB, Cress DE (2003) Improved ecdysone receptor-based inducible gene regulation system. Eur J Biochem 270:1308-1315
    • (2003) Eur J Biochem , vol.270 , pp. 1308-1315
    • Palli, S.R.1    Kapitskaya, M.Z.2    Kumar, M.B.3    Cress, D.E.4
  • 82
    • 21044449615 scopus 로고    scopus 로고
    • Tight control of transgene expression by lentivirus vectors containing second-generation tetracycline-responsive promoters
    • Pluta K, Luce MJ, Bao L, Agha-Mohammadi S, Reiser J (2005) Tight control of transgene expression by lentivirus vectors containing second-generation tetracycline-responsive promoters. J Gene Med 7:803-817
    • (2005) J Gene Med , vol.7 , pp. 803-817
    • Pluta, K.1    Luce, M.J.2    Bao, L.3    Agha-Mohammadi, S.4    Reiser, J.5
  • 83
    • 0041353611 scopus 로고    scopus 로고
    • RU486-inducible retrovirus-mediated caspase-3 overexpression is cytotoxic to bcl-xLexpressing myeloma cells in vitro and in vivo
    • Pollett JB, Zhu YX, Gandhi S, Bali M, Masih-Khan E, Li Z, Wen XY, Stewart AK (2003) RU486-inducible retrovirus-mediated caspase-3 overexpression is cytotoxic to bcl-xLexpressing myeloma cells in vitro and in vivo. Mol Ther 8:230-237
    • (2003) Mol Ther , vol.8 , pp. 230-237
    • Pollett, J.B.1    Zhu, Y.X.2    Gandhi, S.3    Bali, M.4    Masih-Khan, E.5    Li, Z.6    Wen, X.Y.7    Stewart, A.K.8
  • 84
    • 0036810868 scopus 로고    scopus 로고
    • Dimerizer-regulated gene expression
    • Pollock R, Clackson T (2002) Dimerizer-regulated gene expression. Curr Opin Biotechnol 13:459-467
    • (2002) Curr Opin Biotechnol , vol.13 , pp. 459-467
    • Pollock, R.1    Clackson, T.2
  • 85
    • 0035989652 scopus 로고    scopus 로고
    • Regulation of endogenous gene expression with a small-molecule dimerizer
    • Pollock R, Giel M, Linher K, Clackson T (2002) Regulation of endogenous gene expression with a small-molecule dimerizer. Nat Biotechnol 20:729-733
    • (2002) Nat Biotechnol , vol.20 , pp. 729-733
    • Pollock, R.1    Giel, M.2    Linher, K.3    Clackson, T.4
  • 89
  • 91
    • 0030738524 scopus 로고    scopus 로고
    • Monitoring protein-protein interactions in intact eukaryotic cells by beta-galactosidase complementation
    • Rossi F, Charlton CA, Blau HM (1997) Monitoring protein-protein interactions in intact eukaryotic cells by beta-galactosidase complementation. ProcNatl Acad SciUS A 94:8405-8410
    • (1997) ProcNatl Acad SciUS A , vol.94 , pp. 8405-8410
    • Rossi, F.1    Charlton, C.A.2    Blau, H.M.3
  • 92
    • 0036932835 scopus 로고    scopus 로고
    • Mechanisms leading to sustained reversion of betathalassemia in mice by doxycycline-controlled Epo delivery from muscles
    • Samakoglu S, Bohl D, Heard JM (2002) Mechanisms leading to sustained reversion of betathalassemia in mice by doxycycline-controlled Epo delivery from muscles. Mol Ther 6:793-803
    • (2002) Mol Ther , vol.6 , pp. 793-803
    • Samakoglu, S.1    Bohl, D.2    Heard, J.M.3
  • 93
    • 0037794846 scopus 로고    scopus 로고
    • Novel CNBP-and La-based translation control systems for mammalian cells
    • Schlatter S, Fussenegger M (2003) Novel CNBP-and La-based translation control systems for mammalian cells. Biotechnol Bioeng 81:1-12
    • (2003) Biotechnol Bioeng , vol.81 , pp. 1-12
    • Schlatter, S.1    Fussenegger, M.2
  • 94
    • 0037701245 scopus 로고    scopus 로고
    • Modulation of translation-initiation in CHO-K1 cells by rapamycin-induced heterodimerization of engineered eIF4G fusion proteins
    • Schlatter S, Senn C, Fussenegger M (2003) Modulation of translation-initiation in CHO-K1 cells by rapamycin-induced heterodimerization of engineered eIF4G fusion proteins. Biotechnol Bioeng 83:210-225
    • (2003) Biotechnol Bioeng , vol.83 , pp. 210-225
    • Schlatter, S.1    Senn, C.2    Fussenegger, M.3
  • 95
    • 0025943986 scopus 로고
    • The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B
    • Schmitz ML, Baeuerle PA (1991) The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B. Embo J 10:3805-3817
    • (1991) Embo J , vol.10 , pp. 3805-3817
    • Schmitz, M.L.1    Baeuerle, P.A.2
  • 96
    • 17444408968 scopus 로고    scopus 로고
    • Protein farnesylation: Implications for normal physiology, malignant transformation, and cancer therapy
    • Sebti SM (2005) Protein farnesylation: implications for normal physiology, malignant transformation, and cancer therapy. Cancer Cell 7:297-300
    • (2005) Cancer Cell , vol.7 , pp. 297-300
    • Sebti, S.M.1
  • 105
    • 0035788803 scopus 로고    scopus 로고
    • A complex role for the gamma-butyrolactone SCB1 in regulating antibiotic production in Streptomyces coelicolor A3 (2)
    • Takano E, Chakraburtty R, Nihira T, Yamada Y, Bibb MJ (2001) A complex role for the gamma-butyrolactone SCB1 in regulating antibiotic production in Streptomyces coelicolor A3 (2) . Mol Microbiol 41:1015-1028
    • (2001) Mol Microbiol , vol.41 , pp. 1015-1028
    • Takano, E.1    Chakraburtty, R.2    Nihira, T.3    Yamada, Y.4    Bibb, M.J.5
  • 108
    • 0024024137 scopus 로고
    • Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression
    • Triezenberg SJ, Kingsbury RC, McKnight SL (1988) Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression. Genes Dev 2:718-729
    • (1988) Genes Dev , vol.2 , pp. 718-729
    • Triezenberg, S.J.1    Kingsbury, R.C.2    McKnight, S.L.3
  • 109
    • 0034608802 scopus 로고    scopus 로고
    • Exploring the sequence space for tetracycline-dependent transcriptional activators: Novel mutations yield expanded range and sensitivity
    • Urlinger S, Baron U, Thellmann M, Hasan MT, Bujard H, Hillen W (2000) Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity. Proc Natl Acad Sci U S A 97:7963-7968
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 7963-7968
    • Urlinger, S.1    Baron, U.2    Thellmann, M.3    Hasan, M.T.4    Bujard, H.5    Hillen, W.6
  • 110
    • 22644434444 scopus 로고    scopus 로고
    • Novel gene switches for targeted and timed expression of proteins of interest
    • Vilaboa N, Fenna M, Munson J, Roberts SM, Voellmy R (2005) Novel gene switches for targeted and timed expression of proteins of interest. Mol Ther 12:290-298
    • (2005) Mol Ther , vol.12 , pp. 290-298
    • Vilaboa, N.1    Fenna, M.2    Munson, J.3    Roberts, S.M.4    Voellmy, R.5
  • 111
    • 2942750479 scopus 로고    scopus 로고
    • Modeling the quorum sensing regulatory network of human-pathogenic Pseudomonas aeruginosa
    • Viretta AU, Fussenegger M (2004) Modeling the quorum sensing regulatory network of human-pathogenic Pseudomonas aeruginosa. Biotechnol Prog 20:670-678
    • (2004) Biotechnol Prog , vol.20 , pp. 670-678
    • Viretta, A.U.1    Fussenegger, M.2
  • 113
    • 1942473764 scopus 로고    scopus 로고
    • Rapamycin control of exocrine protein levels in saliva after adenoviral vector-mediated gene transfer
    • Wang J, Voutetakis A, Zheng C, Baum BJ (2004) Rapamycin control of exocrine protein levels in saliva after adenoviral vector-mediated gene transfer. Gene Ther 11:729-733
    • (2004) Gene Ther , vol.11 , pp. 729-733
    • Wang, J.1    Voutetakis, A.2    Zheng, C.3    Baum, B.J.4
  • 114
    • 0037174282 scopus 로고    scopus 로고
    • Artificial mammalian gene regulation networks-novel approaches for gene therapy and bioengineering
    • Weber W, Fussenegger M (2002) Artificial mammalian gene regulation networks-novel approaches for gene therapy and bioengineering. J Biotechnol 98:161-187
    • (2002) J Biotechnol , vol.98 , pp. 161-187
    • Weber, W.1    Fussenegger, M.2
  • 115
    • 4644254892 scopus 로고    scopus 로고
    • Approaches for trigger-inducible viral transgene regulation in gene-based tissue engineering
    • WeberW, Fussenegger M (2004a) Approaches for trigger-inducible viral transgene regulation in gene-based tissue engineering. Curr Opin Biotechnol 15:383-391
    • (2004) Curr Opin Biotechnol , vol.15 , pp. 383-391
    • Weber, W.1    Fussenegger, M.2
  • 116
    • 4644317290 scopus 로고    scopus 로고
    • Inducible gene expression in mammalian cells and mice
    • WeberW, Fussenegger M (2004b) Inducible gene expression in mammalian cells and mice. Methods Mol Biol 267:451-466
    • (2004) Methods Mol Biol , vol.267 , pp. 451-466
    • Weber, W.1    Fussenegger, M.2
  • 118
    • 0037146818 scopus 로고    scopus 로고
    • Versatile macrolide-responsive mammalian expression vectors for multiregulated multigene metabolic engineering
    • Weber W, Marty RR, Keller B, Rimann M, Kramer BP, Fussenegger M (2002b) Versatile macrolide-responsive mammalian expression vectors for multiregulated multigene metabolic engineering. Biotechnol Bioeng 80:691-705
    • (2002) Biotechnol Bioeng , vol.80 , pp. 691-705
    • Weber, W.1    Marty, R.R.2    Keller, B.3    Rimann, M.4    Kramer, B.P.5    Fussenegger, M.6
  • 129
    • 0032500736 scopus 로고    scopus 로고
    • Controlling gene expression in living cells through small molecule-RNA interactions
    • Werstuck G, Green MR (1998) Controlling gene expression in living cells through small molecule-RNA interactions. Science 282:296-298
    • (1998) Science , vol.282 , pp. 296-298
    • Werstuck, G.1    Green, M.R.2
  • 130
    • 0036831235 scopus 로고    scopus 로고
    • Hypothalamic delivery of doxycycline-inducible leptin gene allows for reversible transgene expression and physiological responses
    • Wilsey J, Zolotukhin S, Prima V, Shek EW, Matheny MK, Scarpace PJ (2002) Hypothalamic delivery of doxycycline-inducible leptin gene allows for reversible transgene expression and physiological responses. Gene Ther 9:1492-1499
    • (2002) Gene Ther , vol.9 , pp. 1492-1499
    • Wilsey, J.1    Zolotukhin, S.2    Prima, V.3    Shek, E.W.4    Matheny, M.K.5    Scarpace, P.J.6
  • 131
    • 3242798679 scopus 로고    scopus 로고
    • Use of the radiation-inducible WAF1 promoter to drive iNOS gene therapy as a novel anti-cancer treatment
    • Worthington J, McCarthy HO, Barrett E, Adams C, Robson T, Hirst DG (2004) Use of the radiation-inducible WAF1 promoter to drive iNOS gene therapy as a novel anti-cancer treatment. J Gene Med 6:673-680
    • (2004) J Gene Med , vol.6 , pp. 673-680
    • Worthington, J.1    McCarthy, H.O.2    Barrett, E.3    Adams, C.4    Robson, T.5    Hirst, D.G.6
  • 132
  • 133
    • 0032170171 scopus 로고    scopus 로고
    • Tetracycline repressor, tetR, rather than the tetR-mammalian cell transcription factor fusion derivatives, regulates inducible gene expression in mammalian cells
    • Yao F, Svensjo T,Winkler T, Lu M, Eriksson C, Eriksson E (1998) Tetracycline repressor, tetR, rather than the tetR-mammalian cell transcription factor fusion derivatives, regulates inducible gene expression in mammalian cells. Hum Gene Ther 9:1939-1950
    • (1998) Hum Gene Ther , vol.9 , pp. 1939-1950
    • Yao, F.1    Svensjo, T.2    Winkler, T.3    Lu, M.4    Eriksson, C.5    Eriksson, E.6
  • 135
    • 3142742769 scopus 로고    scopus 로고
    • Optimization of the Tet-on system to regulate interleukin 12 expression in the liver for the treatment of hepatic tumors
    • Zabala M, Wang L, Hernandez-Alcoceba R, Hillen W, Qian C, Prieto J, Kramer MG (2004) Optimization of the Tet-on system to regulate interleukin 12 expression in the liver for the treatment of hepatic tumors. Cancer Res 64:2799-2804
    • (2004) Cancer Res , vol.64 , pp. 2799-2804
    • Zabala, M.1    Wang, L.2    Hernandez-Alcoceba, R.3    Hillen, W.4    Qian, C.5    Prieto, J.6    Kramer, M.G.7
  • 137
    • 0344010997 scopus 로고    scopus 로고
    • A coumermycin/novobiocin-regulated gene expression system
    • Zhao HF, Boyd J, Jolicoeur N, Shen SH (2003) A coumermycin/novobiocin- regulated gene expression system. Hum Gene Ther 14:1619-1629
    • (2003) Hum Gene Ther , vol.14 , pp. 1619-1629
    • Zhao, H.F.1    Boyd, J.2    Jolicoeur, N.3    Shen, S.H.4
  • 138
    • 4444356095 scopus 로고    scopus 로고
    • Vivo selection of genetically modified erythroid cells using a jak2-based cell growth switch
    • Zhao S,Weinreich MA, Ihara K, Richard RE, Blau CA (2004) In vivo selection of genetically modified erythroid cells using a jak2-based cell growth switch. Mol Ther 10:456-468
    • (2004) Mol Ther , vol.10 , pp. 456-468
    • Zhao, S.1    Weinreich, M.A.2    Ihara, K.3    Richard, R.E.4    Blau, C.A.5


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