JAK2, complemented by a second signal from c-kit or fit-3, triggers extensive self-renewal of primary multipotential hemopoietic cells

EMBO Journal

Volumn 21, Issue 9, 2002, Pages 2159-2167

  Zhao, Shengming ^a   Zoller, Karen ^a   Masuko, Masayoshi ^a   Rojnuckarin, Ponlapat ^b   Yang, Xuexian O ^c   Parganas, Evan ^d   Kaushansky, Kenneth ^e   Ihle, James N ^e   Papayannopoulou, Thalia ^f   Willerford, Dennis M ^f   Clackson, Tim ^f   Blau, C Anthony ^f  

^a DIVISION OF REPRODUCTIVE BIOLOGY   (United States)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c RESEARCH AND DEVELOPMENT   (Australia)

^d College of Chemistry and Molecular Engineering ^*  (China)

^e UNIVERSITY OF SHEFFIELD   (United Kingdom)

^f UNIVERSITY OF WASHINGTON   (United States)

Author keywords

JAK2; Leukemia; Self renewal; Stem cell

Indexed keywords

FLT3 LIGAND; JANUS KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; STAT5 PROTEIN; STAT5A PROTEIN; STEM CELL FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL RENEWAL; CONTROLLED STUDY; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; CELL DIFFERENTIATION; CELL DIVISION; CELLS, CULTURED; FMS-LIKE TYROSINE KINASE 3; HEMATOPOIETIC STEM CELLS; JANUS KINASE 2; MICE; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-KIT; RECEPTOR PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION;

EID: 18344393249     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.9.2159     Document Type: Article

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